ATE322252T1 - Verfahren zur herstellung und sammlung von kristallinen partikeln - Google Patents

Verfahren zur herstellung und sammlung von kristallinen partikeln

Info

Publication number
ATE322252T1
ATE322252T1 AT01943684T AT01943684T ATE322252T1 AT E322252 T1 ATE322252 T1 AT E322252T1 AT 01943684 T AT01943684 T AT 01943684T AT 01943684 T AT01943684 T AT 01943684T AT E322252 T1 ATE322252 T1 AT E322252T1
Authority
AT
Austria
Prior art keywords
producing
crystalline particles
collecting crystalline
particles
collecting
Prior art date
Application number
AT01943684T
Other languages
English (en)
Inventor
Robert William Lancaster
Hardev Singh
Andrew Lewis Theopilus
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE322252T1 publication Critical patent/ATE322252T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT01943684T 2000-06-29 2001-06-29 Verfahren zur herstellung und sammlung von kristallinen partikeln ATE322252T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0015981.4A GB0015981D0 (en) 2000-06-29 2000-06-29 Novel process for preparing crystalline particles

Publications (1)

Publication Number Publication Date
ATE322252T1 true ATE322252T1 (de) 2006-04-15

Family

ID=9894682

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01943684T ATE322252T1 (de) 2000-06-29 2001-06-29 Verfahren zur herstellung und sammlung von kristallinen partikeln

Country Status (9)

Country Link
US (1) US20030181432A1 (de)
EP (1) EP1294359B1 (de)
JP (1) JP2004500983A (de)
AT (1) ATE322252T1 (de)
AU (1) AU2001266218A1 (de)
DE (1) DE60118558T2 (de)
ES (1) ES2260236T3 (de)
GB (1) GB0015981D0 (de)
WO (1) WO2002000198A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7498019B2 (en) 2001-05-24 2009-03-03 Alexza Pharmaceuticals, Inc. Delivery of compounds for the treatment of headache through an inhalation route
WO2002094238A1 (en) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of anti-migraine compounds through an inhalation route
AU2002310074B2 (en) * 2001-05-24 2008-09-04 Alexza Pharmaceuticals, Inc. Delivery of compounds for the treatment of migraine through an inhalation route
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
JP2005503425A (ja) 2001-05-24 2005-02-03 アレックザ モレキュラー デリヴァリー コーポレイション 所定の吸入ルートによる薬剤エステルの送出
WO2002094243A1 (en) * 2001-05-24 2002-11-28 Alexza Molecular Delivery Corporation Delivery of sumatriptan, frovatriptan or naratriptan through an inhalation route
US6759029B2 (en) 2001-05-24 2004-07-06 Alexza Molecular Delivery Corporation Delivery of rizatriptan and zolmitriptan through an inhalation route
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US7090830B2 (en) 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US20030049323A1 (en) * 2001-08-29 2003-03-13 Hitt James E. Process to precipitate drug particles
GB0208608D0 (en) * 2002-04-13 2002-05-22 Glaxo Group Ltd Composition
ITMI20022674A1 (it) * 2002-12-18 2004-06-19 Chiesi Farma Spa Procedimento per la preparazione di formulazioni sterili a base di principi attivi farmaceutici cristallini micronizzati da somministrare come sospensioni acquose per inalazione.
EP1593417A4 (de) * 2003-01-31 2007-02-28 Ebara Corp Verfahren und vorrichtung zur ionenentfernung aus einer flüssigkeit mittels kristallisierung
WO2004076403A1 (en) * 2003-02-24 2004-09-10 Transform Pharmaceuticals, Inc. Sumatriptan crystalline forms, pharmaceutical compositions and methods
US20040234699A1 (en) 2003-05-21 2004-11-25 Alexza Molecular Delivery Corporation Methods of controlling uniformity of substrate temperature and self-contained heating unit and drug-supply unit employing same
GB0406069D0 (en) * 2004-03-17 2004-04-21 Thompson James Process
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
WO2006010078A2 (en) * 2004-07-08 2006-01-26 Dr. Reddy's Laboratories Ltd. Polymorphic form of naratriptan hydrochloride
EP2246086A3 (de) 2004-08-12 2012-11-21 Alexza Pharmaceuticals, Inc. Aerosolverabreichungsvorrichtung mit Schlag gezündete Heizeinheit
US8420122B2 (en) 2006-04-28 2013-04-16 Merck Sharp & Dohme Corp. Process for the precipitation and isolation of 6,6-dimethyl-3-aza-bicyclo [3.1.0] hexane-amide compounds by controlled precipitation and pharmaceutical formulations containing same
EP2012753A2 (de) * 2006-04-28 2009-01-14 Schering Corporation Verfahren zur ausscheidung und isolierung von 6,6-dimethyl-3-aza-bicyclo [3.1.0]hexan-amid-verbindungen durch kontrollierte ausscheidung und pharmazeutische formulierungen damit
US20090291146A1 (en) * 2006-08-09 2009-11-26 Glaxo Group Limited Process for manufacturing lactose
EP2121088B1 (de) 2007-03-09 2016-07-13 Alexza Pharmaceuticals, Inc. Erhitzungseinheit zur verwendung in einer arzneimittelabgabevorrichtung
GB0705159D0 (en) * 2007-03-19 2007-04-25 Prosonix Ltd Process for making crystals
GB0711680D0 (en) * 2007-06-18 2007-07-25 Prosonix Ltd Process
MX2012008171A (es) * 2010-01-15 2012-12-17 Lithera Inc Formulaciones aglomeradas liofilizadas.
WO2013009591A1 (en) * 2011-07-08 2013-01-17 Pfizer Limited Process for the preparation of fluticasone propionate form 1
US8765725B2 (en) 2012-05-08 2014-07-01 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
CN107880091B (zh) 2012-05-08 2020-12-18 尼科斯眼药公司 疏水性治疗剂的制剂、其制备方法及应用
EP2705838A1 (de) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium-Zubereitungen
US9815865B2 (en) 2013-01-07 2017-11-14 Nicox Ophthalmics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
JP2018126699A (ja) * 2017-02-09 2018-08-16 水ｉｎｇ株式会社 晶析方法及び晶析装置
US12214118B2 (en) 2018-02-02 2025-02-04 Alexza Pharmaceuticals, Inc. Electrical condensation aerosol device

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3154395A (en) * 1961-01-30 1964-10-27 Universal Oil Prod Co Continuous fractional crystallization process
US3984409A (en) * 1973-08-09 1976-10-05 Pfizer Inc. Cyclic n-substituted derivatives of 1,4-benzene disulphonamide
NL7501406A (en) * 1975-02-06 1976-08-10 Dso Pharmachim Crystallisation of tetracycline hydrochloride - accelerated by subjecting to high-frequency vibrations, with purer, less toxic prod. formed
DE69112917T2 (de) * 1990-06-15 1996-05-15 Merck & Co Inc Kristallisationsverfahren zur Verbesserung der Kristallstruktur und -grösse.
GB9313650D0 (en) * 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
SE9501384D0 (sv) * 1995-04-13 1995-04-13 Astra Ab Process for the preparation of respirable particles
AU744536B2 (en) * 1997-09-03 2002-02-28 Merck Sharp & Dohme Corp. Process for enhancing the optical purity of 2R-(1-hydroxy- 1-trifluoromethyl- 3-cyclopropylpropyn-2YL) -4-chloroaniline
KR20010033747A (ko) * 1997-12-29 2001-04-25 태듀스 피. 프러스 Ｎ-Ｈｅｔ-치환 글리세로포스포에탄올아민
CH689805A8 (fr) * 1998-07-02 2000-02-29 Smithkline Beecham Plc Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
JP3416951B2 (ja) * 1998-08-31 2003-06-16 順三 砂本 高純度疎水性基含有多糖類およびその製造方法
SE9802974D0 (sv) * 1998-09-03 1998-09-03 Astra Ab New crystalline forms
GB9828721D0 (en) * 1998-12-24 1999-02-17 Glaxo Group Ltd Novel apparatus and process
TR200101891T2 (tr) * 1999-01-29 2001-12-21 Bristol-Myers Squibb Company Sonik etkili jet kristalleşme aparat ve cihazı.

Also Published As

Publication number Publication date
EP1294359A1 (de) 2003-03-26
DE60118558T2 (de) 2006-08-24
GB0015981D0 (en) 2000-08-23
ES2260236T3 (es) 2006-11-01
US20030181432A1 (en) 2003-09-25
WO2002000198A1 (en) 2002-01-03
JP2004500983A (ja) 2004-01-15
AU2001266218A1 (en) 2002-01-08
EP1294359B1 (de) 2006-04-05
DE60118558D1 (de) 2006-05-18

Similar Documents

Publication Publication Date Title
DE60118558D1 (de) Verfahren zur herstellung und sammlung von kristallinen partikeln
ATE306252T1 (de) Verfahren zur herstellung kristalliner partikel zur inhalation
PL345215A1 (en) Novel form of irbesartan, methods for obtaining said form and pharmaceutical compositions containing same
ATE330970T1 (de) Neue anti-hiv immunogene (toxoide), herstellungsverfahren und verwendungen zur behandlung und vorbeugung von aids
DE60139122D1 (de) Verfahren zur produktion von natürlichen medizin präparaten
DE69920945D1 (de) Verfahren zur herstellung von arzneistoffpartikeln
ATE360653T1 (de) Verfahren zur herstellung von polyisobutenen
DE69531308D1 (de) Verfahren zur Herstellung von gereinigten papillomavirus Proteinen
ATE116541T1 (de) Verfahren zur herstellung mikronisierter bioabbaubarer partikel.
ATE307203T1 (de) Verwendung eines anti-interleukin-9 antikörpers zur herstellung eines medikamentes zur behandlung von asthma
DE60035693D1 (de) Zusammensetzung und verfahren zur behandlung von immunverwandten krankheiten
ATE217191T1 (de) Verwendung von phanquinon zur behandlung von alzheimer's krankheit
ATE282594T1 (de) Verfahren zur herstellung von (+)-trans-4-p- fluorophenyl-3-hydroxymethyl-1-methylpiperidin
DE59800130D1 (de) Verfahren zur Herstellung von Organosilazanen
DE50103009D1 (de) Verfahren zur herstellung von 2-alkyl-3-chlorphenolen
DE60109701D1 (de) Verfahren zur Herstellung von Verbundpartikeln
ATE235461T1 (de) Verfahren zur herstellung von 3-cyano-2,4- dihalogen-5-fluor-benzoesäuren
MY127328A (en) 5-amino-1-pentene-3-ol substituted derivatives
ATE425143T1 (de) Verfahren zur herstellung von indolen
DE50203388D1 (de) Verbessertes verfahren zur herstellung von bisphosphiten
DE59811573D1 (de) Verbessertes Verfahren zur Herstellung von ungesättigten cyclischen Ethern
DE3886234D1 (de) DNA-Sequenzen, Plasmide und Mikroorganismen sowie Verfahren zur Herstellung von Chinolinsäure.
YU67203A (sh) Derivati caloporosida, postupak za njihovu proizvodnju i njihova primena
DE50012273D1 (de) Vorrichtung zur Herstellung von Presslingen
DE50312447D1 (de) Verfahren zur herstellung von 4,6-dichlor-5-fluorpyrimidin

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties