ATE341759T1 - Hochgeschwindigkeits-lichtquelle mit vielfachen wellenlängen für die quantitative verhältnis- lumineszenzmikroskopie - Google Patents

Hochgeschwindigkeits-lichtquelle mit vielfachen wellenlängen für die quantitative verhältnis- lumineszenzmikroskopie

Info

Publication number
ATE341759T1
ATE341759T1 AT95912716T AT95912716T ATE341759T1 AT E341759 T1 ATE341759 T1 AT E341759T1 AT 95912716 T AT95912716 T AT 95912716T AT 95912716 T AT95912716 T AT 95912716T AT E341759 T1 ATE341759 T1 AT E341759T1
Authority
AT
Austria
Prior art keywords
light source
multiple wavelength
wavelength light
quantitative ratio
luminescence
Prior art date
Application number
AT95912716T
Other languages
English (en)
Inventor
Gary Brooker
Original Assignee
Gary Brooker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gary Brooker filed Critical Gary Brooker
Application granted granted Critical
Publication of ATE341759T1 publication Critical patent/ATE341759T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6419—Excitation at two or more wavelengths

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Discharge Lamp (AREA)
AT95912716T 1994-03-25 1995-03-10 Hochgeschwindigkeits-lichtquelle mit vielfachen wellenlängen für die quantitative verhältnis- lumineszenzmikroskopie ATE341759T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/217,883 US5491343A (en) 1994-03-25 1994-03-25 High-speed multiple wavelength illumination source, apparatus containing the same, and applications thereof to methods of irradiating luminescent samples and of quantitative luminescence ratio microscopy

Publications (1)

Publication Number Publication Date
ATE341759T1 true ATE341759T1 (de) 2006-10-15

Family

ID=22812880

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95912716T ATE341759T1 (de) 1994-03-25 1995-03-10 Hochgeschwindigkeits-lichtquelle mit vielfachen wellenlängen für die quantitative verhältnis- lumineszenzmikroskopie

Country Status (8)

Country Link
US (1) US5491343A (de)
EP (1) EP0783680B1 (de)
JP (1) JP3640964B2 (de)
AT (1) ATE341759T1 (de)
AU (1) AU1977995A (de)
CA (1) CA2186241C (de)
DE (1) DE69535254T2 (de)
WO (1) WO1995026498A1 (de)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5734498A (en) * 1994-05-09 1998-03-31 The Regents Of The University Of California Illuminator elements for conventional light microscopes
US5894347A (en) * 1997-06-16 1999-04-13 Johnson & Johnson Clinical Diagnostics, Inc. Fluorimeter and detection method
US6097025A (en) * 1997-10-31 2000-08-01 Ljl Biosystems, Inc. Light detection device having an optical-path switching mechanism
US6469311B1 (en) 1997-07-16 2002-10-22 Molecular Devices Corporation Detection device for light transmitted from a sensed volume
US6071748A (en) * 1997-07-16 2000-06-06 Ljl Biosystems, Inc. Light detection device
GB9717021D0 (en) * 1997-08-12 1997-10-15 Kalibrant Limited A detector
US6576476B1 (en) 1998-09-02 2003-06-10 Ljl Biosystems, Inc. Chemiluminescence detection method and device
US6326605B1 (en) 1998-02-20 2001-12-04 Ljl Biosystems, Inc. Broad range light detection system
US6297018B1 (en) 1998-04-17 2001-10-02 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
US6982431B2 (en) * 1998-08-31 2006-01-03 Molecular Devices Corporation Sample analysis systems
US6992761B2 (en) * 1997-09-20 2006-01-31 Molecular Devices Corporation Broad range light detection system
WO2000050877A1 (en) 1999-02-23 2000-08-31 Ljl Biosystems, Inc. Frequency-domain light detection device
US6825921B1 (en) 1999-11-10 2004-11-30 Molecular Devices Corporation Multi-mode light detection system
US20030135122A1 (en) * 1997-12-12 2003-07-17 Spectrx, Inc. Multi-modal optical tissue diagnostic system
US6055451A (en) 1997-12-12 2000-04-25 Spectrx, Inc. Apparatus and method for determining tissue characteristics
ATE425448T1 (de) * 1998-05-16 2009-03-15 Applera Corp Optisches gerät insbesondere zur überwachung von dns-polymerasekettenreaktionen
US7498164B2 (en) 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
US6818437B1 (en) * 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
AU5223899A (en) 1998-07-27 2000-02-21 Ljl Biosystems, Inc. Apparatus and methods for spectroscopic measurements
AU5667599A (en) 1998-07-27 2000-02-21 Ljl Biosystems, Inc. Apparatus and methods for time-resolved spectroscopic measurements
AU6139199A (en) * 1998-09-11 2000-04-03 Spectrx, Inc. Multi-modal optical tissue diagnostic system
US6320196B1 (en) 1999-01-28 2001-11-20 Agilent Technologies, Inc. Multichannel high dynamic range scanner
EP1169722A1 (de) 1999-03-18 2002-01-09 Cambridge Research & Instrumentation, Inc. Hochwirkames mehrfachsonden-bilderzeugungssystem
US20040147843A1 (en) * 1999-11-05 2004-07-29 Shabbir Bambot System and method for determining tissue characteristics
DE10038185C2 (de) * 2000-08-04 2003-05-28 Siemens Ag Einrichtung zum Erfassen von unterschiedlichen Fluoreszenzsignalen eines mit verschiedenen Anregungswellenlängen ganzflächig beleuchteten Probenträgers
US20040020529A1 (en) * 2000-10-17 2004-02-05 Carla Schutt Device for testing solar cells
AU2002230415A1 (en) 2000-11-17 2002-05-27 Universal Imaging Corporation Rapidly changing dichroic beamsplitter
US6309078B1 (en) 2000-12-08 2001-10-30 Axon Instruments, Inc. Wavelength-selective mirror selector
US6583424B2 (en) * 2001-06-25 2003-06-24 Agilent Technologies Inc. Scanning system with calibrated detection and method
US7186990B2 (en) * 2002-01-22 2007-03-06 Microbiosystems, Limited Partnership Method and apparatus for detecting and imaging the presence of biological materials
US6750006B2 (en) * 2002-01-22 2004-06-15 Microbiosystems, Limited Partnership Method for detecting the presence of microbes and determining their physiological status
US7211377B1 (en) 2002-01-22 2007-05-01 Microbiosystems, Limited Partnership Method for detecting the presence of dormant cryptobiotic microorganisms
GB0216934D0 (en) * 2002-07-20 2002-08-28 Council Cent Lab Res Councils Optical apparatus
WO2004046691A2 (en) * 2002-11-18 2004-06-03 Genospectra, Inc. Uncaging devices
DE10314125B4 (de) * 2003-03-28 2005-02-24 Carl Zeiss Jena Gmbh Anordnung zur Beleuchtung von Objekten mit Licht unterschiedlicher Wellenlänge
JP2005121479A (ja) * 2003-10-16 2005-05-12 Tokyo Instruments Inc 共焦点顕微分光装置
KR100657268B1 (ko) * 2004-07-15 2006-12-14 학교법인 대양학원 컬러 영상의 신축적 부호화, 복호화 방법 및 장치
WO2006010252A1 (en) * 2004-07-27 2006-02-02 National Research Council Of Canada Multi-wavelength fluorometric system for on-line monitoring of bioprocesses
CA2577889A1 (en) * 2004-08-23 2006-03-02 Rajeev Raut Incising cell to basement membrane bonds
DE102005005984B4 (de) * 2005-02-09 2019-10-24 Leica Instruments (Singapore) Pte. Ltd. Fluoreszenz-/Infraroteinrichtung für Operationsmikroskope
US20070122344A1 (en) 2005-09-02 2007-05-31 University Of Rochester Medical Center Office Of Technology Transfer Intraoperative determination of nerve location
WO2007037252A1 (ja) * 2005-09-28 2007-04-05 Olympus Corporation 蛍光分光分析装置
JP2007093370A (ja) * 2005-09-28 2007-04-12 Olympus Corp 蛍光分光分析装置
US20080161744A1 (en) 2006-09-07 2008-07-03 University Of Rochester Medical Center Pre-And Intra-Operative Localization of Penile Sentinel Nodes
US7738094B2 (en) * 2007-01-26 2010-06-15 Becton, Dickinson And Company Method, system, and compositions for cell counting and analysis
US7615761B2 (en) * 2007-09-10 2009-11-10 Coherent, Inc. Trace evidence detection using multiple laser light sources
JP2009081512A (ja) * 2007-09-25 2009-04-16 Fujitsu Ltd 光送信装置および設定値決定方法
US8406860B2 (en) 2008-01-25 2013-03-26 Novadaq Technologies Inc. Method for evaluating blush in myocardial tissue
DE102008057115B4 (de) * 2008-11-13 2013-11-28 Lre Medical Gmbh Verfahren zur quantitativen Bestimmung der Konzentration von Fluorophoren einer Substanz in einer Probe und Vorrichtung zu seiner Durchführung
US9213176B2 (en) * 2008-12-02 2015-12-15 The Regents Of The University Of California Imaging arrangement and microscope
US10492671B2 (en) 2009-05-08 2019-12-03 Novadaq Technologies ULC Near infra red fluorescence imaging for visualization of blood vessels during endoscopic harvest
CN102985809B (zh) * 2010-05-12 2016-11-09 利康股份有限公司 具有减少的通道串扰的高动态范围扫描
CA2842359A1 (en) 2011-08-01 2013-02-07 Denovo Sciences Cell capture system and method of use
US9174216B2 (en) 2013-03-13 2015-11-03 DeNovo Science, Inc. System for capturing and analyzing cells
US9404864B2 (en) 2013-03-13 2016-08-02 Denovo Sciences, Inc. System for imaging captured cells
US10466160B2 (en) 2011-08-01 2019-11-05 Celsee Diagnostics, Inc. System and method for retrieving and analyzing particles
DE102011111315A1 (de) * 2011-08-26 2013-02-28 Bundesrepublik Deutschland, vertreten durch das Bundesministerium für Wirtschaft und Technologie, dieses vertreten durch den Präsidenten der Physikalisch-Technischen Bundesanstalt Verfahren zur Fluoreszenzmessung
WO2013075031A1 (en) 2011-11-16 2013-05-23 Becton, Dickinson And Company Methods and systems for detecting an analyte in a sample
JP6028096B2 (ja) 2012-06-21 2016-11-16 ノバダック テクノロジーズ インコーポレイテッド 血管造影及びかん流の定量化並びに解析手法
JP6296457B2 (ja) 2013-01-11 2018-03-20 ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company 低コストの臨床現場即時アッセイデバイス
US9752181B2 (en) 2013-01-26 2017-09-05 Denovo Sciences, Inc. System and method for capturing and analyzing cells
US9707562B2 (en) 2013-03-13 2017-07-18 Denovo Sciences, Inc. System for capturing and analyzing cells
US10391490B2 (en) 2013-05-31 2019-08-27 Celsee Diagnostics, Inc. System and method for isolating and analyzing cells
US9856535B2 (en) 2013-05-31 2018-01-02 Denovo Sciences, Inc. System for isolating cells
CN106029863A (zh) 2013-11-06 2016-10-12 贝克顿·迪金森公司 微流体性装置和制造和使用其的方法
AU2014348910B2 (en) 2013-11-13 2017-04-20 Becton, Dickinson And Company Optical imaging system and methods for using the same
KR20170067803A (ko) * 2014-09-29 2017-06-16 노바다크 테크놀러지즈 인코포레이티드 자가형광이 존재하는 생물학적 물질에서 타겟 형광체의 이미징
EP3203902B1 (de) 2014-10-09 2021-07-07 Novadaq Technologies ULC Quantifizierung des absoluten blutströmung in gewebe mittels fluoreszenzvermittelter photoplethysmographie
WO2016060795A1 (en) 2014-10-14 2016-04-21 Becton, Dickinson And Company Blood sample management using open cell foam
CA2960313C (en) 2014-10-14 2019-07-23 Becton, Dickinson And Company Blood sample management using open cell foam
JP6426832B2 (ja) 2015-03-10 2018-11-21 ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company 生物体液の極微標本管理装置
WO2017040650A1 (en) 2015-09-01 2017-03-09 Becton, Dickinson And Company Depth filtration device for separating specimen phases
CN106125068B (zh) * 2016-07-22 2018-11-23 武汉海达数云技术有限公司 激光测距中回波信号接收装置
EP4242743A3 (de) 2017-02-10 2023-10-18 Stryker European Operations Limited Handhaltbare offenfeld-fluoreszenzbildgebungssysteme und verfahren
WO2019046307A1 (en) 2017-08-29 2019-03-07 Celsee Diagnostics, Inc. SYSTEM AND METHOD FOR ISOLATING AND ANALYZING CELLS
US10337857B2 (en) 2017-10-17 2019-07-02 Raytheon Company Multi-spectral boresight alignment methods and systems
US10436640B2 (en) 2017-10-17 2019-10-08 Raytheon Company Alignment assembly and method for multi-spectral optical systems
US10633693B1 (en) 2019-04-16 2020-04-28 Celsee Diagnostics, Inc. System and method for leakage control in a particle capture system
US11578322B2 (en) 2019-05-07 2023-02-14 Bio-Rad Laboratories, Inc. System and method for automated single cell processing
US11273439B2 (en) 2019-05-07 2022-03-15 Bio-Rad Laboratories, Inc. System and method for target material retrieval from microwells
EP3982716A4 (de) 2019-06-14 2023-09-06 Bio-Rad Laboratories, Inc. System und verfahren für automatisierte einzelzellenverarbeitung und -analyse
US11504719B2 (en) 2020-03-12 2022-11-22 Bio-Rad Laboratories, Inc. System and method for receiving and delivering a fluid for sample processing
US10793772B1 (en) 2020-03-13 2020-10-06 Accelovant Technologies Corporation Monolithic phosphor composite for sensing systems
US11359976B2 (en) 2020-10-23 2022-06-14 Accelovant Technologies Corporation Multipoint surface temperature measurement system and method thereof
CA3137183C (en) 2020-11-05 2024-02-20 Accelovant Technologies Corporation Optoelectronic transducer module for thermographic temperature measurements
CN118369438A (zh) 2021-12-10 2024-07-19 伯乐实验室有限公司 用形态可调节功能化颗粒进行样品处理的组合物、方法和系统

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE298309C (de) *
EP0241268A3 (de) * 1986-04-11 1989-02-08 Sclavo Inc.West Coast Fluorimeter mit gepulstem Lichtsystem
DD298309A5 (de) * 1987-12-07 1992-02-13 Medizinische Akadmie Magdeburg,De 2-kanal-fluorimeter/reflektometer fuer langzeitmessungen in bioreaktoren
US5053626A (en) * 1989-09-29 1991-10-01 Boston University Dual wavelength spectrofluorometer
US5102625A (en) * 1990-02-16 1992-04-07 Boc Health Care, Inc. Apparatus for monitoring a chemical concentration
US5332905A (en) * 1992-08-26 1994-07-26 Atto Instruments, Inc. Apparatus and method for multiple emission ratio photometry and multiple emission ratio imaging
US5294799A (en) * 1993-02-01 1994-03-15 Aslund Nils R D Apparatus for quantitative imaging of multiple fluorophores

Also Published As

Publication number Publication date
JP3640964B2 (ja) 2005-04-20
DE69535254T2 (de) 2007-04-05
EP0783680A1 (de) 1997-07-16
CA2186241C (en) 2008-07-22
DE69535254D1 (de) 2006-11-16
CA2186241A1 (en) 1995-10-05
WO1995026498A1 (en) 1995-10-05
JPH10500479A (ja) 1998-01-13
EP0783680A4 (de) 1997-05-09
US5491343A (en) 1996-02-13
EP0783680B1 (de) 2006-10-04
AU1977995A (en) 1995-10-17

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