ATE335086T1 - Künstliche chromosomen, die die genetische information für die bildung von rekombinantem virus enthalten - Google Patents

Künstliche chromosomen, die die genetische information für die bildung von rekombinantem virus enthalten

Info

Publication number
ATE335086T1
ATE335086T1 AT99902747T AT99902747T ATE335086T1 AT E335086 T1 ATE335086 T1 AT E335086T1 AT 99902747 T AT99902747 T AT 99902747T AT 99902747 T AT99902747 T AT 99902747T AT E335086 T1 ATE335086 T1 AT E335086T1
Authority
AT
Austria
Prior art keywords
recombinant virus
formation
genetic information
artificial chromosomes
chromosomes containing
Prior art date
Application number
AT99902747T
Other languages
English (en)
Inventor
Brian Horsburgh
Dong Qiang
Francis Tufaro
Jeffrey Ostrove
Original Assignee
Medigene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medigene Inc filed Critical Medigene Inc
Application granted granted Critical
Publication of ATE335086T1 publication Critical patent/ATE335086T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16641—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16643—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16661—Methods of inactivation or attenuation
    • C12N2710/16662—Methods of inactivation or attenuation by genetic engineering

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT99902747T 1998-02-26 1999-01-29 Künstliche chromosomen, die die genetische information für die bildung von rekombinantem virus enthalten ATE335086T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/031,006 US6277621B1 (en) 1998-02-26 1998-02-26 Artificial chromosome constructs containing foreign nucleic acid sequences

Publications (1)

Publication Number Publication Date
ATE335086T1 true ATE335086T1 (de) 2006-08-15

Family

ID=21857171

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99902747T ATE335086T1 (de) 1998-02-26 1999-01-29 Künstliche chromosomen, die die genetische information für die bildung von rekombinantem virus enthalten

Country Status (9)

Country Link
US (3) US6277621B1 (de)
EP (1) EP1056878B1 (de)
JP (1) JP2002504382A (de)
AT (1) ATE335086T1 (de)
AU (1) AU765521B2 (de)
CA (1) CA2321964C (de)
DE (1) DE69932599T2 (de)
ES (1) ES2270580T3 (de)
WO (1) WO1999043842A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19733364A1 (de) * 1997-08-01 1999-02-04 Koszinowski Ulrich H Prof Verfahren zur Klonierung eines großen Virusgenoms
US6277621B1 (en) * 1998-02-26 2001-08-21 Medigene, Inc. Artificial chromosome constructs containing foreign nucleic acid sequences
EP1153136A2 (de) * 1998-12-09 2001-11-14 The General Hospital Corporation Verbessertes verpacken von hsv-amplikons und herstellung von rekombinanten viralen vektoren
US7196066B1 (en) 1999-11-03 2007-03-27 Powderject Vaccines, Inc. DNA-vaccines based on constructs derived from the genomes of human and animal pathogens
ES2170622B1 (es) * 1999-12-03 2004-05-16 Consejo Superior De Investigaciones Cientificas Clones y vectores infectivos derivados de coronavirus y sus aplicaciones.
US6692954B1 (en) * 2000-11-03 2004-02-17 The Scripps Research Institute Generation of human cytomegalovirus yeast artificial chromosome recombinants
US7214515B2 (en) * 2001-01-05 2007-05-08 The General Hospital Corporation Viral delivery system for infectious transfer of large genomic DNA inserts
US20030059934A1 (en) * 2001-04-03 2003-03-27 Nikolaus Osterrieder Artificial chromosomes comprising EHV sequences
US7439346B2 (en) * 2001-10-12 2008-10-21 Perkinelmer Las Inc. Nucleic acids arrays and methods of use therefor
CA2463725A1 (en) 2001-10-12 2003-11-06 Spectral Genomics, Inc. Compilations of nucleic acids and arrays and methods of using them
ES2208051B1 (es) * 2002-01-24 2005-08-16 Consejo Sup. Investig. Cientificas Secuencia de acido nucleico que comprende la señal de encapsidacion del rna de un coronavirus del grupo 1 y sus aplicaciones.
AR040601A1 (es) 2002-07-19 2005-04-13 Boehringer Ingelheim Vetmed Mutantes ehv negativos de gm sin elementos heterologos
WO2004087869A2 (en) * 2003-03-25 2004-10-14 University Of Florida Herpesvirus ribozymes and vectors
US7335763B2 (en) * 2003-03-25 2008-02-26 University Of Florida Research Foundation, Inc. Herpesvirus ribozymes and vectors
EP1678329A4 (de) * 2003-10-30 2008-07-02 Tufts New England Medical Ct Pränataldiagnose unter verwendung von zellfreier fötaler dna in fruchtwasser
EP2383343A3 (de) * 2004-03-05 2012-01-25 The Research Foundation for Microbial Diseases of Osaka University Rekombinanter Varizella-Zoster-Virus
CA2958259C (en) 2004-10-22 2020-06-30 Revivicor, Inc. Ungulates with genetically modified immune systems
US20100119550A1 (en) * 2005-11-24 2010-05-13 Yasuyuki Gomi Recombinant multivalent vaccine
EP1981976A4 (de) * 2006-01-20 2009-05-06 Univ South Florida Verfahren zur erstellung von transkriptosomenprofilen
US20100291142A1 (en) * 2007-10-18 2010-11-18 Roger Maes Bacterial Artificial Chromosome Containing Feline Herpes Virus Type 1 Genome and Uses Thereof
JP5517116B2 (ja) * 2008-05-30 2014-06-11 国立大学法人 東京大学 組換えウイルス、これを保持する大腸菌およびその製造法
JPWO2010038904A1 (ja) * 2008-09-30 2012-03-01 国立大学法人鳥取大学 外来性核初期化因子またはそれをコードするｄｎａを含まない人工多能性幹細胞およびその作製方法
CN102238961A (zh) 2008-10-03 2011-11-09 诺华公司 牛疱疹病毒1型组合物,疫苗及方法
DK2348827T3 (en) 2008-10-27 2015-07-20 Revivicor Inc IMMUNICIPLY COMPROMATED PETS
EP3380605A1 (de) 2015-11-24 2018-10-03 GlaxoSmithKline Intellectual Property Development Limited Transientes transfektionsverfahren zur retroviralen herstellung
GB201609354D0 (en) * 2016-05-26 2016-07-13 Glaxosmithkline Ip Dev Ltd Transient transfection method for retroviral production
WO2018161825A1 (zh) * 2017-03-09 2018-09-13 厦门大学 一种重组单纯疱疹病毒及其用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5288641A (en) 1984-06-04 1994-02-22 Arch Development Corporation Herpes Simplex virus as a vector
JPH04503306A (ja) 1989-02-01 1992-06-18 ザ・ジェネラル・ホスピタル・コーポレーション 単純ヘルペスウイルス１型発現ベクター
CA2039921A1 (en) 1990-04-16 1991-10-17 Xandra O. Breakefield Transfer and expression of gene sequences into central nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication
US5658724A (en) 1992-07-31 1997-08-19 University Of Pittsburgh Of The Commonwealth System Of Higher Education Herpes simplex virus strains deficient for the essential immediate early genes ICP4 and ICP27 and methods for their production, growth and use
WO1995003400A1 (en) 1993-07-23 1995-02-02 Johns Hopkins University School Of Medicine Recombinationally targeted cloning in yeast artificial chromosomes
US5585096A (en) 1994-06-23 1996-12-17 Georgetown University Replication-competent herpes simplex virus mediates destruction of neoplastic cells
GB9415319D0 (en) 1994-07-29 1994-09-21 Medical Res Council HSV viral vector
EP0811057B1 (de) 1995-02-21 2006-04-26 Cantab Pharmaceuticals Research Limited Virale zubereitungen, vektoren, immunogene und impfstoffe
US5851826A (en) 1995-07-26 1998-12-22 Children's Medical Center Corporation Helper virus-free herpesvirus vector packaging system
US6133243A (en) 1996-02-22 2000-10-17 Onyx Pharmaceuticals, Inc. Liposomal-viral DNA complexes for treating disease
US6277621B1 (en) * 1998-02-26 2001-08-21 Medigene, Inc. Artificial chromosome constructs containing foreign nucleic acid sequences

Also Published As

Publication number Publication date
AU2294599A (en) 1999-09-15
WO1999043842A1 (en) 1999-09-02
US6642207B1 (en) 2003-11-04
JP2002504382A (ja) 2002-02-12
DE69932599T2 (de) 2007-09-27
US20040171569A1 (en) 2004-09-02
EP1056878A1 (de) 2000-12-06
ES2270580T3 (es) 2007-04-01
EP1056878B1 (de) 2006-08-02
US6277621B1 (en) 2001-08-21
DE69932599D1 (de) 2006-09-14
CA2321964C (en) 2010-05-25
AU765521B2 (en) 2003-09-18
CA2321964A1 (en) 1999-09-02

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