ATE317701T1 - Diphtheria toxin impfstoffe mit mutierter r domäne - Google Patents

Diphtheria toxin impfstoffe mit mutierter r domäne

Info

Publication number
ATE317701T1
ATE317701T1 AT95921528T AT95921528T ATE317701T1 AT E317701 T1 ATE317701 T1 AT E317701T1 AT 95921528 T AT95921528 T AT 95921528T AT 95921528 T AT95921528 T AT 95921528T AT E317701 T1 ATE317701 T1 AT E317701T1
Authority
AT
Austria
Prior art keywords
mutant
diphtheria toxin
domain
vaccines
toxin vaccines
Prior art date
Application number
AT95921528T
Other languages
English (en)
Inventor
R John Collier
Wei Hai Shen
David Eisenberg
Seunghyon Choe
Original Assignee
Harvard College
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Univ California filed Critical Harvard College
Application granted granted Critical
Publication of ATE317701T1 publication Critical patent/ATE317701T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
AT95921528T 1994-06-08 1995-05-31 Diphtheria toxin impfstoffe mit mutierter r domäne ATE317701T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/257,781 US5917017A (en) 1994-06-08 1994-06-08 Diphtheria toxin vaccines bearing a mutated R domain

Publications (1)

Publication Number Publication Date
ATE317701T1 true ATE317701T1 (de) 2006-03-15

Family

ID=22977726

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95921528T ATE317701T1 (de) 1994-06-08 1995-05-31 Diphtheria toxin impfstoffe mit mutierter r domäne

Country Status (10)

Country Link
US (1) US5917017A (de)
EP (1) EP0762892B1 (de)
JP (1) JP3755773B2 (de)
AT (1) ATE317701T1 (de)
CA (1) CA2191239A1 (de)
DE (1) DE69534786T2 (de)
DK (1) DK0762892T3 (de)
ES (1) ES2258768T3 (de)
PT (1) PT762892E (de)
WO (1) WO1995033481A1 (de)

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US7288254B2 (en) 1995-10-30 2007-10-30 The United States Of America As Represented By The Secretary, Department Of Health And Human Services, Nih Use of immunotoxins to induce immune tolerance to pancreatic islet transplantation
US7696338B2 (en) 1995-10-30 2010-04-13 The United States Of America As Represented By The Department Of Health And Human Services Immunotoxin fusion proteins and means for expression thereof
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Also Published As

Publication number Publication date
JP3755773B2 (ja) 2006-03-15
US5917017A (en) 1999-06-29
EP0762892A1 (de) 1997-03-19
ES2258768T3 (es) 2006-09-01
DE69534786D1 (de) 2006-04-20
DE69534786T2 (de) 2006-11-09
CA2191239A1 (en) 1995-12-14
EP0762892A4 (de) 1999-06-02
WO1995033481A1 (en) 1995-12-14
PT762892E (pt) 2006-07-31
DK0762892T3 (da) 2006-06-19
EP0762892B1 (de) 2006-02-15
JPH10502523A (ja) 1998-03-10

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