ATE341552T1 - Derivate morphinähnlicher opioidverbindungen - Google Patents

Derivate morphinähnlicher opioidverbindungen

Info

Publication number
ATE341552T1
ATE341552T1 AT02753923T AT02753923T ATE341552T1 AT E341552 T1 ATE341552 T1 AT E341552T1 AT 02753923 T AT02753923 T AT 02753923T AT 02753923 T AT02753923 T AT 02753923T AT E341552 T1 ATE341552 T1 AT E341552T1
Authority
AT
Austria
Prior art keywords
compounds
derivatives
morphine
formula
pharmaceutically acceptable
Prior art date
Application number
AT02753923T
Other languages
English (en)
Inventor
William Roy Jackson
Kamani Rupika Subasinghe
Original Assignee
Neuro Therapeutics Ltd
Univ Monash
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPR6938A external-priority patent/AUPR693801A0/en
Priority claimed from AUPR9640A external-priority patent/AUPR964001A0/en
Application filed by Neuro Therapeutics Ltd, Univ Monash filed Critical Neuro Therapeutics Ltd
Application granted granted Critical
Publication of ATE341552T1 publication Critical patent/ATE341552T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AT02753923T 2001-08-10 2002-08-09 Derivate morphinähnlicher opioidverbindungen ATE341552T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPR6938A AUPR693801A0 (en) 2001-08-10 2001-08-10 Therapeutic compounds
AUPR9640A AUPR964001A0 (en) 2001-12-19 2001-12-19 Therapeutic compounds

Publications (1)

Publication Number Publication Date
ATE341552T1 true ATE341552T1 (de) 2006-10-15

Family

ID=25646773

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02753923T ATE341552T1 (de) 2001-08-10 2002-08-09 Derivate morphinähnlicher opioidverbindungen

Country Status (7)

Country Link
US (1) US7199129B2 (de)
EP (1) EP1423392B1 (de)
JP (1) JP2005500373A (de)
AT (1) ATE341552T1 (de)
AU (1) AU2002322169B2 (de)
DE (1) DE60215195T2 (de)
WO (1) WO2003014122A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040204862A1 (en) * 2003-04-11 2004-10-14 Wainer Irving W. Computer-based model for identification and characterization for non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors
TWI630208B (zh) 2008-12-08 2018-07-21 歐陸斯迪公司 二氫羥戊甲嗎啡
US9351973B2 (en) 2011-09-22 2016-05-31 Merck Sharp & Dohme Corp. Pyrazolopyridyl compounds as aldosterone synthase inhibitors
WO2013043518A1 (en) 2011-09-22 2013-03-28 Merck Sharp & Dohme Corp. Imidazopyridyl compounds as aldosterone synthase inhibitors
EP2757883B1 (de) 2011-09-22 2021-01-13 Merck Sharp & Dohme Corp. Triazolopyridylverbindungen als aldosteronsynthasehemmer
WO2014015157A2 (en) 2012-07-19 2014-01-23 Philadelphia Health & Education Corporation Novel sigma receptor ligands and methods of modulating cellular protein homeostasis using same
GB201309654D0 (en) 2013-05-30 2013-07-17 Euro Celtique Sa Method
US9920836B2 (en) * 2013-10-18 2018-03-20 Kabushiki Kaisha Riken Piston ring for internal combustion engine
US11117870B2 (en) 2017-11-01 2021-09-14 Drexel University Compounds, compositions, and methods for treating diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3341538A (en) * 1965-06-18 1967-09-12 Geigy Chem Corp Certain 2, 6-methano-3-benzazocines
WO1999038869A1 (en) 1998-01-29 1999-08-05 Monash University Therapeutic compounds
KR100602929B1 (ko) * 2000-08-31 2006-07-20 에프. 호프만-라 로슈 아게 알파-1 아드레날린성 길항제로서 퀴나졸린 유도체

Also Published As

Publication number Publication date
WO2003014122A1 (en) 2003-02-20
EP1423392A4 (de) 2004-11-17
US20040242616A1 (en) 2004-12-02
DE60215195D1 (de) 2006-11-16
JP2005500373A (ja) 2005-01-06
US7199129B2 (en) 2007-04-03
DE60215195T2 (de) 2007-08-23
EP1423392A1 (de) 2004-06-02
EP1423392B1 (de) 2006-10-04
AU2002322169B2 (en) 2008-10-30

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties