ATE332918T1 - Neoglycoproteine - Google Patents
NeoglycoproteineInfo
- Publication number
- ATE332918T1 ATE332918T1 AT98924125T AT98924125T ATE332918T1 AT E332918 T1 ATE332918 T1 AT E332918T1 AT 98924125 T AT98924125 T AT 98924125T AT 98924125 T AT98924125 T AT 98924125T AT E332918 T1 ATE332918 T1 AT E332918T1
- Authority
- AT
- Austria
- Prior art keywords
- conjugates
- polyamide
- neoglycoproteins
- group
- macromolecular
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
- B01J20/26—Synthetic macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Medicinal Preparation (AREA)
- Polyamides (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Saccharide Compounds (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97810243 | 1997-04-18 | ||
| EP97810244 | 1997-04-18 | ||
| GBGB9802450.8A GB9802450D0 (en) | 1998-02-05 | 1998-02-05 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE332918T1 true ATE332918T1 (de) | 2006-08-15 |
Family
ID=27238761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98924125T ATE332918T1 (de) | 1997-04-18 | 1998-04-16 | Neoglycoproteine |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6399071B1 (de) |
| EP (1) | EP0970114B1 (de) |
| JP (1) | JP3474583B2 (de) |
| CN (1) | CN1185253C (de) |
| AT (1) | ATE332918T1 (de) |
| AU (1) | AU733282B2 (de) |
| CA (1) | CA2284729A1 (de) |
| DE (1) | DE69835201T2 (de) |
| ES (1) | ES2268776T3 (de) |
| IL (1) | IL132156A0 (de) |
| PT (1) | PT970114E (de) |
| WO (1) | WO1998047915A1 (de) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100361933B1 (ko) | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트 |
| PT970114E (pt) * | 1997-04-18 | 2006-12-29 | Novartis Ag | Neoglicoproteínas |
| AU761831B2 (en) | 1998-04-15 | 2003-06-12 | Bioscience 2002 Llc | Inhibition of xenoreactive antibodies |
| JP2002531531A (ja) * | 1998-12-09 | 2002-09-24 | ラ ホヤ ファーマシューティカル カンパニー | 循環している抗体を減少させるための方法および処方物 |
| US6458953B1 (en) | 1998-12-09 | 2002-10-01 | La Jolla Pharmaceutical Company | Valency platform molecules comprising carbamate linkages |
| US6399578B1 (en) * | 1998-12-09 | 2002-06-04 | La Jolla Pharmaceutical Company | Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same |
| DE60044717D1 (de) | 1999-05-10 | 2010-09-02 | Paolo Brenner | Kombination von immunsuppressiven substanzen zur behandlung oder vorbeugung von transplantat abstossungen |
| PL229487B1 (pl) | 2002-11-12 | 2018-07-31 | Brigham & Womens Hospital Inc | Kompozycja zawierająca polimer β-1,6-glukozaminy, kompozycja zawierająca przeciwciało, kompozycja farmaceutyczna, sposób wytwarzania wyodrębnionego polisacharydu, sposób identyfikacji obecności deacetylowanej poli-N-acetyloglukozaminy (dPNAG) i/ lub poli-N-acetyloglukozaminy (PNAG), wyodrębniony polisacharyd do zastosowania w leczeniu lub profilaktyce zakażenia, wyodrębniony polisacharyd do zastosowania do wytwarzania przeciwciał, w tym przeciwciał monoklonalnych, wyodrębniony polisacharyd do zastosowania w identyfikacji przeciwciała monoklonalnego |
| CN100365007C (zh) * | 2003-09-01 | 2008-01-30 | 北京大学 | 三糖和五糖寡糖抗原,它们的合成方法以及在制备抑制排斥反应的药物中的用途 |
| US20060078534A1 (en) * | 2004-10-13 | 2006-04-13 | Dominique Charmot | Toxin binding compositions |
| US20060099169A1 (en) * | 2004-10-13 | 2006-05-11 | Ilypsa, Inc. | Toxin binding compositions |
| GB0502095D0 (en) * | 2005-02-01 | 2005-03-09 | Chiron Srl | Conjugation of streptococcal capsular saccharides |
| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
| ES2442024T3 (es) | 2008-07-15 | 2014-02-07 | Academia Sinica | Matrices de glucano sobre portaobjetos de vidrio revestidos con aluminio de tipo PTFE y métodos relacionados |
| CN102159540B (zh) * | 2008-07-21 | 2015-08-12 | 布赖汉姆妇女医院 | 与合成的β-1,6葡糖胺寡糖相关的方法和组合物 |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US10338069B2 (en) | 2010-04-12 | 2019-07-02 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
| US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
| WO2014031498A1 (en) | 2012-08-18 | 2014-02-27 | Academia Sinica | Cell-permeable probes for identification and imaging of sialidases |
| EP3013365B1 (de) * | 2013-06-26 | 2019-06-05 | Academia Sinica | Rm2-antigene und verwendung davon |
| EP3013347B1 (de) | 2013-06-27 | 2019-12-11 | Academia Sinica | Glykankonjugate und verwendung davon |
| WO2015007326A1 (en) | 2013-07-18 | 2015-01-22 | Institut D'investigació Biomèdica De Bellvitge (Idibell) | Agents comprising a terminal alpha-galactosyl moiety for use in prevention and/or treatment of inflammatory diseases |
| JP6486368B2 (ja) | 2013-09-06 | 2019-03-20 | アカデミア シニカAcademia Sinica | 改変されたグリコシル基を含む糖脂質を用いたヒトiNKT細胞の活性化 |
| US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| AU2015206370A1 (en) | 2014-01-16 | 2016-07-07 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| US9994605B2 (en) | 2014-03-13 | 2018-06-12 | Universitaet Basel | Carbohydrate ligands that bind to IgM antibodies against myelin-associated glycoprotein |
| CN106415244B (zh) | 2014-03-27 | 2020-04-24 | 中央研究院 | 反应性标记化合物及其用途 |
| EP4615169A3 (de) * | 2014-05-15 | 2025-12-10 | Mayo Foundation for Medical Education and Research | Lösungsziel zur zyklotronherstellung von radiometallen |
| CN106661099A (zh) | 2014-05-27 | 2017-05-10 | 中央研究院 | 抗her2醣抗体及其用途 |
| US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| JP7093612B2 (ja) | 2014-05-27 | 2022-06-30 | アカデミア シニカ | Bacteroides由来のフコシダーゼおよびそれを使用する方法 |
| WO2015184001A1 (en) | 2014-05-28 | 2015-12-03 | Academia Sinica | Anti-tnf-alpha glycoantibodies and uses thereof |
| EP2987503A1 (de) * | 2014-08-22 | 2016-02-24 | Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Verfahren und Reagenzien zur Prävention und/oder Behandlung von Infektionen |
| TWI745275B (zh) | 2014-09-08 | 2021-11-11 | 中央研究院 | 使用醣脂激活人類iNKT細胞 |
| US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| JP6779887B2 (ja) | 2015-01-24 | 2020-11-04 | アカデミア シニカAcademia Sinica | 新規なグリカンコンジュゲートおよびその使用方法 |
| CA2996073A1 (en) * | 2015-09-16 | 2017-03-23 | Universitat Basel | Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids |
| EP3426693A4 (de) | 2016-03-08 | 2019-11-13 | Academia Sinica | Verfahren zur modularen synthese von n-glykanen und anordnungen davon |
| CA3034057A1 (en) | 2016-08-22 | 2018-03-01 | CHO Pharma Inc. | Antibodies, binding fragments, and methods of use |
| CA3056206A1 (en) * | 2017-03-15 | 2018-09-20 | Polyneuron Pharmaceuticals Ag | Glycopolymers sequestering carbohydrate-binding proteins |
| US12397014B2 (en) | 2019-02-05 | 2025-08-26 | The Brigham And Women's Hospital, Inc. | Polysaccharide compositions for use in treating filariasis |
| EP3964235A1 (de) * | 2020-09-08 | 2022-03-09 | RemAb Therapeutics SL | Glycokonjugate und deren medizinische verwendungen |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5149425A (en) | 1988-11-09 | 1992-09-22 | Chembiomed, Ltd. | Affinity supports for hemoperfusion |
| US5286846A (en) * | 1991-06-14 | 1994-02-15 | The Government Of The United States Of America As Represented By The Dept. Of Health And Human Services | Amino acid derivative and bromoacetyl modified peptides for the preparation of synthetic peptide polymers, conjugated peptides, and cyclic peptides |
| WO1993003735A1 (en) * | 1991-08-23 | 1993-03-04 | Alberta Research Council | Methods and compositions for attenuating antibody-mediated xenograft rejection in human recipients |
| EP0601417A3 (de) * | 1992-12-11 | 1998-07-01 | Hoechst Aktiengesellschaft | Physiologisch verträglicher und physiologisch abbaubarer, Kohlenhydratrezeptorblocker auf Polymerbasis, ein Verfahren zu seiner Herstellung und seine Verwendung |
| FR2727117A1 (fr) | 1994-11-18 | 1996-05-24 | Geffard Michel | Utilisation de conjugues de la polylysine pour la preparation de medicaments utiles dans le traitement des maladies neurodegeneratives et des affections degeneratives a caractere autoimmun |
| EP0866802A1 (de) * | 1995-11-21 | 1998-09-30 | Novartis AG | Multivalente polymere, deren herstellung und verwendung zur herstellung von biologisch aktiven verbindungen |
| PT970114E (pt) * | 1997-04-18 | 2006-12-29 | Novartis Ag | Neoglicoproteínas |
-
1998
- 1998-04-16 PT PT98924125T patent/PT970114E/pt unknown
- 1998-04-16 CA CA002284729A patent/CA2284729A1/en not_active Abandoned
- 1998-04-16 AU AU76439/98A patent/AU733282B2/en not_active Ceased
- 1998-04-16 US US09/403,111 patent/US6399071B1/en not_active Expired - Fee Related
- 1998-04-16 ES ES98924125T patent/ES2268776T3/es not_active Expired - Lifetime
- 1998-04-16 AT AT98924125T patent/ATE332918T1/de not_active IP Right Cessation
- 1998-04-16 IL IL13215698A patent/IL132156A0/xx unknown
- 1998-04-16 JP JP54496998A patent/JP3474583B2/ja not_active Expired - Fee Related
- 1998-04-16 WO PCT/EP1998/002227 patent/WO1998047915A1/en not_active Ceased
- 1998-04-16 EP EP98924125A patent/EP0970114B1/de not_active Expired - Lifetime
- 1998-04-16 DE DE69835201T patent/DE69835201T2/de not_active Expired - Fee Related
- 1998-04-16 CN CNB988042835A patent/CN1185253C/zh not_active Expired - Fee Related
-
2002
- 2002-04-16 US US10/123,396 patent/US6723831B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2284729A1 (en) | 1998-10-29 |
| US20020164347A1 (en) | 2002-11-07 |
| US6399071B1 (en) | 2002-06-04 |
| IL132156A0 (en) | 2001-03-19 |
| DE69835201D1 (en) | 2006-08-24 |
| EP0970114A1 (de) | 2000-01-12 |
| DE69835201T2 (de) | 2007-06-14 |
| EP0970114B1 (de) | 2006-07-12 |
| ES2268776T3 (es) | 2007-03-16 |
| JP2001500528A (ja) | 2001-01-16 |
| JP3474583B2 (ja) | 2003-12-08 |
| CN1185253C (zh) | 2005-01-19 |
| WO1998047915A1 (en) | 1998-10-29 |
| AU733282B2 (en) | 2001-05-10 |
| CN1252807A (zh) | 2000-05-10 |
| PT970114E (pt) | 2006-12-29 |
| US6723831B2 (en) | 2004-04-20 |
| AU7643998A (en) | 1998-11-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0970114 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |