ATE32721T1 - Benzodiazepin-rezeptoren und ihre herstellung. - Google Patents

Benzodiazepin-rezeptoren und ihre herstellung.

Info

Publication number: ATE32721T1
Authority: AT; Austria
Prior art keywords: hydrogen; formula; image; production; oxadiazolyl
Prior art date: 1982-11-16

Application number

AT83730110T

Other languages

English (en)

Inventor

Claus Thyco Dr Braestrup

Jorgen Anders Dr Christensen

Mogens Dr Engelstoft

Frank Dr Waetjen

Original Assignee

Ferrosan As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-11-16

Filing date

1983-11-12

Publication date

1988-03-15

1983-11-12 Application filed by Ferrosan As filed Critical Ferrosan As

1988-03-15 Application granted granted Critical

1988-03-15 Publication of ATE32721T1 publication Critical patent/ATE32721T1/de

Links

229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
239000000460 chlorine Chemical group 0.000 abstract 2
229910052801 chlorine Inorganic materials 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
RFNRJHRPAYOZLE-UHFFFAOYSA-N 4-imidazo[4,5-i][1,4]benzodiazepin-2-yloxadiazole Chemical class O1N=NC(C=2N=C3C4=NC=CN=CC4=CC=C3N=2)=C1 RFNRJHRPAYOZLE-UHFFFAOYSA-N 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
102000004300 GABA-A Receptors Human genes 0.000 abstract 1
108090000839 GABA-A Receptors Proteins 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Chemical group 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000001715 oxadiazolyl group Chemical group 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Magnetic Resonance Imaging Apparatus (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT83730110T 1982-11-16 1983-11-12 Benzodiazepin-rezeptoren und ihre herstellung. ATE32721T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK510282A DK151808C (da)	1982-11-16	1982-11-16	Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
EP83730110A EP0109921B1 (de)	1982-11-16	1983-11-12	Benzodiazepin-Rezeptoren und ihre Herstellung

Publications (1)

Publication Number	Publication Date
ATE32721T1 true ATE32721T1 (de)	1988-03-15

Family

ID=8139462

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT83730110T ATE32721T1 (de)	1982-11-16	1983-11-12	Benzodiazepin-rezeptoren und ihre herstellung.

Country Status (10)

Country	Link
US (1)	US4507313A (de)
EP (1)	EP0109921B1 (de)
JP (1)	JPS59104385A (de)
AT (1)	ATE32721T1 (de)
DE (1)	DE3375785D1 (de)
DK (1)	DK151808C (de)
ES (3)	ES527295A0 (de)
FI (1)	FI78095C (de)
IE (1)	IE56233B1 (de)
NO (1)	NO163820C (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA845757B (en) *	1983-08-25	1985-04-24	Hoffmann La Roche	Benzodiazepine derivatives
FI850191A7 (fi) *	1984-01-19	1985-07-20	Hoffmann La Roche	Imidatsodiatsepiini-johdannaisia.
AU587802B2 (en) *	1985-03-08	1989-08-31	Ferrosan A/S	Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds
DK476885D0 (da) *	1985-10-17	1985-10-17	Ferrosan As	Heterocycliske forbindelser og fremgangsmaader til fremstilling heraf
DE202441T1 (de) *	1985-05-17	1987-03-19	Aktieselskabet Ferrosan, Soeborg	Oxadiazolylimidazobenzodiazepine, verfahren zu ihrer herstellung und pharmazeutische zubereitungen.
US4622320A (en) *	1985-05-17	1986-11-11	As Ferrosan	Oxadiazolylimidazobenzodiazepine, compositions, and method
US4745112A (en) *	1985-05-17	1988-05-17	A/S Ferrosan	Oxadiazolylimidazobenzodiazepine, compositions, and method III
DE3664211D1 (en) *	1985-10-17	1989-08-10	Ferrosan As	Heterocyclic compounds and their preparation and use
DK174086D0 (da) *	1986-04-16	1986-04-16	Ferrosan As	Nye benzodiazepinderivater samt fremgangsmaade til fremstilling af samme
FI880814A7 (fi) *	1987-03-10	1988-09-11	Hoffmann La Roche	Imidazodiazepin-derivat.
GB8823475D0 (en) *	1988-10-06	1988-11-16	Merck Sharp & Dohme	Chemical compounds
CA2015336A1 (en) *	1989-05-19	1990-11-19	F. Hoffmann-La Roche Ag	Imidazodiazepines for the treatment of neurological symptoms
US4904654A (en) *	1989-07-26	1990-02-27	Merck & Co., Inc.	7-chloro-5,6-dihydro-3-(5-(2-hydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5a][1,4]benzodiazepine
US4939139A (en) *	1989-07-26	1990-07-03	Merck & Co., Inc.	7-chloro-5,6-dihydro-3-(5-(1,2-dihydroxy-isopropyl)-1,2,4-oxadiazol-3-yl)-5-methyl-6-oxo-4H-imidazo[1,5A][1,4]benzodiazepine
GB8923008D0 (en) *	1989-10-12	1989-11-29	Roussel Lab Ltd	Chemical compounds
GB8927928D0 (en) *	1989-12-11	1990-02-14	Roussel Lab Ltd	Chemical compounds
US5428031A (en) *	1991-12-03	1995-06-27	Merck & Co., Inc.	Methods of treating cardiac arrhythmia
US5317018A (en) *	1992-06-09	1994-05-31	Armin Walser	Benzodiazepines and compositions for treating anxiety and panic disorders, and idiopathic and psychomotor epilepsy
ES2162907T3 (es) *	1993-11-22	2002-01-16	Merck & Co Inc	3-acilaminobenzacepinas.
US5439906A (en) *	1993-11-22	1995-08-08	Merck & Co., Inc.	Antiarrhythmic benzodiazepines
CA2143246C (en) *	1994-03-16	2000-08-22	Thierry Godel	Imidazodiazepines
CA2195974C (en) *	1994-08-18	2000-12-05	David A. Claremon	2,3-dihydro-1-(2,2,2-trifluoroethyl)-2-oxo-5-phenyl-1h-1,4-benzodiazepines
US5691331A (en) *	1995-06-07	1997-11-25	Merck & Co., Inc.	N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides
US5631251A (en) *	1995-06-07	1997-05-20	Merck & Co., Inc.	5-cyclopropyl-1,4 benzodiazepine-2-ones
US5726171A (en) *	1995-06-07	1998-03-10	Merck & Co Inc	N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo B! 1,4!diazepin-3yl)-acetamides
JPH11506760A (ja) *	1995-06-07	1999-06-15	メルクエンドカンパニーインコーポレーテッド	新規なｎ−（２，４−ジオキソ−２，３，４，５−テトラヒドロ−１ｈ−１，５−ベンゾジアゼピン−３イル）−３−アミド
US5700797A (en) *	1995-06-07	1997-12-23	Merck & Co, Inc.	N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides
US20090054412A1 (en) *	2007-08-20	2009-02-26	John Alan Kemp	Treatment of Sleep Disorders
CA2696703C (en)	2007-08-20	2016-07-26	Evotec Neurosciences Gmbh	Treatment of sleep disorders
US8119629B2 (en)	2007-10-03	2012-02-21	Bristol-Meyers Squibb Company	Carboxamide GABAA α2 modulators
WO2016037111A1 (en) *	2014-09-05	2016-03-10	Mazak Corporation	Vertical machine tool apparatus and method

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE422580B (sv) *	1975-08-07	1982-03-15	Hoffmann La Roche	Analogiforfarande for framstellning av imidazo (1,5-a)(1,4)diazepin-foreningar
CA1143728A (en) *	1979-10-04	1983-03-29	Max Gerecke	Imidazodiazepine derivatives
JPS57123180A (en) *	1980-12-17	1982-07-31	Schering Ag	3-substituted beta-carboline, manufacture and psychotropic drug containing same
CA1184175A (en) *	1981-02-27	1985-03-19	Walter Hunkeler	Imidazodiazepines
CA1174673A (en) *	1981-02-27	1984-09-18	Walter Hunkeler	Imidazodiazepines
US4352817A (en) *	1981-02-27	1982-10-05	Hoffmann-La Roche Inc.	Imidazo-diazepines and their use

1982
- 1982-11-16 DK DK510282A patent/DK151808C/da not_active IP Right Cessation
1983
- 1983-11-11 FI FI834137A patent/FI78095C/fi not_active IP Right Cessation
- 1983-11-12 EP EP83730110A patent/EP0109921B1/de not_active Expired
- 1983-11-12 DE DE8383730110T patent/DE3375785D1/de not_active Expired
- 1983-11-12 AT AT83730110T patent/ATE32721T1/de not_active IP Right Cessation
- 1983-11-14 IE IE2644/83A patent/IE56233B1/xx unknown
- 1983-11-15 US US06/551,818 patent/US4507313A/en not_active Expired - Lifetime
- 1983-11-15 ES ES83527295A patent/ES527295A0/es active Granted
- 1983-11-15 JP JP58213456A patent/JPS59104385A/ja active Granted
- 1983-11-15 NO NO834187A patent/NO163820C/no unknown
1984
- 1984-01-25 ES ES529150A patent/ES8507144A1/es not_active Expired
- 1984-01-25 ES ES529149A patent/ES529149A0/es active Granted

Also Published As

Publication number	Publication date
NO163820C (no)	1990-08-01
DK151808B (da)	1988-01-04
ES8504196A1 (es)	1985-04-16
JPS59104385A (ja)	1984-06-16
FI834137A0 (fi)	1983-11-11
EP0109921B1 (de)	1988-03-02
ES529150A0 (es)	1985-09-01
DK510282A (da)	1984-05-17
DK151808C (da)	1988-06-20
IE832644L (en)	1984-05-15
FI834137A7 (fi)	1984-05-17
NO834187L (no)	1984-05-18
JPS635031B2 (de)	1988-02-01
ES8507143A1 (es)	1985-09-01
FI78095B (fi)	1989-02-28
EP0109921A1 (de)	1984-05-30
ES8507144A1 (es)	1985-09-01
ES529149A0 (es)	1985-09-01
FI78095C (fi)	1989-06-12
US4507313A (en)	1985-03-26
ES527295A0 (es)	1985-04-16
NO163820B (no)	1990-04-17
IE56233B1 (en)	1991-05-22
DE3375785D1 (en)	1988-04-07

Legal Events

Date	Code	Title	Description
1988-06-15	UEP	Publication of translation of european patent specification
1991-08-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE32721T1 (de)	1988-03-15	Benzodiazepin-rezeptoren und ihre herstellung.
AU577079B2 (en)	1988-09-15	Benzo/thieno-imidazodiazepine derivatives
AR004516A1 (es)	1998-12-16	Derivados de pirimidina, su uso, procedimientos para prepararlos y medicamentos que los contienen
GB2043636B (en)	1983-05-11	Pyrimido benzazepine derivatives
ATE106082T1 (de)	1994-06-15	4,5,7,8-tetrahydro-6h-thiazolo(5,4-d>azepine, ihre herstellung und ihre verwendung als arzneimittel.
ES2062819T3 (es)	1994-12-16	Compuestos heterociclicos, y su preparacion y uso.
ATE42292T1 (de)	1989-05-15	Imidazo(1,2-c)pyrimidine und ihre salze, verfahren zu ihrer herstellung, ihre anwendung als arzneimittel und diese enthaltende zubereitungen.
ES2010089A6 (es)	1989-10-16	Procedimiento para la obtencion de n-oxidos de gamma-carbolina antipsicoticos.
DK123685A (da)	1985-03-19	Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-(1,4)-benzodiazepinderivater
US3980645A (en)	1976-09-14	Fused quinazolinones and a process for production thereof
DE3576822D1 (de)	1990-05-03	Pyrrolo(1,2-b)(1,2,5)triazepine, verfahren und zwischenprodukte zu ihrer herstellung und ihre anwendung als arzneimittel.
GB2020282A (en)	1979-11-14	5,6-Dihydro-5-thioxopyrazolo [1,5-c]quinazoline derivatives