ATE332139T1 - 1,2,4-benzotriazin-oxide enthaltende zubereitungen - Google Patents
1,2,4-benzotriazin-oxide enthaltende zubereitungenInfo
- Publication number
- ATE332139T1 ATE332139T1 AT98915529T AT98915529T ATE332139T1 AT E332139 T1 ATE332139 T1 AT E332139T1 AT 98915529 T AT98915529 T AT 98915529T AT 98915529 T AT98915529 T AT 98915529T AT E332139 T1 ATE332139 T1 AT E332139T1
- Authority
- AT
- Austria
- Prior art keywords
- preparations containing
- benzotriazine oxides
- benzotriazine
- oxides
- treatment
- Prior art date
Links
- GDAXJBDYNVDMDF-UHFFFAOYSA-N 1,2,4-benzotriazine Chemical compound N1=NC=NC2=CC=CC=C21 GDAXJBDYNVDMDF-UHFFFAOYSA-N 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 4
- 201000011510 cancer Diseases 0.000 abstract 2
- GTLQQCMKADHZLK-UHFFFAOYSA-N 1-oxido-1,2,4-benzotriazin-4-ium 4-oxide Chemical class C1=CC=C2N([O-])N=C[N+](=O)C2=C1 GTLQQCMKADHZLK-UHFFFAOYSA-N 0.000 abstract 1
- 239000007979 citrate buffer Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/837,637 US5827850A (en) | 1995-09-25 | 1997-04-21 | 1,2,4-benzotriazine oxides formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE332139T1 true ATE332139T1 (de) | 2006-07-15 |
Family
ID=25275027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98915529T ATE332139T1 (de) | 1997-04-21 | 1998-04-14 | 1,2,4-benzotriazin-oxide enthaltende zubereitungen |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US5827850A (de) |
| EP (1) | EP1044005B1 (de) |
| JP (1) | JP2001523248A (de) |
| AT (1) | ATE332139T1 (de) |
| AU (1) | AU6969098A (de) |
| BR (1) | BR9808958A (de) |
| CA (1) | CA2287257C (de) |
| DE (1) | DE69835167T8 (de) |
| DK (1) | DK1044005T3 (de) |
| ES (1) | ES2267183T3 (de) |
| NO (1) | NO325275B1 (de) |
| PT (1) | PT1044005E (de) |
| WO (1) | WO1998047512A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5616584A (en) * | 1986-09-25 | 1997-04-01 | Sri International | 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents |
| NZ521436A (en) * | 2002-09-17 | 2005-07-29 | Auckland Uniservices Ltd | DNA- targeted benzotriazine 1,4-dioxides and their use in cancer therapy |
| US20050282814A1 (en) * | 2002-10-03 | 2005-12-22 | Targegen, Inc. | Vasculostatic agents and methods of use thereof |
| CA2456569A1 (en) * | 2003-03-14 | 2004-09-14 | Auckland Uniservices Limited | Benzoazine mono-n-oxides and benzoazine 1,4 dioxides and compositions therefrom for the therapeutic use in cancer treatments |
| EP2543376A1 (de) | 2004-04-08 | 2013-01-09 | Targegen, Inc. | Benzotriazin Kinasehemmer |
| MX2007002208A (es) | 2004-08-25 | 2007-05-08 | Targegen Inc | Compuestos hetrociclicos y metodos de uso. |
| US7834178B2 (en) * | 2006-03-01 | 2010-11-16 | Bristol-Myers Squibb Company | Triazine 11-beta hydroxysteroid dehydrogenase type 1 inhibitors |
| CN101683319B (zh) * | 2008-09-24 | 2012-09-05 | 杭州民生药业有限公司 | 一种替拉扎明非肠道给药含水制剂及其制备方法 |
| CN101683346B (zh) * | 2008-09-24 | 2015-04-01 | 杭州民生药业有限公司 | 一种替拉扎明非肠道含水制剂及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3980779A (en) * | 1972-02-01 | 1976-09-14 | Bayer Aktiengesellschaft | 3-Amino-1,2,4-benzotriazine-1,4-di-N-oxide compositions and method of using same |
| US4001410A (en) * | 1972-02-01 | 1977-01-04 | Bayer Aktiengesellschaft | 3-amino-1,2,4-benzotriazine-1,4-di-n-oxide compositions and method of using same |
| US5175287A (en) * | 1986-09-25 | 1992-12-29 | S R I International | Process for preparing 1,2,4-benzotriazine oxides |
| CZ292102B6 (cs) * | 1995-09-25 | 2003-07-16 | Sanofi-Synthelabo Inc. | Vodný parenterální prostředek pro léčbu rakovinových nádorů |
-
1997
- 1997-04-21 US US08/837,637 patent/US5827850A/en not_active Expired - Fee Related
-
1998
- 1998-04-14 JP JP54612298A patent/JP2001523248A/ja not_active Ceased
- 1998-04-14 ES ES98915529T patent/ES2267183T3/es not_active Expired - Lifetime
- 1998-04-14 DE DE69835167T patent/DE69835167T8/de not_active Expired - Fee Related
- 1998-04-14 AT AT98915529T patent/ATE332139T1/de not_active IP Right Cessation
- 1998-04-14 WO PCT/US1998/007391 patent/WO1998047512A1/en not_active Ceased
- 1998-04-14 DK DK98915529T patent/DK1044005T3/da active
- 1998-04-14 BR BR9808958-7A patent/BR9808958A/pt not_active Application Discontinuation
- 1998-04-14 PT PT98915529T patent/PT1044005E/pt unknown
- 1998-04-14 EP EP98915529A patent/EP1044005B1/de not_active Expired - Lifetime
- 1998-04-14 CA CA002287257A patent/CA2287257C/en not_active Expired - Fee Related
- 1998-04-14 AU AU69690/98A patent/AU6969098A/en not_active Abandoned
- 1998-09-21 US US09/157,905 patent/US6153610A/en not_active Expired - Fee Related
-
1999
- 1999-10-20 NO NO19995109A patent/NO325275B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6153610A (en) | 2000-11-28 |
| DE69835167T2 (de) | 2007-06-06 |
| BR9808958A (pt) | 2000-08-01 |
| DE69835167D1 (de) | 2006-08-17 |
| NO325275B1 (no) | 2008-03-17 |
| EP1044005B1 (de) | 2006-07-05 |
| DK1044005T3 (da) | 2006-09-25 |
| PT1044005E (pt) | 2006-10-31 |
| EP1044005A1 (de) | 2000-10-18 |
| JP2001523248A (ja) | 2001-11-20 |
| CA2287257A1 (en) | 1998-10-29 |
| EP1044005A4 (de) | 2001-08-08 |
| CA2287257C (en) | 2007-06-12 |
| US5827850A (en) | 1998-10-27 |
| AU6969098A (en) | 1998-11-13 |
| ES2267183T3 (es) | 2007-03-01 |
| NO995109D0 (no) | 1999-10-20 |
| WO1998047512A1 (en) | 1998-10-29 |
| NO995109L (no) | 1999-12-21 |
| DE69835167T8 (de) | 2007-12-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1044005 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |