ATE321762T1 - Verfahren zur synthese von carbapenem-antibiotika - Google Patents
Verfahren zur synthese von carbapenem-antibiotikaInfo
- Publication number
- ATE321762T1 ATE321762T1 AT99908540T AT99908540T ATE321762T1 AT E321762 T1 ATE321762 T1 AT E321762T1 AT 99908540 T AT99908540 T AT 99908540T AT 99908540 T AT99908540 T AT 99908540T AT E321762 T1 ATE321762 T1 AT E321762T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- synthesis
- compound
- heteroaryl
- aryl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940088710 antibiotic agent Drugs 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7682998P | 1998-03-02 | 1998-03-02 | |
| GBGB9810888.9A GB9810888D0 (en) | 1998-05-20 | 1998-05-20 | Process for synthesizing carbapenem antibiotics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE321762T1 true ATE321762T1 (de) | 2006-04-15 |
Family
ID=26313717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99908540T ATE321762T1 (de) | 1998-03-02 | 1999-02-26 | Verfahren zur synthese von carbapenem-antibiotika |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1060180B1 (de) |
| JP (1) | JP3953274B2 (de) |
| AT (1) | ATE321762T1 (de) |
| AU (1) | AU749234B2 (de) |
| CA (1) | CA2322658C (de) |
| DE (1) | DE69930616T2 (de) |
| ES (1) | ES2260900T3 (de) |
| WO (1) | WO1999045010A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6548492B1 (en) * | 1999-10-29 | 2003-04-15 | Merck & Co., Inc. | Process for formulation of carbapenem antibiotic compositions |
| BR0112393A (pt) | 2000-06-21 | 2003-07-08 | Internat Health Man Associates | Composições e processos para aperfeiçoamento de absorção oral de agentes antimicrobiais |
| AR035728A1 (es) * | 2001-01-16 | 2004-07-07 | Merck & Co Inc | Proceso perfeccionado para la sintesis de carbapenem |
| EP1426376A4 (de) * | 2001-08-13 | 2004-12-22 | Eisai Co Ltd | Verfahren zur herstellung von carbapenem-antibiotika |
| EP1442038A4 (de) * | 2001-09-26 | 2005-01-05 | Merck & Co Inc | Kristalline formen von carbapenem-antibiotika und herstellungsverfahren |
| NZ531174A (en) | 2001-09-26 | 2005-09-30 | Merck & Co Inc | Process for reducing the levels of organic solvents in carbapenem compounds |
| US7538212B2 (en) * | 2002-11-13 | 2009-05-26 | Kaneka Corporation | Intermediate for carbapenem compound for oral administration and process for producing the same |
| EP2974718A1 (de) | 2005-04-29 | 2016-01-20 | Cubist Pharmaceuticals, Inc. | Therapeutische zusammensetzungen |
| CN100344613C (zh) * | 2005-10-20 | 2007-10-24 | 上海交通大学 | (2s,4s)－1－(4－硝基苄氧羰基)－2－[(3－烯丙氧羰基)－苯基氨基甲酰基]－吡咯烷－4－基硫醇的制备方法 |
| EP2303225B1 (de) * | 2008-06-11 | 2013-11-20 | Ranbaxy Laboratories Limited | Zusammensetzungen des Kohlenstoffdioxid Adduktes von Ertapenem und Polymorphe Formen des Mononatriumsalzes von Ertapenem |
| CN102558182B (zh) * | 2010-12-31 | 2015-02-11 | 石药集团中奇制药技术（石家庄）有限公司 | 一种厄他培南钠晶型及其制备方法 |
| CN114105988B (zh) * | 2022-01-24 | 2022-04-29 | 深圳市海滨制药有限公司 | 一种厄他培南钠的合成方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU644008B2 (en) * | 1990-08-10 | 1993-12-02 | Sumitomo Pharmaceuticals Company, Limited | Beta-lactam compounds, and their production and use |
| TW264475B (de) * | 1991-09-20 | 1995-12-01 | Takeda Pharm Industry Co Ltd | |
| GB9202298D0 (en) * | 1992-02-04 | 1992-03-18 | Ici Plc | Antibiotic compounds |
-
1999
- 1999-02-26 CA CA002322658A patent/CA2322658C/en not_active Expired - Lifetime
- 1999-02-26 AT AT99908540T patent/ATE321762T1/de not_active IP Right Cessation
- 1999-02-26 DE DE69930616T patent/DE69930616T2/de not_active Expired - Lifetime
- 1999-02-26 JP JP2000534552A patent/JP3953274B2/ja not_active Expired - Lifetime
- 1999-02-26 EP EP99908540A patent/EP1060180B1/de not_active Expired - Lifetime
- 1999-02-26 WO PCT/US1999/004321 patent/WO1999045010A1/en not_active Ceased
- 1999-02-26 ES ES99908540T patent/ES2260900T3/es not_active Expired - Lifetime
- 1999-02-26 AU AU27947/99A patent/AU749234B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002505331A (ja) | 2002-02-19 |
| CA2322658C (en) | 2005-04-12 |
| JP3953274B2 (ja) | 2007-08-08 |
| AU749234B2 (en) | 2002-06-20 |
| EP1060180A1 (de) | 2000-12-20 |
| ES2260900T3 (es) | 2006-11-01 |
| CA2322658A1 (en) | 1999-09-10 |
| DE69930616D1 (de) | 2006-05-18 |
| EP1060180A4 (de) | 2004-03-10 |
| DE69930616T2 (de) | 2006-11-23 |
| WO1999045010A1 (en) | 1999-09-10 |
| AU2794799A (en) | 1999-09-20 |
| EP1060180B1 (de) | 2006-03-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |