ATE336717T1 - Verfahren und vorrichtung zur feststellung von zieltiefe, helligkeit und grösse in einer körperregion - Google Patents

Verfahren und vorrichtung zur feststellung von zieltiefe, helligkeit und grösse in einer körperregion

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Publication number
ATE336717T1
ATE336717T1 AT02731879T AT02731879T ATE336717T1 AT E336717 T1 ATE336717 T1 AT E336717T1 AT 02731879 T AT02731879 T AT 02731879T AT 02731879 T AT02731879 T AT 02731879T AT E336717 T1 ATE336717 T1 AT E336717T1
Authority
AT
Austria
Prior art keywords
size
subject
light
intensity profile
brightness
Prior art date
Application number
AT02731879T
Other languages
English (en)
Inventor
Bradley W Rice
Daniel G Stearns
Tamara L Troy
Original Assignee
Xenogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenogen Corp filed Critical Xenogen Corp
Application granted granted Critical
Publication of ATE336717T1 publication Critical patent/ATE336717T1/de

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Mathematical Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
AT02731879T 2001-05-17 2002-05-17 Verfahren und vorrichtung zur feststellung von zieltiefe, helligkeit und grösse in einer körperregion ATE336717T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29179401P 2001-05-17 2001-05-17

Publications (1)

Publication Number Publication Date
ATE336717T1 true ATE336717T1 (de) 2006-09-15

Family

ID=23121857

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02731879T ATE336717T1 (de) 2001-05-17 2002-05-17 Verfahren und vorrichtung zur feststellung von zieltiefe, helligkeit und grösse in einer körperregion

Country Status (9)

Country Link
US (4) US7403812B2 (de)
EP (1) EP1402243B1 (de)
JP (1) JP4259879B2 (de)
KR (1) KR20040012844A (de)
AT (1) ATE336717T1 (de)
AU (1) AU2002303819B2 (de)
CA (1) CA2447262A1 (de)
DE (1) DE60213993T2 (de)
WO (1) WO2002093143A2 (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4259879B2 (ja) 2001-05-17 2009-04-30 ゼノジェン コーポレイション 身体領域内の標的の深さ、輝度およびサイズを決定するための方法および装置
US7599731B2 (en) * 2002-07-16 2009-10-06 Xenogen Corporation Fluorescent light tomography
US7616985B2 (en) * 2002-07-16 2009-11-10 Xenogen Corporation Method and apparatus for 3-D imaging of internal light sources
WO2004081865A2 (en) * 2003-03-10 2004-09-23 University Of Iowa Research Foundation Systems and methods for bioliminescent computed tomographic reconstruction
US7190991B2 (en) * 2003-07-01 2007-03-13 Xenogen Corporation Multi-mode internal imaging
CA2544283A1 (en) 2003-10-31 2005-05-12 Art Recherches Et Technologies Avancees Inc./Art Advanced Research Techn A time-domain method and apparatus for determining the depth and concentration of a fluorophore in a turbid medium
JP4327738B2 (ja) * 2005-01-18 2009-09-09 株式会社東芝 生体光計測装置及び生体光計測方法
CN100406874C (zh) * 2005-06-20 2008-07-30 北京源德生物医学工程有限公司 半自动微孔板单光子计数仪的门组件
EP1948008A2 (de) * 2005-11-10 2008-07-30 Philips Intellectual Property & Standards GmbH Absorptions- und streukarten-rekonstruktion für die optische fluoreszenztomographie
GR1005346B (el) * 2005-12-20 2006-11-02 Ιδρυμα Τεχνολογιας Και Ερευνας Αφαιρεση συνοριακων επιφανειων σε διαχυτα μεσα
EP1967886A4 (de) * 2005-12-27 2011-01-05 Olympus Corp Vorrichtung und verfahren zur aufnahme eines bildes einer aus einem organismus stammenden probe
US7865226B2 (en) * 2006-02-03 2011-01-04 Chiodo Chris D Specimen positioning system for imaging machines
US7818154B2 (en) * 2006-03-17 2010-10-19 Duke University Monte Carlo based model of fluorescence in turbid media and methods and systems for using same to determine intrinsic fluorescence of turbid media
WO2007126827A2 (en) * 2006-03-30 2007-11-08 Duke University Optical assay system for intraoperative assessment of tumor margins
EP1865430A3 (de) * 2006-06-05 2009-09-23 Cambridge Research & Instrumentation, Inc. Monte-Carlo-Simulation mittels GPU-Einheiten auf Personalcomputern
US10775308B2 (en) * 2006-08-24 2020-09-15 Xenogen Corporation Apparatus and methods for determining optical tissue properties
US10335038B2 (en) * 2006-08-24 2019-07-02 Xenogen Corporation Spectral unmixing for in-vivo imaging
WO2008024986A2 (en) * 2006-08-24 2008-02-28 Xenogen Corporation Apparatus and methods for determining optical tissue properties
US7990545B2 (en) * 2006-12-27 2011-08-02 Cambridge Research & Instrumentation, Inc. Surface measurement of in-vivo subjects using spot projector
US20080270091A1 (en) * 2007-02-23 2008-10-30 Nirmala Ramanujam Scaling method for fast monte carlo simulation of diffuse reflectance spectra from multi-layered turbid media and methods and systems for using same to determine optical properties of multi-layered turbid medium from measured diffuse reflectance
FR2917831B1 (fr) * 2007-06-25 2009-10-30 Super Sonic Imagine Sa Procede de caracterisation rheologique d'un milieu viscoelastique
US20110059016A1 (en) * 2007-09-27 2011-03-10 Nirmala Ramanujam Optical assay system with a multi-probe imaging array
US9820655B2 (en) * 2007-09-28 2017-11-21 Duke University Systems and methods for spectral analysis of a tissue mass using an instrument, an optical probe, and a Monte Carlo or a diffusion algorithm
US8509879B2 (en) * 2007-11-06 2013-08-13 The Regents Of The University Of California Apparatus and method for widefield functional imaging (WiFI) using integrated structured illumination and laser speckle imaging
EP2067432A3 (de) * 2007-12-05 2012-12-26 FUJIFILM Corporation Bildverarbeitungssystem, -verfahren und -programm
US20110105865A1 (en) * 2008-04-24 2011-05-05 Duke University Diffuse reflectance spectroscopy device for quantifying tissue absorption and scattering
EP3501384B1 (de) 2008-05-20 2024-07-17 University Health Network Verfahren zur bildgebung und überwachung auf fluoreszenzbasis
JP5250342B2 (ja) * 2008-08-26 2013-07-31 富士フイルム株式会社 画像処理装置およびプログラム
KR101011002B1 (ko) * 2008-09-11 2011-01-26 주식회사 효성 가스절연기기
JP2010088627A (ja) * 2008-10-07 2010-04-22 Canon Inc 生体情報処理装置および生体情報処理方法
CA2781393C (en) * 2009-11-19 2017-08-08 Modulated Imaging, Inc. Method and apparatus for analysis of turbid media via single-element detection using structured illumination
US9091637B2 (en) 2009-12-04 2015-07-28 Duke University Smart fiber optic sensors systems and methods for quantitative optical spectroscopy
US20120041302A1 (en) * 2010-08-16 2012-02-16 Caliper Life Sciences, Inc. Portable imaging subject cartridge
US9347894B2 (en) 2010-09-01 2016-05-24 Spectral Instruments Imaging, LLC Methods and systems for producing visible light and x-ray image data
JP2013538350A (ja) 2010-09-01 2013-10-10 スペクトラル・インストゥルメンツ・イメージング・エルエルシー 励起光源組立体
US8729502B1 (en) 2010-10-28 2014-05-20 The Research Foundation For The State University Of New York Simultaneous, single-detector fluorescence detection of multiple analytes with frequency-specific lock-in detection
US9826886B2 (en) * 2011-04-15 2017-11-28 Joel Gerardo Diaz Sanchez Two-way photodynamic therapy stereo colposcope for diagnosing and treating diseases of the female genital tract
EP2714097A4 (de) * 2011-05-23 2015-06-24 Oncofluor Inc Chirurgische lichtquellen zur verwendung mit fluophor-markierten monoklonalen antikörpern oder fluorophor-markierten tumor-aviden verbindungen
US9314218B2 (en) * 2011-06-20 2016-04-19 Caliper Life Sciences, Inc. Integrated microtomography and optical imaging systems
MY166969A (en) * 2011-11-30 2018-07-26 Institute Of Tech Petronas Sdn Bhd Methodology for determining concentration of the types of melanin pigment in the skin
WO2013109130A1 (es) * 2012-01-18 2013-07-25 Joel Gerardo Diaz Sanchez Colpoestereoscopio de diagnóstico fotodinámico (pdd) para enfermedades del tracto genital femenino y detección temprana de lesiones neoplásicas
ES2668320T3 (es) 2012-11-07 2018-05-17 Modulated Imaging Inc. Formación de imágenes modulada eficiente
US9261349B2 (en) * 2012-11-08 2016-02-16 Kabushiki Kaisha Topcon Optical imaging apparatus, optical imaging method, apparatus for setting characteristics of a light source, and method for setting characteristics of a light source
PL3171765T3 (pl) 2014-07-24 2022-01-03 University Health Network Zbieranie i analiza danych do celów diagnostycznych
WO2017136656A1 (en) 2016-02-04 2017-08-10 Northwestern University Methods and systems for identifying non-penetrating brain injuries
WO2018217922A1 (en) * 2017-05-26 2018-11-29 Branson Ultrasonics Corporation Simultaneous laser welding with control by profiling
WO2019040830A1 (en) 2017-08-24 2019-02-28 Northwestern University SYSTEMS AND METHODS FOR THE ACUTE EVALUATION OF TRAUMATIC BRAIN INJURIES
WO2019037088A1 (zh) * 2017-08-25 2019-02-28 深圳市大疆创新科技有限公司 一种曝光的控制方法、装置以及无人机
US11689707B2 (en) * 2018-09-20 2023-06-27 Shoppertrak Rct Llc Techniques for calibrating a stereoscopic camera in a device
US12490927B2 (en) 2019-06-07 2025-12-09 Northwestern University Systems and methods for analyzing frequency-following response to evaluate central nervous system function
WO2024173260A1 (en) * 2023-02-13 2024-08-22 The Regents Of The University Of California Stress-reducing lighting
CN119063629B (zh) * 2024-11-05 2025-02-11 阿普塔恒煜(威海)医疗器材有限公司 一种橡胶模具尺寸参数测量方法及系统

Family Cites Families (207)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4341957A (en) 1975-11-26 1982-07-27 Analytical Radiation Corporation Fluorescent antibody composition for immunofluorometric assay
JPS60256443A (ja) * 1984-05-31 1985-12-18 オムロン株式会社 画像計測装置
US4761071A (en) * 1984-11-06 1988-08-02 Baron William S Apparatus and method for determining corneal and scleral topography
US4687352A (en) * 1984-12-29 1987-08-18 Brother Kogyo Kabushiki Kaisha Printer with an image reader
US4772453A (en) * 1985-03-01 1988-09-20 Lisenbee Wayne F Luminiscence measurement arrangement
US4687325A (en) 1985-03-28 1987-08-18 General Electric Company Three-dimensional range camera
US5205291A (en) * 1988-11-08 1993-04-27 Health Research, Inc. In vivo fluorescence photometer
US5353799A (en) * 1991-01-22 1994-10-11 Non Invasive Technology, Inc. Examination of subjects using photon migration with high directionality techniques
US5148022A (en) 1989-02-15 1992-09-15 Hitachi, Ltd. Method for optically inspecting human body and apparatus for the same
SE8900612D0 (sv) 1989-02-22 1989-02-22 Jonas Johansson Vaevnadskarakterisering utnyttjande ett blodfritt fluorescenskriterium
CA2042075C (en) 1991-05-08 2001-01-23 Branko Palcic Endoscopic imaging system
US5769792A (en) 1991-07-03 1998-06-23 Xillix Technologies Corp. Endoscopic imaging system for diseased tissue
JP2970967B2 (ja) * 1991-11-20 1999-11-02 浜松ホトニクス株式会社 蛍光性プローブ試薬を用いた細胞内イオン濃度測定法
US5242441A (en) * 1992-02-24 1993-09-07 Boaz Avitall Deflectable catheter with rotatable tip electrode
JP3107914B2 (ja) * 1992-07-20 2000-11-13 浜松ホトニクス株式会社 散乱吸収体内部の吸収情報計測装置及び方法
US5452723A (en) * 1992-07-24 1995-09-26 Massachusetts Institute Of Technology Calibrated spectrographic imaging
US5949077A (en) 1992-08-10 1999-09-07 Alfano; Robert R. Technique for imaging an object in or behind a scattering medium
US5746210A (en) * 1993-02-26 1998-05-05 David A. Benaron Device and method for detection, localization, and characterization of inhomogeneities in turbid media
DE4338758C2 (de) * 1992-11-13 2001-08-09 Scimed Life Systems Inc Katheteranordnung
US5334193A (en) * 1992-11-13 1994-08-02 American Cardiac Ablation Co., Inc. Fluid cooled ablation catheter
US5673701A (en) * 1994-10-07 1997-10-07 Non Invasive Technology, Inc. Optical techniques for examination of biological tissue
JPH09504964A (ja) * 1993-10-29 1997-05-20 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルベニア 拡散光を用いた対象物撮像
US5414258A (en) * 1993-11-22 1995-05-09 Angstrom Technologies, Inc. Apparatus and method for calibration of fluorescence detectors
DE4411017C2 (de) 1994-03-30 1995-06-08 Alexander Dr Knuettel Optische stationäre spektroskopische Bildgebung in stark streuenden Objekten durch spezielle Lichtfokussierung und Signal-Detektion von Licht unterschiedlicher Wellenlängen
US6649143B1 (en) * 1994-07-01 2003-11-18 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US5650135A (en) 1994-07-01 1997-07-22 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
IL110538A0 (en) 1994-08-02 1994-11-11 Oren Aharon Tomographic imaging system
US5672881A (en) * 1994-09-14 1997-09-30 Glyko, Inc. Charge-coupled device imaging apparatus
US5840572A (en) * 1994-10-11 1998-11-24 United States Of America As Represented By The Secretary Of The Navy Bioluminescent bioassay system
US5705807A (en) * 1994-10-24 1998-01-06 Nissan Motor Co., Ltd. Photo detecting apparatus for detecting reflected light from an object and excluding an external light componet from the reflected light
JP3433534B2 (ja) * 1994-11-07 2003-08-04 浜松ホトニクス株式会社 散乱吸収体内の散乱特性・吸収特性の測定方法及び装置
AU4594796A (en) * 1994-11-25 1996-06-19 Yuriy Alexandrov System and method for diagnosis of living tissue diseases
JP2675532B2 (ja) * 1994-12-20 1997-11-12 株式会社バイオセンサー研究所 化学発光測定装置
US5594253A (en) 1994-12-28 1997-01-14 Lockheed Missiles And Space Company, Inc. Hybrid luminescent device for imaging of ionizing and penetrating radiation
US5636299A (en) * 1994-12-28 1997-06-03 Lockheed Missiles & Space Company, Inc. Hybrid luminescent device and method for imaging penetrating radiation
US6540981B2 (en) 1997-12-04 2003-04-01 Amersham Health As Light imaging contrast agents
US5813988A (en) * 1995-02-03 1998-09-29 Research Foundation Time-resolved diffusion tomographic imaging in highly scattering turbid media
US5919140A (en) * 1995-02-21 1999-07-06 Massachusetts Institute Of Technology Optical imaging using time gated scattered light
US6070583A (en) * 1995-02-21 2000-06-06 Massachusetts Institute Of Technology Optical imaging of tissue using inelastically scattered light
US5710429A (en) 1995-04-06 1998-01-20 Alfano; Robert R. Ultrafast optical imaging of objects in or behind scattering media
AU5665996A (en) * 1995-05-16 1996-11-29 Afmc Lo/Jaz System and method for enhanced visualization of subcutaneous structures
WO1997008538A1 (en) * 1995-08-24 1997-03-06 Purdue Research Foundation Fluorescence lifetime-based imaging and spectroscopy in tissues and other random media
US7328059B2 (en) 1996-08-23 2008-02-05 The Texas A & M University System Imaging of light scattering tissues with fluorescent contrast agents
JP2879003B2 (ja) 1995-11-16 1999-04-05 株式会社生体光情報研究所 画像計測装置
CA2163914A1 (en) 1995-11-28 1997-05-29 Andre Parent Method and apparatus for detecting malignancies in living tissue
JPH11506839A (ja) * 1995-12-22 1999-06-15 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 混濁媒体中の対象を局部化する装置
GB2309368B (en) 1996-01-18 1999-09-15 Hamamatsu Photonics Kk An optical computer tomographic apparatus and image reconstruction method using optical computer tomography
US5738101A (en) * 1996-01-18 1998-04-14 The Regents Of The University Of California Optical imaging through turbid media with a degenerate four-wave mixing correlation time gate
IL117241A (en) 1996-02-23 2000-09-28 Talia Technology Ltd Three dimensional imaging apparatus and a method for use thereof
US6108576A (en) * 1996-03-18 2000-08-22 The Research Foundation Of City College Of New York Time-resolved diffusion tomographic 2D and 3D imaging in highly scattering turbid media
US8349602B1 (en) 1996-04-19 2013-01-08 Xenogen Corporation Biodetectors targeted to specific ligands
US5988862A (en) * 1996-04-24 1999-11-23 Cyra Technologies, Inc. Integrated system for quickly and accurately imaging and modeling three dimensional objects
US5867250A (en) * 1996-05-03 1999-02-02 Baron; William S. Apparatus and method for optically mapping front and back surface topographies of an object
JP3442220B2 (ja) 1996-05-15 2003-09-02 シスメックス株式会社 光散乱媒体中物体の可視化光学システム
US5864633A (en) * 1996-05-17 1999-01-26 Therma-Wave, Inc. Method and apparatus for optical data analysis
US6026173A (en) 1997-07-05 2000-02-15 Svenson; Robert H. Electromagnetic imaging and therapeutic (EMIT) systems
EP0910790A1 (de) 1996-07-10 1999-04-28 Cambridge Imaging Limited Verbesserte abbildung
US5812310A (en) * 1996-10-16 1998-09-22 Applied Precision, Inc. Orthogonal high accuracy microscope stage
DE29621183U1 (de) * 1996-12-06 1997-02-20 Eder Maschinenfabrik GmbH & Co. KG, 84048 Mainburg Vorrichtung zum Abscheiden von Flüssigkeiten und/oder Feststoffen oder Gasen mit anderem spezifischem Gewicht aus einem Gasstrom
GB9626825D0 (en) * 1996-12-24 1997-02-12 Crampton Stephen J Avatar kiosk
US5963658A (en) * 1997-01-27 1999-10-05 University Of North Carolina Method and apparatus for detecting an abnormality within a host medium
US5936739A (en) 1997-01-29 1999-08-10 Sandia Corporation Gated frequency-resolved optical imaging with an optical parametric amplifier
AU6320798A (en) * 1997-02-07 1998-08-26 Prudue Research Foundation Imaging of light scattering tissues with fluorescent contrast agents
US6208886B1 (en) 1997-04-04 2001-03-27 The Research Foundation Of City College Of New York Non-linear optical tomography of turbid media
US7048716B1 (en) * 1997-05-15 2006-05-23 Stanford University MR-compatible devices
US5943129A (en) * 1997-08-07 1999-08-24 Cambridge Research & Instrumentation Inc. Fluorescence imaging system
US6069698A (en) 1997-08-28 2000-05-30 Olympus Optical Co., Ltd. Optical imaging apparatus which radiates a low coherence light beam onto a test object, receives optical information from light scattered by the object, and constructs therefrom a cross-sectional image of the object
US6316215B1 (en) 1999-12-27 2001-11-13 Edwin L. Adair Methods of cancer screening utilizing fluorescence detection techniques and selectable imager charge integration periods
ES2137879B1 (es) * 1997-12-02 2000-08-16 Francisco Soria Melguizo S A Sistema analizador de imagenes producidas por reacciones bacterianas.
JP3771364B2 (ja) * 1997-12-12 2006-04-26 浜松ホトニクス株式会社 光ｃｔ装置及び画像再構成方法
JP3860412B2 (ja) 1997-12-23 2006-12-20 シーメンス アクチエンゲゼルシヤフト ３次元距離画像を撮影するための方法及び装置
US6364829B1 (en) * 1999-01-26 2002-04-02 Newton Laboratories, Inc. Autofluorescence imaging system for endoscopy
US6267722B1 (en) * 1998-02-03 2001-07-31 Adeza Biomedical Corporation Point of care diagnostic systems
US6205347B1 (en) 1998-02-27 2001-03-20 Picker International, Inc. Separate and combined multi-modality diagnostic imaging system
AU3991799A (en) 1998-05-14 1999-11-29 Metacreations Corporation Structured-light, triangulation-based three-dimensional digitizer
US6252623B1 (en) 1998-05-15 2001-06-26 3Dmetrics, Incorporated Three dimensional imaging system
US6242743B1 (en) * 1998-08-11 2001-06-05 Mosaic Imaging Technology, Inc. Non-orbiting tomographic imaging system
JP2002525603A (ja) 1998-09-18 2002-08-13 セロミックス インコーポレイテッド 細胞ベースのスクリーニングのためのシステム
US6615061B1 (en) * 1998-11-23 2003-09-02 Abbott Laboratories Optical sensor having a selectable sampling distance for determination of analytes
JP3585753B2 (ja) 1998-12-15 2004-11-04 富士写真フイルム株式会社 撮影システム
US6175407B1 (en) 1998-12-17 2001-01-16 Identix Incorporated Apparatus and method for optically imaging features on the surface of a hand
ATE341637T1 (de) 1998-12-17 2006-10-15 Xenogen Corp Unblutige bestimmung einer physiologischen reaktion in einem säugetier
US6610503B1 (en) 1999-03-17 2003-08-26 Xenogen Corporation Animal models for predicting sepsis mortality
EP1169722A1 (de) * 1999-03-18 2002-01-09 Cambridge Research & Instrumentation, Inc. Hochwirkames mehrfachsonden-bilderzeugungssystem
US7107116B2 (en) 1999-03-29 2006-09-12 Genex Technologies, Inc. Diffuse optical tomography system and method of use
US6264610B1 (en) 1999-05-05 2001-07-24 The University Of Connecticut Combined ultrasound and near infrared diffused light imaging system
US6167297A (en) 1999-05-05 2000-12-26 Benaron; David A. Detecting, localizing, and targeting internal sites in vivo using optical contrast agents
US20030026762A1 (en) * 1999-05-05 2003-02-06 Malmros Mark K. Bio-spectral imaging system and methods for diagnosing cell disease state
US6415051B1 (en) 1999-06-24 2002-07-02 Geometrix, Inc. Generating 3-D models using a manually operated structured light source
JP2001017379A (ja) 1999-07-09 2001-01-23 Fuji Photo Film Co Ltd 蛍光診断装置
US6219566B1 (en) * 1999-07-13 2001-04-17 Photonics Research Ontario Method of measuring concentration of luminescent materials in turbid media
EP1208367A4 (de) * 1999-08-06 2007-03-07 Cambridge Res & Instrmnt Inc Vorrichtung zur spektralen abbildung
US6750964B2 (en) * 1999-08-06 2004-06-15 Cambridge Research And Instrumentation, Inc. Spectral imaging methods and systems
AU2589500A (en) 1999-09-03 2001-04-10 Xenogen Corporation Targeting constructs and transgenic animals produced therewith
IT1313918B1 (it) * 1999-10-12 2002-09-26 Sergio Zambelli Dispositivo per il collegamento di una trave a pilastri, o elementistrutturali portanti simili, per la realizzazione di edifici,
US6381302B1 (en) 2000-07-05 2002-04-30 Canon Kabushiki Kaisha Computer assisted 2D adjustment of stereo X-ray images
US6710770B2 (en) 2000-02-11 2004-03-23 Canesta, Inc. Quasi-three-dimensional method and apparatus to detect and localize interaction of user-object and virtual transfer device
US7581191B2 (en) * 1999-11-15 2009-08-25 Xenogen Corporation Graphical user interface for 3-D in-vivo imaging
US6603552B1 (en) 1999-12-22 2003-08-05 Xillix Technologies Corp. Portable system for detecting skin abnormalities based on characteristic autofluorescence
US6337353B1 (en) 2000-01-04 2002-01-08 Exxonmobil Research And Engineering Company Activation of hydrocarbon synthesis catalysts with hydrogen and ammonia
JP3553451B2 (ja) 2000-02-18 2004-08-11 独立行政法人 科学技術振興機構 光干渉断層像観測装置
US6566143B2 (en) * 2000-02-25 2003-05-20 Cambridge Research & Instrumentation, Inc. Multiple label fluorescence polarization assay system and method
US6775567B2 (en) * 2000-02-25 2004-08-10 Xenogen Corporation Imaging apparatus
US6377353B1 (en) 2000-03-07 2002-04-23 Pheno Imaging, Inc. Three-dimensional measuring system for animals using structured light
JP3999437B2 (ja) 2000-03-10 2007-10-31 富士フイルム株式会社 光断層画像化装置
US6429943B1 (en) * 2000-03-29 2002-08-06 Therma-Wave, Inc. Critical dimension analysis with simultaneous multiple angle of incidence measurements
EP1154224A1 (de) 2000-05-09 2001-11-14 Fuji Photo Film Co., Ltd. Optische Kohärenztomographie mit Lichtwellenleiterstruktur zur Reduktion der Pulsweite von kurzkohärentem Licht
US6748259B1 (en) * 2000-06-15 2004-06-08 Spectros Corporation Optical imaging of induced signals in vivo under ambient light conditions
US6693710B1 (en) * 2000-06-16 2004-02-17 Cambridge Research & Instrumentation Inc. Polarization imaging system
US7056728B2 (en) * 2000-07-06 2006-06-06 Xenogen Corporation Compositions and methods for use thereof in modifying the genomes of microorganisms
SE519734C2 (sv) * 2000-07-07 2003-04-01 Axis Ab Bildförändringsanordning för en bildalstrande apparat samt metod och digitalkamera till densamma
DE60122894T2 (de) 2000-07-14 2007-03-15 Xillix Technologies Corp., Richmond Kompaktes fluorezenz endoskopisches video system
US6597931B1 (en) * 2000-09-18 2003-07-22 Photonify Technologies, Inc. System and method for absolute oxygen saturation
US6394965B1 (en) 2000-08-15 2002-05-28 Carbon Medical Technologies, Inc. Tissue marking using biocompatible microparticles
JP2002095663A (ja) 2000-09-26 2002-04-02 Fuji Photo Film Co Ltd センチネルリンパ節光断層画像取得方法および装置
US7383076B2 (en) * 2000-11-27 2008-06-03 The General Hospital Corporation Fluorescence-mediated molecular tomography
US6615063B1 (en) 2000-11-27 2003-09-02 The General Hospital Corporation Fluorescence-mediated molecular tomography
JP4259879B2 (ja) 2001-05-17 2009-04-30 ゼノジェン コーポレイション 身体領域内の標的の深さ、輝度およびサイズを決定するための方法および装置
US6919919B2 (en) * 2002-02-06 2005-07-19 Xenogen Corporation Light calibration device for use in low level light imaging systems
US8078268B2 (en) 2001-06-28 2011-12-13 Chemimage Corporation System and method of chemical imaging using pulsed laser excitation and time-gated detection to determine tissue margins during surgery
US7113217B2 (en) * 2001-07-13 2006-09-26 Xenogen Corporation Multi-view imaging apparatus
US6694159B2 (en) 2001-07-16 2004-02-17 Art, Advanced Research Technologies Inc. Choice of wavelengths for multiwavelength optical imaging
US6678049B1 (en) 2001-07-16 2004-01-13 Art, Advanced Research Technologies Inc. Optical detection system and method
US7428434B2 (en) 2001-07-27 2008-09-23 The Regents Of The Univeristy Of California Quantitative broadband absorption and scattering spectroscopy in turbid media by combined frequency-domain and steady state methodologies
US6775349B2 (en) 2001-10-23 2004-08-10 Washington Univ. In St. Louis System and method for scanning near-field optical tomography
US6899675B2 (en) 2002-01-15 2005-05-31 Xillix Technologies Corp. Fluorescence endoscopy video systems with no moving parts in the camera
US7474399B2 (en) 2002-02-22 2009-01-06 Xenogen Corporation Dual illumination system for an imaging apparatus and method
AU2003218116A1 (en) 2002-03-12 2003-09-29 Beth Israel Deaconess Medical Center Medical imaging systems
US6958815B2 (en) 2002-03-19 2005-10-25 The Regents Of The University Of California Method and apparatus for performing quantitative analysis and imaging surfaces and subsurfaces of turbid media using spatially structured illumination
US6924893B2 (en) * 2002-05-13 2005-08-02 Marine Biological Laboratory Enhancing polarized light microscopy
EP2410315B1 (de) 2002-06-04 2020-04-01 Visen Medical, Inc. Bildgebungsdatenträger mit willkürlichen Geometrien bei Kontakt- und kontaktloser Tomographie
US6628747B1 (en) 2002-06-21 2003-09-30 Washington University In St. Louis System and method for dual-beam internal reflection tomography
US7016717B2 (en) 2002-07-05 2006-03-21 The Regents Of The University Of California Near-infrared spectroscopic tissue imaging for medical applications
US6618463B1 (en) 2002-07-09 2003-09-09 Washington University System and method for single-beam internal reflection tomography
US7616985B2 (en) 2002-07-16 2009-11-10 Xenogen Corporation Method and apparatus for 3-D imaging of internal light sources
US7599731B2 (en) 2002-07-16 2009-10-06 Xenogen Corporation Fluorescent light tomography
US20040027659A1 (en) * 2002-08-08 2004-02-12 Messerschmidt Robert G. Sample holder
US20040085536A1 (en) 2002-11-01 2004-05-06 Schotland John Carl Tomography system and method using nonlinear reconstruction of scattered radiation
US6992762B2 (en) 2002-11-11 2006-01-31 Art Advanced Research Technologies Inc. Method and apparatus for time resolved optical imaging of biological tissues as part of animals
AU2003203069A1 (en) 2003-01-22 2004-08-13 Art, Advanced Research Technologies, Inc. Simultaneous acquisition of different time-gates in tpsf-based optical imaging
US7647091B2 (en) 2003-02-05 2010-01-12 The General Hospital Corporation Method and system for free space optical tomography of diffuse media
US7720525B2 (en) 2003-03-12 2010-05-18 New Art Advanced Research Technologies Inc. Method and apparatus for combining continuous wave and time domain optical imaging
EP1654531A1 (de) 2003-06-20 2006-05-10 The Texas A & M University System Verfahren und system zum fluoreszenz-kontrastverstärkten abbilden im nahinfrarotbereich mit flächiger beleuchtung und flächiger detektion
US7034303B2 (en) 2003-06-27 2006-04-25 Washington University System and method of image reconstruction for optical tomography with limited data
WO2005034747A1 (en) 2003-09-15 2005-04-21 Beth Israel Deaconess Medical Center Medical imaging systems
US7920908B2 (en) 2003-10-16 2011-04-05 David Hattery Multispectral imaging for quantitative contrast of functional and structural features of layers inside optically dense media such as tissue
CA2544283A1 (en) 2003-10-31 2005-05-12 Art Recherches Et Technologies Avancees Inc./Art Advanced Research Techn A time-domain method and apparatus for determining the depth and concentration of a fluorophore in a turbid medium
JP2007528500A (ja) 2004-03-11 2007-10-11 ザ・ゼネラル・ホスピタル・コーポレーション 蛍光タンパク質を使用する断層撮影イメージングのための方法およびシステム
US20080234225A1 (en) 2004-03-15 2008-09-25 John Lezdey Method of treatment
DE102004030550A1 (de) 2004-06-24 2006-01-19 Siemens Ag Bildgebendes Tomographiegerät mit zumindest zwei unter Systemwinkel angeordneten Aufnahmesystemen und Verfahren für ein derartiges Tomographiegerät zur Bestimmung der Systemwinkel der Aufnahmesysteme
US7239383B2 (en) 2004-06-30 2007-07-03 Chemimage Corporation Method and apparatus for spectral modulation compensation
US7394053B2 (en) 2004-09-09 2008-07-01 Beth Israel Deaconess Medical Center, Inc. Systems and methods for multi-modal imaging having a spatial relationship in three dimensions between first and second image data
KR101269455B1 (ko) 2004-09-10 2013-05-30 더 제너럴 하스피탈 코포레이션 광 간섭 영상화를 위한 시스템 및 방법
WO2006089342A1 (en) 2004-10-18 2006-08-31 Macquarie University Fluorescence detection
EP1827238A4 (de) * 2004-12-06 2009-04-22 Cambridge Res & Instrmnt Inc Systeme und verfahren zur optischen bilddarstellung und messung in vivo
EP1824379B1 (de) 2004-12-08 2017-04-12 The General Hospital Corporation System und verfahren zur normalisierten fluoreszenz- oder biolumineszenzabbildung
US7859671B2 (en) 2004-12-30 2010-12-28 Art, Advanced Research Technologies Inc. Method for determining optical properties of turbid media
US7729750B2 (en) 2005-01-20 2010-06-01 The Regents Of The University Of California Method and apparatus for high resolution spatially modulated fluorescence imaging and tomography
CN101151623B (zh) * 2005-01-27 2010-06-23 剑桥研究和仪器设备股份有限公司 对样本图像的特征进行分类的方法和设备
US8044996B2 (en) 2005-05-11 2011-10-25 Xenogen Corporation Surface construction using combined photographic and structured light information
US10231624B2 (en) 2005-08-10 2019-03-19 Nov Adaq Technologies Ulc Intra-operative head and neck nerve mapping
US20070122344A1 (en) 2005-09-02 2007-05-31 University Of Rochester Medical Center Office Of Technology Transfer Intraoperative determination of nerve location
US8504140B2 (en) 2008-04-08 2013-08-06 Bruker Biospin Corporation Apparatus and method for fluorescence imaging and tomography using spatially structured illumination
US8173973B2 (en) 2005-10-06 2012-05-08 Nanyang Technological University Eliminating fluorescence background noise
US7420151B2 (en) 2005-10-17 2008-09-02 Novadaq Technologies Inc. Device for short wavelength visible reflectance endoscopy using broadband illumination
US8320650B2 (en) 2005-11-30 2012-11-27 Lawrence Livermore National Security, Llc In vivo spectral micro-imaging of tissue
WO2007109678A2 (en) 2006-03-20 2007-09-27 Baylor College Of Medicine Method and system for non-contact fluorescence optical tomography with patterned illumination
EP2034890A4 (de) 2006-06-01 2011-02-16 Gen Hospital Corp Optische in-vivo-bildgebungsmethode mit analyse von dynamischen bildern
US20080154102A1 (en) 2006-07-03 2008-06-26 Frangioni John V Intraoperative imaging methods
US8078265B2 (en) 2006-07-11 2011-12-13 The General Hospital Corporation Systems and methods for generating fluorescent light images
FR2904691B1 (fr) 2006-08-02 2009-03-06 Commissariat Energie Atomique Procede et dispositif de reconstruction 3d de la distribution d'elements fluorescents.
US20080161744A1 (en) 2006-09-07 2008-07-03 University Of Rochester Medical Center Pre-And Intra-Operative Localization of Penile Sentinel Nodes
US8554087B2 (en) 2006-09-18 2013-10-08 The Trustees Of Dartmouth College System and method for imaging objects through turbid media
US9080977B2 (en) 2006-10-23 2015-07-14 Xenogen Corporation Apparatus and methods for fluorescence guided surgery
US8498695B2 (en) 2006-12-22 2013-07-30 Novadaq Technologies Inc. Imaging system with a single color image sensor for simultaneous fluorescence and color video endoscopy
EP2120684B1 (de) 2006-12-22 2015-09-09 Washington University Hochleistungsabbildungssystem für eine diffuse optische tomographie und dazugehöriges verwendungsverfahren
JP4954699B2 (ja) 2006-12-28 2012-06-20 オリンパス株式会社 蛍光内視鏡システム
US20080177140A1 (en) 2007-01-23 2008-07-24 Xillix Technologies Corp. Cameras for fluorescence and reflectance imaging
WO2008094794A1 (en) 2007-01-30 2008-08-07 Ge Healthcare Bio-Sciences Corp. Time resolved fluorescent imaging system
US8314406B2 (en) 2007-04-06 2012-11-20 The General Hospital Corporation Systems and methods for optical imaging using early arriving photons
US8134554B1 (en) 2007-05-04 2012-03-13 Topcon Medical Systems, Inc. Method and apparatus for spatially mapping three-dimensional optical coherence tomography data with two-dimensional images
US7692160B2 (en) 2007-05-31 2010-04-06 General Electric Company Method and system of optical imaging for target detection in a scattering medium
US8634082B2 (en) 2007-06-20 2014-01-21 The Trustess of Dartmouth College Pulsed lasers in frequency domain diffuse optical tomography and spectroscopy
US9173554B2 (en) 2008-03-18 2015-11-03 Novadaq Technologies, Inc. Imaging system for combined full-color reflectance and near-infrared imaging
US20090236541A1 (en) 2008-03-24 2009-09-24 General Electric Company System and Methods for Optical Imaging
US20100210931A1 (en) 2008-04-04 2010-08-19 Modulate Imaging Inc. Method for performing qualitative and quantitative analysis of wounds using spatially structured illumination
US10219742B2 (en) 2008-04-14 2019-03-05 Novadaq Technologies ULC Locating and analyzing perforator flaps for plastic and reconstructive surgery
DE102008045634A1 (de) 2008-09-03 2010-03-04 Ludwig-Maximilians-Universität München Wellenlängenabstimmbare Lichtquelle
US7675045B1 (en) 2008-10-09 2010-03-09 Los Alamos National Security, Llc 3-dimensional imaging at nanometer resolutions
WO2010090673A1 (en) 2009-01-20 2010-08-12 The Trustees Of Dartmouth College Method and apparatus for depth-resolved fluorescence, chromophore, and oximetry imaging for lesion identification during surgery
US8254650B2 (en) 2009-02-27 2012-08-28 General Electric Company System and method for contrast enhancement of time-resolved fluorescence images
US20120049088A1 (en) 2009-03-06 2012-03-01 The Trustees Of Columbia University In The City Of New York Systems, methods and computer-accessible media for hyperspectral excitation-resolved fluorescence tomography
US20100241058A1 (en) 2009-03-19 2010-09-23 Ahmed Syed Yosuf Oct guided tissue ablation
JP5449816B2 (ja) 2009-03-26 2014-03-19 オリンパス株式会社 画像処理装置、画像処理プログラムおよび画像処理装置の作動方法
CA2781393C (en) 2009-11-19 2017-08-08 Modulated Imaging, Inc. Method and apparatus for analysis of turbid media via single-element detection using structured illumination
JP5356191B2 (ja) 2009-11-26 2013-12-04 オリンパス株式会社 蛍光観察装置
CN104757936B (zh) 2009-12-15 2018-02-23 爱默蕾大学 用于在诊断或治疗程序中提供实时解剖学指导的系统和方法
JP5506443B2 (ja) 2010-02-10 2014-05-28 オリンパス株式会社 蛍光観察装置
EP2359745A1 (de) 2010-02-12 2011-08-24 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Verfahren und Vorrichtung zur multispektralen photonischen Bildgebung
JP5484997B2 (ja) 2010-04-12 2014-05-07 オリンパス株式会社 蛍光観察装置および蛍光観察装置の作動方法
US20110261179A1 (en) 2010-04-22 2011-10-27 General Electric Company Imaging system for fluorescence guided surgery based on fixed magnification lens and digital zoom
US20110261175A1 (en) 2010-04-22 2011-10-27 General Electric Company Multiple channel imaging system and method for fluorescence guided surgery
US8436321B2 (en) 2010-05-21 2013-05-07 Li-Cor, Inc. Optical background suppression systems and methods for fluorescence imaging
JP5498282B2 (ja) 2010-07-06 2014-05-21 オリンパス株式会社 蛍光観察装置
US20130087719A1 (en) 2010-08-13 2013-04-11 Lumos Technology Co., Ltd. Light source device for time-delayed detection of fluorescence, and image pick-up system and method
US9066657B2 (en) 2010-11-23 2015-06-30 General Electric Company Methods and systems of optical imaging for target detection in a scattering medium
US8692998B2 (en) 2011-04-11 2014-04-08 The Regents Of The University Of California Apparatus and method for light emission detection for in-depth imaging of turbid media

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DE60213993T2 (de) 2007-03-15
KR20040012844A (ko) 2004-02-11
US7403812B2 (en) 2008-07-22
US7764986B2 (en) 2010-07-27
US20120150026A1 (en) 2012-06-14
US20030002028A1 (en) 2003-01-02
US8825140B2 (en) 2014-09-02
WO2002093143A3 (en) 2004-01-08
US8180435B2 (en) 2012-05-15
EP1402243A2 (de) 2004-03-31
EP1402243B1 (de) 2006-08-16
CA2447262A1 (en) 2002-11-21
WO2002093143A2 (en) 2002-11-21
DE60213993D1 (de) 2006-09-28
US20100262019A1 (en) 2010-10-14
US20070270697A1 (en) 2007-11-22
JP2004528916A (ja) 2004-09-24

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