ATE334136T1 - Verfahren zur herstellung von azithromycin - Google Patents

Verfahren zur herstellung von azithromycin

Info

Publication number: ATE334136T1
Authority: AT; Austria
Prior art keywords: azithromycin; producing; producing azithromycin; monohydrate; stable
Prior art date: 1999-06-29

Application number

AT00943902T

Other languages

English (en)

Inventor

Victor Centellas

Rafael Garcia

Marta Poch

Jose Diago

Johannes Ludescher

Immaculada Bosch

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-06-29

Filing date

2000-06-27

Publication date

2006-08-15

1999-06-29 Priority claimed from GBGB9915218.3A external-priority patent/GB9915218D0/en

1999-06-29 Priority claimed from GBGB9915216.7A external-priority patent/GB9915216D0/en

1999-12-20 Priority claimed from GBGB9930059.2A external-priority patent/GB9930059D0/en

2000-06-27 Application filed by Sandoz Ag filed Critical Sandoz Ag

2006-08-15 Application granted granted Critical

2006-08-15 Publication of ATE334136T1 publication Critical patent/ATE334136T1/de

Links

MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 title abstract 3
229960004099 azithromycin Drugs 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title 1
150000004682 monohydrates Chemical class 0.000 abstract 2

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT00943902T 1999-06-29 2000-06-27 Verfahren zur herstellung von azithromycin ATE334136T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9915218.3A GB9915218D0 (en)	1999-06-29	1999-06-29	Organic compounds
GBGB9915216.7A GB9915216D0 (en)	1999-06-29	1999-06-29	Organic compounds
GBGB9930059.2A GB9930059D0 (en)	1999-12-20	1999-12-20	Organic compounds

Publications (1)

Publication Number	Publication Date
ATE334136T1 true ATE334136T1 (de)	2006-08-15

Family

ID=27269768

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT00943902T ATE334136T1 (de)	1999-06-29	2000-06-27	Verfahren zur herstellung von azithromycin
AT06117687T ATE469910T1 (de)	1999-06-29	2000-06-27	Azithromycinmonohydrat

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT06117687T ATE469910T1 (de)	1999-06-29	2000-06-27	Azithromycinmonohydrat

Country Status (10)

Country	Link
US (1)	US6703372B1 (de)
EP (2)	EP1712556B1 (de)
JP (2)	JP4703924B2 (de)
KR (1)	KR100700475B1 (de)
AT (2)	ATE334136T1 (de)
AU (1)	AU5820400A (de)
DE (3)	DE20023815U1 (de)
ES (2)	ES2267549T3 (de)
HR (1)	HRP20010956B1 (de)
WO (1)	WO2001000640A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP20020231A2 (en) *	2002-03-18	2003-12-31	Pliva D D	ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US6245903B1 (en)	1998-08-21	2001-06-12	Apotex, Inc.	Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
ES2260047T3 (es)	2000-07-25	2006-11-01	Laboratorio Silanes, S.A. De C.V.	Proceso de etapa unica para la preparacion de 7,16-deoxi-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihidroxi-6-etil-3,5,9,11,13,15-hexametilbiciclo(11.2.1)hexadeca-1(2)-en-ona y obtencion de una forma nueva de 9-deoxo-9a-metil-9a-homoeritromicina a.
ES2172417B1 (es) *	2000-07-31	2003-09-16	Sint Quimica Sa	Nueva forma mejorada de azitromicina monohidrato de menor higroscopicidad, procedimiento de preparacion y composiciones farmaceuticas que la comprenden.
EE05200B1 (et)	2000-11-27	2009-08-17	Biochemie S.A.	Asitromtsiin monohdraadina, selle valmistamismeetod ja selle kasutamine ravimkoostises
HRP20010301A2 (en) *	2001-04-27	2001-12-31	Pliva D D	New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
DK1390377T3 (da) *	2001-05-22	2006-06-19	Pfizer Prod Inc	Ny krystalform af azithromycin
US6861413B2 (en)	2001-05-22	2005-03-01	Pfizer Inc.	Stable non-dihydrate azithromycin oral suspensions
EP1652851A1 (de) *	2001-05-22	2006-05-03	Pfizer Products Inc.	Neue Kristallforme von Azithromycin
AU2002353316A1 (en) *	2001-12-21	2003-07-09	Pfizer Products Inc.	Methods for wet granulating azithromycin
JPWO2003072589A1 (ja) *	2002-02-26	2005-06-16	明治製菓株式会社	新規１５員環アザライド及び新規１６員環ジアザライド誘導体とその製造法
CN1276919C (zh) *	2002-04-03	2006-09-27	韩美药品株式会社	阿奇霉素的制备方法及其中使用的结晶9－脱氧－9a－氮杂－9a－同型红霉素A水合物
ITMI20021209A1 (it) *	2002-06-04	2003-12-04	Chemi Spa	Processo di preparazione di azitromicina ad elevata purezza
GB0214277D0 (en) *	2002-06-20	2002-07-31	Biochemie Gmbh	Organic compounds
US6855813B2 (en)	2002-07-19	2005-02-15	Alembic Limited	Process for the preparation of azithromycin monohydrate
HRP20020614A2 (en)	2002-07-22	2004-06-30	PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o.	Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
GB0224197D0 (en) *	2002-10-17	2002-11-27	Biochemie Gmbh	Organic compounds
US20050013835A1 (en) *	2003-07-15	2005-01-20	Pfizer Inc.	Stable non-dihydrate azithromycin oral suspensions
US20060189800A1 (en) *	2003-07-24	2006-08-24	Mitsuru Ohkubo	Indolopyrrolocabazole derivative and antitumor agent
EP1648473B1 (de) *	2003-07-24	2009-01-28	PLIVA HRVATSKA d.o.o.	Schnellösliches azithromycin in einzeldosisform
US7384921B2 (en) *	2004-02-20	2008-06-10	Enanta Pharmaceuticals, Inc.	Polymorphic forms of 6-11 bicyclic ketolide derivatives
US7468428B2 (en) *	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation
US20060116336A1 (en) *	2004-03-17	2006-06-01	American Pharmaceutical Partners, Inc.	Lyophilized azithromycin formulation
US7683162B2 (en)	2004-08-30	2010-03-23	Taro Pharmaceutical Industries Limited	Process of preparing a crystalline azithromycin monohydrate
JP2008520686A (ja) *	2004-11-17	2008-06-19	スミスクライン・ビーチャム・コーポレイション	新規な抗菌化合物の使用
CN101177441B (zh) *	2007-12-05	2012-05-23	浙江耐司康药业有限公司	一种稳定的阿奇霉素一水合物结晶的制备方法
CN101445532B (zh) *	2008-12-30	2011-09-21	广东东阳光药业有限公司	阿奇霉素一水合物结晶的制备方法
CA2754604A1 (en)	2009-03-13	2010-09-16	Da Volterra	Compositions and methods for elimination of gram-negative bacteria
CN102417531B (zh) *	2011-12-20	2014-06-11	浙江国邦药业有限公司	一种阿奇霉素一水合物的制备方法
CN105030704B (zh) *	2015-06-29	2018-09-07	石药集团欧意药业有限公司	阿奇霉素片剂及其制备方法
CN110684056B (zh) *	2018-07-05	2021-07-13	青岛农业大学	一种阿奇霉素中间体的化学合成方法
CN114516895A (zh) *	2020-11-19	2022-05-20	江苏威奇达药业有限公司	一种阿奇霉素胺结晶方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA835204B (en) *	1982-07-19	1985-02-27	Pfizer	N-methyl 11-aza-10-deoxo-10-dihydroerythromycin a,intermediates therefor and processes for their preparation
RO107257B1 (ro) *	1987-07-09	1993-10-30	Pfizer	Procedeu de obtinere a unui dihidrat de azitromicina, cristalin
ES2122905B1 (es) *	1996-07-11	1999-11-16	Astur Pharma Sa	Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
GB9705323D0 (en) *	1997-03-14	1997-04-30	Biochemie Sa	Organic compounds
DE69824590T2 (de) *	1997-07-08	2005-06-30	Sandoz Industrial Products S.A., Granollers	Solvate von erythromycin a oxim
PT102130A (pt)	1998-03-13	1999-09-30	Hovione Sociedade Quimica S A	Processo de preparacao de dihidrato de azitromicina
US6245903B1 (en)	1998-08-21	2001-06-12	Apotex, Inc.	Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
GB9824580D0 (en) *	1998-11-10	1999-01-06	Biochemie Sa	Organic compounds

2000
- 2000-06-27 ES ES00943902T patent/ES2267549T3/es not_active Expired - Lifetime
- 2000-06-27 AU AU58204/00A patent/AU5820400A/en not_active Abandoned
- 2000-06-27 ES ES06117687T patent/ES2346782T3/es not_active Expired - Lifetime
- 2000-06-27 US US10/019,500 patent/US6703372B1/en not_active Expired - Lifetime
- 2000-06-27 JP JP2001507048A patent/JP4703924B2/ja not_active Expired - Fee Related
- 2000-06-27 EP EP06117687A patent/EP1712556B1/de not_active Expired - Lifetime
- 2000-06-27 DE DE20023815U patent/DE20023815U1/de not_active Expired - Lifetime
- 2000-06-27 WO PCT/EP2000/005948 patent/WO2001000640A1/en not_active Ceased
- 2000-06-27 DE DE60044515T patent/DE60044515D1/de not_active Expired - Fee Related
- 2000-06-27 HR HR20010956A patent/HRP20010956B1/xx not_active IP Right Cessation
- 2000-06-27 EP EP00943902A patent/EP1189915B1/de not_active Expired - Lifetime
- 2000-06-27 DE DE60029589T patent/DE60029589T2/de not_active Expired - Lifetime
- 2000-06-27 AT AT00943902T patent/ATE334136T1/de not_active IP Right Cessation
- 2000-06-27 KR KR1020017016822A patent/KR100700475B1/ko not_active Expired - Fee Related
- 2000-06-27 AT AT06117687T patent/ATE469910T1/de not_active IP Right Cessation
2011
- 2011-01-31 JP JP2011017553A patent/JP2011126894A/ja active Pending

Also Published As

Publication number	Publication date
HRP20010956A2 (en)	2003-08-31
ATE469910T1 (de)	2010-06-15
EP1712556B1 (de)	2010-06-02
DE60044515D1 (de)	2010-07-15
EP1189915A1 (de)	2002-03-27
KR100700475B1 (ko)	2007-03-28
EP1189915B1 (de)	2006-07-26
HRP20010956B1 (hr)	2010-09-30
EP1712556A1 (de)	2006-10-18
JP4703924B2 (ja)	2011-06-15
KR20020016862A (ko)	2002-03-06
JP2003503417A (ja)	2003-01-28
DE20023815U1 (de)	2006-06-08
DE60029589T2 (de)	2007-07-19
ES2267549T3 (es)	2007-03-16
DE60029589D1 (de)	2006-09-07
WO2001000640A1 (en)	2001-01-04
ES2346782T3 (es)	2010-10-20
US6703372B1 (en)	2004-03-09
JP2011126894A (ja)	2011-06-30
AU5820400A (en)	2001-01-31

Legal Events

Date	Code	Title	Description
2007-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE334136T1 (de)	2006-08-15	Verfahren zur herstellung von azithromycin
ATE386736T1 (de)	2008-03-15	Verfahren zur herstellung von benzimidazol-2-yl - chinolinonderivaten
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ATE516267T1 (de)	2011-07-15	Vefahren zur herstellung von lactamen
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DE69934334D1 (de)	2007-01-18	Verfahren zur herstellung von polyolefinen
ATE366251T1 (de)	2007-07-15	Verfahren zur herstellung von 1,3- disubstituierten-4-oxocyclischen harnstoffen
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DE50006598D1 (de)	2004-07-01	VERFAHREN ZUR HERSTELLUNG VON CYCLO-(Asp-DPhe-NMeVal-Arg-Gly)
DE69901192D1 (de)	2002-05-08	Verfahren zur herstellung von cyclopropanmethylamin
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DE69934258D1 (de)	2007-01-11	Verfahren zur herstellung von polyolefinen
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