ATE339496T1 - Modulation von gamma-secretase aktivität - Google Patents

Modulation von gamma-secretase aktivität

Info

Publication number: ATE339496T1
Authority: AT; Austria
Prior art keywords: app; gamma; secretase; assay; modulation
Prior art date: 2000-05-11

Application number

AT01935260T

Other languages

English (en)

Inventor

Barbara Cordell

Jeffrey N Higaki

Mitchell Mutz

Original Assignee

Scios Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-11

Filing date

2001-05-09

Publication date

2006-10-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22754280&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE339496(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-05-09 Application filed by Scios Inc filed Critical Scios Inc

2006-10-15 Application granted granted Critical

2006-10-15 Publication of ATE339496T1 publication Critical patent/ATE339496T1/de

Links

102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 title abstract 5
108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 title abstract 5
230000000694 effects Effects 0.000 title abstract 2
210000004027 cell Anatomy 0.000 abstract 3
238000003556 assay Methods 0.000 abstract 2
230000035772 mutation Effects 0.000 abstract 2
DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 abstract 1
210000000170 cell membrane Anatomy 0.000 abstract 1
230000037430 deletion Effects 0.000 abstract 1
238000012217 deletion Methods 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
239000012528 membrane Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Neurology (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Neurosurgery (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Hospice & Palliative Care (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Psychiatry (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Holo Graphy (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Investigating Or Analysing Biological Materials (AREA)

AT01935260T 2000-05-11 2001-05-09 Modulation von gamma-secretase aktivität ATE339496T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US20350600P	2000-05-11	2000-05-11

Publications (1)

Publication Number	Publication Date
ATE339496T1 true ATE339496T1 (de)	2006-10-15

Family

ID=22754280

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01935260T ATE339496T1 (de)	2000-05-11	2001-05-09	Modulation von gamma-secretase aktivität

Country Status (8)

Country	Link
US (2)	US6579689B2 (de)
EP (1)	EP1305406B2 (de)
JP (1)	JP2003532413A (de)
AT (1)	ATE339496T1 (de)
AU (1)	AU2001261368A1 (de)
DE (1)	DE60123074T3 (de)
DK (1)	DK1305406T4 (de)
WO (1)	WO2001085924A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001075435A2 (en) *	2000-04-03	2001-10-11	Bristol-Myers Squibb Company	Fluorescence assay for gamma-secretase activity and inhibitors
US20030022251A1 (en) *	2001-07-04	2003-01-30	Boehringer Ingelheim Pharma Kg	Gamma-secretase in vitro screening assay
EP1469810A4 (de) *	2002-01-04	2009-01-14	Univ Rockefeller	Zusammensetzungen und verfahren zur verhütung und behandlung von erkrankungen im zusammenhang mit amyloid-beta peptid
CN1319987C (zh) *	2002-04-24	2007-06-06	森启	γ－分泌酶抑制剂
US20060188938A1 (en) *	2005-01-07	2006-08-24	Mullan Michael J	Compounds for inhibiting beta-amyloid production and methods of identifying the compounds
JP6166534B2 (ja)	2009-08-05	2017-07-19	イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−ＣｅｌｌｕｌａｒＴｈｅｒａｐｉｅｓ，Ｉｎｃ．	新規調節タンパク質および阻害剤

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4372888A (en) †	1980-08-26	1983-02-08	The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services	Nondenaturing zwitterionic detergents
CA2191924A1 (en)	1995-12-05	1997-06-06	Kevin Felsenstein	5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of .beta.-amyloid protein production
GB9608657D0 (en)	1996-04-26	1996-07-03	Smithkline Beecham Plc	Novel treatment
WO1998015828A1 (en)	1996-10-07	1998-04-16	Scios Inc.	Method to identify direct inhibitors of the beta-amyloid forming enzyme gamma-secretase
US6313268B1 (en) †	1998-10-16	2001-11-06	Vivian Y. H. Hook	Secretases related to Alzheimer's dementia
DE19941039A1 (de)	1999-08-28	2001-03-01	Boehringer Ingelheim Pharma	gamma-Sekretase in vitro Testsystem
DE10000161A1 (de)	2000-01-06	2001-07-19	Boehringer Ingelheim Pharma	Verfahren zur Identifikation eines Proteaseinhibitors
WO2001075435A2 (en)	2000-04-03	2001-10-11	Bristol-Myers Squibb Company	Fluorescence assay for gamma-secretase activity and inhibitors

2001
- 2001-05-09 JP JP2001582513A patent/JP2003532413A/ja active Pending
- 2001-05-09 EP EP01935260.8A patent/EP1305406B2/de not_active Expired - Lifetime
- 2001-05-09 DE DE60123074.4T patent/DE60123074T3/de not_active Expired - Lifetime
- 2001-05-09 US US09/852,914 patent/US6579689B2/en not_active Expired - Lifetime
- 2001-05-09 WO PCT/US2001/015089 patent/WO2001085924A2/en not_active Ceased
- 2001-05-09 DK DK01935260.8T patent/DK1305406T4/en active
- 2001-05-09 AU AU2001261368A patent/AU2001261368A1/en not_active Abandoned
- 2001-05-09 AT AT01935260T patent/ATE339496T1/de not_active IP Right Cessation
2003
- 2003-06-17 US US10/464,036 patent/US20030211559A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1305406B1 (de)	2006-09-13
WO2001085924A3 (en)	2003-02-27
DK1305406T4 (en)	2015-02-02
DE60123074T3 (de)	2015-01-29
AU2001261368A1 (en)	2001-11-20
EP1305406B2 (de)	2014-11-12
US20010055782A1 (en)	2001-12-27
JP2003532413A (ja)	2003-11-05
EP1305406A2 (de)	2003-05-02
DK1305406T3 (da)	2007-01-08
WO2001085924A2 (en)	2001-11-15
DE60123074D1 (de)	2006-10-26
US20030211559A1 (en)	2003-11-13
DE60123074T2 (de)	2007-03-01
US6579689B2 (en)	2003-06-17

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Legal Events

Date	Code	Title	Description
2007-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties