ATE322233T1 - Verfahren zur herstellung flexibler schichten aus deminaralisierten,länglichen knochenpartikeln - Google Patents

Verfahren zur herstellung flexibler schichten aus deminaralisierten,länglichen knochenpartikeln

Info

Publication number
ATE322233T1
ATE322233T1 AT97901455T AT97901455T ATE322233T1 AT E322233 T1 ATE322233 T1 AT E322233T1 AT 97901455 T AT97901455 T AT 97901455T AT 97901455 T AT97901455 T AT 97901455T AT E322233 T1 ATE322233 T1 AT E322233T1
Authority
AT
Austria
Prior art keywords
bone particles
demineralized bone
deminaralized
flexible layers
producing flexible
Prior art date
Application number
AT97901455T
Other languages
English (en)
Inventor
Michael Dowd
Nelson Scarborough
Mark Daugherty
Jack Mcmickle
Original Assignee
Osteotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osteotech Inc filed Critical Osteotech Inc
Application granted granted Critical
Publication of ATE322233T1 publication Critical patent/ATE322233T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools for implanting artificial joints
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/365—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A61F2002/30957—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using a positive or a negative model, e.g. moulds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools for implanting artificial joints
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A61F2002/4649—Bone graft or bone dowel harvest sites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/901—Method of manufacturing prosthetic device
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/915—Method or apparatus for preparing biological material
    • Y10S623/919—Bone

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Laminated Bodies (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
AT97901455T 1996-01-17 1997-01-16 Verfahren zur herstellung flexibler schichten aus deminaralisierten,länglichen knochenpartikeln ATE322233T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1012796P 1996-01-17 1996-01-17

Publications (1)

Publication Number Publication Date
ATE322233T1 true ATE322233T1 (de) 2006-04-15

Family

ID=21744037

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97901455T ATE322233T1 (de) 1996-01-17 1997-01-16 Verfahren zur herstellung flexibler schichten aus deminaralisierten,länglichen knochenpartikeln

Country Status (8)

Country Link
US (1) US6436138B1 (de)
EP (1) EP0880345B1 (de)
AT (1) ATE322233T1 (de)
AU (1) AU1535097A (de)
CA (1) CA2243365C (de)
DE (1) DE69735625T2 (de)
ES (1) ES2260783T3 (de)
WO (1) WO1997025941A1 (de)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6652592B1 (en) 1997-10-27 2003-11-25 Regeneration Technologies, Inc. Segmentally demineralized bone implant
US6090998A (en) * 1997-10-27 2000-07-18 University Of Florida Segmentally demineralized bone implant
US6123731A (en) * 1998-02-06 2000-09-26 Osteotech, Inc. Osteoimplant and method for its manufacture
US8563232B2 (en) 2000-09-12 2013-10-22 Lifenet Health Process for devitalizing soft-tissue engineered medical implants, and devitalized soft-tissue medical implants produced
US20080077251A1 (en) * 1999-06-07 2008-03-27 Chen Silvia S Cleaning and devitalization of cartilage
US6293970B1 (en) 1998-06-30 2001-09-25 Lifenet Plasticized bone and soft tissue grafts and methods of making and using same
US20100030340A1 (en) * 1998-06-30 2010-02-04 Wolfinbarger Jr Lloyd Plasticized Grafts and Methods of Making and Using Same
US20030114936A1 (en) * 1998-10-12 2003-06-19 Therics, Inc. Complex three-dimensional composite scaffold resistant to delimination
US8133421B2 (en) 1999-02-23 2012-03-13 Warsaw Orthopedic, Inc. Methods of making shaped load-bearing osteoimplant
US6696073B2 (en) 1999-02-23 2004-02-24 Osteotech, Inc. Shaped load-bearing osteoimplant and methods of making same
US6294187B1 (en) * 1999-02-23 2001-09-25 Osteotech, Inc. Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same
US6162258A (en) * 1999-08-25 2000-12-19 Osteotech, Inc. Lyophilized monolithic bone implant and method for treating bone
US20030228288A1 (en) 1999-10-15 2003-12-11 Scarborough Nelson L. Volume maintaining osteoinductive/osteoconductive compositions
AR027685A1 (es) 2000-03-22 2003-04-09 Synthes Ag Forma de tejido y metodo para realizarlo
WO2001070137A2 (en) * 2000-03-22 2001-09-27 Synthes (U.S.A) Multipiece implants formed of bone material
TR200400527T4 (tr) 2000-07-03 2004-07-21 Osteotech Inc. Kemikten türetilmiş osteojenik implantlar
US6863694B1 (en) 2000-07-03 2005-03-08 Osteotech, Inc. Osteogenic implants derived from bone
AU2001275999B2 (en) * 2000-07-19 2007-03-29 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
US9387094B2 (en) 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
AU1086201A (en) * 2000-10-13 2002-04-29 Osteotech Inc Volume maintaining osteoinductive/oesteoconductive compositions
CA2423603C (en) 2000-11-03 2010-05-04 Osteotech, Inc. Spinal intervertebral implant and method of making
US7323193B2 (en) 2001-12-14 2008-01-29 Osteotech, Inc. Method of making demineralized bone particles
US6776800B2 (en) * 2001-02-28 2004-08-17 Synthes (U.S.A.) Implants formed with demineralized bone
US20050107795A1 (en) * 2001-08-10 2005-05-19 John Morris Bone plating system and method of use
EP1434608B1 (de) 2001-10-12 2018-08-22 Warsaw Orthopedic, Inc. Verbessertes knochenimplantat
AR038680A1 (es) 2002-02-19 2005-01-26 Synthes Ag Implante intervertebral
WO2004069106A1 (de) 2003-02-06 2004-08-19 Synthes Ag Chur Zwischenwirbelimplantat
US7819903B2 (en) 2003-03-31 2010-10-26 Depuy Spine, Inc. Spinal fixation plate
NZ544050A (en) * 2003-06-11 2009-03-31 Osteotech Inc Osteoimplants and methods for their manufacture
US7226482B2 (en) 2003-09-02 2007-06-05 Synthes (U.S.A.) Multipiece allograft implant
EP1701729B1 (de) 2003-12-31 2018-05-02 Warsaw Orthopedic, Inc. Verbesserte knochenmatrixzusammensetzungen und verfahren
US8734525B2 (en) 2003-12-31 2014-05-27 Warsaw Orthopedic, Inc. Osteoinductive demineralized cancellous bone
EP1789088A4 (de) * 2004-03-24 2009-12-30 Doctor S Res Group Inc Verfahren zur durchführung von medizinischen verfahren zur förderung des knochenwachstums, verfahren zur herstellung von zusammensetzungen zur förderung des knochenwachstums und gerät zur verwendung bei solchen verfahren
US20060083769A1 (en) * 2004-10-14 2006-04-20 Mukesh Kumar Method and apparatus for preparing bone
US7670384B2 (en) 2004-10-14 2010-03-02 Biomet Manufacturing Corp. Bone graft composition comprising a bone material and a carrier comprising denatured demineralized bone
JP5154427B2 (ja) * 2005-10-24 2013-02-27 エー・デー・ガイストリヒ・ゾーネ・アクチェンゲゼルシャフト・フュール・ヒェーミシェ・インダストリー 滑膜細胞が充填されるコラーゲン膜またはゲルのための方法および装置
CA2627907C (en) 2005-11-01 2014-06-17 Osteotech, Inc. Osteoinductive composition comprising osteoinductive factors recovered from mineralized bone and a carrier
WO2007056671A1 (en) 2005-11-02 2007-05-18 Osteotech, Inc. Hemostatic bone graft
WO2007098288A2 (en) 2006-02-27 2007-08-30 Synthes (U.S.A.) Intervertebral implant with fixation geometry
US9554920B2 (en) 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
CA2945295C (en) 2007-06-15 2020-01-14 Warsaw Orthopedic, Inc. Method of treating tissue
AU2008265850B2 (en) 2007-06-15 2014-06-26 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
WO2009009688A1 (en) 2007-07-10 2009-01-15 Osteotech, Inc. Delivery system
US9125743B2 (en) * 2007-07-16 2015-09-08 Lifenet Health Devitalization and recellularization of cartilage
US20090024224A1 (en) 2007-07-16 2009-01-22 Chen Silvia S Implantation of cartilage
US9138509B2 (en) * 2007-09-14 2015-09-22 Musculoskeletal Transplant Foundation Composition for filling bone defects
EP2211921B1 (de) 2007-10-19 2013-12-25 Warsaw Orthopedic, Inc. Demineralisierte knochenmatrix-zusammensetzungen und verfahren
EP2217293B1 (de) 2007-11-09 2019-05-22 Warsaw Orthopedic, Inc. Knochenmatrixzusammensetzungen mit texturierten nanoskaligen oberflächen
CN101909551A (zh) 2007-11-16 2010-12-08 新特斯有限责任公司 小外形椎间植入物
US8722075B2 (en) 2008-10-24 2014-05-13 Warsaw Orthopedic, Inc. Compositions and methods for promoting bone formation
CA2742812A1 (en) 2008-11-07 2010-05-14 DePuy Synthes Products, Inc. Zero-profile interbody spacer and coupled plate assembly
US9192695B2 (en) 2008-11-20 2015-11-24 Allosource Allografts combined with tissue derived stem cells for bone healing
US12377189B2 (en) 2008-12-13 2025-08-05 Bioventus Llc Osteoinductive bone implant including harvested demineralized bone and bone morphogenetic proteins bound thereto obtained from the same donor
WO2010093950A1 (en) 2009-02-12 2010-08-19 Osteotech, Inc. Delivery system cartridge
WO2011017284A2 (en) 2009-08-03 2011-02-10 Osteotech, Inc. Bone matrix compositions and methods
AU2010328427B2 (en) 2009-12-13 2014-06-05 Advanced Biologics, Inc. Bioactive grafts and composites
US8790321B2 (en) * 2010-04-21 2014-07-29 Genesis Medical Devices, LLC Apparatus, system, and method for harvesting improved bone graft material with reamer-irrigator-aspirator (RIA) device
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
WO2012088238A2 (en) 2010-12-21 2012-06-28 Synthes Usa, Llc Intervertebral implants, systems, and methods of use
US9241809B2 (en) 2010-12-21 2016-01-26 DePuy Synthes Products, Inc. Intervertebral implants, systems, and methods of use
WO2013075091A1 (en) 2011-11-17 2013-05-23 Allosource Multi-piece machine graft systems and methods
US9186253B2 (en) * 2013-02-22 2015-11-17 Allosource Cartilage mosaic compositions and methods
EP2964154A4 (de) 2013-03-07 2016-08-17 Allosource Knochenallotransplatsysteme und -verfahren mit konsistentem kalziumgehalt
WO2014150784A1 (en) 2013-03-15 2014-09-25 Allosource Cell repopulated collagen matrix for soft tissue repair and regeneration
WO2014151939A1 (en) 2013-03-15 2014-09-25 Allosource Perforated osteochondral allograft compositions
US9572912B2 (en) 2013-04-19 2017-02-21 Theracell, Inc. Demineralized bone fibers having controlled geometry and shapes and methods thereof
US10173375B2 (en) 2014-03-05 2019-01-08 Bacterin International, Inc. Shaped fiber-based products and method of manufacture thereof
US9730796B2 (en) 2014-05-16 2017-08-15 Allosource Composite bone constructs and methods
US9867718B2 (en) 2014-10-22 2018-01-16 DePuy Synthes Products, Inc. Intervertebral implants, systems, and methods of use
CA2986702C (en) 2015-05-21 2023-04-04 David Wang Modified demineralized cortical bone fibers
US10821004B2 (en) 2015-06-30 2020-11-03 Bacterin Interational, Inc. Expandable bone grafts and methods of manufacture thereof
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
WO2019006328A1 (en) 2017-06-30 2019-01-03 Allosource CELL BONE GRAFTS, AND METHODS OF MAKING AND USING
US12311076B1 (en) 2018-06-07 2025-05-27 Seaspine, Inc. Demineralized bone matrix composition with enhanced osteoinductivity and osteoconductivity
US11896736B2 (en) 2020-07-13 2024-02-13 Globus Medical, Inc Biomaterial implants and methods of making the same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4743259A (en) * 1986-10-29 1988-05-10 The University Of Virginia Alumni Patents Foundation Use of demineralized bone matrix in the repair of segmental defects
US4865602A (en) 1986-11-06 1989-09-12 Collagen Corporation Gamma irradiation of collagen/mineral mixtures
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
EP0483944B1 (de) 1990-10-31 1995-07-05 El Gendler Flexible Membrane hergestellt aus organischer Knochenmatrix zum Ausbessern und Wiederherstellen von Knochen
DE4120325A1 (de) * 1991-06-20 1992-12-24 Merck Patent Gmbh Implantatwerkstoff
US5314476A (en) * 1992-02-04 1994-05-24 Osteotech, Inc. Demineralized bone particles and flowable osteogenic composition containing same
US5531791A (en) * 1993-07-23 1996-07-02 Bioscience Consultants Composition for repair of defects in osseous tissues, method of making, and prosthesis
US5507813A (en) * 1993-12-09 1996-04-16 Osteotech, Inc. Shaped materials derived from elongate bone particles

Also Published As

Publication number Publication date
AU1535097A (en) 1997-08-11
CA2243365A1 (en) 1997-07-24
US6436138B1 (en) 2002-08-20
WO1997025941A1 (en) 1997-07-24
EP0880345B1 (de) 2006-04-05
EP0880345A4 (de) 2002-07-17
CA2243365C (en) 2006-07-25
DE69735625T2 (de) 2006-12-21
DE69735625D1 (de) 2006-05-18
ES2260783T3 (es) 2006-11-01
EP0880345A1 (de) 1998-12-02

Similar Documents

Publication Publication Date Title
DE69735625D1 (de) Verfahren zur herstellung flexibler schichten aus deminaralisierten,länglichen knochenpartikeln
DE69725193D1 (de) Verfahren zur Herstellung in situ von einem Füllmaterial für Brust-, Penis- und Hodenprothese, und Gewebedilatatoren
ATE300406T1 (de) Verfahren und vorrichtung zur herstellung und behandlung von elastomeren verbundwerkstoffen, und durch das verfahren herstellbarer elastomerer verbundwerkstoff
DE69635127D1 (de) Verfahren zur herstellung von vernetzten wasserlöslichen polymerpartikel, die partikel und ihre verwendung
ATE94456T1 (de) Verfahren zur herstellung von neuen formkoerpern, insbesondere fuer strukturelemente, isolierungen und/oder verpackung, vorrichtung zur durchfuehrung des verfahrens sowie insbesondere danach bzw. damit erhaltener formkoerper.
DE59502541D1 (de) Biologisch abbaubare polymere, verfahren zu deren herstellung sowie deren verwendung zur herstellung bioabbaubarer formkörper
ATE184541T1 (de) Schichtverbundmaterial, verfahren zur herstellung und davon abgeleitete produkten
DE69617957D1 (de) Feine teilchen aus blütenförmigem porösem hydroxyapatit und verfahren zur herstellung
DE69528854D1 (de) Beschichtetes Aluminium-enthaltendes Material und Verfahren zur dessen Herstellung
DE69533433D1 (de) Verfahren und Mischung zur Herstellung von Polymerprodukten für die Zahnmedizin
DE69512362D1 (de) Verfahren zur kontinuierlichen Herstellung von Siliconharz-gebundenen pyrotechnischen Ladungen und Zusammensetzung zur Verwendung in einem solchen Verfahren
DE69604399D1 (de) Verfahren und vorrichtung zur herstellung von ringförmigen werkstücken aus verbundmaterial und vorformlinge für diese werkstücke
DE69619992D1 (de) Verfahren zur Herstellung von geschichteten und teilchenförmiges Material enthaltenden Strukturen, sowie nach dem Verfahren hergestellte Struktur
DE59506072D1 (de) Verfahren zur Herstellung von Presslingen aus pulverförmigem Material sowie entsprechende Presse
DE69505164D1 (de) Verfahren zur Herstellung von modifizierten vernetzten Polymerpartikeln
DE59606654D1 (de) Verfahren und Vorrichtung zur Herstellung von Aerosolen sowie deren Verwendung
DE59610741D1 (de) Verfahren zur Herstellung von Deckelmaterial sowie dessen Verwendung
DE69602696D1 (de) Verfahren zur Herstellung von modifiziertem Polytetrafluorethylen-Feinpulver
DE69516339D1 (de) Verfahren zur Herstellung von Druckgas mit variabelen Mengen
ATE192131T1 (de) Verfahren zur gemeinsamen herstellung von ethern und kohlenwasserstoffen mit hoher oktanzahl
DE58902131D1 (de) Verfahren zur kontinuierlichen herstellung von hartbonbonmassen sowie vorrichtung zur durchfuehrung dieses verfahrens.
DE69522884D1 (de) Verfahren und Vorrichtung zum Herstellen von Rohren aus Verbundwerkstoff mit guten mechanischen und tribologischen Eigenschaften, und durch das Verfahren hergestellte Rohre
DE69902105D1 (de) Biozides material und verfahren zur dessen herstellung
DE69607556D1 (de) Verfahren und Vorrichtung zur in-line Herstellung und Umwandlung von faserigen Verbundmaterialen in ein Verbundprodukt
DE69906241D1 (de) Beschichtetes material und verfahren zur herstellung des materials

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties