ATE332914T1 - Mimotope und antimimotope des menschlichen plättchen-glykoproteins ib/ix - Google Patents

Mimotope und antimimotope des menschlichen plättchen-glykoproteins ib/ix

Info

Publication number
ATE332914T1
ATE332914T1 AT96942734T AT96942734T ATE332914T1 AT E332914 T1 ATE332914 T1 AT E332914T1 AT 96942734 T AT96942734 T AT 96942734T AT 96942734 T AT96942734 T AT 96942734T AT E332914 T1 ATE332914 T1 AT E332914T1
Authority
AT
Austria
Prior art keywords
mimotopes
peptide
molecule
mimotope
monoclonal antibody
Prior art date
Application number
AT96942734T
Other languages
English (en)
Inventor
Jonathan L Miller
Vicki A Lyle
Original Assignee
Rcbt Llc Series Ii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rcbt Llc Series Ii filed Critical Rcbt Llc Series Ii
Application granted granted Critical
Publication of ATE332914T1 publication Critical patent/ATE332914T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Table Devices Or Equipment (AREA)
AT96942734T 1995-11-13 1996-11-08 Mimotope und antimimotope des menschlichen plättchen-glykoproteins ib/ix ATE332914T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/556,597 US5877155A (en) 1995-03-17 1995-11-13 Mimotopes and anti-mimotopes of human platelet glycoprotein Ib/IX

Publications (1)

Publication Number Publication Date
ATE332914T1 true ATE332914T1 (de) 2006-08-15

Family

ID=24222017

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96942734T ATE332914T1 (de) 1995-11-13 1996-11-08 Mimotope und antimimotope des menschlichen plättchen-glykoproteins ib/ix

Country Status (7)

Country Link
US (1) US5877155A (de)
EP (1) EP0876396B1 (de)
JP (1) JP3979448B2 (de)
CN (1) CN1140536C (de)
AT (1) ATE332914T1 (de)
DE (1) DE69636346T2 (de)
WO (1) WO1997018236A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7074888B1 (en) * 1995-03-17 2006-07-11 The Research Foundation Of State University Of New York Mimotopes and anti-mimotopes of human platelet glycoprotein Ib/IX
US6528061B1 (en) * 1997-09-04 2003-03-04 Pasteur Institut Immunogenic polypeptides that mimic a surface polysaccharide antigen of a pathogenic microorganism, method for obtaining the same, and their use in vaccine compositions
JP2002509859A (ja) * 1998-01-23 2002-04-02 ルードヴィッヒ・インスティテュート・フォア・キャンサー・リサーチ Ｈｌａ−ａ２９分子に結合する単離ポリペプチド、それらをコードする分子である核酸、およびそれらの使用
US20020029391A1 (en) * 1998-04-15 2002-03-07 Claude Geoffrey Davis Epitope-driven human antibody production and gene expression profiling
US7481999B2 (en) 1998-05-05 2009-01-27 Adherex Technologies, Inc. Compounds and methods for modulating OB-cadherin-mediated function
NZ508812A (en) * 1998-06-12 2002-11-26 Aventis Pasteur Peptides for the prevention or treatment of HIV
US7112661B1 (en) 1998-10-30 2006-09-26 The Research Foundation Of State University Of New York Variable heavy chain and variable light chain regions of antibodies to human platelet glycoprotein Ib alpha
JP2002529054A (ja) * 1998-10-30 2002-09-10 エル．ミラー ジョナサン ヒト血小板糖タンパク質ｉｂアルファに対する抗体の可変重鎖領域及び可変軽鎖領域
ATE298346T1 (de) 1999-12-06 2005-07-15 Chu Sainte Justine Verbindungen zur behandlung von abnormaler glomerularer filtration, patent ductus arteriosus und osteoporosis
US6632616B2 (en) * 2000-03-16 2003-10-14 Duke University Compounds that selectively bind to expanded polyglutamine repeat domains and methods of use thereof
IL145926A0 (en) 2001-10-15 2002-07-25 Mor Research Applic Ltd Peptide epitopes of mimotopes useful in immunomodulation
MXPA05002219A (es) 2002-08-28 2005-07-05 Immunex Corp Composiciones y metodos para tratar una enfermedad cardiovascular.
EP2284192A3 (de) * 2002-11-08 2011-07-20 Ablynx N.V. Antikörper aus Camelidae zur sublingualen Verabreichung
ATE554108T1 (de) 2003-07-25 2012-05-15 Amgen Inc Verfahren bezüglich ldcam und crtam
US20090181057A1 (en) 2004-05-04 2009-07-16 The Board Of Trustees Of The University Of Illinois Methods and Compositions for the Inhibition of Thrombus Formation
US20080015145A1 (en) 2006-07-11 2008-01-17 Maria Gyongyossy-Issa Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions
US20090304719A1 (en) 2007-08-22 2009-12-10 Patrick Daugherty Activatable binding polypeptides and methods of identification and use thereof
EP2108657A1 (de) * 2008-04-08 2009-10-14 DKFZ Deutsches Krebsforschungszentrum Peptide zur HPV-E6-Onkoproteinhemmung
AU2009262199B2 (en) 2008-06-27 2012-08-09 Amgen Inc. Ang-2 inhibition to treat multiple sclerosis
WO2010081173A2 (en) 2009-01-12 2010-07-15 Cytomx Therapeutics, Llc Modified antibody compositions, methods of making and using thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5114842A (en) * 1987-07-08 1992-05-19 The Scripps Research Institute Peptides and antibodies that inhibit platelet adhesion
US5340727A (en) * 1987-11-17 1994-08-23 The Scripps Research Institute GPIbα fragments and recombinant DNA expression vectors
US5177188A (en) * 1990-12-03 1993-01-05 The Scripps Research Institute Methods and compositions for diagnosing chronic immune thrombocytopenic purpura

Also Published As

Publication number Publication date
US5877155A (en) 1999-03-02
DE69636346T2 (de) 2007-08-09
JP3979448B2 (ja) 2007-09-19
DE69636346D1 (de) 2006-08-24
EP0876396A4 (de) 1999-09-22
CN1202175A (zh) 1998-12-16
EP0876396A1 (de) 1998-11-11
JP2001511111A (ja) 2001-08-07
EP0876396B1 (de) 2006-07-12
WO1997018236A1 (en) 1997-05-22
CN1140536C (zh) 2004-03-03

Similar Documents

Publication Publication Date Title
DE69636346D1 (de) MIMOTOPE UND ANTIMIMOTOPE DES MENSCHLICHEN PLÄTTCHEN-GLYKOPROTEINS Ib/IX
DE69737683D1 (de) Antikörper gegen die ed-b domäne von fibronektin, ihre herstellung und verwendungen
EP0746398A4 (de) Antikörperreinigung
ATE215831T1 (de) Monoklonale antikörper, die an den vorläufer des tumorabstossantigen mage-1 anbinden, rekombinantes mage-1, und von mage-1 abgebieteteimmunogene peptide
ATE377027T1 (de) Tetravalente antikörperkonstrukte
ATE316982T1 (de) Mehrere zytokin-antikörper komplexen
DE69433406T2 (de) Antikörper gegen cd40
EP1461073A4 (de) Peptidagonisten für prostata-spezifisches antigen und ihre verwendung
DE69840412D1 (de) Methoden und zusammensetzungen bestehend aus glykoprotein-glykoformen
DE69429095D1 (de) Humanisierte antikoerper
WO2002020569A3 (en) Mammalian genes; related reagents and methods
ATE204480T1 (de) Monoklonaler antikörper, welcher spezifisch an vaskularisiertes tumorendothelium bindet und verwendungen davon
BR0315123A (pt) Composições farmacêuticas direcionadas a receptores erb-b1
SI1629011T1 (sl) Humane molekule za vezavo anti hu cd
PT929578E (pt) Anticorpos humanos que se ligam a tnfalfa humano
DE69738138D1 (de) Induktion von immunologischer Toleranz gegen einen therapeutischen Antikörper durch Varianten des therapeutischen Antikörpers
TR200102493T2 (tr) IgE'nin C-epsilon-3 veya C-epsilon-4 alanlarından türetilmiş epitoplar veya mimotoplar.
WO2002024222A3 (en) Ligands for g protein coupled receptors and methods of using them
PT877803E (pt) Receptor da proteina ob e composicoes e metodos afins
DE69938725D1 (de) Monoklonale antikörper gegen das protein g3bp und deren verwendungen
ATE247130T1 (de) Inhibitoren für den urokinaserezeptor
ATE209041T1 (de) Durch hla-b44 moleküle präsentierte tumor- abstossungsantigene und ihre verwendung
DE69010897D1 (de) Verwendung von monoklonalen Antikörpern gegen B2-Mikroglobulin.
SE0203226D0 (sv) Immunoglobulin bindning site
RU94026276A (ru) Рецепторы интерлейкина-12 и антител

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties