ATE338273T1 - Vorrichtung zur halterung und präsentation von mindestens einer mikrokugelmatrix zu lösungen und/oder zu optischen abbildungssystemen - Google Patents

Vorrichtung zur halterung und präsentation von mindestens einer mikrokugelmatrix zu lösungen und/oder zu optischen abbildungssystemen

Info

Publication number
ATE338273T1
ATE338273T1 AT00937613T AT00937613T ATE338273T1 AT E338273 T1 ATE338273 T1 AT E338273T1 AT 00937613 T AT00937613 T AT 00937613T AT 00937613 T AT00937613 T AT 00937613T AT E338273 T1 ATE338273 T1 AT E338273T1
Authority
AT
Austria
Prior art keywords
holder
bundles
bundle
openings
presenting
Prior art date
Application number
AT00937613T
Other languages
English (en)
Inventor
John R Stuelpnagel
Mark S Chee
Richard J Pytelewski
Todd Alan Dickinson
Gan G Wang
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Inc filed Critical Illumina Inc
Application granted granted Critical
Publication of ATE338273T1 publication Critical patent/ATE338273T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00646—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
    • B01J2219/00648—Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of solid beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Display Devices Of Pinball Game Machines (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
AT00937613T 1999-05-20 2000-05-19 Vorrichtung zur halterung und präsentation von mindestens einer mikrokugelmatrix zu lösungen und/oder zu optischen abbildungssystemen ATE338273T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13508999P 1999-05-20 1999-05-20

Publications (1)

Publication Number Publication Date
ATE338273T1 true ATE338273T1 (de) 2006-09-15

Family

ID=22466488

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00937613T ATE338273T1 (de) 1999-05-20 2000-05-19 Vorrichtung zur halterung und präsentation von mindestens einer mikrokugelmatrix zu lösungen und/oder zu optischen abbildungssystemen

Country Status (7)

Country Link
US (1) US6396995B1 (de)
EP (1) EP1190233B1 (de)
AT (1) ATE338273T1 (de)
AU (1) AU779835B2 (de)
CA (1) CA2374596A1 (de)
DE (1) DE60030436T2 (de)
WO (1) WO2000071992A1 (de)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
DE69527585T2 (de) * 1994-06-08 2003-04-03 Affymetrix, Inc. Verfahren und Vorrichtung zum Verpacken von Chips
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US6720149B1 (en) * 1995-06-07 2004-04-13 Affymetrix, Inc. Methods for concurrently processing multiple biological chip assays
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
JP4294740B2 (ja) 1997-05-23 2009-07-15 ソレクサ・インコーポレイテッド 分析物の系列的プロセシングのためのシステムおよび装置
US7060431B2 (en) 1998-06-24 2006-06-13 Illumina, Inc. Method of making and decoding of array sensors with microspheres
US7510841B2 (en) * 1998-12-28 2009-03-31 Illumina, Inc. Methods of making and using composite arrays for the detection of a plurality of target analytes
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
AU7569600A (en) 1999-05-20 2000-12-28 Illumina, Inc. Combinatorial decoding of random nucleic acid arrays
US8080380B2 (en) 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
ATE542916T1 (de) 1999-08-18 2012-02-15 Illumina Inc Methoden zur erzeugung von oligonukleotidlösungen
US7211390B2 (en) * 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7244559B2 (en) * 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
GB9929668D0 (en) * 1999-12-15 2000-02-09 Moore David F Microclamps
US7611869B2 (en) 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7361488B2 (en) 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
WO2001057268A2 (en) 2000-02-07 2001-08-09 Illumina, Inc. Nucleic acid detection methods using universal priming
US6913884B2 (en) 2001-08-16 2005-07-05 Illumina, Inc. Compositions and methods for repetitive use of genomic DNA
JP2003521252A (ja) 2000-02-07 2003-07-15 イルミナ インコーポレイテッド ユニバーサルプライミングを用いる核酸検出方法
CA2399908A1 (en) * 2000-02-10 2001-08-16 Todd Dickinson Array of individual arrays as substrate for bead-based simultaneous processing of samples and manufacturing method therefor
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
EP1967595A3 (de) 2000-02-16 2008-12-03 Illumina, Inc. Paralleles Genotypisieren von mehreren Patientenproben
WO2001083825A2 (en) * 2000-05-04 2001-11-08 The Center For Blood Research, Inc. Colloid compositions for solid phase biomolecular analytical systems
US6595698B2 (en) * 2000-06-13 2003-07-22 Siwave, Inc. High density fiber terminator/connector
DE10057127A1 (de) * 2000-11-16 2002-06-06 Schott Glas Verfahren zum Verbringen einer Vielzahl von Faserenden in eine vorgegebene Position
US6633707B1 (en) * 2000-12-29 2003-10-14 Intel Corporation Lithographically defined optic array
GB2390155B (en) * 2001-01-03 2004-04-21 Packard Instrument Co Inc Luminescence imager
US7572642B2 (en) 2001-04-18 2009-08-11 Ambrigen, Llc Assay based on particles, which specifically bind with targets in spatially distributed characteristic patterns
US6827500B2 (en) * 2001-06-29 2004-12-07 Lucent Technologies Inc. Precision two dimensional optical fiber array
US20030015139A1 (en) * 2001-07-17 2003-01-23 3M Innovative Properties Company Protective packaging
EP1425090A2 (de) * 2001-09-07 2004-06-09 Corning Incorporated Mikrosäulenbasierte anordnung zur hochdurchsatz analyse
JP2005504996A (ja) * 2001-09-26 2005-02-17 ローム・アンド・ハース・エレクトロニック・マテリアルズ，エル．エル．シー． 可変のファイバー角度配列を有する光ファイバーアレイおよびその製造方法
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US6956114B2 (en) 2001-10-30 2005-10-18 '454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US8765484B2 (en) * 2002-02-07 2014-07-01 The Regents Of The University Of California Optically encoded particles
AU2003215240A1 (en) 2002-02-14 2003-09-04 Illumina, Inc. Automated information processing in randomly ordered arrays
CA2496741A1 (en) * 2002-08-28 2004-04-29 Bionexus Ventures L.L.C. Screening compound libraries using an optical fiber array device capable of simultaneously performing multiple functional assays
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
US7575865B2 (en) 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
DE602004026033D1 (de) 2003-01-29 2010-04-29 454 Corp Zweiendige sequenzierung
US8652774B2 (en) * 2003-04-16 2014-02-18 Affymetrix, Inc. Automated method of manufacturing polyer arrays
US6816654B1 (en) * 2003-06-27 2004-11-09 Dimitry Grabbe Fiber array ferrule and method of making
US8308066B2 (en) * 2003-12-22 2012-11-13 The Regents Of The University Of California Method for forming optically encoded thin films and particles with grey scale spectra
AU2004308380A1 (en) * 2003-12-22 2005-07-14 The Regents Of The University Of California Optically encoded particles, system and high-throughput screening
US7547424B2 (en) * 2004-09-21 2009-06-16 Van Andel Research Institute Method and apparatus for making partitioned slides
CN100562750C (zh) * 2005-02-05 2009-11-25 北京源德生物医学工程有限公司 一种搭载试剂盒的传送机构
US20070108465A1 (en) * 2005-03-10 2007-05-17 The Regents Of The University Of California Porous microstructure multi layer spectroscopy and biosensing
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
DK1907571T3 (en) 2005-06-15 2017-08-21 Complete Genomics Inc NUCLEIC ACID ANALYSIS USING INCIDENTAL MIXTURES OF NON-OVERLAPPING FRAGMENTS
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US8492098B2 (en) * 2006-02-21 2013-07-23 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of reaction components that affect a reaction
US9423397B2 (en) 2006-03-10 2016-08-23 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
US8288157B2 (en) * 2007-09-12 2012-10-16 Plc Diagnostics, Inc. Waveguide-based optical scanning systems
US7951583B2 (en) * 2006-03-10 2011-05-31 Plc Diagnostics, Inc. Optical scanning system
US8675199B2 (en) * 2006-03-10 2014-03-18 Plc Diagnostics, Inc. Waveguide-based detection system with scanning light source
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
US20080003667A1 (en) * 2006-05-19 2008-01-03 Affymetrix, Inc. Consumable elements for use with fluid processing and detection systems
AU2007260676A1 (en) 2006-06-14 2007-12-21 Artemis Health, Inc. Rare cell analysis using sample splitting and DNA tags
WO2007147076A2 (en) 2006-06-14 2007-12-21 Living Microsystems, Inc. Methods for the diagnosis of fetal abnormalities
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
US9586346B2 (en) * 2006-06-28 2017-03-07 Swinburne University Of Technology Bead immobilisation method and bead arrays made thereby
EP2527501A1 (de) 2006-11-15 2012-11-28 The University Of British Columbia Für Anthrazyklin-induzierte Kardiotoxizität prädiktive Polymorphismen
EP2171097A2 (de) 2007-06-29 2010-04-07 Population Genetics Technologies LTD. Verfahren und zusammensetzungen zur isolierung der varianten von nukleinsäuresequenzen
EP2201374B1 (de) 2007-08-30 2015-10-07 Trustees Of Tufts College Verfahren zur bestimmung der konzentration eines analyten in lösung
CN105349647B (zh) * 2007-10-30 2020-08-28 完整基因有限公司 用于核酸高通量测序的方法
US9551026B2 (en) 2007-12-03 2017-01-24 Complete Genomincs, Inc. Method for nucleic acid detection using voltage enhancement
EP2229600A1 (de) * 2007-12-06 2010-09-22 Koninklijke Philips Electronics N.V. Optische frontplatte und verfahren zu ihrer herstellung
US20090181390A1 (en) * 2008-01-11 2009-07-16 Signosis, Inc. A California Corporation High throughput detection of micrornas and use for disease diagnosis
US8778667B2 (en) * 2008-05-29 2014-07-15 Toyo Kohan Co., Ltd. Method and unit for detection of interactions of biologically relevant molecules
GB2461026B (en) * 2008-06-16 2011-03-09 Plc Diagnostics Inc System and method for nucleic acids sequencing by phased synthesis
US8568659B2 (en) * 2008-09-11 2013-10-29 Mabgen, Llc Fiber optic device
US8222047B2 (en) * 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
DK2496720T3 (da) 2009-11-06 2020-09-28 Univ Leland Stanford Junior Ikke-invasiv diagnose af transplantatafstødning i organ-transplanterede patienter
EP2539717B1 (de) 2010-02-22 2019-07-24 PerkinElmer Health Sciences, Inc. Mikroplattenhalterungssystem und messverfahren
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US9678068B2 (en) * 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
WO2011109379A1 (en) 2010-03-01 2011-09-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US8774494B2 (en) 2010-04-30 2014-07-08 Complete Genomics, Inc. Method and system for accurate alignment and registration of array for DNA sequencing
US9671344B2 (en) 2010-08-31 2017-06-06 Complete Genomics, Inc. High-density biochemical array chips with asynchronous tracks for alignment correction by moiré averaging
US9880089B2 (en) 2010-08-31 2018-01-30 Complete Genomics, Inc. High-density devices with synchronous tracks for quad-cell based alignment correction
WO2012051476A1 (en) 2010-10-15 2012-04-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Mid-infrared imaging of microarrays
EP3151015A1 (de) 2010-11-15 2017-04-05 F. Hoffmann-La Roche AG Instrument und verfahren zur automatisierten wärmebehandlung von flüssigkeitsproben
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
EP2525211B1 (de) 2011-05-16 2018-01-03 F. Hoffmann-La Roche AG Instrument und verfahren zum detektieren von analyten
US9435812B2 (en) 2011-08-31 2016-09-06 Ventana Medical Systems, Inc. Expression of ETS related gene (ERG) and phosphatase and tensin homolog (PTEN) correlates with prostate cancer capsular penetration
CA3069089A1 (en) 2011-09-22 2013-03-28 Lineage Biosciences, Inc. Compositions and methods for analyzing heterogeneous samples
US10837879B2 (en) 2011-11-02 2020-11-17 Complete Genomics, Inc. Treatment for stabilizing nucleic acid arrays
US9803239B2 (en) 2012-03-29 2017-10-31 Complete Genomics, Inc. Flow cells for high density array chips
US9488823B2 (en) 2012-06-07 2016-11-08 Complete Genomics, Inc. Techniques for scanned illumination
US9628676B2 (en) 2012-06-07 2017-04-18 Complete Genomics, Inc. Imaging systems with movable scan mirrors
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
EP2970959B1 (de) 2013-03-15 2018-05-30 Lineage Biosciences, Inc. Verfahren und zusammensetzungen zum markieren und analysieren von proben
DE102013210204A1 (de) * 2013-05-31 2014-12-18 Gilupi Gmbh Detektionsvorrichtung zur in vivo und/oder in vitro Anreicherung von Probenmaterial
JP2017506080A (ja) 2014-02-21 2017-03-02 プレジデント アンド フェローズ オブ ハーバード カレッジ アロステリックタンパク質の新規設計
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
US10119964B2 (en) * 2014-12-22 2018-11-06 Digital Biotech, LLC Multiplex assay strip, beads, device and method
US11181479B2 (en) 2015-02-27 2021-11-23 Ldip, Llc Waveguide-based detection system with scanning light source
FI4112741T3 (fi) 2017-01-04 2025-05-15 Mgi Tech Co Ltd Vaiheittainen sekvensointi ei-leimatuilla, reversiibeleillä terminaattoreilla tai luonnollisilla nukleotideilla
GB201700936D0 (en) * 2017-01-19 2017-03-08 Univ Bath Optical fibre apparatus and method
US10379297B2 (en) * 2017-04-21 2019-08-13 Intuitive Surgical Operations, Inc. Sealing a fiber bundle end with glass fritting
WO2019190954A1 (en) 2018-03-26 2019-10-03 Rootpath Genomics, Inc. Target binding moiety compositions and methods of use
WO2021185320A1 (en) 2020-03-18 2021-09-23 Mgi Tech Co., Ltd. Restoring phase in massively parallel sequencing
US20250235872A1 (en) * 2022-04-29 2025-07-24 Singular Genomics Systems, Inc. Microplate carrier

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853658A (en) * 1971-07-12 1974-12-10 R Ney Fiber optical image magnifier panel and method of manufacture
US4046454A (en) * 1976-05-18 1977-09-06 Bell Telephone Laboratories, Incorporated Optical fiber connector
DE2740376C3 (de) * 1977-09-08 1980-06-04 Fa. A. Raymond, 7850 Loerrach Elastische Klemmhalterung für Rundstäbe mit variablen Durchmessern
US5206568A (en) * 1986-03-26 1993-04-27 Beckman Instruments, Inc. Coordinated control of stepper motors
US4744627A (en) * 1986-11-03 1988-05-17 General Electric Company Optical fiber holder
US4973128A (en) * 1989-05-01 1990-11-27 Hodges Marvin P High gain optical fiber viewing device
JP3105624B2 (ja) * 1992-03-30 2000-11-06 日本碍子株式会社 多心コネクタおよびその製造法
US5589351A (en) * 1994-12-06 1996-12-31 Nps Pharmaceuticals, Inc. Fluorescence detection apparatus
GB2315131B (en) * 1996-07-10 2000-11-29 Cambridge Imaging Ltd Improvements in and relating to imaging
GB2315130B (en) * 1996-07-10 2001-05-09 Cambridge Imaging Ltd Improved imaging system for fluorescence assays
US6043880A (en) * 1997-09-15 2000-03-28 Becton Dickinson And Company Automated optical reader for nucleic acid assays
JP3813730B2 (ja) * 1998-03-19 2006-08-23 浜松ホトニクス株式会社 蛍光測定装置

Also Published As

Publication number Publication date
EP1190233B1 (de) 2006-08-30
AU5275900A (en) 2000-12-12
DE60030436T2 (de) 2007-03-29
WO2000071992A1 (en) 2000-11-30
US6396995B1 (en) 2002-05-28
CA2374596A1 (en) 2000-11-30
DE60030436D1 (de) 2006-10-12
AU779835B2 (en) 2005-02-10
EP1190233A1 (de) 2002-03-27

Similar Documents

Publication Publication Date Title
DE60030436D1 (de) Vorrichtung zur halterung und präsentation von mindestens einer mikrokugelmatrix zu lösungen und/oder zu optischen abbildungssystemen
DE2522740C3 (de) Vorrichtung zum Verbinden eines ankommenden Lichtleitfaserkabels mit einem weiterführenden und Verfahren zur Herstellung der Vorrichtung
DE69825142D1 (de) Vorrichtung zur gleichzeitigen Überwachung von Reaktionen, die in einer Vielzahl von Reaktionsgefässen stattfinden
DE3873860D1 (de) Verfahren und vorrichtung zur beschichtung einer optischen faser.
EP0897547A4 (de) Optische vorrichtung,die eine virtuell abgebildete phasenmatrix zur herstellung von chromatischer dispersion verwendet
CN100381848C (zh) 用于将光缆中的光纤插入套圈的方法和系统
EP2315002A3 (de) Filtermodul für ein optisches Gerät insbesondere zur Überwachung von DNS-Polymerasekettenreaktionen
EP1199589A3 (de) Glasfaseraufbewahrungsbehälter
FR2594330B1 (fr) Composition tinctoriale pour fibres keratiniques et en particulier pour cheveux humains, a base de nitro-anilines halogenees, procede de teinture utilisant ladite composition tinctoriale et nouvelles 2-nitroanilines halogenees utilisees
DE69426178D1 (de) Herstellung einer optischen Kopplungsstruktur, die einen abgespaltenen optischen Wellenleiter und eine Halterung für optische Fasern integriert
DE69008915D1 (de) Verfahren und Vorrichtung zur Fabrikation von Mikrolinsen an optischen Fasern.
ATE124790T1 (de) Rückwand für optische fasern.
SE9401421D0 (sv) Fiberorganiserare
ES2002369A6 (es) Metodo de fabricar terminaciones de fibras opticas y terminacion y disposicion optica correspondientes
DE69023798D1 (de) Halterung für eine Vorrichtung zur Bearbeitung des Endes einer optischen Faser.
EP1168027A1 (de) Vorrichtung zum Objektivwechsel und Mikroskop mit Vorrichtung zum Objektivwechsel
EP1406100A3 (de) Symmetrische biaspherische Linse zur Verwendung in faseroptischen Kollimatoren
DE59402366D1 (de) Vorrichtung zum Beschichten einer optischen Faser
DE102010051816A1 (de) Patronenaufnahme und Verfahren zur Herstellung der Patronenaufnahme
KR20170142729A (ko) 세포 배양 장치
Douglas A new method of cross-sectioning hair of larger mammals
EP1113304A3 (de) Vorrichtung zum optischen Abtasten mehrerer Objekte
DE69619986D1 (de) Gerät zum einbau einer lichtquelle innerhalb eines systems zur kopplung von licht in eine optische faser oder ein faserbündel
DE3763502D1 (de) Verfahren und vorrichtung zur herstellung einer optischen faservorform zur benutzung im mittelinfrarotbereich.
DE3878007D1 (de) Methode zur identifizierung einer beschichteten faser in einem optischen uebertragungsnetzwerk.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties