ATE339521T1 - Verfahren zur bestimmung der expression des dihydropyrimidindehydrogenasegens - Google Patents

Verfahren zur bestimmung der expression des dihydropyrimidindehydrogenasegens

Info

Publication number
ATE339521T1
ATE339521T1 AT02704432T AT02704432T ATE339521T1 AT E339521 T1 ATE339521 T1 AT E339521T1 AT 02704432 T AT02704432 T AT 02704432T AT 02704432 T AT02704432 T AT 02704432T AT E339521 T1 ATE339521 T1 AT E339521T1
Authority
AT
Austria
Prior art keywords
expression
determining
dihydropyrimidine dehydrogenase
gen
dehydrogenase gen
Prior art date
Application number
AT02704432T
Other languages
English (en)
Inventor
Kathleen D Danenberg
Original Assignee
Response Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/796,807 external-priority patent/US6956111B2/en
Application filed by Response Genetics Inc filed Critical Response Genetics Inc
Application granted granted Critical
Publication of ATE339521T1 publication Critical patent/ATE339521T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT02704432T 2001-03-02 2002-02-22 Verfahren zur bestimmung der expression des dihydropyrimidindehydrogenasegens ATE339521T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/796,807 US6956111B2 (en) 2001-03-02 2001-03-02 Method of determining dihydropyrimidine dehydrogenase gene expression
US09/842,111 US6905821B2 (en) 2001-03-02 2001-04-26 Method of determining Dihydropyrimidine dehydrogenase gene expression
US09/879,217 US7005278B2 (en) 2001-03-02 2001-06-13 Method of determining dihydropyrimidine dehydrogenase gene expression

Publications (1)

Publication Number Publication Date
ATE339521T1 true ATE339521T1 (de) 2006-10-15

Family

ID=27419931

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02704432T ATE339521T1 (de) 2001-03-02 2002-02-22 Verfahren zur bestimmung der expression des dihydropyrimidindehydrogenasegens

Country Status (14)

Country Link
US (1) US7005278B2 (de)
EP (1) EP1409723B1 (de)
JP (1) JP2005508603A (de)
CN (1) CN1250744C (de)
AR (1) AR032917A1 (de)
AT (1) ATE339521T1 (de)
AU (1) AU2002238115B2 (de)
CA (1) CA2439313C (de)
DE (1) DE60214725T2 (de)
IL (1) IL157694A0 (de)
MX (1) MXPA03007884A (de)
NZ (1) NZ528374A (de)
TW (1) TWI274076B (de)
WO (1) WO2002070750A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020142328A1 (en) 2000-12-01 2002-10-03 Danenberg Kathleen D. Method of determining a chemotherapeutic regimen by assaying gene expression in primary tumors
CA2479446C (en) * 2003-08-28 2013-05-07 F.Hoffmann-La Roche Ag Correlation of the ratio of tp and dpd mrna expression levels in colorectal cancer with disease-free survival in 5-fu treated patients
CN102580084B (zh) 2005-01-21 2016-11-23 健泰科生物技术公司 Her抗体的固定剂量给药
EP1850874B1 (de) * 2005-02-23 2013-10-16 Genentech, Inc. Verzögerung des krankheitsverlauf bei eierstockkrebspatienten durch pertuzumab
JP2006316040A (ja) 2005-05-13 2006-11-24 Genentech Inc Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法
JP4880621B2 (ja) * 2006-01-25 2012-02-22 大鵬薬品工業株式会社 ５−フルオロウラシル系抗癌剤に対する感受性を予測する方法
SI2132573T1 (sl) 2007-03-02 2014-07-31 Genentech, Inc. Napovedovanje odziva na inhibitor dimerizacije HER na osnovi nizke ekspresije HER3
PL2171090T3 (pl) 2007-06-08 2013-09-30 Genentech Inc Markery ekspresji genów odporności guza na leczenie hamujące HER2
US9551033B2 (en) * 2007-06-08 2017-01-24 Genentech, Inc. Gene expression markers of tumor resistance to HER2 inhibitor treatment
KR20100012056A (ko) 2007-06-22 2010-02-04 리스판스 지네틱스, 인크. 고정 표본에서 긴 단편 ｒｎａ를 분리하는 방법
BRPI0812682A2 (pt) 2008-06-16 2010-06-22 Genentech Inc tratamento de cáncer de mama metastático
MY152068A (en) 2009-03-20 2014-08-15 Genentech Inc Bispecific anti-her antibodies
CN102421448A (zh) 2009-05-29 2012-04-18 霍夫曼-拉罗奇有限公司 Her2信号传导调控剂在表达her2的胃癌患者中
US8079170B2 (en) * 2009-08-28 2011-12-20 Loftin Thomas E Gun barrel cleaning apparatus and method
US9556249B2 (en) 2010-02-18 2017-01-31 Genentech, Inc. Neuregulin antagonists and use thereof in treating cancer
WO2011146568A1 (en) 2010-05-19 2011-11-24 Genentech, Inc. Predicting response to a her inhibitor
WO2012069466A1 (en) 2010-11-24 2012-05-31 Novartis Ag Multispecific molecules
SG191153A1 (en) 2010-12-23 2013-07-31 Hoffmann La Roche Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
MX2014001766A (es) 2011-08-17 2014-05-01 Genentech Inc Anticuerpos de neuregulina y sus usos.
US9327023B2 (en) 2011-10-25 2016-05-03 The Regents Of The University Of Michigan HER2 targeting agent treatment in non-HER2-amplified cancers having HER2 expressing cancer stem cells
BR112014012979A2 (pt) 2011-11-30 2020-10-20 Genentech, Inc. mutações erbb3 em câncer
US9376715B2 (en) 2011-12-09 2016-06-28 Roche Molecular Systems, Inc Methods for detecting mutations in the catalytic subunit of the phosphoinositol-3 kinase (PIK3CA) gene
US20130259867A1 (en) 2012-03-27 2013-10-03 Genentech, Inc. Diagnosis and treatments relating to her3 inhibitors
KR102291355B1 (ko) 2012-11-30 2021-08-19 에프. 호프만-라 로슈 아게 Pd-l1 억제제 공동치료를 필요로 하는 환자의 식별방법
US20190151346A1 (en) 2016-05-10 2019-05-23 INSERM (Institute National de la Santé et de la Recherche Médicale) Combinations therapies for the treatment of cancer

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4830969A (en) * 1981-08-31 1989-05-16 The Research Foundation Of State University Of New York Process for the rapid and simple isolation of nucleic acids
US4843155A (en) * 1987-11-19 1989-06-27 Piotr Chomczynski Product and process for isolating RNA
US5128247A (en) * 1989-08-14 1992-07-07 Board Of Regents, The University Of Texas System Methods for isolation of nucleic acids from eukaryotic and prokaryotic sources
US5284940A (en) * 1990-11-14 1994-02-08 Hri Research, Inc. Preparation for nucleic acid samples
US5654179A (en) * 1990-11-14 1997-08-05 Hri Research, Inc. Nucleic acid preparation methods
US5620852A (en) * 1990-11-14 1997-04-15 Hri Research, Inc. Nucleic acid preparation methods
US5346994A (en) * 1992-01-28 1994-09-13 Piotr Chomczynski Shelf-stable product and process for isolating RNA, DNA and proteins
US5502166A (en) * 1992-02-26 1996-03-26 Mitsubishi Chemical Corporation NMDH receptor proteins and genes encoding the same
AU6230594A (en) * 1993-02-01 1994-08-29 University Of Iowa Research Foundation, The Quartenary amine surfactants and methods of using same in isolation of rna
US5637687A (en) * 1993-08-31 1997-06-10 Wiggins; James C. Methods and compositions for isolating nucleic acids
AU2289495A (en) 1994-04-13 1995-11-10 Uab Research Foundation, The Dihydropyrimidine dehydrogenase compositions and methods of use
US5643767A (en) * 1994-05-02 1997-07-01 The Rockefeller University Process for isolating cellular components
CA2153215A1 (en) * 1994-07-06 1996-01-07 Lu Wang Treatment of paraffin embedded tissue for gene analysis
US5856454A (en) * 1994-09-12 1999-01-05 The United States Of America As Represented By The Department Of Health And Human Services CDNA for human and pig dihydropyrimidine dehydrogenase
US5707802A (en) * 1995-01-13 1998-01-13 Ciba Corning Diagnostics Corp. Nucleic acid probes for the detection and identification of fungi
US5777099A (en) * 1995-02-24 1998-07-07 Biotecx Laboratories, Inc. RNA separation
US5945515A (en) * 1995-07-31 1999-08-31 Chomczynski; Piotr Product and process for isolating DNA, RNA and proteins
DE29601618U1 (de) * 1996-01-31 1996-07-04 InViTek GmbH, 13125 Berlin Vorrichtung zur gleichzeitigen multiplen Isolierung
EP0791654A1 (de) * 1996-02-21 1997-08-27 Jürgen A. Dr. Richt Polypeptide, die Aminosäuresequenzen der p57 oder p9.5 Proteine aus Borna-Krankheit Virus entsprechen, dafür kodierende Nukleinsäurefragmente und ihre Verwendung zu Diagnose- und Immunisierungzwecke
EP0896629B8 (de) 1996-03-20 2003-01-02 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services Verfahren und zusammensetzungen zum nachweis von spleiss-mutationen in dihydropyremudine dehydrogenase
CA2253937A1 (en) * 1996-05-10 1997-11-20 Phylomed Corporation Methods for oxidizing disulfide bonds using ozone
CA2283636A1 (en) 1997-03-20 1998-09-24 Variagenics, Inc. Target genes for allele-specific drugs
DE19837391A1 (de) 1997-08-22 1999-02-25 Hoffmann La Roche Immunologische Materialien und Verfahren zum Nachweis von Dihydropyrimidindehydrogenase
US5952202A (en) * 1998-03-26 1999-09-14 The Perkin Elmer Corporation Methods using exogenous, internal controls and analogue blocks during nucleic acid amplification
NZ546252A (en) * 2000-12-01 2008-03-28 Response Genetics Inc Method of determining HER2-neu gene expression in paraffin embedded tissue samples
TWI319010B (en) 2000-12-01 2010-01-01 Response Genetics Inc Method of determining a chemotherapeutic regimen by assaying gene expression in primary tumors

Also Published As

Publication number Publication date
TWI274076B (en) 2007-02-21
DE60214725D1 (de) 2006-10-26
CA2439313C (en) 2012-08-07
DE60214725T2 (de) 2007-09-06
HK1068375A1 (en) 2005-04-29
EP1409723B1 (de) 2006-09-13
WO2002070750A3 (en) 2004-02-19
US7005278B2 (en) 2006-02-28
IL157694A0 (en) 2004-03-28
CN1518603A (zh) 2004-08-04
JP2005508603A (ja) 2005-04-07
WO2002070750A2 (en) 2002-09-12
AU2002238115B2 (en) 2007-06-14
NZ528374A (en) 2008-01-31
CN1250744C (zh) 2006-04-12
AR032917A1 (es) 2003-12-03
US20030165840A1 (en) 2003-09-04
CA2439313A1 (en) 2002-09-12
EP1409723A2 (de) 2004-04-21
MXPA03007884A (es) 2004-10-15

Similar Documents

Publication Publication Date Title
ATE339521T1 (de) Verfahren zur bestimmung der expression des dihydropyrimidindehydrogenasegens
DE60323192D1 (de) Verfahren zur Herstellung von Hydroxyalkylstärkederivaten
DE60120114D1 (de) Verfahren zur Verbesserung der Knochenmineralisierung
DE60045595D1 (de) Verfahren zur Bestimmung des Gasgehalts
DE60210265D1 (de) Verfahren und zwischenprodukte zur herstellung von 4-aminochinolin-cetp-inhibitoren
DE50308659D1 (de) Verfahren zur kontinuierlichen herstellung von propylenglykolen
DE60307710D1 (de) Verfahren zur Herstellung von Eisenoxiden
DE60232117D1 (de) Verfahren zur Dickenmessung
ATE286011T1 (de) Verfahren zur herstellung von 1-octen
ATE336597T1 (de) Verfahren zur gewinnung von gold
DE602004021388D1 (de) Verfahren zur herstellung von cpla 2-inhibitoren
DE60301283D1 (de) Verfahren zur Bestimmung von Biopolymeren
DE50311721D1 (de) Verfahren zur Herstellung von Aryl-aminopropanolen
DE60137288D1 (de) Verfahren zur Bestimmung des Basalstoffwechsels
DE60028935D1 (de) Verfahren zur verminderung des ausleierns des hüftgelenks
FI20000325A0 (fi) Menetelmä rakenteen rasituksen määrittämiseksi
DE50207028D1 (de) Verfahren zur bestimmung des enantiomerenverhältnisses von trimethylcyclopenten-derivaten
DE60118367D1 (de) Verfahren zur fluormethylierung von alkoholen
DE60301444T2 (de) Verfahren zur Herstellung von Polyalkylphenoxyaminoalkanen
DE60330749D1 (de) Verfahren zur herstellung von 7-alpha-methylsteroide
DE50115505D1 (de) Verfahren zur bestimmung des kritischen pfades einer integrierten schaltung
DE60302979D1 (de) Verfahren zur Herstellung von Epsilon-Caprolactone
DE60324881D1 (de) Verfahren zur Herstellung von Polyalkylphenoxyaminoalkanen
DE60308294D1 (de) Verfahren zur Herstellung von Dijodhalogenalkanen
DE60115563D1 (de) Verfahren zur Korrosionsverminderung

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1409723

Country of ref document: EP