ATE335477T1 - Indolylalkylamin-derivate als 5-hydroxytryptamin- 6 liganden - Google Patents

Indolylalkylamin-derivate als 5-hydroxytryptamin- 6 liganden

Info

Publication number
ATE335477T1
ATE335477T1 AT02805601T AT02805601T ATE335477T1 AT E335477 T1 ATE335477 T1 AT E335477T1 AT 02805601 T AT02805601 T AT 02805601T AT 02805601 T AT02805601 T AT 02805601T AT E335477 T1 ATE335477 T1 AT E335477T1
Authority
AT
Austria
Prior art keywords
hydroxytryptamine
ligands
indolylalkylamine
derivatives
indolylalkylamine derivatives
Prior art date
Application number
AT02805601T
Other languages
English (en)
Inventor
Derek Cecil Cole
Joseph Raymond Stock
William Joseph Lennox
Ping Zhou
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of ATE335477T1 publication Critical patent/ATE335477T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT02805601T 2001-12-20 2002-12-17 Indolylalkylamin-derivate als 5-hydroxytryptamin- 6 liganden ATE335477T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34290701P 2001-12-20 2001-12-20

Publications (1)

Publication Number Publication Date
ATE335477T1 true ATE335477T1 (de) 2006-09-15

Family

ID=23343804

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02805601T ATE335477T1 (de) 2001-12-20 2002-12-17 Indolylalkylamin-derivate als 5-hydroxytryptamin- 6 liganden

Country Status (29)

Country Link
US (2) US6770642B2 (de)
EP (1) EP1455779B1 (de)
JP (1) JP4335684B2 (de)
KR (1) KR100985140B1 (de)
CN (1) CN1309385C (de)
AR (1) AR037906A1 (de)
AT (1) ATE335477T1 (de)
AU (1) AU2002357270B2 (de)
BR (1) BR0215222A (de)
CA (1) CA2470863C (de)
CO (1) CO5590924A2 (de)
CY (1) CY1105705T1 (de)
DE (1) DE60213856T2 (de)
DK (1) DK1455779T3 (de)
EC (1) ECSP045156A (de)
ES (1) ES2269827T3 (de)
HU (1) HUP0402640A3 (de)
IL (1) IL162243A0 (de)
MX (1) MXPA04005889A (de)
NO (1) NO330338B1 (de)
NZ (1) NZ533666A (de)
PL (1) PL210413B1 (de)
PT (1) PT1455779E (de)
RU (1) RU2309157C2 (de)
SI (1) SI1455779T1 (de)
TW (1) TWI254705B (de)
UA (1) UA78536C2 (de)
WO (1) WO2003053433A1 (de)
ZA (1) ZA200405731B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002212749A1 (en) * 2000-11-09 2002-05-21 Mitsui Chemicals, Inc. Optically active amine derivative and method of synthesis
TW200301251A (en) * 2001-12-20 2003-07-01 Wyeth Corp Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
CA2532071A1 (en) * 2003-07-23 2005-02-03 Wyeth Sulfonyldihydro- benzimidazolone compounds as 5-hydroxytryptamine-6 ligands
US20050032873A1 (en) * 2003-07-30 2005-02-10 Wyeth 3-Amino chroman and 2-amino tetralin derivatives
WO2005012311A1 (en) * 2003-07-31 2005-02-10 Wyeth N-sulfonylheterocyclopyrrolylalkylamine compounds as 5-hydroxytryptamine-6 ligands
BRPI0413234A (pt) * 2003-08-01 2006-10-03 Genelabs Tech Inc derivados de imidazola bicìclica contra flaviviridae
ATE430752T1 (de) 2004-01-02 2009-05-15 Suven Life Sciences Ltd Neue indenoä2,1-aüindene und isoindolä2,1-aüindol
PE20060303A1 (es) * 2004-06-23 2006-05-19 Wyeth Corp Metabolitos de indolilalquilamina como ligandos de 5-hidroxitriptamina-6
BRPI0519036A2 (pt) * 2004-12-14 2008-12-23 Wyeth Corp mÉtodo para o tratamento de um paciente acometido por uma doenÇa neuro-degenerativa; composiÇço farmacÊutica para tratar uma doenÇa neuro-degenerativa; e uso de um agonista 5-ht6 ou de um agonista 5-ht6
CN101103026A (zh) * 2005-01-14 2008-01-09 健亚生物科技公司 用于治疗病毒感染的吲哚衍生物
EP1953153A1 (de) * 2007-01-31 2008-08-06 Laboratorios del Dr. Esteve S.A. Heterocyclyl-substituierte Sulfonamide für die Behandlung von Wahrnehmungsstörungen bzw. Ernährungserkrankungen
KR20100031578A (ko) * 2007-05-24 2010-03-23 메모리 파마슈티칼스 코포레이션 5-ｈｔ6 수용체 친화성을 갖는 4'-치환된 화합물
DE602007012683D1 (de) * 2007-07-19 2011-04-07 Esteve Labor Dr Substituierte Tetrahydro-Chinolinsulfonamidverbindungen, ihre Herstellung und ihre Verwendung als Medikamente
EP2053052A1 (de) * 2007-10-23 2009-04-29 Laboratorios del Dr. Esteve S.A. Verfahren zur Herstellung von 6-substituiertem Imidazo[2,1-b]thiazol-5-sulfonylhalogenid
JP2011505418A (ja) * 2007-12-04 2011-02-24 メルク・シャープ・エンド・ドーム・コーポレイション ５−ｈｔ６アンタゴニストとしてのトリプタミンスルホンアミド
EP2236511A4 (de) 2007-12-21 2011-04-13 Alla Chem Llc Liganden von alpha-adrenoceptoren und von dopamin-, histamin-, imidazolin- und serotoninrezeptoren und anwendung davon
US20100016297A1 (en) * 2008-06-24 2010-01-21 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
US20100022581A1 (en) * 2008-07-02 2010-01-28 Memory Pharmaceuticals Corporation Pyrrolidine-substituted azaindole compounds having 5-ht6 receptor affinity
US20100029629A1 (en) * 2008-07-25 2010-02-04 Memory Pharmaceuticals Corporation Acyclic compounds having 5-ht6 receptor affinity
US20100056531A1 (en) * 2008-08-22 2010-03-04 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
CN104725295B (zh) 2013-12-20 2019-05-24 广东东阳光药业有限公司 芳杂环类衍生物及其在药物上的应用
SG11201701580XA (en) 2014-08-29 2017-03-30 Chdi Foundation Inc Probes for imaging huntingtin protein
HRP20211778T1 (hr) 2014-08-29 2022-03-18 Chdi Foundation, Inc. Kontrastna sredstva za slikovnu dijagnostiku huntingtin proteina
EP4396162A4 (de) 2021-09-03 2025-11-12 Alexander Shulgin Res Institute Inc Asymmetrische allyltryptamine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
AU670579B2 (en) * 1992-04-07 1996-07-25 Pfizer Inc. Indole derivatives as 5-HT1 agonists
US6194410B1 (en) * 1998-03-11 2001-02-27 Hoffman-La Roche Inc. Pyrazolopyrimidine and pyrazolines and process for preparation thereof
US6133287A (en) * 1998-03-24 2000-10-17 Allelix Biopharmaceuticals Inc. Piperidine-indole compounds having 5-HT6 affinity
GB9820113D0 (en) * 1998-09-15 1998-11-11 Merck Sharp & Dohme Therapeutic agents
US6403808B1 (en) * 1999-12-10 2002-06-11 Virginia Commonwealth University Selective 5-HT6 receptor ligands
AU779832B2 (en) * 1999-08-12 2005-02-10 Nps Pharmaceuticals, Inc. Azaindoles having serotonin receptor affinity
WO2001032660A1 (en) * 1999-11-05 2001-05-10 Nps Allelix Corp. Compounds having 5-ht6 receptor antagonist activity
WO2001034146A1 (en) * 1999-11-08 2001-05-17 Smithkline Beecham Corporation Novel anti-infectives

Also Published As

Publication number Publication date
JP2005517661A (ja) 2005-06-16
US7022701B2 (en) 2006-04-04
HK1065949A1 (en) 2005-03-11
CA2470863A1 (en) 2003-07-03
EP1455779A1 (de) 2004-09-15
US20040209867A1 (en) 2004-10-21
PL370711A1 (en) 2005-05-30
CO5590924A2 (es) 2005-12-30
TWI254705B (en) 2006-05-11
HUP0402640A3 (en) 2012-09-28
NO330338B1 (no) 2011-03-28
KR100985140B1 (ko) 2010-10-05
PL210413B1 (pl) 2012-01-31
ES2269827T3 (es) 2007-04-01
IL162243A0 (en) 2005-11-20
RU2004122129A (ru) 2005-05-10
EP1455779B1 (de) 2006-08-09
DE60213856D1 (de) 2006-09-21
MXPA04005889A (es) 2004-11-01
AU2002357270A1 (en) 2003-07-09
PT1455779E (pt) 2006-11-30
ZA200405731B (en) 2007-02-28
TW200301252A (en) 2003-07-01
NZ533666A (en) 2006-03-31
CN1620290A (zh) 2005-05-25
NO20043100L (no) 2004-08-26
AR037906A1 (es) 2004-12-22
US20030171353A1 (en) 2003-09-11
RU2309157C2 (ru) 2007-10-27
CY1105705T1 (el) 2010-12-22
UA78536C2 (en) 2007-04-10
CN1309385C (zh) 2007-04-11
US6770642B2 (en) 2004-08-03
KR20040075892A (ko) 2004-08-30
CA2470863C (en) 2012-05-15
HUP0402640A2 (hu) 2005-04-28
DK1455779T3 (da) 2006-10-30
AU2002357270B2 (en) 2007-06-14
WO2003053433A1 (en) 2003-07-03
ECSP045156A (es) 2004-07-23
BR0215222A (pt) 2005-05-24
SI1455779T1 (sl) 2006-12-31
DE60213856T2 (de) 2007-09-13
JP4335684B2 (ja) 2009-09-30

Similar Documents

Publication Publication Date Title
ATE396191T1 (de) Azaindolylalkylaminderivate als 5- hydroxytryptamin-6-liganden
ATE312078T1 (de) 1-aryl-oder 1-alkylsulfonylbenzazol derivate als 5-hydroxytryptamin-6 liganden
ATE368658T1 (de) Hetorocyclindazole und -azaindazole verbindungen als 5-hydroxytryptamine-6 liganden
ATE355289T1 (de) 1-(aminoalkyl)-3-sulfonylazaindole als 5- hydroxytryptamin-6 liganden
ATE319451T1 (de) Tetrahydrochinolin-derivate
ATE327232T1 (de) Heterozyklylalkylindole oder -azaindole als 5- hydroxytryptamine-6 liganden
ATE312827T1 (de) 3-substituierte-4-pyrimidonderivate
NO20034168L (no) Koagulasjonsfaktor VII-derivater
DK1455779T3 (da) Indolylalkylaminderivater som 5-hydroxytryptamin-6-ligander
IL158445A0 (en) Heterocyclyloxy-, -thioxy-and-aminobenzazole derivatives as 5-hydroxytryptamine-6 ligands
DE50202178D1 (de) Neue sulfonat-substituierte pyrazolopyridinderivate
EE200300447A (et) Asendatud bensofuraan-2-karboksamiidide derivaadid
IL158448A0 (en) Heterocyclylalkoxy- alkylthio-and-alkylaminobenzazole derivatives as 5-hydroxytryptamine-6 ligands
DE60223031D1 (de) Arylpiperazin gebundene tetrahydroindolonderivate
DE60201463D1 (de) Indanon-Derivate als Duftstoffe
ATE382601T1 (de) Substituierte 4-aminocyclohexanolderivate
DE60202381D1 (de) Paroxetin-n-formyl-derivate
ITMI20011758A0 (it) Ligandi
SE9901140D0 (sv) Fluidumcylinder

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1455779

Country of ref document: EP