ATE319738T1 - Verfahren zur herstellung eines sets von kombinatorischen polypeptidantigenen - Google Patents

Verfahren zur herstellung eines sets von kombinatorischen polypeptidantigenen

Info

Publication number
ATE319738T1
ATE319738T1 AT93916641T AT93916641T ATE319738T1 AT E319738 T1 ATE319738 T1 AT E319738T1 AT 93916641 T AT93916641 T AT 93916641T AT 93916641 T AT93916641 T AT 93916641T AT E319738 T1 ATE319738 T1 AT E319738T1
Authority
AT
Austria
Prior art keywords
combinatory
producing
polypeptide antigens
variants
protein
Prior art date
Application number
AT93916641T
Other languages
English (en)
Inventor
Roberto Crea
Original Assignee
Creagen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Creagen Inc filed Critical Creagen Inc
Application granted granted Critical
Publication of ATE319738T1 publication Critical patent/ATE319738T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT93916641T 1992-06-18 1993-06-18 Verfahren zur herstellung eines sets von kombinatorischen polypeptidantigenen ATE319738T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90012392A 1992-06-18 1992-06-18

Publications (1)

Publication Number Publication Date
ATE319738T1 true ATE319738T1 (de) 2006-03-15

Family

ID=25412008

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93916641T ATE319738T1 (de) 1992-06-18 1993-06-18 Verfahren zur herstellung eines sets von kombinatorischen polypeptidantigenen

Country Status (10)

Country Link
US (1) US6432675B1 (de)
EP (1) EP0728015B1 (de)
JP (2) JP3764476B2 (de)
AT (1) ATE319738T1 (de)
AU (1) AU678371B2 (de)
DE (1) DE69333992T2 (de)
DK (1) DK0728015T3 (de)
ES (1) ES2260754T3 (de)
PT (1) PT728015E (de)
WO (1) WO1994000151A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7118874B2 (en) 1998-10-09 2006-10-10 Variation Biotechnologies Inc. Immunogenic formulation and process for preparation thereof
ATE533113T1 (de) * 2002-02-08 2011-11-15 Variation Biotechnologies Inc Verfahren zur herstellung von immunogenen zusammensetzungen aus variablen peptidepitopen
MXPA04010222A (es) * 2002-04-17 2005-03-07 Roberto Crea Dopacion en mutagenesis en ruta.
RU2237065C2 (ru) * 2002-10-03 2004-09-27 Государственный научный центр вирусологии и биотехнологии "Вектор" Иммуногенная библиотека химерных пептидов, мимикрирующая генетическое многообразие гипервариабельного района v3 белка оболочки gp120 вируса иммунодефицита человека
WO2007030518A2 (en) * 2005-09-06 2007-03-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Conformationally stabilized hiv envelope immunogens and triggering hiv-1 envelope to reveal cryptic v3-loop epitopes
CA2627105A1 (en) * 2005-10-26 2007-05-03 Protelix, Inc. Influenza combinatorial antigen vaccine
EP2025762A3 (de) 2006-01-17 2009-09-30 Health Research Inc. Heteroduplex-Trackingassay
JP5247009B2 (ja) * 2006-06-16 2013-07-24 独立行政法人理化学研究所 配列抽出装置、配列抽出方法、プログラムおよび記録媒体
CA2724569A1 (en) * 2008-05-19 2009-11-26 Virginia Tech Intellectual Properties, Inc. Compositions and methods to protect cells by blocking entry of pathogen proteins

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0255190A3 (de) 1986-08-01 1990-08-29 Repligen Corporation Rekombinante Polypeptide und ihre Verwendungen sowie Test für den AIDS-Virus
EP0311228A3 (de) 1987-10-09 1990-05-02 Repligen Corporation Rekombinante Polypeptide und ihre Verwendung einschliesslich Nachweisverfahren für AIDS-Virus
US5010175A (en) * 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
EP0768377A1 (de) 1988-09-02 1997-04-16 Protein Engineering Corporation Herstellung und Auswahl von Rekombinantproteinen mit verschiedenen Bindestellen
EP0436634A1 (de) 1988-10-03 1991-07-17 Repligen Corporation Hiv-proteine und peptide und deren verwendung zur diagnose, prophylaxe und therapie von aids
PT94276A (pt) 1989-06-05 1991-02-08 Anticorpo monoclonal capaz de neutralizar o prototipo mn de hiv
WO1991006575A1 (en) 1989-11-03 1991-05-16 Repligen Corporation Hiv-1 specific human monoclonal antibody
US5270170A (en) * 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method

Also Published As

Publication number Publication date
PT728015E (pt) 2006-07-31
ES2260754T3 (es) 2006-11-01
AU4642893A (en) 1994-01-24
AU678371B2 (en) 1997-05-29
JPH07508520A (ja) 1995-09-21
DE69333992T2 (de) 2006-11-30
EP0728015B1 (de) 2006-03-08
EP0728015A1 (de) 1996-08-28
JP3764476B2 (ja) 2006-04-05
JP2004121266A (ja) 2004-04-22
WO1994000151A1 (en) 1994-01-06
EP0728015A4 (de) 1997-01-29
DE69333992D1 (de) 2006-05-04
DK0728015T3 (da) 2006-07-17
US6432675B1 (en) 2002-08-13

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