ATE332911T1 - Synthese von oligonukleotiden - Google Patents

Synthese von oligonukleotiden

Info

Publication number: ATE332911T1
Authority: AT; Austria
Prior art keywords: oligonucleotide; free; solid support; oligonucleotides; synthesis
Prior art date: 1997-05-14

Application number

AT98923266T

Other languages

English (en)

Inventor

Marek Kwiatkowski

Ulf Landegren

Mats Nilsson

Original Assignee

Quiatech Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-14

Filing date

1998-05-14

Publication date

2006-08-15

1998-05-14 Application filed by Quiatech Ab filed Critical Quiatech Ab

2006-08-15 Application granted granted Critical

2006-08-15 Publication of ATE332911T1 publication Critical patent/ATE332911T1/de

Links

108091034117 Oligonucleotide Proteins 0.000 title abstract 6
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
239000007787 solid Substances 0.000 abstract 3

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Microbiology (AREA)
Immunology (AREA)
Physics & Mathematics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biophysics (AREA)
Analytical Chemistry (AREA)
Saccharide Compounds (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

AT98923266T 1997-05-14 1998-05-14 Synthese von oligonukleotiden ATE332911T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE9701783A SE9701783D0 (sv)	1997-05-14	1997-05-14	In situ synthesis of oligonucleotides of inverse orientation

Publications (1)

Publication Number	Publication Date
ATE332911T1 true ATE332911T1 (de)	2006-08-15

Family

ID=20406926

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98923266T ATE332911T1 (de)	1997-05-14	1998-05-14	Synthese von oligonukleotiden

Country Status (8)

Country	Link
US (2)	US6313284B1 (de)
EP (1)	EP0983288B1 (de)
JP (1)	JP2001525821A (de)
AT (1)	ATE332911T1 (de)
CA (1)	CA2289204A1 (de)
DE (1)	DE69835207D1 (de)
SE (1)	SE9701783D0 (de)
WO (1)	WO1998051698A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9701783D0 (sv) *	1997-05-14	1997-05-14	Marek Kwiatkowski	In situ synthesis of oligonucleotides of inverse orientation
US6309836B1 (en)	1999-10-05	2001-10-30	Marek Kwiatkowski	Compounds for protecting hydroxyls and methods for their use
AU783841B2 (en) *	1999-11-26	2005-12-15	454 Life Sciences Corporation	Nucleic acid probe arrays
EP1283881A2 (de) *	2000-05-26	2003-02-19	Noxxon Pharma AG	Immobilisierte nukleinsäuren und verwendungen davon
US6932943B1 (en)	2001-01-26	2005-08-23	Third Wave Technologies	Nucleic acid synthesizers
US7435390B2 (en) *	2001-01-26	2008-10-14	Third Wave Technologies, Inc.	Nucleic acid synthesizers
JP2004533257A (ja)	2001-06-15	2004-11-04	キアテックアクチボラゲット	増幅可能なプローブ
US7345163B2 (en) *	2002-08-28	2008-03-18	Quiatech Ab	Process for separating and deprotecting oligonucleotides
EP1756307A1 (de) *	2004-05-20	2007-02-28	Trillion Genomics Limited	Verwendung massenmarkierter sonden zum nachweis von zielnukleinsäuren mittels massenspektrometrie
US20060068424A1 (en) *	2004-08-13	2006-03-30	Fuji Photo Film Co., Ltd.	Biosensor
WO2006033730A2 (en) *	2004-08-20	2006-03-30	Dharmacon, Inc.	Novel polynucleotide synthesis labeling chemistry
AU2012304328B2 (en)	2011-09-09	2017-07-20	The Board Of Trustees Of The Leland Stanford Junior University	Methods for obtaining a sequence
US10378051B2 (en) *	2011-09-29	2019-08-13	Illumina Cambridge Limited	Continuous extension and deblocking in reactions for nucleic acids synthesis and sequencing
JP2013198425A (ja) *	2012-03-24	2013-10-03	Kanagawa Univ	オリゴヌクレオチドの製造方法
WO2015179790A1 (en)	2014-05-23	2015-11-26	Centrillion Technology Holding Corporation	Oligonucleotide probe inversion process for in situ synthesized probe arrays
WO2017031278A1 (en) *	2015-08-18	2017-02-23	Centrillion Technology Holdings Corporation	Probe inversion process for in situ synthesized probe arrays
US10695735B2 (en)	2015-08-18	2020-06-30	Centrillion Technology Holdings Corporation	Probe inversion process for in situ synthesized probe arrays
WO2018102660A1 (en) *	2016-12-02	2018-06-07	Centrillion Technologies, Inc.	In situ probe inversion process for constructing probe arrays
US20210032776A1 (en) *	2018-03-21	2021-02-04	Centrillion Technology Holdings Corporation	Method and system for fabricating dna sequencing arrays
EP4069731A4 (de)	2019-12-03	2024-05-29	Alamar Biosciences, Inc.	Nukleinsäure-gekoppelter immun-sandwich-assay (nulisa)
EP4530358A3 (de) *	2020-09-15	2025-06-18	10x Genomics, Inc.	Verfahren zur freisetzung einer erweiterten erfassungssonde aus einem substrat und verwendungen davon
WO2024006816A1 (en) *	2022-06-29	2024-01-04	10X Genomics, Inc.	Compositions and methods for oligonucleotide inversion on arrays

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0366685B1 (de) *	1987-06-24	1994-10-19	Howard Florey Institute Of Experimental Physiology And Medicine	Nukleosid-derivate
SE9003743D0 (sv)	1990-11-26	1990-11-26	Pharmacia Ab	Method and means for oligonucleotide synthesis
US5550215A (en) *	1991-11-22	1996-08-27	Holmes; Christopher P.	Polymer reversal on solid surfaces
US5462854A (en) *	1993-04-19	1995-10-31	Beckman Instruments, Inc.	Inverse linkage oligonucleotides for chemical and enzymatic processes
SE9701783D0 (sv) *	1997-05-14	1997-05-14	Marek Kwiatkowski	In situ synthesis of oligonucleotides of inverse orientation

1997
- 1997-05-14 SE SE9701783A patent/SE9701783D0/xx unknown
1998
- 1998-05-14 DE DE69835207T patent/DE69835207D1/de not_active Expired - Lifetime
- 1998-05-14 US US09/423,742 patent/US6313284B1/en not_active Expired - Fee Related
- 1998-05-14 CA CA002289204A patent/CA2289204A1/en not_active Abandoned
- 1998-05-14 WO PCT/SE1998/000893 patent/WO1998051698A1/en not_active Ceased
- 1998-05-14 JP JP54915198A patent/JP2001525821A/ja not_active Abandoned
- 1998-05-14 AT AT98923266T patent/ATE332911T1/de not_active IP Right Cessation
- 1998-05-14 EP EP98923266A patent/EP0983288B1/de not_active Expired - Lifetime
2001
- 2001-09-12 US US09/952,944 patent/US6790946B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US6313284B1 (en)	2001-11-06
EP0983288B1 (de)	2006-07-12
CA2289204A1 (en)	1998-11-19
US6790946B2 (en)	2004-09-14
US20020051994A1 (en)	2002-05-02
WO1998051698A8 (en)	1999-06-10
WO1998051698A1 (en)	1998-11-19
EP0983288A1 (de)	2000-03-08
SE9701783D0 (sv)	1997-05-14
JP2001525821A (ja)	2001-12-11
DE69835207D1 (de)	2006-08-24

Legal Events

Date	Code	Title	Description
2007-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69835207D1 (de)	2006-08-24	Synthese von oligonukleotiden
EP0987653A3 (de)	2007-08-22	Selbstzusammengebaute Nano-anlagen mit DNS
FR2782280B1 (fr)	2000-09-22	Catalyseurs supportes utilisables dans des reactions de transformation de composes organiques
DE69807507D1 (de)	2002-10-02	Slurrykohlenwasserstoffsyntheseverfahren mit katalysatorwiederbelebung in auswendigem steigrohr
EP0841984A4 (de)	1999-05-12	Geträgerter ni-cv katalysator zur wasserstoffumwandlung
DE68912380D1 (de)	1994-03-03	Vorrichtung zur Synthese von analogen Signalen in PCM.
DE69612440D1 (de)	2001-05-17	Rührbioreaktor
DE69507618D1 (de)	1999-03-11	Fester träger-reagenzien zur synthese von 3'-stickstoffhaltigen polynukleotiden
FR2767721B1 (fr)	1999-10-22	Nouveaux catalyseurs utilisables dans les reactions de transformation de composes organiques
FR2767824B1 (fr)	1999-10-08	Synthese d'acides carboxyalkylthiosucciniques
DE58901731D1 (de)	1992-07-30	Synthesemittel fuer lithiumorganische reaktionen.
Tedford et al.	1994	Key to the carnivores.
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Stone	1994	Mice to rescue Italian role in EMBL?
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Jaquet	1997	Indies' reservations.
Hochelova	1995	World literature in review: Slovak.
DE50014381D1 (de)	2007-07-19	Stereoselektive Synthese von 2-Hydroxyketonen
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Hardin	1995	Southwest runner peanut resists blight.
Reina	1996	Scammed.
Morreau	1996	Cellos in Kronberg.
Wade	1995	Adopt-a-highway's popularity begins in Texas.
ITRM950071V0 (it)	1995-04-05	Cellula sanitaria montata su veicolo, utilizzabile come auto-ambulanzae disimpegnabile a comando dal veicolo stesso, per essere utilizzata come infermeria campale autosufficiente.
ATE399211T1 (de)	2008-07-15	Enzymatische synthese von gangliosiden