ATE321762T1 - Verfahren zur synthese von carbapenem-antibiotika - Google Patents
Verfahren zur synthese von carbapenem-antibiotikaInfo
- Publication number
- ATE321762T1 ATE321762T1 AT99908540T AT99908540T ATE321762T1 AT E321762 T1 ATE321762 T1 AT E321762T1 AT 99908540 T AT99908540 T AT 99908540T AT 99908540 T AT99908540 T AT 99908540T AT E321762 T1 ATE321762 T1 AT E321762T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- synthesis
- compound
- heteroaryl
- aryl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 229940088710 antibiotic agent Drugs 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- YZBQHRLRFGPBSL-RXMQYKEDSA-N carbapenem Chemical compound C1C=CN2C(=O)C[C@H]21 YZBQHRLRFGPBSL-RXMQYKEDSA-N 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000008346 aqueous phase Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7682998P | 1998-03-02 | 1998-03-02 | |
| GBGB9810888.9A GB9810888D0 (en) | 1998-05-20 | 1998-05-20 | Process for synthesizing carbapenem antibiotics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE321762T1 true ATE321762T1 (de) | 2006-04-15 |
Family
ID=26313717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99908540T ATE321762T1 (de) | 1998-03-02 | 1999-02-26 | Verfahren zur synthese von carbapenem-antibiotika |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1060180B1 (de) |
| JP (1) | JP3953274B2 (de) |
| AT (1) | ATE321762T1 (de) |
| AU (1) | AU749234B2 (de) |
| CA (1) | CA2322658C (de) |
| DE (1) | DE69930616T2 (de) |
| ES (1) | ES2260900T3 (de) |
| WO (1) | WO1999045010A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6548492B1 (en) | 1999-10-29 | 2003-04-15 | Merck & Co., Inc. | Process for formulation of carbapenem antibiotic compositions |
| AU2001267011B2 (en) | 2000-06-21 | 2006-02-02 | Cubist Pharmaceuticals, Inc. | Compositions and methods to improve the oral absorption of antimicrobial agents |
| AR035728A1 (es) * | 2001-01-16 | 2004-07-07 | Merck & Co Inc | Proceso perfeccionado para la sintesis de carbapenem |
| EP1426376A4 (de) * | 2001-08-13 | 2004-12-22 | Eisai Co Ltd | Verfahren zur herstellung von carbapenem-antibiotika |
| KR100628676B1 (ko) | 2001-09-26 | 2006-09-27 | 머크 앤드 캄파니 인코포레이티드 | 카바페넴 화합물의 제조방법 |
| WO2003026572A2 (en) * | 2001-09-26 | 2003-04-03 | Merck & Co., Inc. | Crystalline forms of ertapenem sodium |
| JP4481829B2 (ja) * | 2002-11-13 | 2010-06-16 | 株式会社カネカ | 経口投与用カルバペネム化合物の新規合成中間体及びその製造方法 |
| NZ580951A (en) | 2005-04-29 | 2011-06-30 | Cubist Pharm Inc | Therapeutic compositions |
| CN100344613C (zh) * | 2005-10-20 | 2007-10-24 | 上海交通大学 | (2s,4s)－1－(4－硝基苄氧羰基)－2－[(3－烯丙氧羰基)－苯基氨基甲酰基]－吡咯烷－4－基硫醇的制备方法 |
| WO2009150630A2 (en) | 2008-06-11 | 2009-12-17 | Ranbaxy Laboratories Limited | Process for preparing a carbapenem antibiotic composition |
| CN102558182B (zh) * | 2010-12-31 | 2015-02-11 | 石药集团中奇制药技术（石家庄）有限公司 | 一种厄他培南钠晶型及其制备方法 |
| CN114105988B (zh) * | 2022-01-24 | 2022-04-29 | 深圳市海滨制药有限公司 | 一种厄他培南钠的合成方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU644008B2 (en) * | 1990-08-10 | 1993-12-02 | Sumitomo Pharmaceuticals Company, Limited | Beta-lactam compounds, and their production and use |
| TW264475B (de) * | 1991-09-20 | 1995-12-01 | Takeda Pharm Industry Co Ltd | |
| GB9202298D0 (en) * | 1992-02-04 | 1992-03-18 | Ici Plc | Antibiotic compounds |
-
1999
- 1999-02-26 AT AT99908540T patent/ATE321762T1/de not_active IP Right Cessation
- 1999-02-26 JP JP2000534552A patent/JP3953274B2/ja not_active Expired - Lifetime
- 1999-02-26 ES ES99908540T patent/ES2260900T3/es not_active Expired - Lifetime
- 1999-02-26 EP EP99908540A patent/EP1060180B1/de not_active Expired - Lifetime
- 1999-02-26 WO PCT/US1999/004321 patent/WO1999045010A1/en not_active Ceased
- 1999-02-26 AU AU27947/99A patent/AU749234B2/en not_active Ceased
- 1999-02-26 CA CA002322658A patent/CA2322658C/en not_active Expired - Lifetime
- 1999-02-26 DE DE69930616T patent/DE69930616T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU749234B2 (en) | 2002-06-20 |
| AU2794799A (en) | 1999-09-20 |
| WO1999045010A1 (en) | 1999-09-10 |
| EP1060180B1 (de) | 2006-03-29 |
| JP3953274B2 (ja) | 2007-08-08 |
| ES2260900T3 (es) | 2006-11-01 |
| EP1060180A4 (de) | 2004-03-10 |
| JP2002505331A (ja) | 2002-02-19 |
| CA2322658C (en) | 2005-04-12 |
| CA2322658A1 (en) | 1999-09-10 |
| DE69930616D1 (de) | 2006-05-18 |
| DE69930616T2 (de) | 2006-11-23 |
| EP1060180A1 (de) | 2000-12-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |