ATE318905T1 - Homologe des tie-rezeptortyrosinekinase liganden - Google Patents

Homologe des tie-rezeptortyrosinekinase liganden

Info

Publication number
ATE318905T1
ATE318905T1 AT98946988T AT98946988T ATE318905T1 AT E318905 T1 ATE318905 T1 AT E318905T1 AT 98946988 T AT98946988 T AT 98946988T AT 98946988 T AT98946988 T AT 98946988T AT E318905 T1 ATE318905 T1 AT E318905T1
Authority
AT
Austria
Prior art keywords
homologue
ligand
tie receptor
nucleic acid
tyrosinekinase
Prior art date
Application number
AT98946988T
Other languages
English (en)
Inventor
Sherman Fong
Napoleone Ferrara
Audrey Goddard
Paul J Godowski
Austin L Gurney
Kenneth Hillan
P Mickey Williams
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE318905T1 publication Critical patent/ATE318905T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT98946988T 1997-09-19 1998-09-14 Homologe des tie-rezeptortyrosinekinase liganden ATE318905T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/934,494 US6030831A (en) 1997-09-19 1997-09-19 Tie ligand homologues

Publications (1)

Publication Number Publication Date
ATE318905T1 true ATE318905T1 (de) 2006-03-15

Family

ID=25465645

Family Applications (3)

Application Number Title Priority Date Filing Date
AT04012204T ATE435912T1 (de) 1997-09-19 1998-09-14 Homolog nl6 des tie rezeptor tyrosinekinase liganden
AT04012203T ATE329028T1 (de) 1997-09-19 1998-09-14 Nl3 tie rezeptortyrosinekinase ligandhomologe
AT98946988T ATE318905T1 (de) 1997-09-19 1998-09-14 Homologe des tie-rezeptortyrosinekinase liganden

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT04012204T ATE435912T1 (de) 1997-09-19 1998-09-14 Homolog nl6 des tie rezeptor tyrosinekinase liganden
AT04012203T ATE329028T1 (de) 1997-09-19 1998-09-14 Nl3 tie rezeptortyrosinekinase ligandhomologe

Country Status (16)

Country Link
US (3) US6030831A (de)
EP (3) EP1015586B1 (de)
JP (3) JP3668795B2 (de)
KR (3) KR100467186B1 (de)
AT (3) ATE435912T1 (de)
AU (1) AU744285B2 (de)
CA (1) CA2304810C (de)
CY (1) CY1105248T1 (de)
DE (3) DE69834852T2 (de)
DK (3) DK1015586T3 (de)
ES (2) ES2268538T3 (de)
IL (3) IL134647A0 (de)
NZ (1) NZ502945A (de)
PT (2) PT1482040E (de)
WO (1) WO1999015654A2 (de)
ZA (1) ZA988392B (de)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001005972A1 (en) * 1999-07-20 2001-01-25 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US6057435A (en) * 1997-09-19 2000-05-02 Genentech, Inc. Tie ligand homologues
US7169906B2 (en) 1997-09-17 2007-01-30 Genentech, Inc. PRO211 polypeptides
US20030049676A1 (en) * 1997-09-17 2003-03-13 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6974689B1 (en) 1997-09-18 2005-12-13 Genentech, Inc. Nucleic acid encoding PRO211 polypeptides
US6030831A (en) * 1997-09-19 2000-02-29 Genetech, Inc. Tie ligand homologues
AU1931599A (en) * 1997-12-19 1999-07-12 Zymogenetics Inc. Angiopoietin homolog, dna encoding it, and method of making it
US6706869B1 (en) * 1998-02-11 2004-03-16 Wyeth Map kinase phosphatases and polynucleotides encoding them
US20030099994A1 (en) * 1998-03-02 2003-05-29 Millennium Pharamceuticals, Inc. Novel FDRG protein and nucleic acid molecules and uses therefor
CA2322425A1 (en) * 1998-03-02 1999-09-10 Millennium Pharmaceuticals, Inc. Novel fdrg protein and nucleic acid molecules and uses therefor
WO1999055869A1 (en) * 1998-04-27 1999-11-04 Zymogenetics, Inc. Novel polypeptide growth factors and materials and methods for making them
SV1999000069A (es) * 1998-06-02 2000-04-11 Lilly Co Eli Angiopoyetina relacionada con secuencia del gen 3 en la cicatrizacion de la cara ref. x-12261
WO1999067382A2 (en) * 1998-06-24 1999-12-29 Compugen Ltd. Angiopoietin-like growth factor sequences
US7488590B2 (en) * 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
ES2327785T3 (es) * 1998-12-22 2009-11-03 Genentech, Inc. Procedimientos y compuestos para inhibir el crecimiento de celulas neoplasticas.
KR20010104373A (ko) * 1999-03-08 2001-11-24 제넨테크, 인크. 혈관신생 및 심혈관형성의 촉진 또는 억제 방법
DK1623990T3 (da) * 1999-03-08 2008-04-07 Genentech Inc Sammensætninger og fremgangsmåder til tumorbehandling
ES2223705T3 (es) 1999-04-28 2005-03-01 Board Of Regents, The University Of Texas System Composiciones y metodos para el tratamiento de cancer mediante inhibi cion selectiva del vegf.
US6703020B1 (en) 1999-04-28 2004-03-09 Board Of Regents, The University Of Texas System Antibody conjugate methods for selectively inhibiting VEGF
WO2001002429A2 (en) * 1999-07-02 2001-01-11 Bayer Aktiengesellschaft Angiopoietin-6 and uses thereof
EP1210363A2 (de) * 1999-07-16 2002-06-05 Hyseq, Inc. Nukleinsäuresequenzen, die für putative angiopoietine codieren
EP1484401A1 (de) * 1999-07-20 2004-12-08 Curagen Corporation Sekretionspolypeptiden und übereinstimmende Polynukleotiden
WO2001005971A2 (en) * 1999-07-20 2001-01-25 Curagen Corporation Secreted polypeptides and corresponding polynucleotides
US7001766B2 (en) * 1999-07-20 2006-02-21 Curagen Corporation Nucleic acid sequences encoding human angiopoietin-like polypeptides
CN1433482A (zh) * 1999-12-09 2003-07-30 三共株式会社 高脂血症的治疗或预防剂的检验方法
WO2001072339A2 (en) * 2000-03-30 2001-10-04 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of treatment of conditions involving obstruction of blood flow
US20060073549A1 (en) * 2000-09-05 2006-04-06 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
EP1341771A2 (de) * 2000-11-29 2003-09-10 Glaxo Group Limited Benzimidazolderivate und ihre verwendung als tie-2 und/oder vegfr-2 hemmer
US7658924B2 (en) * 2001-10-11 2010-02-09 Amgen Inc. Angiopoietin-2 specific binding agents
US7521053B2 (en) * 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
US7138370B2 (en) * 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
US7205275B2 (en) * 2001-10-11 2007-04-17 Amgen Inc. Methods of treatment using specific binding agents of human angiopoietin-2
AU2002365261A1 (en) * 2001-10-18 2003-09-02 The Children's Hospital Of Philadelphia Methods and materials for the recruitment of endothelial cells
US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US20040067882A1 (en) * 2001-10-22 2004-04-08 Alsobrook John P. Therapeutic polypeptides, nucleic acids encoding same, and methods of use
EP1451578B1 (de) * 2001-11-16 2013-08-21 Genentech, Inc. Verwendung von angptl3 antagonisten zur behandlung von entzündlichen lebererkrankungen
AU2002359464A1 (en) * 2001-11-30 2003-06-17 Genvec, Inc. Angiopioetin related factors
US20090181092A1 (en) * 2004-07-16 2009-07-16 Spinal Restoration, Inc. Methods for Treating Joints and Discs with a Carrier Matrix and Cells
US8604185B2 (en) 2004-07-20 2013-12-10 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
GB0423554D0 (en) * 2004-10-22 2004-11-24 Cancer Rec Tech Ltd Therapeutic compounds
US20080119367A1 (en) * 2004-12-17 2008-05-22 Mayo Foundation For Medical Education And Research Prognosis of Renal Cell Carcinoma
GB0428082D0 (en) * 2004-12-22 2005-01-26 Welcome Trust The Ltd Therapeutic compounds
US7951819B2 (en) 2006-04-26 2011-05-31 Cancer Research Technology Limited Imidazo[4, 5-B]pyridin-2-one and oxazolo[4, 5-B] pyridin-2-one compounds and analogs thereof as cancer therapeutic compounds
CN101855241B (zh) * 2006-12-08 2013-11-06 莱克康制药公司 针对angptl3的单克隆抗体
UA105763C2 (uk) * 2007-12-19 2014-06-25 Кансер Рісерч Текнолоджі Лімітед 8-ЗАМІЩЕНІ ПІРИДО[2,3-b]ПІРАЗИНИ ТА ЇХ ЗАСТОСУВАННЯ
JO2913B1 (en) 2008-02-20 2015-09-15 امجين إنك, Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses
GB0807609D0 (en) * 2008-04-25 2008-06-04 Cancer Rec Tech Ltd Therapeutic compounds and their use
NZ706154A (en) 2010-02-01 2016-09-30 Cancer Rec Tech Ltd 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy
JO3412B1 (ar) 2011-06-17 2019-10-20 Regeneron Pharma أجسام مضادة ل angptl3 واستخداماتها
UY35368A (es) * 2013-03-08 2014-10-31 Irm Llc Péptidos y composiciones para el tratamiento de daño articular
US9301971B2 (en) 2013-03-08 2016-04-05 Novartis Ag Peptides and compositions for treatment of joint damage
GB201320732D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Methods of chemical synthesis
GB201320729D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Therapeutic compounds and their use
PT3177642T (pt) 2014-08-07 2022-02-14 Novartis Ag Anticorpos semelhantes a angiopoietina 4 e métodos de uso
WO2016020882A2 (en) 2014-08-07 2016-02-11 Novartis Ag Angiopoetin-like 4 (angptl4) antibodies and methods of use
KR102456731B1 (ko) 2016-03-03 2022-10-24 리제너론 파아마슈티컬스, 인크. Pcsk9 억제제를 angptl3 억제제와 병용하여 투여함으로써 고지혈증을 갖는 환자를 치료하기 위한 방법
AR116566A1 (es) 2018-10-03 2021-05-19 Novartis Ag Administración sostenida de polipéptidos similares a la angiopoyetina 3
US12559551B2 (en) 2019-05-24 2026-02-24 Regeneron Pharmaceuticals, Inc. Stabilized formulations containing anti-ANGPTL3 antibodies

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229495A (en) * 1991-06-18 1993-07-20 Ludwig Institute For Cancer Research Substantially pure receptor like TGF-β 1 binding molecules and uses thereof
US5955291A (en) * 1992-01-09 1999-09-21 Alitalo; Kari Antibodies recognizing tie receptor tyrosine kinase and uses thereof
AU3353293A (en) * 1992-01-09 1993-08-03 Helsinki University Holding, Ltd. Tie, a novel endothelial cell receptor tyrosine kinase
AU4651893A (en) * 1992-06-26 1994-01-24 Immunex Corporation Novel tyrosine kinase
WO1995013387A1 (en) * 1993-11-12 1995-05-18 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Tie-2, a novel receptor tyrosine kinase
US5643755A (en) * 1994-10-07 1997-07-01 Regeneron Pharmaceuticals Inc. Nucleic acid encoding tie-2 ligand
AUPM379494A0 (en) * 1994-02-10 1994-03-03 Ludwig Institute For Cancer Research Immunointeractive molecules - ii
AU701568B2 (en) * 1994-09-22 1999-02-04 Licentia Ltd Promoter for the receptor tyrosine kinase, tie
US5814464A (en) * 1994-10-07 1998-09-29 Regeneron Pharma Nucleic acids encoding TIE-2 ligand-2
US5650490A (en) * 1994-10-07 1997-07-22 Regeneron Pharmaceuticals, Inc. Tie-2 ligand 2
EP0821728B1 (de) * 1995-04-06 2004-08-11 Regeneron Pharmaceuticals, Inc. Tie-2 liganden, herstellungsverfahren und verwendung
AU724467B2 (en) * 1996-06-19 2000-09-21 Regeneron Pharmaceuticals, Inc. TIE-2 receptor ligand (TIE ligand-4) and its uses
US6265564B1 (en) * 1996-08-02 2001-07-24 Regeneron Pharmaceuticals, Inc. Expressed ligand-vascular intercellular signalling molecule
US5972338A (en) * 1997-09-19 1999-10-26 Genentech, Inc. Tie ligands homologues
US6030831A (en) * 1997-09-19 2000-02-29 Genetech, Inc. Tie ligand homologues
WO1999055869A1 (en) * 1998-04-27 1999-11-04 Zymogenetics, Inc. Novel polypeptide growth factors and materials and methods for making them
SV1999000069A (es) * 1998-06-02 2000-04-11 Lilly Co Eli Angiopoyetina relacionada con secuencia del gen 3 en la cicatrizacion de la cara ref. x-12261
WO1999067382A2 (en) * 1998-06-24 1999-12-29 Compugen Ltd. Angiopoietin-like growth factor sequences

Also Published As

Publication number Publication date
EP1482040A2 (de) 2004-12-01
JP2001517438A (ja) 2001-10-09
JP3668795B2 (ja) 2005-07-06
KR20040097229A (ko) 2004-11-17
ATE329028T1 (de) 2006-06-15
EP1015586B1 (de) 2006-03-01
IL134647A0 (en) 2001-04-30
CY1105248T1 (el) 2010-03-03
KR100467186B1 (ko) 2005-01-24
DE69834852D1 (de) 2006-07-20
DE69833670T2 (de) 2006-09-21
WO1999015654A2 (en) 1999-04-01
AU744285B2 (en) 2002-02-21
PT1015586E (pt) 2006-07-31
DE69840966D1 (de) 2009-08-20
WO1999015654A3 (en) 1999-10-21
EP1482041A1 (de) 2004-12-01
DE69833670D1 (de) 2006-04-27
IL177638A0 (en) 2006-12-31
CA2304810C (en) 2011-05-10
US6030831A (en) 2000-02-29
US6348351B1 (en) 2002-02-19
KR100472262B1 (ko) 2005-03-07
EP1482040A3 (de) 2004-12-08
KR100467185B1 (ko) 2005-01-24
US6074873A (en) 2000-06-13
DE69834852T2 (de) 2007-05-24
NZ502945A (en) 2001-11-30
ZA988392B (en) 2000-03-22
KR20010024143A (ko) 2001-03-26
ES2268538T3 (es) 2007-03-16
IL187847A (en) 2011-06-30
IL187847A0 (en) 2008-03-20
KR20040097230A (ko) 2004-11-17
PT1482040E (pt) 2006-10-31
EP1482041B1 (de) 2009-07-08
AU9388198A (en) 1999-04-12
ES2260848T3 (es) 2006-11-01
CA2304810A1 (en) 1999-04-01
ATE435912T1 (de) 2009-07-15
DK1482041T3 (da) 2009-11-02
DK1482040T3 (da) 2006-10-02
JP4239018B2 (ja) 2009-03-18
EP1482040B1 (de) 2006-06-07
JP2005185284A (ja) 2005-07-14
EP1015586A2 (de) 2000-07-05
DK1015586T3 (da) 2006-07-03
JP2005176848A (ja) 2005-07-07

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