ATE318905T1 - Homologe des tie-rezeptortyrosinekinase liganden - Google Patents

Homologe des tie-rezeptortyrosinekinase liganden

Info

Publication number
ATE318905T1
ATE318905T1 AT98946988T AT98946988T ATE318905T1 AT E318905 T1 ATE318905 T1 AT E318905T1 AT 98946988 T AT98946988 T AT 98946988T AT 98946988 T AT98946988 T AT 98946988T AT E318905 T1 ATE318905 T1 AT E318905T1
Authority
AT
Austria
Prior art keywords
homologue
ligand
tie receptor
nucleic acid
tyrosinekinase
Prior art date
Application number
AT98946988T
Other languages
English (en)
Inventor
Sherman Fong
Napoleone Ferrara
Audrey Goddard
Paul J Godowski
Austin L Gurney
Kenneth Hillan
P Mickey Williams
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE318905T1 publication Critical patent/ATE318905T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Plant Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT98946988T 1997-09-19 1998-09-14 Homologe des tie-rezeptortyrosinekinase liganden ATE318905T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/934,494 US6030831A (en) 1997-09-19 1997-09-19 Tie ligand homologues

Publications (1)

Publication Number Publication Date
ATE318905T1 true ATE318905T1 (de) 2006-03-15

Family

ID=25465645

Family Applications (3)

Application Number Title Priority Date Filing Date
AT04012203T ATE329028T1 (de) 1997-09-19 1998-09-14 Nl3 tie rezeptortyrosinekinase ligandhomologe
AT04012204T ATE435912T1 (de) 1997-09-19 1998-09-14 Homolog nl6 des tie rezeptor tyrosinekinase liganden
AT98946988T ATE318905T1 (de) 1997-09-19 1998-09-14 Homologe des tie-rezeptortyrosinekinase liganden

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT04012203T ATE329028T1 (de) 1997-09-19 1998-09-14 Nl3 tie rezeptortyrosinekinase ligandhomologe
AT04012204T ATE435912T1 (de) 1997-09-19 1998-09-14 Homolog nl6 des tie rezeptor tyrosinekinase liganden

Country Status (16)

Country Link
US (3) US6030831A (de)
EP (3) EP1015586B1 (de)
JP (3) JP3668795B2 (de)
KR (3) KR100467186B1 (de)
AT (3) ATE329028T1 (de)
AU (1) AU744285B2 (de)
CA (1) CA2304810C (de)
CY (1) CY1105248T1 (de)
DE (3) DE69840966D1 (de)
DK (3) DK1482041T3 (de)
ES (2) ES2260848T3 (de)
IL (3) IL134647A0 (de)
NZ (1) NZ502945A (de)
PT (2) PT1015586E (de)
WO (1) WO1999015654A2 (de)
ZA (1) ZA988392B (de)

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US20030092002A1 (en) * 1997-09-17 2003-05-15 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US6974689B1 (en) 1997-09-18 2005-12-13 Genentech, Inc. Nucleic acid encoding PRO211 polypeptides
US6030831A (en) * 1997-09-19 2000-02-29 Genetech, Inc. Tie ligand homologues
AU1931599A (en) * 1997-12-19 1999-07-12 Zymogenetics Inc. Angiopoietin homolog, dna encoding it, and method of making it
US6706869B1 (en) * 1998-02-11 2004-03-16 Wyeth Map kinase phosphatases and polynucleotides encoding them
US20030099994A1 (en) * 1998-03-02 2003-05-29 Millennium Pharamceuticals, Inc. Novel FDRG protein and nucleic acid molecules and uses therefor
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SV1999000069A (es) * 1998-06-02 2000-04-11 Lilly Co Eli Angiopoyetina relacionada con secuencia del gen 3 en la cicatrizacion de la cara ref. x-12261
AU4643699A (en) * 1998-06-24 2000-01-10 Compugen Ltd. Angiopoietin-like growth factor sequences
US7488590B2 (en) * 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
ES2327785T3 (es) * 1998-12-22 2009-11-03 Genentech, Inc. Procedimientos y compuestos para inhibir el crecimiento de celulas neoplasticas.
KR100553300B1 (ko) * 1999-03-08 2006-02-20 제넨테크, 인크. 혈관신생 및 심혈관형성의 촉진 또는 억제 방법
PT1626058E (pt) * 1999-03-08 2008-02-15 Genentech Inc Composições e métodos para o diagnóstico de tumores
US6703020B1 (en) 1999-04-28 2004-03-09 Board Of Regents, The University Of Texas System Antibody conjugate methods for selectively inhibiting VEGF
US6342219B1 (en) 1999-04-28 2002-01-29 Board Of Regents, The University Of Texas System Antibody compositions for selectively inhibiting VEGF
AU5979300A (en) * 1999-07-02 2001-01-22 Bayer Aktiengesellschaft Angiopoietin-6 and uses thereof
EP1210363A2 (de) * 1999-07-16 2002-06-05 Hyseq, Inc. Nukleinsäuresequenzen, die für putative angiopoietine codieren
EP1196576A2 (de) * 1999-07-20 2002-04-17 Curagen Corporation Sekretionspolypeptiden und übereinstimmende polynukleotiden
US7001766B2 (en) * 1999-07-20 2006-02-21 Curagen Corporation Nucleic acid sequences encoding human angiopoietin-like polypeptides
EP1484401A1 (de) * 1999-07-20 2004-12-08 Curagen Corporation Sekretionspolypeptiden und übereinstimmende Polynukleotiden
EP1198568B1 (de) * 1999-07-20 2007-07-25 Genentech, Inc. Zusammensetzung und verfahren zur behandlung von immunverwandten krankheiten
IL149849A0 (en) * 1999-12-09 2002-11-10 Sankyo Co A method and kit for testing an agent for treatment of hyperlipemia
WO2001072339A2 (en) * 2000-03-30 2001-10-04 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of treatment of conditions involving obstruction of blood flow
US20060073549A1 (en) * 2000-09-05 2006-04-06 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
JP2004517080A (ja) * 2000-11-29 2004-06-10 グラクソ グループ リミテッド Ｔｉｅ−２および／またはｖｅｇｆｒ−２の阻害剤として有用なベンゾイミダゾール誘導体
US7658924B2 (en) * 2001-10-11 2010-02-09 Amgen Inc. Angiopoietin-2 specific binding agents
US7138370B2 (en) 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
US7521053B2 (en) * 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
US7205275B2 (en) * 2001-10-11 2007-04-17 Amgen Inc. Methods of treatment using specific binding agents of human angiopoietin-2
WO2003062373A2 (en) * 2001-10-18 2003-07-31 The Children's Hospital Of Philadelphia Methods and materials for the recruitment of endothelial cells
US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US20040067882A1 (en) * 2001-10-22 2004-04-08 Alsobrook John P. Therapeutic polypeptides, nucleic acids encoding same, and methods of use
EP1451578B1 (de) * 2001-11-16 2013-08-21 Genentech, Inc. Verwendung von angptl3 antagonisten zur behandlung von entzündlichen lebererkrankungen
WO2003048185A2 (en) * 2001-11-30 2003-06-12 Genvec, Inc. Angiopioetin related factors
US20090181092A1 (en) * 2004-07-16 2009-07-16 Spinal Restoration, Inc. Methods for Treating Joints and Discs with a Carrier Matrix and Cells
US8604185B2 (en) 2004-07-20 2013-12-10 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
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JO2913B1 (en) 2008-02-20 2015-09-15 امجين إنك, Antibodies directed towards angiopoietin-1 and angiopoietin-2 proteins and their uses
GB0807609D0 (en) * 2008-04-25 2008-06-04 Cancer Rec Tech Ltd Therapeutic compounds and their use
JP5760010B2 (ja) 2010-02-01 2015-08-05 キャンサー・リサーチ・テクノロジー・リミテッド １−（５−ｔｅｒｔ−ブチル−２−フェニル−２Ｈ−ピラゾール−３−イル）−３−［２−フルオロ−４−（１−メチル−２−オキソ−２，３−ジヒドロ−１Ｈ−イミダゾ［４，５−Ｂ］ピリジン−７−イルオキシ）−フェニル］−尿素および関連化合物ならびに治療におけるそれらの使用
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Also Published As

Publication number Publication date
DE69833670D1 (de) 2006-04-27
DK1482041T3 (da) 2009-11-02
KR100472262B1 (ko) 2005-03-07
EP1482040A2 (de) 2004-12-01
DK1015586T3 (da) 2006-07-03
JP3668795B2 (ja) 2005-07-06
US6074873A (en) 2000-06-13
WO1999015654A3 (en) 1999-10-21
ZA988392B (en) 2000-03-22
CA2304810C (en) 2011-05-10
PT1482040E (pt) 2006-10-31
KR20040097230A (ko) 2004-11-17
KR20010024143A (ko) 2001-03-26
EP1482040B1 (de) 2006-06-07
EP1482041B1 (de) 2009-07-08
IL177638A0 (en) 2006-12-31
US6348351B1 (en) 2002-02-19
IL187847A0 (en) 2008-03-20
EP1015586A2 (de) 2000-07-05
ATE329028T1 (de) 2006-06-15
IL187847A (en) 2011-06-30
JP2005176848A (ja) 2005-07-07
ATE435912T1 (de) 2009-07-15
PT1015586E (pt) 2006-07-31
EP1015586B1 (de) 2006-03-01
DE69834852T2 (de) 2007-05-24
DE69834852D1 (de) 2006-07-20
IL134647A0 (en) 2001-04-30
ES2260848T3 (es) 2006-11-01
DK1482040T3 (da) 2006-10-02
DE69833670T2 (de) 2006-09-21
CY1105248T1 (el) 2010-03-03
NZ502945A (en) 2001-11-30
JP4239018B2 (ja) 2009-03-18
US6030831A (en) 2000-02-29
EP1482040A3 (de) 2004-12-08
KR100467185B1 (ko) 2005-01-24
DE69840966D1 (de) 2009-08-20
JP2005185284A (ja) 2005-07-14
KR20040097229A (ko) 2004-11-17
KR100467186B1 (ko) 2005-01-24
WO1999015654A2 (en) 1999-04-01
JP2001517438A (ja) 2001-10-09
AU744285B2 (en) 2002-02-21
ES2268538T3 (es) 2007-03-16
CA2304810A1 (en) 1999-04-01
AU9388198A (en) 1999-04-12
EP1482041A1 (de) 2004-12-01

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