ATE341637T1 - Unblutige bestimmung einer physiologischen reaktion in einem säugetier - Google Patents

Unblutige bestimmung einer physiologischen reaktion in einem säugetier

Info

Publication number
ATE341637T1
ATE341637T1 AT99967380T AT99967380T ATE341637T1 AT E341637 T1 ATE341637 T1 AT E341637T1 AT 99967380 T AT99967380 T AT 99967380T AT 99967380 T AT99967380 T AT 99967380T AT E341637 T1 ATE341637 T1 AT E341637T1
Authority
AT
Austria
Prior art keywords
mammal
physiological response
bloodless
determination
expression cassettes
Prior art date
Application number
AT99967380T
Other languages
English (en)
Inventor
Pamela R Contag
Ning Zhang
Original Assignee
Xenogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenogen Corp filed Critical Xenogen Corp
Application granted granted Critical
Publication of ATE341637T1 publication Critical patent/ATE341637T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Husbandry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Electrotherapy Devices (AREA)
AT99967380T 1998-12-17 1999-12-16 Unblutige bestimmung einer physiologischen reaktion in einem säugetier ATE341637T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11264698P 1998-12-17 1998-12-17
US15285399P 1999-09-08 1999-09-08

Publications (1)

Publication Number Publication Date
ATE341637T1 true ATE341637T1 (de) 2006-10-15

Family

ID=26810191

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99967380T ATE341637T1 (de) 1998-12-17 1999-12-16 Unblutige bestimmung einer physiologischen reaktion in einem säugetier

Country Status (7)

Country Link
US (1) US7449615B2 (de)
EP (1) EP1141359B1 (de)
AT (1) ATE341637T1 (de)
AU (1) AU774183B2 (de)
CA (1) CA2355900A1 (de)
DE (1) DE69933471T2 (de)
WO (1) WO2000036106A2 (de)

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US6217847B1 (en) 1994-07-01 2001-04-17 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US7255851B2 (en) 1994-07-01 2007-08-14 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
AUPP362898A0 (en) * 1998-05-21 1998-06-11 University Of Sydney, The Xenobiotic induction of gene expression
ATE341637T1 (de) 1998-12-17 2006-10-15 Xenogen Corp Unblutige bestimmung einer physiologischen reaktion in einem säugetier
US6610503B1 (en) 1999-03-17 2003-08-26 Xenogen Corporation Animal models for predicting sepsis mortality
US6737245B1 (en) 1999-09-08 2004-05-18 Xenogen Corporation Luciferase expression cassettes and methods of use
US6867348B1 (en) 1999-12-16 2005-03-15 Xenogen Corporation Methods and compositions for screening for angiogenesis modulating compounds
IT1311335B1 (it) 1999-12-21 2002-03-12 Otc Optical Technologies Ct S Procedimento e dispositivo per realizzare reticoli in fibra ottica.
US7056728B2 (en) 2000-07-06 2006-06-06 Xenogen Corporation Compositions and methods for use thereof in modifying the genomes of microorganisms
AUPR116100A0 (en) * 2000-11-01 2000-11-23 University Of Sydney, The P450 gene regulation
CN1596306A (zh) * 2001-03-07 2005-03-16 荧合金股份有限公司 用于将dna导入靶细胞的筛选方法
WO2002093143A2 (en) 2001-05-17 2002-11-21 Xenogen Corporation Method and apparatus for determining target depth, brightness and size within a body region
US7298415B2 (en) 2001-07-13 2007-11-20 Xenogen Corporation Structured light imaging apparatus
US7599731B2 (en) 2002-07-16 2009-10-06 Xenogen Corporation Fluorescent light tomography
US7616985B2 (en) 2002-07-16 2009-11-10 Xenogen Corporation Method and apparatus for 3-D imaging of internal light sources
WO2004089189A2 (en) * 2003-04-04 2004-10-21 Sloan-Kettering Institute For Cancer Research Minimally-invasive imaging of viral gene therapy and presurgical applications thereof
WO2005116070A2 (en) * 2004-04-28 2005-12-08 Five Prime Therapeutics, Inc. Reporter system for detecting signal pathway activation in multiple cell types
US8044996B2 (en) 2005-05-11 2011-10-25 Xenogen Corporation Surface construction using combined photographic and structured light information
JP5346583B2 (ja) * 2005-09-28 2013-11-20 アッタゲネ インコーポレーテッド 生物検体の生物活性を解析するための方法及び構築物、並びに生物の状態を測定するための方法及び構築物
JP2009512853A (ja) 2005-10-19 2009-03-26 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ 動物個体の神経系の非侵襲的インビボ蛍光イメージング
US7807429B2 (en) 2006-02-13 2010-10-05 Connecticut College Isolated luciferase gene of L. italica
US10775308B2 (en) 2006-08-24 2020-09-15 Xenogen Corporation Apparatus and methods for determining optical tissue properties
US10335038B2 (en) 2006-08-24 2019-07-02 Xenogen Corporation Spectral unmixing for in-vivo imaging
US20100175139A1 (en) * 2007-03-13 2010-07-08 Simon Nicholas Waddington Somatotransgenic bioimaging
NZ720946A (en) 2009-04-29 2017-09-29 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
EP2478113B1 (de) 2009-09-18 2020-09-02 Caliper Life Sciences, Inc. Zusammensetzungen und verfahren zur in-vivo-evaluation einer biolumineszenz
WO2012030973A2 (en) 2010-09-01 2012-03-08 Spectral Instruments Imaging, LLC Methods and systems for producing visible light and x-ray image data
JP2013538350A (ja) 2010-09-01 2013-10-10 スペクトラル・インストゥルメンツ・イメージング・エルエルシー 励起光源組立体
WO2012040108A2 (en) 2010-09-20 2012-03-29 Caliper Life Sciences Multivalent fluorescent probes
EP2719703A1 (de) 2012-10-12 2014-04-16 Ecole Polytechnique Fédérale de Lausanne (EPFL) Vorläufermolekül für die Synthese von D-Luciferin
WO2016054079A1 (en) 2014-09-29 2016-04-07 Zyomed Corp. Systems and methods for blood glucose and other analyte detection and measurement using collision computing
US10683552B2 (en) 2014-11-25 2020-06-16 Presidents And Fellows Of Harvard College Clonal haematopoiesis
US11168369B2 (en) 2014-11-25 2021-11-09 The Brigham And Women's Hospital, Inc. Method of identifying and treating a person having a predisposition to or afflicted with a cardiometabolic disease
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ATE341637T1 (de) 1998-12-17 2006-10-15 Xenogen Corp Unblutige bestimmung einer physiologischen reaktion in einem säugetier
US6610503B1 (en) 1999-03-17 2003-08-26 Xenogen Corporation Animal models for predicting sepsis mortality
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Also Published As

Publication number Publication date
CA2355900A1 (en) 2000-06-22
DE69933471D1 (de) 2006-11-16
WO2000036106A3 (en) 2000-11-02
US20020138855A1 (en) 2002-09-26
DE69933471T2 (de) 2007-08-30
AU774183B2 (en) 2004-06-17
EP1141359B1 (de) 2006-10-04
WO2000036106A2 (en) 2000-06-22
US7449615B2 (en) 2008-11-11
WO2000036106A9 (en) 2001-08-02
EP1141359A2 (de) 2001-10-10
AU2366700A (en) 2000-07-03

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