ATE331530T1 - Proteasom-influenzavirus-impfstoffzusammensetzu g - Google Patents
Proteasom-influenzavirus-impfstoffzusammensetzu gInfo
- Publication number
- ATE331530T1 ATE331530T1 AT01910923T AT01910923T ATE331530T1 AT E331530 T1 ATE331530 T1 AT E331530T1 AT 01910923 T AT01910923 T AT 01910923T AT 01910923 T AT01910923 T AT 01910923T AT E331530 T1 ATE331530 T1 AT E331530T1
- Authority
- AT
- Austria
- Prior art keywords
- proteasome
- influenza virus
- vaccine composition
- virus vaccine
- vaccines
- Prior art date
Links
- 229940124873 Influenza virus vaccine Drugs 0.000 title 1
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 title 1
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 title 1
- 229960005486 vaccine Drugs 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 206010022000 influenza Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18247600P | 2000-02-15 | 2000-02-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE331530T1 true ATE331530T1 (de) | 2006-07-15 |
Family
ID=22668645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01910923T ATE331530T1 (de) | 2000-02-15 | 2001-02-15 | Proteasom-influenzavirus-impfstoffzusammensetzu g |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US6743900B2 (de) |
| EP (1) | EP1255561B1 (de) |
| JP (2) | JP3980884B2 (de) |
| AT (1) | ATE331530T1 (de) |
| AU (4) | AU3847801A (de) |
| CA (1) | CA2400468C (de) |
| DE (1) | DE60121136T2 (de) |
| ES (1) | ES2267724T3 (de) |
| IL (2) | IL150602A0 (de) |
| NO (1) | NO20023829D0 (de) |
| WO (1) | WO2001060402A2 (de) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1211192A (zh) * | 1995-09-18 | 1999-03-17 | 美国陆军医疗材料研究指挥部 | 生产非共价复合的多价蛋白体亚基疫苗的改进方法 |
| US7022683B1 (en) | 1998-05-13 | 2006-04-04 | Carrington Laboratories, Inc. | Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation |
| CA2400468C (en) * | 2000-02-15 | 2012-12-18 | Intellivax International Inc. | Proteosome influenza vaccine |
| US7524509B2 (en) * | 2001-03-09 | 2009-04-28 | Id Biomedical Corporation Of Quebec | Proteosome-liposaccharide vaccine adjuvant |
| AU2002346424A1 (en) | 2001-11-19 | 2003-06-10 | Becton, Dickinson And Company | Pharmaceutical compositions in particulate form |
| NZ536859A (en) * | 2002-05-14 | 2007-11-30 | Chiron Srl | Mucosal combination vaccines for bacterial meningitis |
| US7255867B2 (en) * | 2002-11-15 | 2007-08-14 | Id Biomedical Corporation Of Quebec | Vaccine |
| US7491395B2 (en) | 2002-11-20 | 2009-02-17 | Bestewil Holding B.V. | Compositions comprising antigen-complexes, method of making same as well as methods of using the antigen-complexes for vaccination |
| AU2003296592A1 (en) | 2002-11-20 | 2004-06-15 | Crucell Holland B.V. | Antigen-complexes |
| EP1447080A1 (de) | 2003-02-13 | 2004-08-18 | Bestewil Holding B.V. | Methode zur Herstellung von Virosomen-artigen Partikeln |
| AR056245A1 (es) | 2003-06-19 | 2007-10-03 | Bestewil Holding Bv | Membranas virales reconstituidas funcionales que contienen un coadyuvante |
| US7368537B2 (en) * | 2003-07-15 | 2008-05-06 | Id Biomedical Corporation Of Quebec | Subunit vaccine against respiratory syncytial virus infection |
| US20050152919A1 (en) * | 2003-09-15 | 2005-07-14 | Id Biomedical Corporation Of Quebec | Measles subunit vaccine |
| GB0323231D0 (en) * | 2003-10-03 | 2003-11-05 | Chiron Srl | Immunodiffusion assays |
| WO2005042017A1 (en) | 2003-10-22 | 2005-05-12 | Id Biomedical Corporation Of Quebec | Compositions and methods for activating innate and allergic immunity |
| CN101039691B (zh) * | 2004-06-25 | 2013-07-31 | 魁北克益得生物医学公司 | 用于治疗神经疾病的组合物和方法 |
| EP1778283A2 (de) * | 2004-06-30 | 2007-05-02 | ID Biomedical Corporation of Quebec | Vaccinzusammensetzungen zur behandlung von coronavirusinfektion |
| US20060275170A1 (en) * | 2005-06-02 | 2006-12-07 | Mahmoud Ameri | Method for terminal sterilization of transdermal delivery devices |
| US8535683B2 (en) * | 2006-03-22 | 2013-09-17 | Abbott Biologicals B.V. | Intranasal or inhalational administration of virosomes |
| US20080038294A1 (en) * | 2006-03-22 | 2008-02-14 | Kersten Alexander J | Intranasal or inhalational administration of virosomes |
| WO2008073490A1 (en) * | 2006-12-12 | 2008-06-19 | Carrington Laboratories Inc., | Purification of influenza viral antigens |
| CN101679974B (zh) | 2007-03-27 | 2015-09-30 | 航道生物技术有限责任公司 | 包含抗体替代轻链序列的构建体和文库 |
| JP5518041B2 (ja) * | 2008-03-18 | 2014-06-11 | ノバルティス アーゲー | インフルエンザウイルスワクチン抗原の調製における改良 |
| JP2011516423A (ja) | 2008-03-28 | 2011-05-26 | シー レーン バイオテクノロジーズ, エルエルシー | ウイルス抗原に対する中和分子 |
| KR100966566B1 (ko) | 2009-01-29 | 2010-06-29 | 엘지전자 주식회사 | 효율적인 공용 e-dch 관리를 위한 신호 전송 기법 |
| CA2761681A1 (en) | 2009-05-13 | 2010-11-18 | Sea Lane Biotechnologies, Llc | Neutralizing molecules to influenza viruses |
| WO2010144797A2 (en) | 2009-06-12 | 2010-12-16 | Vaccine Technologies, Incorporated | Influenza vaccines with enhanced immunogenicity and uses thereof |
| CA2803282C (en) | 2009-07-06 | 2018-05-01 | David E. Anderson | Methods for preparing vesicles and formulations produced therefrom |
| JP5854559B2 (ja) | 2009-07-06 | 2016-02-09 | ヴァリエーション バイオテクノロジーズ インコーポレイテッド | 小胞を調製する方法及びこれから製造される製剤 |
| WO2011106525A2 (en) | 2010-02-26 | 2011-09-01 | The Brigham And Women's Hospital, Inc. | Methods of treating cerebral amyloid angiopathy |
| CN114010776A (zh) | 2010-06-09 | 2022-02-08 | 疫苗技术股份有限公司 | 用于增强抗逆转录病毒治疗的hiv感染者的治疗性免疫 |
| WO2012006367A2 (en) | 2010-07-06 | 2012-01-12 | Variation Biotechnologies, Inc. | Compositions and methods for treating influenza |
| US10736844B2 (en) | 2011-01-13 | 2020-08-11 | Variation Biotechnologies Inc. | Compositions and methods for treating viral infections |
| BR112013018074A2 (pt) | 2011-01-13 | 2020-12-01 | Variation Biotechnologies, Inc. | métodos para a preparação de vesículas e formulações produzidas a partir dessas |
| EP2736928B1 (de) | 2011-07-28 | 2019-01-09 | i2 Pharmaceuticals, Inc. | Gegen erbb3-gerichtete sur-bindende proteine |
| US20140328876A1 (en) | 2011-11-18 | 2014-11-06 | Variation Biotechnologies Inc. | Synthetic derivatives of mpl and uses thereof |
| US9975956B2 (en) | 2011-12-22 | 2018-05-22 | I2 Pharmaceuticals, Inc. | Surrogate binding proteins which bind DR4 and/or DR5 |
| AU2013208693B2 (en) | 2012-01-12 | 2017-12-07 | Variation Biotechnologies Inc. | Compositions and methods for treating viral infections |
| EP2806894A4 (de) | 2012-01-27 | 2015-11-04 | Variation Biotechnologies Inc | Verfahren und zusammensetzungen für therapeutika |
| KR101601393B1 (ko) | 2014-02-20 | 2016-03-09 | 현대자동차주식회사 | 차량용 비상 버튼 |
| CA3040288A1 (en) | 2016-11-04 | 2018-07-12 | Baxalta Incorporated | Adeno-associated virus purification methods |
| WO2019035972A1 (en) * | 2017-08-16 | 2019-02-21 | Georgia State University Research Foundation, Inc. | SEQUENTIAL IMMUNIZATIONS WITH HIV-1 ENV VIRUS TYPE PARTICLES |
| CA3208643A1 (en) | 2021-01-18 | 2022-07-21 | Conserv Bioscience Limited | Coronavirus immunogenic compositions, methods and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4707543A (en) | 1985-09-17 | 1987-11-17 | The United States Of America As Represented By The Secretary Of The Army | Process for the preparation of detoxified polysaccharide-outer membrane protein complexes, and their use as antibacterial vaccines |
| US5726292A (en) | 1987-06-23 | 1998-03-10 | Lowell; George H. | Immuno-potentiating systems for preparation of immunogenic materials |
| DE3830496C1 (de) * | 1988-09-08 | 1996-09-19 | Daimler Benz Aerospace Ag | Vorrichtung zum Erkennen und Verfolgen von Objekten |
| SK279209B6 (sk) * | 1992-12-21 | 1998-08-05 | Virologický Ústav Sav | Bivalentné imunogény a spôsob ich prípravy |
| US5576016A (en) | 1993-05-18 | 1996-11-19 | Pharmos Corporation | Solid fat nanoemulsions as drug delivery vehicles |
| US5961970A (en) | 1993-10-29 | 1999-10-05 | Pharmos Corporation | Submicron emulsions as vaccine adjuvants |
| WO1995011700A1 (en) | 1993-10-29 | 1995-05-04 | Pharmos Corp. | Submicron emulsions as vaccine adjuvants |
| CN1211192A (zh) | 1995-09-18 | 1999-03-17 | 美国陆军医疗材料研究指挥部 | 生产非共价复合的多价蛋白体亚基疫苗的改进方法 |
| ES1032221Y (es) * | 1995-10-04 | 1996-11-01 | Ferre Jose Manuel Rodriguez | Tobogan componible perfeccionado para uso infantil. |
| AU739723B2 (en) * | 1996-07-10 | 2001-10-18 | Government Of The United States Of America, As Represented By The Secretary Of The Army, The | Protein and peptide vaccines for inducing mucosal immunity |
| JP3426177B2 (ja) * | 1999-12-28 | 2003-07-14 | 明智セラミックス株式会社 | 鋳造用ストッパー |
| CA2400468C (en) * | 2000-02-15 | 2012-12-18 | Intellivax International Inc. | Proteosome influenza vaccine |
| US6726292B1 (en) * | 2000-07-27 | 2004-04-27 | Daimlerchrysler Corporation | Full off-set two-piece fiber reinforced composite wheel using spoke or web area box sections |
-
2001
- 2001-02-15 CA CA2400468A patent/CA2400468C/en not_active Expired - Lifetime
- 2001-02-15 WO PCT/US2001/005222 patent/WO2001060402A2/en not_active Ceased
- 2001-02-15 IL IL15060201A patent/IL150602A0/xx unknown
- 2001-02-15 AU AU3847801A patent/AU3847801A/xx active Pending
- 2001-02-15 AU AU2001238478A patent/AU2001238478C1/en not_active Expired
- 2001-02-15 DE DE60121136T patent/DE60121136T2/de not_active Expired - Lifetime
- 2001-02-15 AT AT01910923T patent/ATE331530T1/de not_active IP Right Cessation
- 2001-02-15 JP JP2001559498A patent/JP3980884B2/ja not_active Expired - Lifetime
- 2001-02-15 US US09/788,280 patent/US6743900B2/en not_active Expired - Lifetime
- 2001-02-15 EP EP01910923A patent/EP1255561B1/de not_active Expired - Lifetime
- 2001-02-15 ES ES01910923T patent/ES2267724T3/es not_active Expired - Lifetime
-
2002
- 2002-07-04 IL IL150602A patent/IL150602A/en not_active IP Right Cessation
- 2002-08-13 NO NO20023829A patent/NO20023829D0/no not_active Application Discontinuation
-
2004
- 2004-02-03 US US10/771,737 patent/US7399840B2/en not_active Expired - Lifetime
-
2006
- 2006-05-12 AU AU2006202003A patent/AU2006202003A1/en not_active Abandoned
- 2006-10-30 JP JP2006294115A patent/JP2007051157A/ja active Pending
-
2008
- 2008-06-24 US US12/144,722 patent/US20080260781A1/en not_active Abandoned
-
2009
- 2009-04-27 AU AU2009201657A patent/AU2009201657A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US6743900B2 (en) | 2004-06-01 |
| AU2001238478C1 (en) | 2006-11-09 |
| EP1255561A2 (de) | 2002-11-13 |
| NO20023829L (no) | 2002-08-13 |
| IL150602A0 (en) | 2003-02-12 |
| US20010053368A1 (en) | 2001-12-20 |
| DE60121136D1 (de) | 2006-08-10 |
| WO2001060402A2 (en) | 2001-08-23 |
| AU3847801A (en) | 2001-08-27 |
| AU2009201657A1 (en) | 2009-05-21 |
| US20080260781A1 (en) | 2008-10-23 |
| DE60121136T2 (de) | 2007-06-06 |
| JP2003522802A (ja) | 2003-07-29 |
| ES2267724T3 (es) | 2007-03-16 |
| NO20023829D0 (no) | 2002-08-13 |
| CA2400468A1 (en) | 2001-08-23 |
| EP1255561B1 (de) | 2006-06-28 |
| US7399840B2 (en) | 2008-07-15 |
| HK1052629A1 (en) | 2003-09-26 |
| AU2001238478B2 (en) | 2006-06-01 |
| AU2006202003A1 (en) | 2006-06-01 |
| US20040156867A1 (en) | 2004-08-12 |
| WO2001060402A3 (en) | 2002-03-21 |
| JP2007051157A (ja) | 2007-03-01 |
| JP3980884B2 (ja) | 2007-09-26 |
| CA2400468C (en) | 2012-12-18 |
| IL150602A (en) | 2010-12-30 |
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