ATE317265T1 - Peptidnukleinsäure monomere und oligomere - Google Patents
Peptidnukleinsäure monomere und oligomereInfo
- Publication number
- ATE317265T1 ATE317265T1 AT98923764T AT98923764T ATE317265T1 AT E317265 T1 ATE317265 T1 AT E317265T1 AT 98923764 T AT98923764 T AT 98923764T AT 98923764 T AT98923764 T AT 98923764T AT E317265 T1 ATE317265 T1 AT E317265T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- oligomers
- peptide nucleic
- acid monomers
- pna
- Prior art date
Links
- 108091093037 Peptide nucleic acid Proteins 0.000 title abstract 4
- 239000000178 monomer Substances 0.000 title abstract 2
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 abstract 1
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 abstract 1
- 239000000470 constituent Substances 0.000 abstract 1
- 229940104230 thymidine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Polyamides (AREA)
- Quinoline Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/862,629 US6617422B1 (en) | 1997-05-23 | 1997-05-23 | Peptide nucleic acid monomers and oligomers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE317265T1 true ATE317265T1 (de) | 2006-02-15 |
Family
ID=25338899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98923764T ATE317265T1 (de) | 1997-05-23 | 1998-05-22 | Peptidnukleinsäure monomere und oligomere |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6617422B1 (de) |
| EP (1) | EP0988045B1 (de) |
| JP (1) | JP3595345B2 (de) |
| AT (1) | ATE317265T1 (de) |
| AU (1) | AU737528B2 (de) |
| CA (1) | CA2290950A1 (de) |
| DE (1) | DE69833435D1 (de) |
| IL (1) | IL133054A0 (de) |
| NZ (1) | NZ501290A (de) |
| WO (1) | WO1998052595A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1357112A4 (de) * | 2000-12-26 | 2005-08-17 | Applied Biosystems Japan Ltd | Neue funktionelle peptidnukleinsäuremonomere und verfahren zu deren herstellung |
| LT1576138T (lt) | 2002-11-15 | 2017-06-26 | Idenix Pharmaceuticals Llc | 2`-šakoti nukleozidai derinyje su interferonu ir flaviviridae mutacija |
| US8658608B2 (en) * | 2005-11-23 | 2014-02-25 | Yale University | Modified triple-helix forming oligonucleotides for targeted mutagenesis |
| WO2007137430A1 (en) * | 2006-05-31 | 2007-12-06 | The University Of Western Ontario | Preparation of supramolecular polymers containing sequence-selective hydrogen bonding subunits in their backbone which form double helices |
| WO2008086529A2 (en) * | 2007-01-11 | 2008-07-17 | Yale University | Compositions and methods for targeted inactivation of hiv cell surface receptors |
| US20100284959A1 (en) * | 2008-01-23 | 2010-11-11 | Gene Arrest Ltd. | Sequence specific double-stranded dna/rna binding compounds and uses thereof |
| KR20090098710A (ko) * | 2008-03-14 | 2009-09-17 | 주식회사 씨티아이바이오 | 세포투과성과 핵산 결합력이 좋은 펩타이드 핵산 유도체 |
| JP2013075830A (ja) * | 2010-02-03 | 2013-04-25 | Taisho Pharmaceutical Co Ltd | キノリン誘導体 |
| US8673998B2 (en) | 2010-09-22 | 2014-03-18 | Bridgestone Corporation | Polymer compositions with improved cold flow |
| JP2019508037A (ja) | 2016-02-16 | 2019-03-28 | イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔ | 標的化遺伝子編集を増強するための組成物およびその使用方法 |
| WO2018029517A1 (en) * | 2016-08-08 | 2018-02-15 | Olipass Corporation | Androgen receptor antisense oligonucleotides |
| US20190218255A1 (en) * | 2016-09-16 | 2019-07-18 | Olipass Corporation | Scn9a antisense oligonucleotides |
| AU2017385962B2 (en) * | 2016-12-30 | 2021-09-02 | Olipass Corporation | Exon skipping by peptide nucleic acid derivatives |
| TWI769208B (zh) * | 2017-01-06 | 2022-07-01 | 韓商奧利通公司 | Ｓｎａｐ２５反義寡核苷酸 |
| SG11201905601VA (en) | 2017-01-24 | 2019-08-27 | Olipass Corp | Scn9a antisense pain killer |
| WO2018187493A1 (en) | 2017-04-04 | 2018-10-11 | Yale University | Compositions and methods for in utero delivery |
| KR102236495B1 (ko) * | 2017-07-24 | 2021-04-06 | 올리패스 주식회사 | 티로시나아제 안티센스 올리고뉴클레오티드 |
| TWI832851B (zh) * | 2018-05-18 | 2024-02-21 | 韓商奧利通公司 | 基質金屬蛋白酶-1之反義寡核苷酸 |
| KR102304280B1 (ko) | 2018-08-14 | 2021-09-23 | 올리패스 주식회사 | 아세틸코에이카복실라제2 안티센스 올리고뉴클레오티드 |
| CN114502571B (zh) * | 2019-07-18 | 2024-09-13 | 奥利通公司 | 黑素亲和素反义寡核苷酸 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3687808A (en) | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5641625A (en) | 1992-05-22 | 1997-06-24 | Isis Pharmaceuticals, Inc. | Cleaving double-stranded DNA with peptide nucleic acids |
| US5719262A (en) | 1993-11-22 | 1998-02-17 | Buchardt, Deceased; Ole | Peptide nucleic acids having amino acid side chains |
| US6451968B1 (en) | 1991-05-24 | 2002-09-17 | Isis Pharmaceuticals, Inc. | Peptide nucleic acids |
| DK51092D0 (da) | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
| MX9207334A (es) | 1991-12-18 | 1993-08-01 | Glaxo Inc | Acidos nucleicos peptidicos y formulacion farma- ceutica que los contiene |
| GB9211979D0 (en) | 1992-06-05 | 1992-07-15 | Buchard Ole | Uses of nucleic acid analogues |
| US7825215B1 (en) | 1993-04-26 | 2010-11-02 | Peter E. Nielsen | Substituted nucleic acid mimics |
| GB9311386D0 (en) | 1993-06-02 | 1993-07-21 | Pna Diagnostics As | Nucleic acid analogue assay procedures |
| US5502177A (en) | 1993-09-17 | 1996-03-26 | Gilead Sciences, Inc. | Pyrimidine derivatives for labeled binding partners |
| GB2284208A (en) | 1993-11-25 | 1995-05-31 | Pna Diagnostics As | Nucleic acid analogues with a chelating functionality for metal ions |
| GB2284209A (en) | 1993-11-25 | 1995-05-31 | Ole Buchardt | Nucleic acid analogue-induced transcription of RNA from a double-stranded DNA template |
| GB2289677A (en) | 1993-12-06 | 1995-11-29 | Pna Diagnostics As | Labelling of nucleic acid analogue-peptide chimerae |
| GB2285445A (en) | 1993-12-06 | 1995-07-12 | Pna Diagnostics As | Protecting nucleic acids and methods of analysis |
| US5539083A (en) | 1994-02-23 | 1996-07-23 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid combinatorial libraries and improved methods of synthesis |
| DE19504891A1 (de) | 1995-02-14 | 1996-08-22 | Bayerische Motoren Werke Ag | Hubkolbenmaschine, insbesondere Brennkraftmaschine mit hypozykloidischem Kurbelgetriebe |
-
1997
- 1997-05-23 US US08/862,629 patent/US6617422B1/en not_active Expired - Lifetime
-
1998
- 1998-05-22 JP JP55074898A patent/JP3595345B2/ja not_active Expired - Fee Related
- 1998-05-22 DE DE69833435T patent/DE69833435D1/de not_active Expired - Lifetime
- 1998-05-22 NZ NZ501290A patent/NZ501290A/en unknown
- 1998-05-22 EP EP98923764A patent/EP0988045B1/de not_active Expired - Lifetime
- 1998-05-22 WO PCT/US1998/010672 patent/WO1998052595A1/en not_active Ceased
- 1998-05-22 US US09/083,235 patent/US6632919B1/en not_active Expired - Lifetime
- 1998-05-22 AU AU75981/98A patent/AU737528B2/en not_active Ceased
- 1998-05-22 IL IL13305498A patent/IL133054A0/xx unknown
- 1998-05-22 CA CA002290950A patent/CA2290950A1/en not_active Abandoned
- 1998-05-22 AT AT98923764T patent/ATE317265T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU737528B2 (en) | 2001-08-23 |
| WO1998052595A1 (en) | 1998-11-26 |
| EP0988045A1 (de) | 2000-03-29 |
| US6617422B1 (en) | 2003-09-09 |
| NZ501290A (en) | 2002-03-28 |
| EP0988045A4 (de) | 2002-07-24 |
| JP2001500387A (ja) | 2001-01-16 |
| AU7598198A (en) | 1998-12-11 |
| IL133054A0 (en) | 2001-03-19 |
| EP0988045B1 (de) | 2006-02-08 |
| DE69833435D1 (de) | 2006-04-20 |
| US6632919B1 (en) | 2003-10-14 |
| JP3595345B2 (ja) | 2004-12-02 |
| CA2290950A1 (en) | 1998-11-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |