ATE324587T1 - Verfahren zum nachweis von bioanalyten mittels metallische nanohüllen - Google Patents

Verfahren zum nachweis von bioanalyten mittels metallische nanohüllen

Info

Publication number
ATE324587T1
ATE324587T1 AT00952155T AT00952155T ATE324587T1 AT E324587 T1 ATE324587 T1 AT E324587T1 AT 00952155 T AT00952155 T AT 00952155T AT 00952155 T AT00952155 T AT 00952155T AT E324587 T1 ATE324587 T1 AT E324587T1
Authority
AT
Austria
Prior art keywords
core
nanoshells
particles
shell
metal shell
Prior art date
Application number
AT00952155T
Other languages
English (en)
Inventor
Jennifer L West
Nancy L Halas
Steven J Oldenburg
Richard D Averitt
Original Assignee
Univ Wm Marsh Rice
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Wm Marsh Rice filed Critical Univ Wm Marsh Rice
Application granted granted Critical
Publication of ATE324587T1 publication Critical patent/ATE324587T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587Nanoparticles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • G01N21/658Raman scattering enhancement Raman, e.g. surface plasmons
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01PINDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2002/00Crystal-structural characteristics
    • C01P2002/80Crystal-structural characteristics defined by measured data other than those specified in group C01P2002/70
    • C01P2002/82Crystal-structural characteristics defined by measured data other than those specified in group C01P2002/70 by IR- or Raman-data
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01PINDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2002/00Crystal-structural characteristics
    • C01P2002/80Crystal-structural characteristics defined by measured data other than those specified in group C01P2002/70
    • C01P2002/84Crystal-structural characteristics defined by measured data other than those specified in group C01P2002/70 by UV- or VIS- data
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01PINDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00Particle morphology
    • C01P2004/01Particle morphology depicted by an image
    • C01P2004/04Particle morphology depicted by an image obtained by TEM, STEM, STM or AFM
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01PINDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00Particle morphology
    • C01P2004/10Particle morphology extending in one dimension, e.g. needle-like
    • C01P2004/12Particle morphology extending in one dimension, e.g. needle-like with a cylindrical shape
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01PINDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00Particle morphology
    • C01P2004/30Particle morphology extending in three dimensions
    • C01P2004/32Spheres
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01PINDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00Particle morphology
    • C01P2004/30Particle morphology extending in three dimensions
    • C01P2004/38Particle morphology extending in three dimensions cube-like
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01PINDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00Particle morphology
    • C01P2004/54Particles characterised by their aspect ratio, i.e. the ratio of sizes in the longest to the shortest dimension
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01PINDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00Particle morphology
    • C01P2004/60Particles characterised by their size
    • C01P2004/61Micrometer sized, i.e. from 1-100 micrometer
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01PINDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00Particle morphology
    • C01P2004/60Particles characterised by their size
    • C01P2004/62Submicrometer sized, i.e. from 0.1-1 micrometer
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01PINDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
    • C01P2004/00Particle morphology
    • C01P2004/60Particles characterised by their size
    • C01P2004/64Nanometer sized, i.e. from 1-100 nanometer

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Nanotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT00952155T 1999-07-16 2000-07-14 Verfahren zum nachweis von bioanalyten mittels metallische nanohüllen ATE324587T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14413699P 1999-07-16 1999-07-16

Publications (1)

Publication Number Publication Date
ATE324587T1 true ATE324587T1 (de) 2006-05-15

Family

ID=22507232

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00952155T ATE324587T1 (de) 1999-07-16 2000-07-14 Verfahren zum nachweis von bioanalyten mittels metallische nanohüllen

Country Status (6)

Country Link
EP (1) EP1210600B1 (de)
JP (2) JP2003504642A (de)
AT (1) ATE324587T1 (de)
CA (1) CA2377722A1 (de)
DE (1) DE60027578T2 (de)
WO (1) WO2001006257A1 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2343047B2 (de) 2000-02-08 2021-03-17 Rice University Optisch aktive Nanopartikel zur Verwendung in Therapie- und Diagnoseverfahren
US6707548B2 (en) 2001-02-08 2004-03-16 Array Bioscience Corporation Systems and methods for filter based spectrographic analysis
US7198957B2 (en) * 2001-03-09 2007-04-03 Takao Fukuoka Method for analyzing substance
GB0112238D0 (en) * 2001-05-18 2001-07-11 Medical Biosystems Ltd Sequencing method
US7147687B2 (en) 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
US7238472B2 (en) * 2001-05-25 2007-07-03 Nanosphere, Inc. Non-alloying core shell nanoparticles
DE10131173C2 (de) * 2001-06-29 2003-12-04 Itn Nanovation Gmbh Verfahren zur Herstellung von Kern-Hülle-Teilchen und deren Verwendung
CA2491093A1 (en) * 2002-06-28 2004-01-08 Purdue Research Foundation Magnetic nanomaterials and methods for detection of biological materials
US7500953B2 (en) 2003-01-25 2009-03-10 Seno Medical Instruments, Inc. High contrast optoacoustic imaging using nanoparticles
MXPA05009074A (es) * 2003-02-25 2006-05-19 Kuehnle Manfred R Nanoparticulas encapsuladas para la absorcion de energia electromagnetica en indice ultravioleta.
DE112004000337T5 (de) * 2003-02-25 2006-07-06 Manfred R. Lincoln Kuehnle Eingekapselte Nanopartikel zur Absorption von elektromagnetischer Energie
CN1514243A (zh) * 2003-04-30 2004-07-21 成都夸常科技有限公司 对目标物进行定性和/或定量分析的方法、装置和标记物及检测试剂盒
WO2004102196A1 (fr) * 2003-04-30 2004-11-25 Chengdu Kuachang Medical Industrial Limited Dispositif comprenant des nanostructures destine a une separation ou une analyse, et preparation et mise en oeuvre de ce dispositif
IL156626A (en) * 2003-06-24 2009-12-24 Yeda Res & Dev System for selective cell destruction
JP2005195441A (ja) * 2004-01-07 2005-07-21 Fuji Photo Film Co Ltd ラマン分光方法および装置並びにラマン分光用デバイス
JP5502279B2 (ja) * 2004-10-28 2014-05-28 エコー セラピューティクス, インコーポレイテッド ヒドロゲルを使用した検体のサンプリングおよび分析のためのシステムおよび方法
US7599066B2 (en) 2005-06-01 2009-10-06 Canon Kabushiki Kaisha Localized plasmon resonance sensor
US20070164271A1 (en) * 2005-10-24 2007-07-19 Wait W B Jr Resonant nanostructures and methods of use
US20090155811A1 (en) * 2006-01-27 2009-06-18 Oxonica, Inc. Lateral Flow Immunoassay With Encapsulated Detection Modality
EP2013608A4 (de) * 2006-05-01 2011-07-06 Fujirebio Kk Mit metallischem überzug verkapselte nichtmetallische leuchtstoffpartikel
KR20100061603A (ko) * 2008-11-29 2010-06-08 한국전자통신연구원 바이오 물질 감지용 나노 입자 및 이를 이용한 바이오 센서
WO2011038335A1 (en) * 2009-09-25 2011-03-31 Immunolight, Llc Up and down conversion systems for improved solar cell performance or other energy conversion
ES2359411B1 (es) * 2009-10-19 2012-04-03 Universidad De Zaragoza Método de autenticación de objetos.
AU2010328768B2 (en) * 2009-12-11 2014-01-16 Korea Research Institute Of Chemical Technology A dimeric core-shell nanostructure labeled with a raman active molecule localized at an interparticle junction, use thereof, and method for preparing the same
US20130196915A1 (en) * 2010-01-23 2013-08-01 Yong Wang Affinity hydrogels for controlled protein release
DK2550513T3 (en) * 2010-03-22 2017-03-13 Sicpa Holding Sa WAVE SELECTIVE SERS NANOTAGS
US9572880B2 (en) 2010-08-27 2017-02-21 Sienna Biopharmaceuticals, Inc. Ultrasound delivery of nanoparticles
HUE038539T2 (hu) 2010-08-27 2018-10-29 Sienna Biopharmaceuticals Inc Készítmények eljárások célzott hõmodulációhoz
US10994992B2 (en) 2011-01-20 2021-05-04 Technion Research & Development Foundation Limited Method and system for manipulating a cell
WO2012149026A2 (en) * 2011-04-25 2012-11-01 The Research Foundation Of State University Of New York Spectral modification
JP2012242387A (ja) * 2011-05-13 2012-12-10 Imec 一体型sers測定のための導波路一体型プラズモン共鳴装置
JP5762225B2 (ja) * 2011-09-08 2015-08-12 新留 康郎 銀シェル金ナノロッドを用いる分析方法
JP6325552B2 (ja) 2012-10-11 2018-05-16 ナノコンポジックス,インコーポレイテッド 銀ナノプレート組成物および方法
CN103808706A (zh) * 2012-11-06 2014-05-21 厦门大学 一种含针孔的壳层纳米粒子拉曼光谱检测增强剂及应用该增强剂进行拉曼光谱检测的方法
DE102013008104A1 (de) * 2013-05-14 2014-11-20 Laser-Laboratorium Göttingen e.V. SERS-Substrat
DE102013106432A1 (de) * 2013-06-20 2014-12-24 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Optische Indikator-Einheit und Vorrichtung und Verfahren zur Bestimmung einer physikalisch-chemischen Eigenschaft eines Prozessmediums in einer prozesstechnischen Anlage
JP6245664B2 (ja) * 2013-08-23 2017-12-13 株式会社右近工舎 表面増強ラマン散乱分光測定用基板及びそれを用いた装置
WO2016051666A1 (ja) * 2014-09-30 2016-04-07 富士フイルム株式会社 炭酸ガスセンシング用の光電場増強デバイス
US11111396B2 (en) * 2014-10-17 2021-09-07 C3 Nano, Inc. Transparent films with control of light hue using nanoscale colorants
KR102127146B1 (ko) * 2017-08-08 2020-06-26 사회복지법인 삼성생명공익재단 플라즈모닉 효과를 이용한 질병의 진단에 필요한 정보 제공 방법 및 질병 진단용 슬라이드
CN110554018A (zh) * 2018-05-31 2019-12-10 上海市刑事科学技术研究院 检测水溶液中4-溴甲卡西酮的表面增强拉曼材料及其制备方法
JP7079923B2 (ja) * 2018-07-18 2022-06-03 公立大学法人名古屋市立大学 Sers測定用材料及びその製造方法
CN111375759B (zh) * 2018-12-28 2021-10-01 同方威视技术股份有限公司 一种拉曼纳米增强材料及其制备方法和应用
CN110849863B (zh) * 2019-10-15 2020-11-24 中国人民解放军第二军医大学 一种检测适配体与配体小分子结合过程中构象改变的方法
CN114942240B (zh) * 2022-05-30 2022-12-13 武汉太赫光学科技有限公司 上转换拉曼传感器及应用
CN115266680B (zh) * 2022-08-30 2024-07-16 中国计量大学 一种桑椹汁中胭脂红的定量检测方法
CN118425121A (zh) * 2024-04-26 2024-08-02 华中师范大学 一种利用芯片与纳米粒子结合的三明治结构对呼吸道六种病毒进行sers特异性检测的方法
JP7756407B1 (ja) * 2024-11-20 2025-10-20 シンバイオ製薬株式会社 イムノアッセイ方法及びイムノアッセイ装置

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5935779A (en) * 1988-11-03 1999-08-10 Igen International Inc. Methods for improved particle electrochemiluminescence assay
US5779976A (en) * 1988-11-03 1998-07-14 Igen International, Inc. Apparatus for improved luminescence assays
US5962218A (en) * 1988-11-03 1999-10-05 Igen International Inc. Methods and apparatus for improved luminescence assays
US5023139A (en) * 1989-04-04 1991-06-11 Research Corporation Technologies, Inc. Nonlinear optical materials
US5376556A (en) * 1989-10-27 1994-12-27 Abbott Laboratories Surface-enhanced Raman spectroscopy immunoassay
IL100866A (en) * 1991-02-06 1995-10-31 Igen Inc Method and apparatus for magnetic microparticulate based luminescence assay including plurality of magnets
USH1447H (en) * 1992-11-20 1995-06-06 E. I. Du Pont De Nemours And Company Coated silica shells
JPH07146295A (ja) * 1993-11-19 1995-06-06 Kyoto Daiichi Kagaku:Kk ラマン分光測定による免疫分析方法及び装置
JP2965502B2 (ja) * 1996-02-20 1999-10-18 株式会社京都第一科学 表面増強ラマン散乱測定による分析方法
WO1998004740A1 (en) * 1996-07-29 1998-02-05 Nanosphere Llc Nanoparticles having oligonucleotides attached thereto and uses therefor
US5898004A (en) * 1996-11-06 1999-04-27 University Of Pittsburgh Of The Commonwealth System Of Higher Education Polymerized crystalline colloidal array sensors
US5939021A (en) * 1997-01-23 1999-08-17 Hansen; W. Peter Homogeneous binding assay
US6344272B1 (en) * 1997-03-12 2002-02-05 Wm. Marsh Rice University Metal nanoshells
US5990479A (en) * 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
EP1208005B1 (de) * 1999-07-16 2010-04-07 Wm. MARSH RICE UNIVERSITY Temperaturabhängiges polymer/nanohüllen-komposite für photothermische modulierte arzneimittelabgabe

Also Published As

Publication number Publication date
JP2003504642A (ja) 2003-02-04
CA2377722A1 (en) 2001-01-25
JP2010230679A (ja) 2010-10-14
EP1210600A4 (de) 2003-05-21
EP1210600A1 (de) 2002-06-05
WO2001006257A1 (en) 2001-01-25
WO2001006257A8 (en) 2001-11-29
DE60027578T2 (de) 2007-01-25
EP1210600B1 (de) 2006-04-26
DE60027578D1 (de) 2006-06-01

Similar Documents

Publication Publication Date Title
DE60027578D1 (de) Verfahren zum Nachweis von Bioanalyten mittels metallische Nanohüllen
Yuan et al. Mercaptopyridine-functionalized gold nanoparticles for fiber-optic surface plasmon resonance Hg2+ sensing
Reokrungruang et al. A simple paper-based surface enhanced Raman scattering (SERS) platform and magnetic separation for cancer screening
Joyce et al. Recent advances in gold-based metal enhanced fluorescence platforms for diagnosis and imaging in the near-infrared
Capocefalo et al. Exploring the potentiality of a SERS-active pH nano-biosensor
Procházka Surface-enhanced Raman spectroscopy: bioanalytical, biomolecular and medical applications
David et al. SERS detection of biomolecules using lithographed nanoparticles towards a reproducible SERS biosensor
Abalde-Cela et al. Surface-enhanced Raman scattering biomedical applications of plasmonic colloidal particles
Kumeria et al. Ultrasensitive nanoporous interferometric sensor for label-free detection of gold (III) ions
Wang et al. Graphene-based nanoplatforms for surface-enhanced Raman scattering sensing
Santos et al. Optically optimized photoluminescent and interferometric biosensors based on nanoporous anodic alumina: a comparison
Ma et al. Electrotunable nanoplasmonics for amplified surface enhanced Raman spectroscopy
Hahm et al. Multilayer Ag-embedded silica nanostructure as a surface-enhanced raman scattering-based chemical sensor with dual-function internal standards
Fraire et al. Rational design of plasmonic nanostructures for biomolecular detection: interplay between theory and experiments
Cao et al. Effective surface modification of gold nanorods for localized surface plasmon resonance-based biosensors
Ma et al. Individual plasmonic nanoprobes for biosensing and bioimaging: recent advances and perspectives
Lee et al. Biomolecular plasmonics for quantitative biology and nanomedicine
WO2004113880A3 (en) Chemical sensor and chemicalsensor apparatus
Lin et al. Recent advances in localized surface plasmon resonance (LSPR) sensing technologies
Tadi et al. Recent advances in the design of SERS substrates and sensing systems for (bio) sensing applications: Systems from single cell to single molecule detection
Shahine et al. Nanoporous gold stacked layers as substrates for SERS detection in liquids or gases with ultralow detection limits and long-term stability
Zhang et al. Silver nanopillar arrayed thin films with highly surface-enhanced Raman scattering for ultrasensitive detection
Ortega-Gomez et al. Cytochrome c detection by plasmonic nanospectroscopy on optical fiber facets
Wang et al. Self-assembly flexible SERS imprinted membrane based on Ag nanocubes for selective detection of microcystin-LR
Wei et al. Polymer microbead-based surface enhanced Raman scattering immunoassays

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties