ATE335477T1 - Indolylalkylamin-derivate als 5-hydroxytryptamin- 6 liganden - Google Patents

Indolylalkylamin-derivate als 5-hydroxytryptamin- 6 liganden

Info

Publication number
ATE335477T1
ATE335477T1 AT02805601T AT02805601T ATE335477T1 AT E335477 T1 ATE335477 T1 AT E335477T1 AT 02805601 T AT02805601 T AT 02805601T AT 02805601 T AT02805601 T AT 02805601T AT E335477 T1 ATE335477 T1 AT E335477T1
Authority
AT
Austria
Prior art keywords
hydroxytryptamine
ligands
indolylalkylamine
derivatives
indolylalkylamine derivatives
Prior art date
Application number
AT02805601T
Other languages
English (en)
Inventor
Derek Cecil Cole
Joseph Raymond Stock
William Joseph Lennox
Ping Zhou
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of ATE335477T1 publication Critical patent/ATE335477T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT02805601T 2001-12-20 2002-12-17 Indolylalkylamin-derivate als 5-hydroxytryptamin- 6 liganden ATE335477T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US34290701P 2001-12-20 2001-12-20

Publications (1)

Publication Number Publication Date
ATE335477T1 true ATE335477T1 (de) 2006-09-15

Family

ID=23343804

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02805601T ATE335477T1 (de) 2001-12-20 2002-12-17 Indolylalkylamin-derivate als 5-hydroxytryptamin- 6 liganden

Country Status (29)

Country Link
US (2) US6770642B2 (de)
EP (1) EP1455779B1 (de)
JP (1) JP4335684B2 (de)
KR (1) KR100985140B1 (de)
CN (1) CN1309385C (de)
AR (1) AR037906A1 (de)
AT (1) ATE335477T1 (de)
AU (1) AU2002357270B2 (de)
BR (1) BR0215222A (de)
CA (1) CA2470863C (de)
CO (1) CO5590924A2 (de)
CY (1) CY1105705T1 (de)
DE (1) DE60213856T2 (de)
DK (1) DK1455779T3 (de)
EC (1) ECSP045156A (de)
ES (1) ES2269827T3 (de)
HU (1) HUP0402640A3 (de)
IL (1) IL162243A0 (de)
MX (1) MXPA04005889A (de)
NO (1) NO330338B1 (de)
NZ (1) NZ533666A (de)
PL (1) PL210413B1 (de)
PT (1) PT1455779E (de)
RU (1) RU2309157C2 (de)
SI (1) SI1455779T1 (de)
TW (1) TWI254705B (de)
UA (1) UA78536C2 (de)
WO (1) WO2003053433A1 (de)
ZA (1) ZA200405731B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7026515B2 (en) * 2000-11-09 2006-04-11 Mitsui Chemicals, Inc. Optically active amine derivatives and preparation process therefor
TW200301251A (en) * 2001-12-20 2003-07-01 Wyeth Corp Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
WO2005009996A1 (en) * 2003-07-23 2005-02-03 Wyeth Sulfonyldihydro- benzimidazolone compounds as 5-hydroxytryptamine-6 ligands
US20050032873A1 (en) * 2003-07-30 2005-02-10 Wyeth 3-Amino chroman and 2-amino tetralin derivatives
MXPA06000957A (es) * 2003-07-31 2006-03-30 Wyeth Corp Compuestos de n-sulfonil heterociclopirrolilalquilamina como ligandos de 5-hidroxitriptamina-6.
JP2007501189A (ja) * 2003-08-01 2007-01-25 ジェネラブス テクノロジーズ，インコーポレイテッド フラビウイルス科に対する二環式イミダゾール誘導体
AU2004312229B2 (en) * 2004-01-02 2010-05-20 Suven Life Sciences Limited Novel Indeno[2,1a]indenes and isoindolo[2,1-a]indoles
PE20060303A1 (es) * 2004-06-23 2006-05-19 Wyeth Corp Metabolitos de indolilalquilamina como ligandos de 5-hidroxitriptamina-6
WO2006065710A1 (en) * 2004-12-14 2006-06-22 Wyeth Use of a 5-ht6 agonist for the treatment and prevention of neurodegenerative disorders
CN101103026A (zh) * 2005-01-14 2008-01-09 健亚生物科技公司 用于治疗病毒感染的吲哚衍生物
EP1953153A1 (de) * 2007-01-31 2008-08-06 Laboratorios del Dr. Esteve S.A. Heterocyclyl-substituierte Sulfonamide für die Behandlung von Wahrnehmungsstörungen bzw. Ernährungserkrankungen
MX2009012471A (es) * 2007-05-24 2010-02-24 Memory Pharm Corp Compuestos 4´sustituidos que tienen afinidad al receptor 5-hidroxitriptamina 6.
DE602007012683D1 (de) * 2007-07-19 2011-04-07 Esteve Labor Dr Substituierte Tetrahydro-Chinolinsulfonamidverbindungen, ihre Herstellung und ihre Verwendung als Medikamente
EP2053052A1 (de) * 2007-10-23 2009-04-29 Laboratorios del Dr. Esteve S.A. Verfahren zur Herstellung von 6-substituiertem Imidazo[2,1-b]thiazol-5-sulfonylhalogenid
EP2231160B1 (de) * 2007-12-04 2013-08-14 Merck Sharp & Dohme Corp. Tryptamin-sulfonamide als 5-ht6-antagonisten
JP2011507835A (ja) 2007-12-21 2011-03-10 アンドレイ・アレクサンドロビッチ・イワシェンコ α−アドレナリン受容体、ドーパミン、ヒスタミン、イミダゾリン及びセロトニン受容体のリガンド並びにその使用
US20100016297A1 (en) * 2008-06-24 2010-01-21 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
US20100022581A1 (en) * 2008-07-02 2010-01-28 Memory Pharmaceuticals Corporation Pyrrolidine-substituted azaindole compounds having 5-ht6 receptor affinity
US20100029629A1 (en) * 2008-07-25 2010-02-04 Memory Pharmaceuticals Corporation Acyclic compounds having 5-ht6 receptor affinity
US20100056531A1 (en) * 2008-08-22 2010-03-04 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
EP3083588B1 (de) 2013-12-20 2020-12-09 Sunshine Lake Pharma Co., Ltd. Aromatische heterocyclische verbindungen und deren anwendung in pharmazeutika
CA2959505A1 (en) 2014-08-29 2016-03-03 Chdi Foundation, Inc. Probes for imaging huntingtin protein
EA035646B1 (ru) 2014-08-29 2020-07-21 Сиэйчдиай Фаундэйшн, Инк. Зонды для визуализации белка хантингтина
EP4396162A4 (de) 2021-09-03 2025-11-12 Alexander Shulgin Res Institute Inc Asymmetrische allyltryptamine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5747501A (en) * 1992-04-07 1998-05-05 Pfizer, Inc. Indole derivatives
US6194410B1 (en) * 1998-03-11 2001-02-27 Hoffman-La Roche Inc. Pyrazolopyrimidine and pyrazolines and process for preparation thereof
US6133287A (en) * 1998-03-24 2000-10-17 Allelix Biopharmaceuticals Inc. Piperidine-indole compounds having 5-HT6 affinity
GB9820113D0 (en) 1998-09-15 1998-11-11 Merck Sharp & Dohme Therapeutic agents
US6403808B1 (en) * 1999-12-10 2002-06-11 Virginia Commonwealth University Selective 5-HT6 receptor ligands
EP1204662B1 (de) * 1999-08-12 2004-06-02 NPS Allelix Corp. Azaidole mit serotonin rezeptor affinität
WO2001032660A1 (en) * 1999-11-05 2001-05-10 Nps Allelix Corp. Compounds having 5-ht6 receptor antagonist activity
WO2001034146A1 (en) * 1999-11-08 2001-05-17 Smithkline Beecham Corporation Novel anti-infectives

Also Published As

Publication number Publication date
CN1309385C (zh) 2007-04-11
PL210413B1 (pl) 2012-01-31
US20030171353A1 (en) 2003-09-11
BR0215222A (pt) 2005-05-24
CN1620290A (zh) 2005-05-25
IL162243A0 (en) 2005-11-20
HUP0402640A3 (en) 2012-09-28
RU2309157C2 (ru) 2007-10-27
KR20040075892A (ko) 2004-08-30
JP4335684B2 (ja) 2009-09-30
NO330338B1 (no) 2011-03-28
DE60213856T2 (de) 2007-09-13
NO20043100L (no) 2004-08-26
SI1455779T1 (sl) 2006-12-31
US6770642B2 (en) 2004-08-03
JP2005517661A (ja) 2005-06-16
AR037906A1 (es) 2004-12-22
WO2003053433A1 (en) 2003-07-03
ZA200405731B (en) 2007-02-28
NZ533666A (en) 2006-03-31
CA2470863A1 (en) 2003-07-03
TW200301252A (en) 2003-07-01
DK1455779T3 (da) 2006-10-30
CY1105705T1 (el) 2010-12-22
HUP0402640A2 (hu) 2005-04-28
KR100985140B1 (ko) 2010-10-05
RU2004122129A (ru) 2005-05-10
PL370711A1 (en) 2005-05-30
US20040209867A1 (en) 2004-10-21
MXPA04005889A (es) 2004-11-01
EP1455779A1 (de) 2004-09-15
ECSP045156A (es) 2004-07-23
ES2269827T3 (es) 2007-04-01
PT1455779E (pt) 2006-11-30
TWI254705B (en) 2006-05-11
UA78536C2 (en) 2007-04-10
US7022701B2 (en) 2006-04-04
CO5590924A2 (es) 2005-12-30
DE60213856D1 (de) 2006-09-21
EP1455779B1 (de) 2006-08-09
HK1065949A1 (en) 2005-03-11
CA2470863C (en) 2012-05-15
AU2002357270B2 (en) 2007-06-14
AU2002357270A1 (en) 2003-07-09

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