ATE317009T1 - Chimäre phagen - Google Patents

Chimäre phagen

Info

Publication number
ATE317009T1
ATE317009T1 AT02743959T AT02743959T ATE317009T1 AT E317009 T1 ATE317009 T1 AT E317009T1 AT 02743959 T AT02743959 T AT 02743959T AT 02743959 T AT02743959 T AT 02743959T AT E317009 T1 ATE317009 T1 AT E317009T1
Authority
AT
Austria
Prior art keywords
phages
protein
phage
helper
coat
Prior art date
Application number
AT02743959T
Other languages
English (en)
Inventor
Erwin Houtzager
Ton Logtenberg
Kruif Cornelis Adriaan De
Original Assignee
Crucell Holland Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP01202304A external-priority patent/EP1266963A1/de
Priority claimed from US09/882,621 external-priority patent/US7070926B2/en
Application filed by Crucell Holland Bv filed Critical Crucell Holland Bv
Application granted granted Critical
Publication of ATE317009T1 publication Critical patent/ATE317009T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Holo Graphy (AREA)
AT02743959T 2001-06-15 2002-06-14 Chimäre phagen ATE317009T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01202304A EP1266963A1 (de) 2001-06-15 2001-06-15 Chimäre Phagen
US09/882,621 US7070926B2 (en) 2001-06-15 2001-06-15 Chimaeric phages

Publications (1)

Publication Number Publication Date
ATE317009T1 true ATE317009T1 (de) 2006-02-15

Family

ID=26076931

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02743959T ATE317009T1 (de) 2001-06-15 2002-06-14 Chimäre phagen

Country Status (10)

Country Link
US (2) US7329530B2 (de)
EP (1) EP1402025B1 (de)
AT (1) ATE317009T1 (de)
AU (1) AU2002345421B2 (de)
CA (1) CA2449071C (de)
DE (1) DE60209010T2 (de)
DK (1) DK1402025T3 (de)
ES (1) ES2257560T3 (de)
NZ (1) NZ529465A (de)
WO (1) WO2002103012A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7070926B2 (en) 2001-06-15 2006-07-04 Crucell Holland B.V. Chimaeric phages
ES2257560T3 (es) 2001-06-15 2006-08-01 Crucell Holland B.V. Fagos quimericos.
AU2002349905A1 (en) * 2001-12-17 2003-06-30 Ribapharm Inc. Nucleoside libraries and compounds by mcc combinatorial strategies on solid support
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
DK2314629T4 (da) 2002-07-18 2023-02-06 Merus Nv Rekombinant produktion af blandinger af antistoffer
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
WO2004106375A1 (en) 2003-05-30 2004-12-09 Merus Biopharmaceuticals B.V. I.O. Fab library for the preparation of anti vegf and anti rabies virus fabs
EP2322547A1 (de) 2003-06-25 2011-05-18 Crucell Holland B.V. Myeloidzellen-spezifisches Lectin
EP2314620B1 (de) 2004-05-27 2013-06-05 Crucell Holland B.V. Verfahren zur Identifikation von Bindungsmoleküle, die zur Neutralisierung des Tollwutvirus fähig sind
JP4852046B2 (ja) * 2004-10-12 2012-01-11 クルセル ホランド ベー ヴェー 癌の治療及び検出に用いる結合分子
US8106170B2 (en) 2004-11-11 2012-01-31 Crucell Holland B.V. Compositions against SARS-coronavirus and uses thereof
CA2591665C (en) 2004-12-20 2015-05-05 Crucell Holland B.V. Binding molecules capable of neutralizing west nile virus and uses thereof
US20060235795A1 (en) * 2005-04-19 2006-10-19 Microsoft Corporation Secure network commercial transactions
WO2006120230A2 (en) 2005-05-12 2006-11-16 Crucell Holland B.V. Host cell specific binding molecules capable of neutralizing viruses and uses thereof
CA2622603C (en) 2005-09-15 2014-06-17 Crucell Holland B.V. Method for preparing immunoglobulin libraries
WO2007064462A1 (en) * 2005-11-29 2007-06-07 The Trustees Of The University Of Pennsylvania Phage particle diagnostic reagents
US8227242B2 (en) * 2005-12-07 2012-07-24 Los Alamos National Security, Llc Plasmids and packaging cell lines for use in phage display
CA2881717C (en) 2006-06-06 2018-06-12 Cecilia Anna Wilhelmina Geuijen Human binding molecules having killing activity against staphylococci and uses thereof
MX2008014978A (es) 2006-06-06 2008-12-09 Crucell Holland Bv Moleculas de union humanas que tienen actividad exterminadora contra enterococos y staphylococcus aureus y usos de las mismas.
SI2059532T1 (sl) 2006-09-07 2013-04-30 Crucell Holland B.V. Humane vezne molekule, ki so zmoĹľne nevtralizirati virus influence H5N1 in njihove uporabe
EP2450377A1 (de) 2006-09-07 2012-05-09 Crucell Holland B.V. Zur Neutralisierung des Influenzavirus H5N1 fähige humane Bindungsmoleküle sowie deren Verwendungen
JP5513398B2 (ja) 2007-11-02 2014-06-04 ザ スクリプス リサーチ インスティチュート 非天然アミノ酸を含有する蛋白質を使用する指向的進化
CA2761648C (en) 2009-05-11 2019-03-12 Crucell Holland B.V. Human binding molecules capable of neutralizing influenza virus h3n2 and uses thereof
US8961978B2 (en) 2011-07-14 2015-02-24 Crucell Holland B.V. Human binding molecules capable of neutralizing influenza A viruses of phylogenetic group 1 and phylogenetic group 2 and influenza B viruses
CA2791109C (en) 2011-09-26 2021-02-16 Merus B.V. Generation of binding molecules
SG11201405226TA (en) 2012-03-08 2014-11-27 Crucell Holland Bv Human binding molecules capable of binding to and neutralizing influenza b viruses and uses thereof
US9248181B2 (en) 2012-04-20 2016-02-02 Merus B.V. Methods and means for the production of Ig-like molecules
WO2017091467A1 (en) * 2015-11-25 2017-06-01 Eli Lilly And Company Phage display vectors and methods of use
US12371817B2 (en) 2019-03-04 2025-07-29 The Texas A&M University System Methods of making and utilizing amber-obligated phage display libraries

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9500851D0 (en) * 1995-01-17 1995-03-08 Bionvent International Ab Method of selecting specific bacteriophages
ES2257560T3 (es) 2001-06-15 2006-08-01 Crucell Holland B.V. Fagos quimericos.
EP1266963A1 (de) 2001-06-15 2002-12-18 Crucell Holland B.V. Chimäre Phagen
US7070926B2 (en) * 2001-06-15 2006-07-04 Crucell Holland B.V. Chimaeric phages

Also Published As

Publication number Publication date
EP1402025A1 (de) 2004-03-31
US7901919B2 (en) 2011-03-08
US7329530B2 (en) 2008-02-12
US20050014261A1 (en) 2005-01-20
CA2449071C (en) 2008-12-16
EP1402025B1 (de) 2006-02-01
AU2002345421B2 (en) 2006-11-16
CA2449071A1 (en) 2002-12-27
NZ529465A (en) 2005-05-27
ES2257560T3 (es) 2006-08-01
WO2002103012A1 (en) 2002-12-27
DK1402025T3 (da) 2006-06-06
DE60209010T2 (de) 2006-09-28
US20090017521A1 (en) 2009-01-15
DE60209010D1 (de) 2006-04-13

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