ATE330633T1 - Epoxy-steroidaler aldosteronantagonist und beta- adrenergischer antagonist-kombinationstherapie zur behandlung von kongestivem herzversagen - Google Patents

Epoxy-steroidaler aldosteronantagonist und beta- adrenergischer antagonist-kombinationstherapie zur behandlung von kongestivem herzversagen

Info

Publication number
ATE330633T1
ATE330633T1 AT01957290T AT01957290T ATE330633T1 AT E330633 T1 ATE330633 T1 AT E330633T1 AT 01957290 T AT01957290 T AT 01957290T AT 01957290 T AT01957290 T AT 01957290T AT E330633 T1 ATE330633 T1 AT E330633T1
Authority
AT
Austria
Prior art keywords
beta
epoxy
antagonist
combination therapy
adrenergic
Prior art date
Application number
AT01957290T
Other languages
English (en)
Inventor
John C Alexander
Joseph R Schuh
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Application granted granted Critical
Publication of ATE330633T1 publication Critical patent/ATE330633T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT01957290T 2000-07-27 2001-07-27 Epoxy-steroidaler aldosteronantagonist und beta- adrenergischer antagonist-kombinationstherapie zur behandlung von kongestivem herzversagen ATE330633T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22136500P 2000-07-27 2000-07-27

Publications (1)

Publication Number Publication Date
ATE330633T1 true ATE330633T1 (de) 2006-07-15

Family

ID=22827509

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01957290T ATE330633T1 (de) 2000-07-27 2001-07-27 Epoxy-steroidaler aldosteronantagonist und beta- adrenergischer antagonist-kombinationstherapie zur behandlung von kongestivem herzversagen

Country Status (11)

Country Link
US (3) US20040235809A1 (de)
EP (1) EP1303306B1 (de)
JP (1) JP2004511435A (de)
AT (1) ATE330633T1 (de)
AU (2) AU7905001A (de)
CA (1) CA2415789A1 (de)
DE (1) DE60120982T2 (de)
DK (1) DK1303306T3 (de)
ES (1) ES2265437T3 (de)
PT (1) PT1303306E (de)
WO (1) WO2002009760A2 (de)

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WO2003049745A1 (en) 2001-12-12 2003-06-19 Pharmacia Corporation Method of treating ophthalmic disorders with epoxy-steroidal aldosterone receptor antagonists
EP1469862A2 (de) * 2002-01-30 2004-10-27 Pharmacia Corporation Kombination von einem aldosterone rezeptor antagonisten und einem alpha-adrenergen modulierenden agens zur vorbeugung und behandlung von kardiovaskulären beschwerden
MXPA04009033A (es) * 2002-03-18 2005-01-25 Pharmacia Corp Combinacion de un antagonista de receptor de aldosterona y acido nicotinico o un derivado de acido nicotinico.
US6967194B1 (en) * 2002-09-18 2005-11-22 Susan Matsuo Bio-identical hormones and method of use
US20040229901A1 (en) * 2003-02-24 2004-11-18 Lauren Otsuki Method of treatment of disease using an adenosine A1 receptor antagonist
WO2004100871A2 (en) * 2003-05-09 2004-11-25 Pharmacia Corporation Combination of an aldosterone receptor antagonist and a renin inhibitor
CA2558034A1 (en) 2004-03-09 2005-09-22 Elan Pharmaceuticals, Inc. Substituted hydroxyethylamine aspartyl protease inhibitors
US7803838B2 (en) 2004-06-04 2010-09-28 Forest Laboratories Holdings Limited Compositions comprising nebivolol
US7838552B2 (en) 2004-06-04 2010-11-23 Forest Laboratories Holdings Limited Compositions comprising nebivolol
DE102004035322A1 (de) * 2004-07-21 2006-02-16 Universität des Saarlandes Selektive Hemmstoffe humaner Corticoidsynthasen
CN104644627A (zh) 2004-09-14 2015-05-27 科罗拉多大学董事会 基于基因靶向使用布新洛尔的治疗方法
EP1853261B1 (de) * 2005-03-03 2017-01-11 Universität des Saarlandes Selektive hemmstoffe humaner corticoidsynthasen
WO2007047305A1 (en) 2005-10-12 2007-04-26 Elan Pharmaceuticals, Inc. Methods of treating amyloidosis using cyclopropyl derivative aspartyl protease inhibitors
DE102008022221A1 (de) 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
US8541404B2 (en) * 2009-11-09 2013-09-24 Elexopharm Gmbh Inhibitors of the human aldosterone synthase CYP11B2
KR102474326B1 (ko) * 2016-06-22 2022-12-05 반더빌트유니버시티 무스카린성 아세틸콜린 수용체 m4의 양성 알로스테릭 조절제
EP3534901B1 (de) 2016-11-07 2022-06-22 Vanderbilt University Positive allosterische modulatoren des muskarinischen acetylcholinrezeptors m4
EP3558309B1 (de) 2016-11-07 2023-07-26 Vanderbilt University Positive allosterische modulatoren des muskarinischen acetylcholinrezeptors m4
JP7097623B2 (ja) 2016-11-07 2022-07-08 ヴァンダービルト ユニヴァーシティ ムスカリン性アセチルコリンレセプターｍ４のポジティブアロステリック調節因子
WO2019113174A1 (en) 2017-12-05 2019-06-13 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor m4
TW201930311A (zh) 2017-12-05 2019-08-01 泛德比爾特大學 蕈毒鹼型乙醯膽鹼受體m4之正向別構調節劑
WO2023060245A1 (en) * 2021-10-08 2023-04-13 The United States Government As Represented By The Department Of Veterans Affairs Methods for predicting drug responsiveness in heart failure subjects

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Also Published As

Publication number Publication date
DE60120982T2 (de) 2007-02-08
US20040235809A1 (en) 2004-11-25
WO2002009760A2 (en) 2002-02-07
US20020123485A1 (en) 2002-09-05
JP2004511435A (ja) 2004-04-15
EP1303306A2 (de) 2003-04-23
ES2265437T3 (es) 2007-02-16
PT1303306E (pt) 2006-11-30
DK1303306T3 (da) 2006-10-23
US20050215537A1 (en) 2005-09-29
AU2001279050B2 (en) 2006-10-19
WO2002009760A9 (en) 2003-09-04
AU7905001A (en) 2002-02-13
WO2002009760A3 (en) 2003-01-23
DE60120982D1 (de) 2006-08-03
EP1303306B1 (de) 2006-06-21
CA2415789A1 (en) 2002-02-07

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