ATE315571T1 - Kristallines amrubicin-hydrochlorid - Google Patents

Kristallines amrubicin-hydrochlorid

Info

Publication number
ATE315571T1
ATE315571T1 AT98955916T AT98955916T ATE315571T1 AT E315571 T1 ATE315571 T1 AT E315571T1 AT 98955916 T AT98955916 T AT 98955916T AT 98955916 T AT98955916 T AT 98955916T AT E315571 T1 ATE315571 T1 AT E315571T1
Authority
AT
Austria
Prior art keywords
amrubicin hydrochloride
crystalline amrubicin
crystalline
hydrochloride
2theta
Prior art date
Application number
AT98955916T
Other languages
English (en)
Inventor
Kozo Shimago
Yuko Uenishi
Original Assignee
Dainippon Sumitomo Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Sumitomo Pharma Co filed Critical Dainippon Sumitomo Pharma Co
Application granted granted Critical
Publication of ATE315571T1 publication Critical patent/ATE315571T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Metallurgy (AREA)
  • Public Health (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT98955916T 1997-11-28 1998-11-25 Kristallines amrubicin-hydrochlorid ATE315571T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP34385897 1997-11-28

Publications (1)

Publication Number Publication Date
ATE315571T1 true ATE315571T1 (de) 2006-02-15

Family

ID=18364786

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98955916T ATE315571T1 (de) 1997-11-28 1998-11-25 Kristallines amrubicin-hydrochlorid

Country Status (11)

Country Link
US (1) US6376469B1 (de)
EP (1) EP1034181B1 (de)
KR (1) KR100540714B1 (de)
AT (1) ATE315571T1 (de)
AU (1) AU1259899A (de)
CA (1) CA2311486C (de)
DE (1) DE69833220T2 (de)
DK (1) DK1034181T3 (de)
ES (1) ES2253834T3 (de)
TW (1) TW565565B (de)
WO (1) WO1999028331A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003035660A1 (en) * 2001-10-23 2003-05-01 Sumitomo Chemical Company, Limited Stabilization of amrubicin hydrochloride
KR101059715B1 (ko) * 2002-11-29 2011-08-29 다이닛본 스미토모 세이야꾸 가부시끼가이샤 안정화된 안트라사이클린계 화합물의 동결 건조 제제
US20090099346A1 (en) * 2003-07-02 2009-04-16 Victor Matvienko Thermally stable crystalline epirubicin hydrochloride
CN100412084C (zh) * 2003-07-02 2008-08-20 獀洛克斯股份有限公司 热稳定的结晶盐酸表柔比星及其制造方法
US7388083B2 (en) * 2005-03-07 2008-06-17 Solux Corporation Epimerization of 4′-C bond and modification of 14-CH3-(CO)-fragment in anthracyclin antibiotics
RU2450013C2 (ru) * 2005-12-13 2012-05-10 Солюкс Корпорейшен Способ получения 4-деметилдаунорубицина
US8802830B2 (en) * 2005-12-20 2014-08-12 Solux Corporation Synthesis of epirubicin from 13-dihydrodaunorubicine
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
ES2524700T3 (es) 2009-05-27 2014-12-11 Sumitomo Dainippon Pharma Co., Ltd. Formulación estabilizada y liofilizada de compuestos de antraciclina
EP2636676A3 (de) * 2009-09-08 2014-01-01 Heraeus Precious Metals GmbH & Co. KG Kristallisierung von Epidaunorubicin x HCI
DE102011103751A1 (de) 2011-05-31 2012-12-06 Heraeus Precious Metals Gmbh & Co. Kg Kristallisierung von Epirubicinhydrochlorid
WO2019147755A1 (en) * 2018-01-26 2019-08-01 AL Pharma, Inc. Manufacturing and packaging of a sterile drug product

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5976099A (ja) * 1982-10-22 1984-04-28 Sumitomo Chem Co Ltd アミノナフタセン誘導体とその製造方法
JP2603480B2 (ja) * 1987-08-05 1997-04-23 住友製薬株式会社 安定化されたアンスラサイクリン系製剤
JPH10175992A (ja) * 1996-12-16 1998-06-30 Microbial Chem Res Found ４−アミノ−２，４，６−トリデオキシ−２−フルオロ−α−Ｌ−タロピラノシル基を有する新規アンスラサイクリン誘導体
GB9727546D0 (en) * 1997-12-31 1998-03-18 Pharmacia & Upjohn Spa Anthracycline glycosides

Also Published As

Publication number Publication date
AU1259899A (en) 1999-06-16
CA2311486A1 (en) 1999-06-01
DE69833220T2 (de) 2006-07-13
ES2253834T3 (es) 2006-06-01
US6376469B1 (en) 2002-04-23
KR100540714B1 (ko) 2006-01-10
EP1034181B1 (de) 2006-01-11
TW565565B (en) 2003-12-11
EP1034181A2 (de) 2000-09-13
DE69833220D1 (de) 2006-04-06
WO1999028331A2 (en) 1999-06-10
DK1034181T3 (da) 2006-03-20
WO1999028331A3 (en) 1999-07-29
CA2311486C (en) 2008-09-02
KR20010032555A (ko) 2001-04-25

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