ATE338770T1 - Mit bh4 fusionierte polypeptide - Google Patents
Mit bh4 fusionierte polypeptideInfo
- Publication number
- ATE338770T1 ATE338770T1 AT00985913T AT00985913T ATE338770T1 AT E338770 T1 ATE338770 T1 AT E338770T1 AT 00985913 T AT00985913 T AT 00985913T AT 00985913 T AT00985913 T AT 00985913T AT E338770 T1 ATE338770 T1 AT E338770T1
- Authority
- AT
- Austria
- Prior art keywords
- amino acid
- acid sequence
- apoptosis
- ischemic disease
- sequence
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 6
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 6
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 7
- 208000023589 ischemic disease Diseases 0.000 abstract 5
- 230000006907 apoptotic process Effects 0.000 abstract 3
- 230000004927 fusion Effects 0.000 abstract 3
- 229940088872 Apoptosis inhibitor Drugs 0.000 abstract 2
- 239000000158 apoptosis inhibitor Substances 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940124597 therapeutic agent Drugs 0.000 abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 1
- 208000001940 Massive Hepatic Necrosis Diseases 0.000 abstract 1
- 208000034486 Multi-organ failure Diseases 0.000 abstract 1
- 208000010718 Multiple Organ Failure Diseases 0.000 abstract 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 abstract 1
- 108010090931 Proto-Oncogene Proteins c-bcl-2 Proteins 0.000 abstract 1
- 102000013535 Proto-Oncogene Proteins c-bcl-2 Human genes 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 230000002424 anti-apoptotic effect Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002458 infectious effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP37144999 | 1999-12-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE338770T1 true ATE338770T1 (de) | 2006-09-15 |
Family
ID=18498735
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00985913T ATE338770T1 (de) | 1999-12-27 | 2000-12-26 | Mit bh4 fusionierte polypeptide |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20030152946A1 (de) |
| EP (1) | EP1243595B1 (de) |
| JP (1) | JP3906078B2 (de) |
| AT (1) | ATE338770T1 (de) |
| DE (1) | DE60030587T2 (de) |
| WO (1) | WO2001048014A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030077826A1 (en) * | 2001-02-02 | 2003-04-24 | Lena Edelman | Chimeric molecules containing a module able to target specific cells and a module regulating the apoptogenic function of the permeability transition pore complex (PTPC) |
| EP3211084B1 (de) * | 2003-05-16 | 2019-03-27 | Acorda Therapeutics, Inc. | Proteoglycan-abbauende mutanten zur behandlung des zns |
| FR2860237B1 (fr) | 2003-09-30 | 2006-03-10 | Centre Nat Rech Scient | Polypeptide d'interaction comprenant un motif heptapeptidique et un domaine de penetration cellulaire |
| US20070154962A1 (en) * | 2005-12-23 | 2007-07-05 | Giulio Taglialatela | Bcl-2 promoted cell death |
| CN102272142A (zh) * | 2008-12-23 | 2011-12-07 | 帷幄生物技术公司 | 非遗传修饰性重编程细胞的组合物和方法 |
| WO2016018454A2 (en) * | 2014-06-18 | 2016-02-04 | Cisthera, Inc. | Compositions and methods employing bcl2 and bcl2 family members |
| WO2017189826A1 (en) * | 2016-04-29 | 2017-11-02 | Portage Pharmaceuticals Ltd. | Use of cell-permeable peptides and non-peptide carriers conjugated with nemo binding domain cargo sequence for the treatment of dry eye disease and uveitis |
| JP7204734B2 (ja) | 2017-08-01 | 2023-01-16 | オーアンドエム ハリヤード インターナショナル アンリミテッド カンパニー | 滅菌野を提供するためのポケットアンドドレープシステム |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5646008A (en) * | 1993-06-22 | 1997-07-08 | The Regent Of The University Of Michigan | Vertebrate apoptosis gene: compositions and methods |
-
2000
- 2000-12-26 AT AT00985913T patent/ATE338770T1/de not_active IP Right Cessation
- 2000-12-26 JP JP2001548554A patent/JP3906078B2/ja not_active Expired - Fee Related
- 2000-12-26 EP EP00985913A patent/EP1243595B1/de not_active Expired - Lifetime
- 2000-12-26 WO PCT/JP2000/009274 patent/WO2001048014A1/ja not_active Ceased
- 2000-12-26 DE DE60030587T patent/DE60030587T2/de not_active Expired - Fee Related
- 2000-12-26 US US10/169,223 patent/US20030152946A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1243595A1 (de) | 2002-09-25 |
| EP1243595B1 (de) | 2006-09-06 |
| JP3906078B2 (ja) | 2007-04-18 |
| DE60030587T2 (de) | 2007-05-31 |
| EP1243595A4 (de) | 2004-08-04 |
| WO2001048014A1 (fr) | 2001-07-05 |
| US20030152946A1 (en) | 2003-08-14 |
| DE60030587D1 (de) | 2006-10-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |