ATE319450T1 - Benzocycloheptha-thiophen verbindungen - Google Patents

Benzocycloheptha-thiophen verbindungen

Info

Publication number
ATE319450T1
ATE319450T1 AT98914461T AT98914461T ATE319450T1 AT E319450 T1 ATE319450 T1 AT E319450T1 AT 98914461 T AT98914461 T AT 98914461T AT 98914461 T AT98914461 T AT 98914461T AT E319450 T1 ATE319450 T1 AT E319450T1
Authority
AT
Austria
Prior art keywords
thiophene compounds
benzocycloheptha
compounds
analogs
substituted
Prior art date
Application number
AT98914461T
Other languages
English (en)
Inventor
A K Gunnar Aberg
George E Wright
Jan L Chen
Original Assignee
Bridge Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bridge Pharma Inc filed Critical Bridge Pharma Inc
Application granted granted Critical
Publication of ATE319450T1 publication Critical patent/ATE319450T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT98914461T 1997-04-03 1998-04-02 Benzocycloheptha-thiophen verbindungen ATE319450T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4390597P 1997-04-03 1997-04-03

Publications (1)

Publication Number Publication Date
ATE319450T1 true ATE319450T1 (de) 2006-03-15

Family

ID=21929513

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98914461T ATE319450T1 (de) 1997-04-03 1998-04-02 Benzocycloheptha-thiophen verbindungen

Country Status (17)

Country Link
US (1) US6207683B1 (de)
EP (1) EP0977568B1 (de)
JP (1) JP2001519789A (de)
KR (1) KR20010005791A (de)
CN (1) CN1128789C (de)
AT (1) ATE319450T1 (de)
AU (1) AU733325B2 (de)
BR (1) BR9807911A (de)
CA (1) CA2283663C (de)
DE (1) DE69833748T2 (de)
ID (1) ID24487A (de)
IL (1) IL131999A (de)
NO (1) NO311934B1 (de)
NZ (1) NZ337843A (de)
PL (1) PL336007A1 (de)
RU (1) RU2193557C2 (de)
WO (1) WO1998043640A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9908014D0 (en) * 1999-04-08 1999-06-02 Scherer Corp R P Pharmaceutical compositions
DK1218007T3 (da) 1999-09-13 2011-11-07 Bridge Pharma Inc Optisk aktive isomerer af ketotifen og terapeutiske aktive metaboliter deraf
RU2266115C2 (ru) * 1999-09-13 2005-12-20 Бридж Фарма, Инк. Оптически активные изомеры кетотифена и их терапевтически активные метаболиты
RU2235536C1 (ru) * 2003-02-10 2004-09-10 Государственное образовательное учреждение высшего профессионального образования башкирский государственный медицинский университет Средство для лечения заболевания глаз с метронидазолом
RU2242977C1 (ru) * 2003-09-30 2004-12-27 Плотников Евгений Владимирович Антивирусная и бактерицидная композиция
US20100166804A1 (en) * 2007-05-23 2010-07-01 Dennis Penn Methods
NZ587050A (en) * 2008-01-30 2012-08-31 Nippon Zoki Pharmaceutical Co Compounds featuring a tricyclic group double bonded to a piperidine group, as an antihistamine
WO2009142772A2 (en) * 2008-05-23 2009-11-26 Mastcell Pharmaceuticals, Inc. Methods and treatment for allergies and inflammation associated with gastrointestinal diseases
JP5083989B2 (ja) * 2008-11-20 2012-11-28 日本臓器製薬株式会社 ピペリジン誘導体を含有する医薬
CA2754996A1 (en) * 2009-03-17 2010-09-23 Aciex Therapeutics, Inc. Ophthalmic formulations of ketotifen and methods of use
JP5978296B2 (ja) * 2011-06-28 2016-08-24 フジアン・ミンドン・レジュヴネイション・ファーマスーティカル・カンパニー・リミテッド 抗アレルギ性ベンゾシクロヘプタチオフェン誘導体
US8778971B2 (en) 2012-10-23 2014-07-15 Bridge Pharma, Inc. Medicinal treatment of dermal diseases in companion animals
US8557846B1 (en) 2012-10-23 2013-10-15 Bridge Pharma, Inc. Medicinal treatment of dermal diseases in dogs
US20140120121A1 (en) 2012-10-30 2014-05-01 Bridge Pharma, Inc. Medicinal treatment of atopic inflammatory diseases
US20150272941A1 (en) 2012-10-30 2015-10-01 Bridge Pharma, Inc. Medicinal treatment of chronic pulmonary inflammatory diseases with norketotifen
US9439895B2 (en) 2013-08-06 2016-09-13 Bridge Pharma, Inc. Methods of treating pruritic conditions mediated through non-histaminergic mechanisms in diabetic patients
US9345697B2 (en) 2013-08-06 2016-05-24 Bridge Pharma, Inc. Methods of treatment of non-histaminic pruritus
US9138431B2 (en) 2013-08-06 2015-09-22 Bridge Pharma, Inc. Methods of treatment of histamine H-4 receptor-related pruritus
CN104031035B (zh) * 2014-06-26 2017-08-25 福建省闽东力捷迅药业有限公司 一种富马酸卢帕替芬混晶及其制备方法
CN104045633B (zh) * 2014-06-26 2017-07-21 福建省闽东力捷迅药业有限公司 一种富马酸卢帕替芬晶型a及其制备方法
WO2016200578A1 (en) * 2015-06-11 2016-12-15 Bridge Pharma, Inc. Methods of treatment of non-histaminic pruritus in mammals
US10501527B2 (en) 2016-09-08 2019-12-10 Emergo Therapeutics, Inc. Mast cell stabilizers for treatment of hypercytokinemia and viral infection
US11478463B2 (en) 2016-10-18 2022-10-25 Emergo Therapeutics, Inc. Mast cell stabilizers for treatment of chronic inflammatory conditions
CN109180666A (zh) * 2018-09-07 2019-01-11 福建省闽东力捷迅药业有限公司 一种富马酸卢帕替芬的杂质c及其制备方法和检测方法
CN115960135B (zh) * 2022-07-21 2025-03-25 华创合成制药股份有限公司 抗组胺类化合物及其制备方法和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1470263A1 (de) * 1963-12-19 1969-05-29 Sandoz Ag Neue Heterocyclische Verbindungen und Verfahren zu ihrer Herstellung
DE2626583A1 (de) * 1975-06-24 1977-01-13 Sandoz Ag Neue benzocycloheptathiophenderivate ihre herstellung und ihre verwendung als heilmittel
US4255036A (en) * 1979-05-25 1981-03-10 Pincetich Vincent J Handheld support for camera and photographic lamp
US4355036A (en) * 1980-06-19 1982-10-19 Schering Corporation Tricyclic-substituted piperidine antihistamines
US5250681A (en) 1988-06-02 1993-10-05 Ajinomoto Co., Inc. Piperidine derivatives and hypotensives containing the same
GB2309948A (en) * 1996-02-10 1997-08-13 Michael Anthony Mumford Limiting vehicle roll

Also Published As

Publication number Publication date
BR9807911A (pt) 2000-02-22
NO311934B1 (no) 2002-02-18
CA2283663C (en) 2006-07-25
DE69833748T2 (de) 2006-11-23
CN1128789C (zh) 2003-11-26
CA2283663A1 (en) 1998-10-08
JP2001519789A (ja) 2001-10-23
IL131999A (en) 2004-06-20
US6207683B1 (en) 2001-03-27
NZ337843A (en) 2001-11-30
RU2193557C2 (ru) 2002-11-27
CN1258219A (zh) 2000-06-28
IL131999A0 (en) 2001-03-19
HK1027961A1 (en) 2001-02-02
ID24487A (id) 2000-07-20
EP0977568A1 (de) 2000-02-09
WO1998043640A1 (en) 1998-10-08
AU733325B2 (en) 2001-05-10
NO994823L (no) 1999-10-07
EP0977568B1 (de) 2006-03-08
EP0977568A4 (de) 2001-03-21
PL336007A1 (en) 2000-06-05
KR20010005791A (ko) 2001-01-15
DE69833748D1 (de) 2006-05-04
NO994823D0 (no) 1999-10-04
AU6881298A (en) 1998-10-22

Similar Documents

Publication Publication Date Title
ATE319450T1 (de) Benzocycloheptha-thiophen verbindungen
UA72881C2 (uk) Похідні тієнопіридину, фармацевтична композиція з використанням таких сполук (варіанти), проміжна сполука
BG104561A (en) Aryl fused azapolycyclic compounds
EE9900413A (et) Medikamentide kontrollitud väljutamine silma eeskambrisse
BG106586A (en) Pyrazolopyramidines as therapeutic agents
SE9504661D0 (sv) New compounds
ATE76747T1 (de) Levodopa-methyl-ester enthaltende pharmazeutische zusammensetzungen, ihre herstellung und therapeutische verwendungen.
ATE240344T1 (de) Nor-pregnane zur induzierung hypothalamischer effekte
MX9305248A (es) Compuestos de diarilpiperazinoacetamida.
EP0781561A4 (de) Eine neuartige medizinische verwendung eines 5ht 3?-antagonisten
FI912621A7 (fi) Farmakologisesti aktiivisia keskushermostoon vaikuttavia yhdisteitä
IL143105A0 (en) Fused polycyclic heterocyclic compounds and pharmaceutical compositions containing the same
DK0966277T3 (da) Anvendelse af R-NSAID'er til forebyggelse af Alzheimer's sygdom
FI912622A7 (fi) Farmakologisesti aktiivisia keskushermostoon vaikuttavia yhdisteitä
SE9504662D0 (sv) New compounds
CA2260863A1 (en) Treatment of psychotic disorders
MY118384A (en) Benzocycloheptathiophene compounds
FI914923L (fi) Foerfarande foer framstaellning av 5,11 -dihydro-6h-dipyrido-/3,2-b:2',3'-e//1,4/diazepiner. knippe.
IT1296613B1 (it) Farmaco per la cura dell'ircismo contenente un adrenocorticosteroide.
ATE224716T1 (de) Pharmazeutische zusammensetzungen von cinchonin dihydrochlorid
IT1266787B1 (it) Composizioni terapeutiche ad attivita' antitumorale a base di derivati 1,3,8,10 tetrasostituiti del 4,5,6,7-tetratiocino-(1,2-b: 3,4-b')-
KR930010200U (ko) 무좀, 습진방지용 발가락 밴드
FR2714058B1 (fr) Dérivés de 1,3-dioxane trisubstitués, leur préparation et leur application en thérapeutique.
ITMI930017A0 (it) Composizione polimerizzabile per l'impreganzione di un supporto tessile, avente elevate caratteristiche tixotropiche
KR940018814U (ko) 신의 조립식 굽

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties