ATE317687T1 - Methode zur herstellung von beschichteten partikeln und diese enthaltende pharmazeutische formulierungen - Google Patents

Methode zur herstellung von beschichteten partikeln und diese enthaltende pharmazeutische formulierungen

Info

Publication number
ATE317687T1
ATE317687T1 AT99967110T AT99967110T ATE317687T1 AT E317687 T1 ATE317687 T1 AT E317687T1 AT 99967110 T AT99967110 T AT 99967110T AT 99967110 T AT99967110 T AT 99967110T AT E317687 T1 ATE317687 T1 AT E317687T1
Authority
AT
Austria
Prior art keywords
controlled
coated
pharmaceutical formulations
formulations containing
coated particles
Prior art date
Application number
AT99967110T
Other languages
English (en)
Inventor
James D Talton
Guenther Hochhaus
Rajiv K Singh
James M Fitz-Gerald
Original Assignee
Univ Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida filed Critical Univ Florida
Application granted granted Critical
Publication of ATE317687T1 publication Critical patent/ATE317687T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C14/00—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
    • C23C14/22—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the process of coating
    • C23C14/223—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the process of coating specially adapted for coating particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C14/00—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
    • C23C14/22—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material characterised by the process of coating
    • C23C14/24—Vacuum evaporation
    • C23C14/28—Vacuum evaporation by wave energy or particle radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Mechanical Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Metallurgy (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT99967110T 1998-11-18 1999-11-18 Methode zur herstellung von beschichteten partikeln und diese enthaltende pharmazeutische formulierungen ATE317687T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10884798P 1998-11-18 1998-11-18
US11029198P 1998-11-30 1998-11-30

Publications (1)

Publication Number Publication Date
ATE317687T1 true ATE317687T1 (de) 2006-03-15

Family

ID=26806343

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99967110T ATE317687T1 (de) 1998-11-18 1999-11-18 Methode zur herstellung von beschichteten partikeln und diese enthaltende pharmazeutische formulierungen

Country Status (19)

Country Link
EP (1) EP1131054B1 (de)
JP (1) JP2003516926A (de)
KR (1) KR20010082309A (de)
CN (1) CN1200693C (de)
AT (1) ATE317687T1 (de)
AU (1) AU757121B2 (de)
BR (1) BR9915462A (de)
CA (1) CA2350894C (de)
CZ (1) CZ300323B6 (de)
DE (1) DE69929904T2 (de)
ES (1) ES2257881T3 (de)
HK (1) HK1043548B (de)
HU (1) HUP0104687A3 (de)
IL (2) IL143234A0 (de)
NO (1) NO20012395L (de)
NZ (1) NZ511689A (de)
PL (1) PL349953A1 (de)
TR (1) TR200101401T2 (de)
WO (1) WO2000028969A2 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6984404B1 (en) 1998-11-18 2006-01-10 University Of Florida Research Foundation, Inc. Methods for preparing coated drug particles and pharmaceutical formulations thereof
AU2005201757B2 (en) * 1999-06-07 2007-04-26 Nanotherapeutics, Inc. Methods for coating particles and particles produced thereby
RU2250764C2 (ru) * 1999-06-07 2005-04-27 Наносфер, Инк. Способ нанесения покрытий на частицы и частицы, полученные этим способом
US6406745B1 (en) 1999-06-07 2002-06-18 Nanosphere, Inc. Methods for coating particles and particles produced thereby
AU2001263242A1 (en) * 2000-05-19 2001-12-03 Ppg Industries Ohio, Inc. Coating compositions having a geometrically ordered array of polymeric particlesand substrates coated therewith
EP2283817B1 (de) * 2000-11-30 2016-05-18 Vectura Limited Herstellungsverfahren für Partikel zur Verwendung in einer Arrzneizusammensetzung
US8580306B2 (en) 2000-11-30 2013-11-12 Vectura Limited Particles for use in a pharmaceutical composition
AU2002232824A1 (en) * 2000-12-21 2002-07-01 Inhale Therapeutic Systems, Inc. Induced phase transition method for the production of microparticles containing hydrophobic active agents
JP2003342196A (ja) * 2002-05-31 2003-12-03 Mukku:Kk 静脈注射用組成物、その製造法およびその製剤
CN1935155A (zh) 2002-08-27 2007-03-28 寺田弘 治疗药
PT1479379E (pt) 2003-05-19 2007-10-23 Euro Celtique Sa ''composições lipossomais secas de pvp-iodo''
US20060251584A1 (en) * 2003-06-11 2006-11-09 Nara Machinery Co., Ltd. Drug nano-particle, method and apparatus for preparing pharmaceutical preparation using the particle
JP2006218346A (ja) * 2005-02-08 2006-08-24 Honda Motor Co Ltd 水素吸着材及びその製造方法
AR065865A1 (es) * 2007-03-30 2009-07-08 Hirofumi Takeuchi Liposoma para la administracion pulmonar para controlar el suministro de la droga
US20090004231A1 (en) 2007-06-30 2009-01-01 Popp Shane M Pharmaceutical dosage forms fabricated with nanomaterials for quality monitoring
EP2211841A4 (de) * 2007-10-15 2013-03-13 Cooperative Res Ct For Asthma Verfahren zur prophylaxe und mittel zur verwendung darin
WO2009118034A1 (de) * 2008-03-27 2009-10-01 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur herstellung eines mehrkomponentigen, polymer- und metallhaltigen schichtsystems, vorrichtung und beschichteter gegenstand
US20110104282A1 (en) * 2008-04-25 2011-05-05 Karolinska Institutet Innovations Ab New Therapy of Treatment of the Irritable Bowel Syndrome
GB0814302D0 (en) 2008-08-05 2008-10-01 Coretherapix Slu Compounds and methods
EP2334290A4 (de) * 2008-10-15 2012-10-03 Lifecare Innovations Pvt Ltd Arzneiabgabesystem für econazol, moxifloxacin und rifampicin
JPWO2010058840A1 (ja) * 2008-11-20 2012-04-19 テルモ株式会社 リポソームからの薬物放出手段および放出性評価法
SE535381C2 (sv) 2010-02-24 2012-07-17 Plasmadvance Ab Plasmasputtringsprocess för att producera partiklar
KR102170339B1 (ko) * 2011-10-14 2020-10-27 디에스엠 아이피 어셋츠 비.브이. 신규 코팅 시스템
JP6334214B2 (ja) * 2013-03-08 2018-05-30 学校法人慶應義塾 レーザーを用いた薬剤放出方法
CA3136305A1 (en) 2019-04-08 2020-10-15 R.P. Scherer Technologies, Llc Analytical method for determining the total amount of a coating polymer in a dosage form
JP7756097B2 (ja) * 2020-02-19 2025-10-17 ナノ ファーマソリューションズ， インコーポレイテッド 治療剤ナノ粒子および調製方法
EP4687852A1 (de) * 2023-04-06 2026-02-11 Applied Materials, Inc. Pharmazeutische zusammensetzungen mit verbesserter auflösung
KR20260112101A (ko) 2023-08-17 2026-07-16 씨오2인 파르티시파코에스 엘티디에이. 표적 물질로부터의 원자들의 제어된 방출 및 분말 기재 물질 상으로의 후속적인 증착을 통한 분말 물질 제조 방법
CN121102547B (zh) * 2025-11-17 2026-04-28 厦门市兴泉医药科技有限公司 一种智能变色的可吸收缝合线及其制备方法

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US4200669A (en) * 1978-11-22 1980-04-29 The United States Of America As Represented By The Secretary Of The Navy Laser spraying
US4623588A (en) * 1984-02-06 1986-11-18 Biotek, Inc. Controlled release composite core coated microparticles
DE3541999A1 (de) * 1985-11-28 1987-06-04 Bbc Brown Boveri & Cie Verfahren und vorrichtung zur beschichtung von flaechen
WO1990002546A1 (en) * 1988-09-09 1990-03-22 The Ronald T. Dodge Company Pharmaceuticals microencapsulated by vapor deposited polymers and method
DE4239244A1 (de) * 1992-11-21 1994-05-26 Basf Ag Retard-Form für pharmazeutische Wirkstoffe
US6025036A (en) * 1997-05-28 2000-02-15 The United States Of America As Represented By The Secretary Of The Navy Method of producing a film coating by matrix assisted pulsed laser deposition
AU6472798A (en) * 1998-03-19 1999-10-11 University Of Florida Process for depositing atomic to nanometer particle coatings on host particles

Also Published As

Publication number Publication date
NO20012395D0 (no) 2001-05-15
PL349953A1 (en) 2002-10-21
CZ300323B6 (cs) 2009-04-22
TR200101401T2 (tr) 2001-11-21
NO20012395L (no) 2001-07-16
NZ511689A (en) 2003-03-28
HK1043548B (zh) 2006-01-06
WO2000028969A2 (en) 2000-05-25
IL143234A0 (en) 2002-04-21
DE69929904T2 (de) 2006-08-31
EP1131054A2 (de) 2001-09-12
HK1043548A1 (en) 2002-09-20
CZ20011747A3 (cs) 2001-10-17
CN1200693C (zh) 2005-05-11
BR9915462A (pt) 2001-12-11
HUP0104687A3 (en) 2006-07-28
KR20010082309A (ko) 2001-08-29
IL143234A (en) 2007-05-15
ES2257881T3 (es) 2006-08-01
WO2000028969A3 (en) 2000-11-09
AU2345700A (en) 2000-06-05
CA2350894C (en) 2009-01-27
HUP0104687A2 (en) 2002-06-29
EP1131054B1 (de) 2006-02-15
CN1348361A (zh) 2002-05-08
CA2350894A1 (en) 2000-05-25
JP2003516926A (ja) 2003-05-20
AU757121B2 (en) 2003-02-06
DE69929904D1 (de) 2006-04-20

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