ATE324454T1 - Faktor x-analoge mit modifizierter proteasespaltstelle - Google Patents

Faktor x-analoge mit modifizierter proteasespaltstelle

Info

Publication number
ATE324454T1
ATE324454T1 AT98903943T AT98903943T ATE324454T1 AT E324454 T1 ATE324454 T1 AT E324454T1 AT 98903943 T AT98903943 T AT 98903943T AT 98903943 T AT98903943 T AT 98903943T AT E324454 T1 ATE324454 T1 AT E324454T1
Authority
AT
Austria
Prior art keywords
factor
Prior art date
Application number
AT98903943T
Other languages
English (en)
Inventor
Michele Himmelspach
Uwe Schlokat
Friedrich Dorner
Andreas Fisch
Johann Eibl
Original Assignee
Baxter Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Ag filed Critical Baxter Ag
Application granted granted Critical
Publication of ATE324454T1 publication Critical patent/ATE324454T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT98903943T 1997-02-27 1998-02-27 Faktor x-analoge mit modifizierter proteasespaltstelle ATE324454T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0033597A AT405516B (de) 1997-02-27 1997-02-27 Faktor x-analoge mit modifizierter proteasespaltstelle
EP98903943A EP0966536B1 (de) 1997-02-27 1998-02-27 Faktor x-analoge mit modifizierter proteasespaltstelle

Publications (1)

Publication Number Publication Date
ATE324454T1 true ATE324454T1 (de) 2006-05-15

Family

ID=3487868

Family Applications (2)

Application Number Title Priority Date Filing Date
AT0033597A AT405516B (de) 1997-02-27 1997-02-27 Faktor x-analoge mit modifizierter proteasespaltstelle
AT98903943T ATE324454T1 (de) 1997-02-27 1998-02-27 Faktor x-analoge mit modifizierter proteasespaltstelle

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT0033597A AT405516B (de) 1997-02-27 1997-02-27 Faktor x-analoge mit modifizierter proteasespaltstelle

Country Status (17)

Country Link
US (2) US6573071B1 (de)
EP (1) EP0966536B1 (de)
JP (1) JP4317976B2 (de)
AR (1) AR012034A1 (de)
AT (2) AT405516B (de)
AU (1) AU744428B2 (de)
BR (1) BR9807627A (de)
CA (1) CA2282707A1 (de)
CZ (1) CZ298298B6 (de)
DE (1) DE59813518D1 (de)
ES (1) ES2263199T3 (de)
HU (1) HU225246B1 (de)
IL (2) IL131346A0 (de)
NO (1) NO327878B1 (de)
PL (1) PL190734B1 (de)
SK (1) SK286359B6 (de)
WO (1) WO1998038317A1 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT405517B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-deletionsmutanten und analoge davon
IL129427A0 (en) * 1999-04-13 2000-02-17 Yeda Res & Dev Preparation of biologically active molecules
AT410216B (de) * 1999-08-10 2003-03-25 Baxter Ag Faktor x-analogon mit verbesserter aktivierbarkeit
US20040102388A1 (en) * 2000-03-22 2004-05-27 High Katherine A. Modified blood clotting factors and methods of use
US7223577B2 (en) * 2000-11-17 2007-05-29 Allergan, Inc. Post-translational modifications and Clostridial neurotoxins
FR2831170B1 (fr) * 2001-10-19 2004-03-19 Inst Nat Sante Rech Med Proteines c modifiees activables directement par la thrombine
FR2841904B1 (fr) * 2002-07-03 2004-08-20 Inst Nat Sante Rech Med Analogues de facteurs x clivables par la thrombine
US20040132156A1 (en) * 2002-10-04 2004-07-08 Schering Aktiengesellschaft Modified hepsin molecules having a substitute activation sequence and uses thereof
BRPI0514396A2 (pt) * 2004-08-17 2009-05-12 Csl Behring Gmbh polipeptìdeos dependentes de vitamina k modificada
EP1728798A1 (de) * 2005-06-01 2006-12-06 ZLB Behring GmbH Blutgerinnungsfaktor X Polypeptide mit veränderten Aktivierungseigenschaften
US7855279B2 (en) * 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
US7846445B2 (en) * 2005-09-27 2010-12-07 Amunix Operating, Inc. Methods for production of unstructured recombinant polymers and uses thereof
MX336958B (es) 2005-11-15 2016-02-05 Philadelphia Children Hospital Metodos y composiciones para modular la hemostasia.
EP1820508A1 (de) * 2006-02-21 2007-08-22 CSL Behring GmbH Polypeptide des Gerinnfaktors X mit geänderten Aktivierungseigenschaften
EP2014676B1 (de) 2006-04-20 2012-03-07 Kringle Pharma Inc. Mutante des hgf-precursor-proteins und aktivierte form davon
US9956272B2 (en) 2007-05-30 2018-05-01 Bio Products Laboratory Limited Methods for preparing factor X, activated factor X, inactivated factor X and inactivated factor Xa, and pharmaceutical compositions comprising same
GB0710321D0 (en) * 2007-05-30 2007-07-11 Nhs Blood & Transplant Method
MX2010001684A (es) * 2007-08-15 2010-04-21 Amunix Inc Composiciones y metodos para modificar propiedades de polipeptidos biologicamente activos.
EP2193196B1 (de) 2007-09-28 2016-07-13 Portola Pharmaceuticals, Inc. Gegenmittel für faktor-xa-hemmer und verwendungsverfahren dafür
EP2364165B1 (de) * 2008-11-14 2018-01-03 Portola Pharmaceuticals, Inc. Antidote für faktor-xa-inhibitoren und verfahren zu ihrer verwendung in kombination mit blutgerinnungsmitteln
US8680050B2 (en) * 2009-02-03 2014-03-25 Amunix Operating Inc. Growth hormone polypeptides fused to extended recombinant polypeptides and methods of making and using same
US8703717B2 (en) 2009-02-03 2014-04-22 Amunix Operating Inc. Growth hormone polypeptides and methods of making and using same
CN108530543B (zh) 2009-02-03 2023-06-23 阿穆尼克斯制药公司 延伸重组多肽和包含该延伸重组多肽的组合物
LT3604510T (lt) * 2009-03-30 2025-07-10 Alexion Pharmaceuticals, Inc. Faktoriaus xa inhibitorius neutralizuojančios medžiagos ir jų naudojimo būdai
US9849188B2 (en) 2009-06-08 2017-12-26 Amunix Operating Inc. Growth hormone polypeptides and methods of making and using same
JP5839597B2 (ja) * 2009-06-08 2016-01-06 アムニクス オペレーティング インコーポレイテッド グルコース調節ポリペプチド並びにその作成及び使用方法
JP6163304B2 (ja) 2009-07-15 2017-07-12 ポートラ ファーマシューティカルズ， インコーポレイテッド 第Ｘａ因子インヒビターの解毒剤の単位用量処方物およびその使用方法
CN102741275B (zh) 2009-08-24 2016-08-03 阿穆尼克斯运营公司 凝血因子ix组合物及其制备和使用方法
US8557961B2 (en) 2010-04-02 2013-10-15 Amunix Operating Inc. Alpha 1-antitrypsin compositions and methods of making and using same
US9371522B2 (en) 2011-09-30 2016-06-21 The Children's Hospital Of Philadelphia Compositions and methods for modulating hemostasis
LT3564260T (lt) 2012-02-15 2023-01-10 Bioverativ Therapeutics Inc. Viii faktoriaus kompozicijos ir jų gamybos bei panaudojimo būdai
EP2822577B1 (de) 2012-02-15 2019-02-06 Bioverativ Therapeutics Inc. Rekombinante faktor-viii-proteine
CA2865578C (en) 2012-02-27 2023-01-17 Amunix Operating Inc. Xten conjugate compositions and methods of making same
GB201211617D0 (en) * 2012-06-29 2012-08-15 Univ Aberdeen Production of cyclic peptides
SG11201500579SA (en) 2012-07-25 2015-02-27 Catalyst Biosciences Inc Modified factor x polypeptides and uses thereof
KR20150103205A (ko) 2013-01-31 2015-09-09 화이자 인코포레이티드 인자 Xa 억제를 길항하기 위한 조성물 및 방법
FR3001729B1 (fr) * 2013-02-04 2015-03-06 Lab Francais Du Fractionnement Mutants du facteur x
US20160024487A1 (en) * 2013-03-12 2016-01-28 Novo Nordisk A/S Thrombin sensitive coagulation factor x molecules
TWI667255B (zh) 2013-08-14 2019-08-01 美商生物化學醫療公司 因子ｖｉｉｉ－ｘｔｅｎ融合物及其用途
SG11201601221XA (en) 2013-09-24 2016-04-28 Pfizer Compositions comprising heterogeneous populations of recombinant human clotting factor xa proteins
SG11201605242YA (en) 2014-01-10 2016-07-28 Biogen Ma Inc Factor viii chimeric proteins and uses thereof
RU2585532C2 (ru) * 2014-01-31 2016-05-27 Федеральное государственное учреждение "Федеральный исследовательский центр "Фундаментальные основы биотехнологии" Российской академии наук"(ФИЦ Биотехнологии РАН) Плазмида для экспрессии рекомбинантного фактора свёртываемости крови ix человека, клетка сно - продуцент рекомбинантного фактора свёртываемости крови ix человека и способ получения указанного фактора
US10676731B2 (en) 2014-08-19 2020-06-09 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor IX function
IL257231B (en) 2015-08-03 2022-09-01 Bioverativ Therapeutics Inc Factor ix fusion proteins and methods of making and using same
IL319047A (en) 2015-08-28 2025-04-01 Amunix Operating Inc Chimeric polypeptide composition and methods for its preparation and use
MX2019006444A (es) 2016-12-02 2019-10-30 Bioverativ Therapeutics Inc Métodos de tratamiento de artropatía hemofílica utilizando factores de coagulación quiméricos.
SI3793588T1 (sl) 2018-05-18 2025-07-31 Bioverativ Therapeutics Inc. Postopki zdravljenja hemofilije A
KR102613936B1 (ko) * 2020-11-13 2023-12-15 한국생명공학연구원 자가분해능이 저하된 켁신 효소 및 이의 생산 방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT366916B (de) * 1980-04-02 1982-05-25 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen
US4501731A (en) 1983-06-27 1985-02-26 Tishkoff Garson H Treatment of disparate bleeding disorders with factor X zymogen
AT382783B (de) * 1985-06-20 1987-04-10 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes
US5597799A (en) * 1990-09-04 1997-01-28 Cor Therapeutics, Inc. Recombinant agents affecting thrombosis
EP0785273A1 (de) 1990-11-26 1997-07-23 Genetics Institute, Inc. Gepaarte basische Aminosäuren konvertierendes Enzym und dafür kodierende DNA Sequenz
US5621039A (en) 1993-06-08 1997-04-15 Hallahan; Terrence W. Factor IX- polymeric conjugates
DE4325872C1 (de) 1993-08-02 1994-08-04 Immuno Ag Virusinaktivierte Faktor Xa-Präparation
AT401270B (de) 1994-09-26 1996-07-25 Immuno Ag Verfahren zur quantifizierung von genomischer dna
AT404838B (de) 1995-11-24 1999-03-25 Immuno Ag Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen
AT405517B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-deletionsmutanten und analoge davon

Also Published As

Publication number Publication date
EP0966536A1 (de) 1999-12-29
AR012034A1 (es) 2000-09-27
JP4317976B2 (ja) 2009-08-19
JP2001513631A (ja) 2001-09-04
WO1998038317A1 (de) 1998-09-03
NO994139D0 (no) 1999-08-26
AU744428B2 (en) 2002-02-21
PL190734B1 (pl) 2005-12-30
SK117199A3 (en) 2000-05-16
IL131346A0 (en) 2001-01-28
ATA33597A (de) 1999-01-15
CZ298298B6 (cs) 2007-08-22
IL131346A (en) 2007-05-15
CA2282707A1 (en) 1998-09-03
PL335382A1 (en) 2000-04-25
DE59813518D1 (de) 2006-06-01
EP0966536B1 (de) 2006-04-26
NO994139L (no) 1999-10-27
CZ303299A3 (cs) 2000-02-16
HUP0100652A1 (hu) 2001-06-28
HUP0100652A3 (en) 2003-01-28
BR9807627A (pt) 2000-02-22
US7220569B2 (en) 2007-05-22
AT405516B (de) 1999-09-27
NO327878B1 (no) 2009-10-12
SK286359B6 (sk) 2008-08-05
HU225246B1 (en) 2006-08-28
US6573071B1 (en) 2003-06-03
AU6200298A (en) 1998-09-18
US20030181381A1 (en) 2003-09-25
ES2263199T3 (es) 2006-12-01

Similar Documents

Publication Publication Date Title
DE59813518D1 (de) Faktor x-analoge mit modifizierter proteasespaltstelle
NO985668D0 (no) Modifisert faktor VII
ATE241787T1 (de) Behälter
DE69832623D1 (de) Mikrogefertigte kreisel
NO971878L (no) Modifiert faktor VII
ID21303A (id) Wadah
NO984679D0 (no) Container
ES1037514Y (es) Recipiente
FI970156A0 (fi) Foerfarande foer framstaellning av fiberplattor
FI971696A0 (fi) Foerfarande foer heat-soak-behandling av haerdade glasskivor
FI970477A0 (fi) Foerfarande foer behandling av en oevantad nedkopplingsbegaeran
FI973312A0 (fi) Foerfarande foer indikering av en abonnent i en kedjad V5-anslutning
NO975605D0 (no) Faktor X
FI971222A0 (fi) Tillverkning av vaegmaerken
ID21647A (id) Wadah
UA25881C2 (uk) Фарба
FI971841A0 (fi) Foerfarande foer framstaellning av bestrykningssmet foer papper
ID24117A (id) Pelapisan dasar
NO981914D0 (no) Container
DE69807614D1 (de) Tank
FI971902A0 (fi) Foerfarande foer behandling av mjoelk
IT1291549B1 (it) Contenitore spezza-compressa
ES1036258Y (es) Envase
UA2220S (uk) Контейнер
ATA204397A (de) Behälter