ATE318896T1 - Rekombinante rna-replikase von hepatitis-c-virus - Google Patents

Rekombinante rna-replikase von hepatitis-c-virus

Info

Publication number: ATE318896T1
Authority: AT; Austria
Prior art keywords: hcv; rdrp; hepatitis; virus; vitro
Prior art date: 1995-09-27

Application number

AT96933178T

Other languages

German (de)

English (en)

Inventor

Curt H Hagedorn

Reinoldus H Al

Original Assignee

Univ Emory

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-09-27

Filing date

1996-09-27

Publication date

2006-03-15

1996-09-27 Application filed by Univ Emory filed Critical Univ Emory

2006-03-15 Application granted granted Critical

2006-03-15 Publication of ATE318896T1 publication Critical patent/ATE318896T1/de

Links

241000711549 Hepacivirus C Species 0.000 title abstract 2
108060004795 Methyltransferase Proteins 0.000 title abstract 2
238000000034 method Methods 0.000 abstract 3
150000001413 amino acids Chemical class 0.000 abstract 2
238000000338 in vitro Methods 0.000 abstract 2
238000001727 in vivo Methods 0.000 abstract 2
239000003112 inhibitor Substances 0.000 abstract 2
108090000790 Enzymes Proteins 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
239000013592 cell lysate Substances 0.000 abstract 1
210000004962 mammalian cell Anatomy 0.000 abstract 1
238000012216 screening Methods 0.000 abstract 1
210000002966 serum Anatomy 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
- C12N9/127—RNA-directed RNA polymerase (2.7.7.48), i.e. RNA replicase

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Enzymes And Modification Thereof (AREA)
Peptides Or Proteins (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT96933178T 1995-09-27 1996-09-27 Rekombinante rna-replikase von hepatitis-c-virus ATE318896T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US438395P	1995-09-27	1995-09-27

Publications (1)

Publication Number	Publication Date
ATE318896T1 true ATE318896T1 (de)	2006-03-15

Family

ID=21710540

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96933178T ATE318896T1 (de)	1995-09-27	1996-09-27	Rekombinante rna-replikase von hepatitis-c-virus

Country Status (8)

Country	Link
US (2)	US5981247A (2)
EP (1)	EP0859833B1 (2)
JP (1)	JP4191797B2 (2)
AT (1)	ATE318896T1 (2)
AU (1)	AU719122B2 (2)
CA (1)	CA2233309A1 (2)
DE (1)	DE69635864T2 (2)
WO (1)	WO1997012033A1 (2)

Families Citing this family (54)

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AU2002330154A1 (en)	2001-09-28	2003-04-07	Centre National De La Recherche Scientifique	Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides
KR100447578B1 (ko) *	2001-11-01	2004-09-07	주식회사 이매진	Ｈｃｖ 자가 복제 효소 활성의 세포내 측정용 키트 및측정 방법
WO2003044168A2 (en) *	2001-11-16	2003-05-30	University Of Massachusetts	Facilitation of rna interference
BR0312271A (pt)	2002-06-28	2007-11-06	Idenix Cayman Ltd	compostos, composições e seus usos para o tratamento de infecções por flaviviridae
US7608600B2 (en)	2002-06-28	2009-10-27	Idenix Pharmaceuticals, Inc.	Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
HUE033832T2 (en)	2002-11-15	2018-01-29	Idenix Pharmaceuticals Llc	2'-methyl nucleosides in combination with interferon and Flaviviridae mutation
EP2345657A1 (en)	2003-05-30	2011-07-20	Pharmasset, Inc.	Modified fluorinated nucleoside analogues
EP1658302B1 (en)	2003-07-25	2010-08-25	IDENIX Pharmaceuticals, Inc.	Purine nucleoside analogues for treating diseases caused by flaviviridae including hepatitis c
WO2005070957A1 (en) *	2004-01-09	2005-08-04	Merck & Co., Inc.	Hcv rna-dependent rna polymerase
WO2006121468A1 (en)	2004-11-22	2006-11-16	Genelabs Technologies, Inc.	5-nitro-nucleoside compounds for treating viral infections
HRP20070436A2 (hr)	2005-02-28	2008-02-29	Genelabs Technologies	Triciklički nukleozidni predlijekovi za liječenjevirusnih infekcija
AR056327A1 (es)	2005-04-25	2007-10-03	Genelabs Tech Inc	Compuestos de nucleosidos para el tratamiento de infecciones virales
US7964580B2 (en)	2007-03-30	2011-06-21	Pharmasset, Inc.	Nucleoside phosphoramidate prodrugs
US20090318380A1 (en)	2007-11-20	2009-12-24	Pharmasset, Inc.	2',4'-substituted nucleosides as antiviral agents
KR20110065440A (ko)	2008-07-02	2011-06-15	아이데닉스 파마슈티칼스, 인코포레이티드	바이러스 감염의 치료를 위한 화합물 및 제약 조성물
EP2166016A1 (en)	2008-09-18	2010-03-24	Centocor Ortho Biotech Products L.P.	Phosphoramidate Derivatives of Nucleosides
PT2376088T (pt)	2008-12-23	2017-05-02	Gilead Pharmasset Llc	Fosforamidatos de nucleósidos de 2-amino-purina 6-osubstituída
KR20110098849A (ko)	2008-12-23	2011-09-01	파마셋 인코포레이티드	뉴클레오시드 유사체
SG194404A1 (en)	2008-12-23	2013-11-29	Gilead Pharmasset Llc	Synthesis of purine nucleosides
US8618076B2 (en)	2009-05-20	2013-12-31	Gilead Pharmasset Llc	Nucleoside phosphoramidates
TWI598358B (zh)	2009-05-20	2017-09-11	基利法瑪席特有限責任公司	核苷磷醯胺
WO2011023801A1 (en)	2009-08-31	2011-03-03	F. Hoffmann-La Roche Ag	Hcv ns3/4a replicon shuttle vectors
MX2012005528A (es)	2009-11-14	2012-06-12	Hoffmann La Roche	Biomarcadores para pronosticar rapida respuesta a tratamiento hcv.
MX2012005703A (es)	2009-12-02	2012-06-12	Hoffmann La Roche	Biomarcadores para pronosticar una respuesta prolongada al tratamiento contra el vhc.
US20110245328A1 (en)	2010-03-31	2011-10-06	Hyunsoon Kang	HCV NS5A Replicon Shuttle Vectors
PT2609923T (pt)	2010-03-31	2017-08-30	Gilead Pharmasset Llc	Processo para a cristalização de 2-(((s)- (perfluorofenoxi)(fenoxi)fosforil)amino)propanoato de (s)-isopropilo
UY33312A (es)	2010-03-31	2011-10-31	Pharmasset Inc	Fosforamidato de nucleosido de purina
MX2012011222A (es)	2010-04-01	2013-01-18	Centre Nat Rech Scient	Compuestos y composiciones farmaceuticas para el tratamiento de infecciones virales.
AR082453A1 (es)	2010-04-21	2012-12-12	Novartis Ag	Compuestos de furopiridina, composiciones farmaceuticas que los contienen y usos de los mismos
EP2595983A1 (en)	2010-07-22	2013-05-29	Novartis AG	2,3,5-trisubstituted thiophene compounds and uses thereof
AU2011336632B2 (en)	2010-11-30	2015-09-03	Gilead Pharmasset Llc	Compounds
US9351989B2 (en)	2010-12-29	2016-05-31	Inhibitex, Inc.	Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections
EP2691409B1 (en)	2011-03-31	2018-02-21	Idenix Pharmaceuticals LLC.	Compounds and pharmaceutical compositions for the treatment of viral infections
TW201329096A (zh)	2011-09-12	2013-07-16	Idenix Pharmaceuticals Inc	經取代羰氧基甲基磷酸醯胺化合物及用於治療病毒感染之藥學組成物
EP2755985B1 (en)	2011-09-12	2017-11-01	Idenix Pharmaceuticals LLC	Compounds and pharmaceutical compositions for the treatment of viral infections
US8507460B2 (en)	2011-10-14	2013-08-13	Idenix Pharmaceuticals, Inc.	Substituted 3′,5′-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections
US8889159B2 (en)	2011-11-29	2014-11-18	Gilead Pharmasset Llc	Compositions and methods for treating hepatitis C virus
EA201690473A1 (ru)	2013-08-27	2017-03-31	ГАЙЛИД ФАРМАССЕТ ЭлЭлСи	Комбинированный состав двух противовирусных соединений

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US5683864A (en) *	1987-11-18	1997-11-04	Chiron Corporation	Combinations of hepatitis C virus (HCV) antigens for use in immunoassays for anti-HCV antibodies
US5350671A (en) *	1987-11-18	1994-09-27	Chiron Corporation	HCV immunoassays employing C domain antigens
US5726155A (en) *	1993-08-02	1998-03-10	The Scripps Research Institute	Regulation of oxidative burst using LMWG-derived peptides and analogs
IT1278077B1 (it) *	1995-05-25	1997-11-17	Angeletti P Ist Richerche Bio	Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal

1996
- 1996-09-27 EP EP96933178A patent/EP0859833B1/en not_active Expired - Lifetime
- 1996-09-27 AU AU72007/96A patent/AU719122B2/en not_active Ceased
- 1996-09-27 AT AT96933178T patent/ATE318896T1/de not_active IP Right Cessation
- 1996-09-27 CA CA002233309A patent/CA2233309A1/en not_active Abandoned
- 1996-09-27 WO PCT/US1996/015571 patent/WO1997012033A1/en not_active Ceased
- 1996-09-27 US US08/722,806 patent/US5981247A/en not_active Expired - Lifetime
- 1996-09-27 DE DE69635864T patent/DE69635864T2/de not_active Expired - Fee Related
- 1996-09-27 JP JP51370797A patent/JP4191797B2/ja not_active Expired - Fee Related
1999
- 1999-06-25 US US09/337,028 patent/US6248589B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPH11514862A (ja)	1999-12-21
US5981247A (en)	1999-11-09
US6248589B1 (en)	2001-06-19
EP0859833A4 (en)	2001-03-28
DE69635864D1 (de)	2006-04-27
CA2233309A1 (en)	1997-04-03
AU7200796A (en)	1997-04-17
DE69635864T2 (de)	2006-10-26
WO1997012033A1 (en)	1997-04-03
AU719122B2 (en)	2000-05-04
EP0859833A1 (en)	1998-08-26
EP0859833B1 (en)	2006-03-01
JP4191797B2 (ja)	2008-12-03

Legal Events

Date	Code	Title	Description
2006-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69635864D1 (de)	2006-04-27	Rekombinante rna-replikase von hepatitis-c-virus
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Wirth et al.	1977	How a single Sindbis virus mRNA directs the synthesis of one soluble protein and two integral membrane glycoproteins
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LU91237I2 (fr)	2007-02-22	Palifermin et ses dérivés pharmaceutiquement acceptables (kepivance)
HUP0202882A2 (en)	2002-12-28	Novel b7-4 molecules and uses therefor
AP1678A (en)	2006-11-27	Novel modified nucleic acid sequences and methods for increasing mRNA levels and protein expression in cell systems.
DK1187852T3 (da)	2007-11-26	Ekspression og eksport af interferon-alpha-proteiner som Fc-fusionsproteiner
EP1026240A3 (en)	2004-04-07	Generation and selection of recombinant varied binding proteins
ATE366814T1 (de)	2007-08-15	Gl50 moleküle, sowie verwendungen derselben
UA48936C2 (uk)	2002-09-16	Спосіб одержання вірусу курячої анемії (cav) у дволанцюговій формі, рекомбінантна нуклеїнова кислота (варіанти), діагностичний набір (варіанти), вакцинний препарат (варіанти), культура клітин (варіанти), спосіб одержання діагностичного набору (варіанти)
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AP2368A (en)	2012-02-27	Novel expression vectors and uses thereof.
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