ATE320006T1 - Methode zum nachweis von zell-apoptose - Google Patents

Methode zum nachweis von zell-apoptose

Info

Publication number
ATE320006T1
ATE320006T1 AT97946547T AT97946547T ATE320006T1 AT E320006 T1 ATE320006 T1 AT E320006T1 AT 97946547 T AT97946547 T AT 97946547T AT 97946547 T AT97946547 T AT 97946547T AT E320006 T1 ATE320006 T1 AT E320006T1
Authority
AT
Austria
Prior art keywords
apoptosis
methods
detection
cell apoptosis
detecting cell
Prior art date
Application number
AT97946547T
Other languages
English (en)
Inventor
Robert Siman
Donna Bozyczko-Coyne
Sheryl L Meyer
Ratan Venkatraman Bhat
Original Assignee
Cephalon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon Inc filed Critical Cephalon Inc
Application granted granted Critical
Publication of ATE320006T1 publication Critical patent/ATE320006T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT97946547T 1996-11-15 1997-11-13 Methode zum nachweis von zell-apoptose ATE320006T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3096196P 1996-11-15 1996-11-15
US08/967,625 US6048703A (en) 1996-11-15 1997-11-12 Methods for detecting cell apoptosis

Publications (1)

Publication Number Publication Date
ATE320006T1 true ATE320006T1 (de) 2006-03-15

Family

ID=26706638

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97946547T ATE320006T1 (de) 1996-11-15 1997-11-13 Methode zum nachweis von zell-apoptose

Country Status (8)

Country Link
US (2) US6048703A (de)
EP (1) EP0975971B1 (de)
AT (1) ATE320006T1 (de)
AU (1) AU5169998A (de)
CA (1) CA2270866A1 (de)
DE (1) DE69735436T2 (de)
DK (1) DK0975971T3 (de)
WO (1) WO1998021590A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342611B1 (en) * 1997-10-10 2002-01-29 Cytovia, Inc. Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for capsases and other enzymes and the use thereof
DE69937835T2 (de) * 1998-09-24 2009-01-02 Promega Corp., Madison Antikörper für apoptosemarker und anwendungsverfahren
EP1173486A1 (de) * 1999-04-15 2002-01-23 Merck Frosst Canada & Co. Antikörper, die durch caspase gespaltenes app erkennen und verfahren ihrer anwendung
WO2001016180A2 (en) * 1999-08-27 2001-03-08 Board Of Regents, The University Of Texas System Cd40 agonist compositions and methods of use
ATE311595T1 (de) * 2000-07-21 2005-12-15 Evotec Ag Verfahren zur detektion der apoptose durch ermittlung von cytochrom c als apoptosespezifischem marker, der durch zelluläre ausschüttungsvorgänge ins extrazelluläre medium abgegeben wird
WO2003044482A2 (en) * 2001-11-16 2003-05-30 The University Of Tennessee Research Corporation Recombinant antibody fusion proteins and methods for detection of apoptotic cells
US7541150B2 (en) * 2002-04-08 2009-06-02 University Of Louisville Research Foundation, Inc Method for the diagnosis and prognosis of malignant diseases
US7357928B2 (en) 2002-04-08 2008-04-15 University Of Louisville Research Foundation, Inc. Method for the diagnosis and prognosis of malignant diseases
WO2004003554A1 (en) * 2002-06-26 2004-01-08 University Of Louisville Research Foundation, Inc. A method for the detection of apoptosis
JP4885122B2 (ja) * 2004-04-15 2012-02-29 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド 癌、器官傷害、および筋肉リハビリテーション／運動過剰訓練についての診断の生物マーカーとしてのタンパク質分解マーカー
US7396654B2 (en) 2004-04-15 2008-07-08 University Of Florida Research Foundation, Inc. Neural proteins as biomarkers for traumatic brain injury
US8492107B2 (en) 2004-04-15 2013-07-23 University Of Florida Research Foundation, Inc. Neural proteins as biomarkers for nervous system injury and other neural disorders
WO2006081190A2 (en) 2005-01-25 2006-08-03 Five Prime Therapeutics, Inc. Compositions and methods for treating cardiac conditions
US8379197B2 (en) * 2006-01-05 2013-02-19 Chemimage Corporation Spectroscopic systems and methods for classifying and pharmaceutically treating cells
RU2461572C2 (ru) 2006-06-07 2012-09-20 Биоэллаенс К.В. Антитела, распознающие содержащий углеводы эпитоп на cd-43 и сеа, экспрессируемых на злокачественных клетках, и способы их применения
WO2008021211A2 (en) * 2006-08-10 2008-02-21 Fred Hutchinson Cancer Research Center Compositions and methods for modulating apoptosis in cells over-expressing bcl-2 family member proteins
CN105732813A (zh) 2007-12-18 2016-07-06 生物联合公司 识别癌细胞上表达的cd-43和cea的含糖表位的抗体及其使用方法
WO2009088837A2 (en) * 2007-12-31 2009-07-16 The University Of Louisville Research Foundation, Inc. Methods and products to target, capture and characterize stem cells
CA2733990C (en) 2008-08-11 2018-12-11 Banyan Biomarkers, Inc. Biomarker detection process and assay of neurological condition
WO2011041731A2 (en) 2009-10-02 2011-04-07 Fred Hutchinson Cancer Research Center Method of inhibiting bcl-2-related survival proteins
WO2011041737A2 (en) 2009-10-02 2011-04-07 Fred Hutchinson Cancer Research Center Gain-of-function bcl-2 inhibitors
CN102770529B (zh) 2009-11-17 2018-06-05 Musc研究发展基金会 针对人核仁素的人单克隆抗体
WO2012167173A1 (en) 2011-06-02 2012-12-06 The University Of Louisville Research Foundation, Inc. Anti-nucleolin agent-conjugated nanoparticles
WO2016179394A1 (en) 2015-05-05 2016-11-10 Malik Mohammad Tariq Anti-nucleolin agent-conjugated nanoparticles as radio-sensitizers and mri and/or x-ray contrast agents
JP2020500508A (ja) 2016-10-28 2020-01-16 バンヤン・バイオマーカーズ・インコーポレーテッド ユビキチンｃ末端ヒドロラーゼｌ１（ｕｃｈ−ｌ１）およびグリア線維酸性タンパク質（ｇｆａｐ）に対する抗体および関連する方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083735A (en) * 1993-06-24 2000-07-04 The General Hospital Corporation Programmed cell death genes and proteins
US5536639A (en) * 1994-03-25 1996-07-16 Cephalon, Inc. Methods for detecting calpain activation by detection of calpain activated spectrin breakdown products
US5605826A (en) * 1994-06-10 1997-02-25 Panorama Research, Inc. 24 kilodalton cytoplasmic protease activating DNA fragmentation in apoptosis
US6288037B1 (en) * 1996-01-29 2001-09-11 Basf Aktiengesellschaft Substrates and inhibitors for cysteine protease ICH-1

Also Published As

Publication number Publication date
HK1026739A1 (en) 2000-12-22
CA2270866A1 (en) 1998-05-22
EP0975971A4 (de) 2002-09-25
US6048703A (en) 2000-04-11
AU5169998A (en) 1998-06-03
DK0975971T3 (da) 2006-07-03
EP0975971B1 (de) 2006-03-08
WO1998021590A1 (en) 1998-05-22
US7256252B1 (en) 2007-08-14
DE69735436D1 (de) 2006-05-04
EP0975971A1 (de) 2000-02-02
DE69735436T2 (de) 2006-10-26

Similar Documents

Publication Publication Date Title
ATE320006T1 (de) Methode zum nachweis von zell-apoptose
PT991421E (pt) Deteccao e modulacao das iap e naip para o diagnostico e tratamento de doenca proliferativa
DK1200832T3 (da) Annexiner og autoantistoffer anvendt som markörer for lungecancer og ösofageal cancer
DE69737788D1 (de) Reagenzien und methoden zum nachweis von erkrankungen der brust
DE69937368D1 (de) Nachweis von erkrankungen der nieren und behandlung
DK0943097T3 (da) Fremgangsmåde til at påvise IgE
DE60325628D1 (de) Gene und polypeptide in verbindung mit menschlichen pankreaskarzinomen
DE3484832D1 (de) Nachweis von bakterien mittels nukleinsaeuren-hybridisation, markierte sonden und testsatz dafuer.
ATE353974T1 (de) Verfahren, zusammensetzungen und kits zur identifizierung und überwachung von brustkrebs
ATE414149T1 (de) Survivin, ein protein das zelluläre apoptosis hemmt, und dessen modulation
DE69938662D1 (de) Spurendetektion von analyten mit hilfe artifizieller olfaktometrie
EA200702203A1 (ru) Способы и нуклеиновые кислоты для анализов клеточных пролиферативных нарушений
DE60033555D1 (de) Verfahren und zusammestellungen zum nachweis und behandlung von brustkrebs, beruhend auf brustkrebs-assoziierten polypeptiden
DE69930404D1 (de) Methode zum nachweis von analyten
ATE292801T1 (de) Verfahren zum screening von inhibitoren von asp2
DE69507470D1 (de) Diagnose von krebs, dessen zellen das am tyrosin phosphorylierte crkl-protein exprimieren
ATE415488T1 (de) Träger zum nachweis von genen und seine verwendung zur feststellung der wirksamkeit einer interferontherapie
DE60038894D1 (de) Screeningverfahren für geeignete wirkstoffe
DE60325382D1 (de) Verfahren zur diagnose von gebärmutterhalskrebs
DE69033511D1 (de) Verfahren zum Nachweis von Knochen- und anderen Bindegewebeerkrankungen in Menschen und Tieren
EP0876491A4 (de) Ein gen des "langen qt syndroms" (long qt syndrom), welches kvlqt1 kodiert und seine wechselwirkung mit mink
ATE301192T1 (de) Verwendung von neuronalem apoptose- inhibitorprotein
NO982588D0 (no) FremgangsmÕte for diagnose og behandling av plate epizelkarsinom
DE68919387D1 (de) DNS- und RNS-Proben, Methoden und Testsätze zum Nachweis von Salmonella.
WO2001038581A3 (en) Vigilance nucleic acids and related diagnostic, screening and therapeutic methods

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0975971

Country of ref document: EP