ATE341T1 - IMPLANTABLE BONE REPLACEMENT MATERIALS BASED ON CALCIUM PHOSPHATE CERAMIC IN A MATRIX MATERIAL AND PROCESS FOR THEIR MANUFACTURE. - Google Patents

IMPLANTABLE BONE REPLACEMENT MATERIALS BASED ON CALCIUM PHOSPHATE CERAMIC IN A MATRIX MATERIAL AND PROCESS FOR THEIR MANUFACTURE.

Info

Publication number
ATE341T1
ATE341T1 AT79101946T AT79101946T ATE341T1 AT E341 T1 ATE341 T1 AT E341T1 AT 79101946 T AT79101946 T AT 79101946T AT 79101946 T AT79101946 T AT 79101946T AT E341 T1 ATE341 T1 AT E341T1
Authority
AT
Austria
Prior art keywords
calcium phosphate
particles
phosphate ceramic
matrix material
bone replacement
Prior art date
Application number
AT79101946T
Other languages
German (de)
Inventor
Helmut Dr. Heide
Eva Dr. Poeschel
Ulrich Roth
Original Assignee
Battelle-Institut E.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Battelle-Institut E.V. filed Critical Battelle-Institut E.V.
Application granted granted Critical
Publication of ATE341T1 publication Critical patent/ATE341T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/32—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/427—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of other specific inorganic materials not covered by A61L27/422 or A61L27/425
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/02—Elements
    • C08K3/08—Metals
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/32—Phosphorus-containing compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
    • A61C8/0013—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/30004—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis
    • A61F2002/30032—Material related properties of the prosthesis or of a coating on the prosthesis the prosthesis being made from materials having different values of a given property at different locations within the same prosthesis differing in absorbability or resorbability, i.e. in absorption or resorption time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2002/30929—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth having at least two superposed coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/12—All metal or with adjacent metals
    • Y10T428/12014—All metal or with adjacent metals having metal particles
    • Y10T428/12021—All metal or with adjacent metals having metal particles having composition or density gradient or differential porosity

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Cardiology (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Ceramic Engineering (AREA)
  • Dentistry (AREA)
  • Materials For Medical Uses (AREA)
  • Dental Preparations (AREA)
  • Prostheses (AREA)

Abstract

An implantable bone replacement material (body) based on completely or partially resorbable particles incorporated in a matrix material. The particles are composed of bioactive sintered calcium phosphate ceramic material having a CaO:P2O5 composition ratio between 3:1 and 4:1. The replacement material (body) consists of a metal containing calcium phosphate ceramic material in the form of a monolayer of particles in the peripheral areas of the material (body) which serve as interfaces to the body tissue. The metal is compatible with body tissue. The ceramic particles have a size range between about 500 mu m and a few millimeters. The calcium phosphate particles are located so that they lie exposed on the upper surface of the material (body). Other embodiments and processes are also disclosed.
AT79101946T 1978-06-23 1979-06-15 IMPLANTABLE BONE REPLACEMENT MATERIALS BASED ON CALCIUM PHOSPHATE CERAMIC IN A MATRIX MATERIAL AND PROCESS FOR THEIR MANUFACTURE. ATE341T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2827529A DE2827529C2 (en) 1978-06-23 1978-06-23 Implantable bone replacement material consisting of a metal core and bioactive, sintered calcium phosphate ceramic particles and a process for its production
EP79101946A EP0006544B1 (en) 1978-06-23 1979-06-15 Implantable material for bone replacement based on calcium phosphate ceramics in a matrix and method of preparing same

Publications (1)

Publication Number Publication Date
ATE341T1 true ATE341T1 (en) 1981-11-15

Family

ID=6042527

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79101946T ATE341T1 (en) 1978-06-23 1979-06-15 IMPLANTABLE BONE REPLACEMENT MATERIALS BASED ON CALCIUM PHOSPHATE CERAMIC IN A MATRIX MATERIAL AND PROCESS FOR THEIR MANUFACTURE.

Country Status (6)

Country Link
US (1) US4309488A (en)
EP (1) EP0006544B1 (en)
JP (1) JPS558797A (en)
AT (1) ATE341T1 (en)
CA (1) CA1121102A (en)
DE (1) DE2827529C2 (en)

Families Citing this family (141)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2807132C2 (en) 1978-02-20 1983-11-03 Battelle-Institut E.V., 6000 Frankfurt Implantable pharmaceutical depot
DE2928007A1 (en) * 1979-07-11 1981-01-15 Riess Guido Dr BONE IMPLANT BODY FOR PROSTHESES AND BONE CONNECTORS AND METHOD FOR THE PRODUCTION THEREOF
JPS5654841A (en) 1979-10-08 1981-05-15 Mitsubishi Mining & Cement Co Bone broken portion and filler for void portion and method of treating bone of animal using said filler
EP0030583B1 (en) * 1979-12-18 1984-06-13 Oscobal Ag Bone replacement material and process for producing a bone replacement material
DE3164658D1 (en) * 1980-03-27 1984-08-16 Nat Res Dev Orthopaedic implants
DE3034086C2 (en) * 1980-09-10 1983-02-17 Guido Prof. Dr.med.dent. 8100 Garmisch-Partenkirchen Riess Anchoring device for fastening teeth or dentures
JPS58501160A (en) * 1981-07-27 1983-07-21 バッテル・デイベロプメント・コ−ポレ−シヨン Prosthesis and method of forming a porous coating on its surface
US4644942A (en) * 1981-07-27 1987-02-24 Battelle Development Corporation Production of porous coating on a prosthesis
DE3274519D1 (en) * 1981-07-30 1987-01-15 Ceraver Prosthetic stem composed of titanium or its alloys for the cementless fixation in a long bone
US4834756A (en) * 1982-02-18 1989-05-30 Pfizer Hospital Products Group, Inc. Bone prosthesis with porous coating
CA1227002A (en) * 1982-02-18 1987-09-22 Robert V. Kenna Bone prosthesis with porous coating
US5192324A (en) * 1982-02-18 1993-03-09 Howmedica Inc. Bone prosthesis with porous coating
DE3301122A1 (en) * 1983-01-14 1984-07-19 Johannes-Friedrich Dr. 2000 Hamburg Osborn CERAMIC BONE REPLACEMENT MATERIAL AND METHOD FOR THE PRODUCTION THEREOF
JPS59189842A (en) * 1983-04-08 1984-10-27 アイシン精機株式会社 Composite implant material by centrifugal dispersion moldingand production thereof
DE3316801A1 (en) * 1983-05-07 1984-11-08 Friedrichsfeld Gmbh, Steinzeug- Und Kunststoffwerke, 6800 Mannheim SEMI-IMPLANT
NL8402158A (en) * 1983-07-09 1985-02-01 Sumitomo Cement Co POROUS CERAMIC MATERIAL AND METHOD FOR THE PREPARATION THEREOF.
DE3403589A1 (en) * 1984-02-02 1985-08-08 Deutsche Carbone Ag, 6000 Frankfurt Method of producing an implant
JPS6131163A (en) * 1984-07-23 1986-02-13 京セラ株式会社 Ceramic living body prosthetic material and its production
US4863475A (en) * 1984-08-31 1989-09-05 Zimmer, Inc. Implant and method for production thereof
JPS62501132A (en) * 1984-12-14 1987-05-07 ドレナ−ト・クラウス bone substitute material
DE3447583A1 (en) * 1984-12-28 1986-07-10 Battelle-Institut E.V., 6000 Frankfurt METHOD FOR PRODUCING IMPLANTABLE BONE REPLACEMENT MATERIALS
LU85727A1 (en) * 1985-01-11 1986-08-04 Professeur Andre Vincent JOINT PROSTHESIS AND TOOL FOR MOUNTING CELLE-DI
US4722870A (en) * 1985-01-22 1988-02-02 Interpore International Metal-ceramic composite material useful for implant devices
DE3524020A1 (en) * 1985-03-30 1986-10-02 M A N Technologie GmbH, 8000 München METHOD FOR TREATING BONE REPLACEMENT IMPLANTS
DE3516411A1 (en) * 1985-05-07 1986-11-13 Plasmainvent AG, Zug COATING OF AN IMPLANT BODY
US5053049A (en) * 1985-05-29 1991-10-01 Baxter International Flexible prostheses of predetermined shapes and process for making same
US4627853A (en) * 1985-05-29 1986-12-09 American Hospital Supply Corporation Method of producing prostheses for replacement of articular cartilage and prostheses so produced
US4678470A (en) * 1985-05-29 1987-07-07 American Hospital Supply Corporation Bone-grafting material
US4964868A (en) * 1985-07-25 1990-10-23 Harrington Arthritis Research Center Knee prosthesis
US4714473A (en) * 1985-07-25 1987-12-22 Harrington Arthritis Research Center Knee prosthesis
DD246028A1 (en) * 1986-02-12 1987-05-27 Karl Marx Stadt Tech Hochschul CERAMIZED METAL IMPLANT
DE3615732A1 (en) * 1986-05-09 1987-11-12 Leitz Ernst Gmbh COMPOSITE MATERIAL FOR PROSTHETIC PURPOSES, METHOD FOR THE PRODUCTION THEREOF AND USE OF THE COMPOSITE MATERIAL OR. APPLICATION OF THE PRODUCTION METHOD FOR COATING PROSTHESES
JPS6346171A (en) * 1986-06-06 1988-02-27 旭光学工業株式会社 Support of medical device stayed in living body
US4728335A (en) * 1986-12-15 1988-03-01 Jurgutis John A Hip prosthesis
US4843112A (en) * 1987-03-12 1989-06-27 The Beth Israel Hospital Association Bioerodable implant composition
US5085861A (en) * 1987-03-12 1992-02-04 The Beth Israel Hospital Association Bioerodable implant composition comprising crosslinked biodegradable polyesters
FI78232C (en) * 1987-06-15 1989-07-10 Trident Oy IMPLANTS, SOM ERSAETTER EN TAND ELLER EN DEL AV BENVAEVNADEN MED SYNTETISKT MATERIAL.
DE3723650A1 (en) * 1987-07-17 1989-01-26 Krupp Gmbh METHOD FOR COATING TITANIUM AND TITANIUM ALLOYS
JP2829318B2 (en) * 1988-06-10 1998-11-25 春幸 川原 Frameless, coreless porous endosseous implant
DD282180A5 (en) * 1989-03-03 1990-09-05 Univ Schiller Jena PROCESS FOR THE PRODUCTION OF BIOACTIVELY AND MECHANICALLY HIGHLY BELATIBLE IMPLANTS
US5147403A (en) * 1989-03-15 1992-09-15 United States Gypsum Company Prosthesis implantation method
EP0410010B1 (en) * 1989-07-22 1993-10-27 Johannes Friedrich Prof. Dr. Osborn Osteotropic implant material
US5097843A (en) * 1990-04-10 1992-03-24 Siemens-Pacesetter, Inc. Porous electrode for a pacemaker
US6464713B2 (en) * 1990-06-28 2002-10-15 Peter M. Bonutti Body tissue fastening
US7208013B1 (en) 1990-06-28 2007-04-24 Bonutti Ip, Llc Composite surgical devices
US5330826A (en) * 1990-08-13 1994-07-19 Mcdonnell Douglas Corporation Preparation of ceramic-metal coatings
ATE139126T1 (en) * 1990-09-10 1996-06-15 Synthes Ag MEMBRANE FOR BONE REGENERATION
WO1992014422A1 (en) * 1991-02-20 1992-09-03 Tdk Corporation Composite bio-implant and production method therefor
JPH06205794A (en) * 1993-01-11 1994-07-26 Tdk Corp Composite implant to living body and its manufacture
US5368881A (en) * 1993-06-10 1994-11-29 Depuy, Inc. Prosthesis with highly convoluted surface
DE19581649T1 (en) * 1994-05-24 1997-05-07 Implico Bv Biological material and bone implant for bone restoration and exchange
DE19504386C2 (en) * 1995-02-10 1997-08-28 Univ Dresden Tech Process for the production of a graded coating from calcium phosphate phases and metal oxide phases on metallic implants
US5702449A (en) * 1995-06-07 1997-12-30 Danek Medical, Inc. Reinforced porous spinal implants
US6039762A (en) * 1995-06-07 2000-03-21 Sdgi Holdings, Inc. Reinforced bone graft substitutes
US6209621B1 (en) * 1995-07-07 2001-04-03 Depuy Orthopaedics, Inc. Implantable prostheses with metallic porous bead preforms applied during casting and method of forming the same
US5718717A (en) * 1996-08-19 1998-02-17 Bonutti; Peter M. Suture anchor
US6033438A (en) * 1997-06-03 2000-03-07 Sdgi Holdings, Inc. Open intervertebral spacer
US20050216059A1 (en) * 2002-09-05 2005-09-29 Bonutti Peter M Method and apparatus for securing a suture
WO1999030632A1 (en) * 1997-12-18 1999-06-24 Comfort Biomedical, Inc. Bone augmentation for prosthetic implants and the like
US6214049B1 (en) 1999-01-14 2001-04-10 Comfort Biomedical, Inc. Method and apparatus for augmentating osteointegration of prosthetic implant devices
US6045551A (en) 1998-02-06 2000-04-04 Bonutti; Peter M. Bone suture
SE513036C2 (en) * 1998-10-02 2000-06-26 Doxa Certex Ab Methods to prepare improved biofunctional composite materials based on apatite by minimizing unwanted reactions in the preparation of the materials
US6174311B1 (en) * 1998-10-28 2001-01-16 Sdgi Holdings, Inc. Interbody fusion grafts and instrumentation
US6592609B1 (en) * 1999-08-09 2003-07-15 Bonutti 2003 Trust-A Method and apparatus for securing tissue
US6368343B1 (en) 2000-03-13 2002-04-09 Peter M. Bonutti Method of using ultrasonic vibration to secure body tissue
US6447516B1 (en) 1999-08-09 2002-09-10 Peter M. Bonutti Method of securing tissue
US6635073B2 (en) 2000-05-03 2003-10-21 Peter M. Bonutti Method of securing body tissue
US8932330B2 (en) 2000-03-13 2015-01-13 P Tech, Llc Method and device for securing body tissue
US9138222B2 (en) 2000-03-13 2015-09-22 P Tech, Llc Method and device for securing body tissue
US7094251B2 (en) * 2002-08-27 2006-08-22 Marctec, Llc. Apparatus and method for securing a suture
US6495168B2 (en) 2000-03-24 2002-12-17 Ustherapeutics, Llc Nutritional supplements formulated from bioactive materials
US20020106611A1 (en) * 2001-01-19 2002-08-08 Sutapa Bhaduri Metal part having a dense core and porous periphery, biocompatible prosthesis and microwave sintering
US7597715B2 (en) 2005-04-21 2009-10-06 Biomet Manufacturing Corp. Method and apparatus for use of porous implants
US8123814B2 (en) 2001-02-23 2012-02-28 Biomet Manufacturing Corp. Method and appartus for acetabular reconstruction
WO2003002243A2 (en) 2001-06-27 2003-01-09 Remon Medical Technologies Ltd. Method and device for electrochemical formation of therapeutic species in vivo
US6719765B2 (en) 2001-12-03 2004-04-13 Bonutti 2003 Trust-A Magnetic suturing system and method
US9155544B2 (en) 2002-03-20 2015-10-13 P Tech, Llc Robotic systems and methods
FR2850282B1 (en) * 2003-01-27 2007-04-06 Jerome Asius INJECTABLE IMPLANT BASED ON CERAMIC FOR THE FILLING OF WRINKLES, CUTANEOUS DEPRESSIONS AND SCARS, AND ITS PREPARATION
US7497864B2 (en) * 2003-04-30 2009-03-03 Marctec, Llc. Tissue fastener and methods for using same
DE10360813A1 (en) * 2003-12-23 2005-07-28 Universität Hamburg Hydroxylapatite-metal composite and a method for its production
US20080039873A1 (en) * 2004-03-09 2008-02-14 Marctec, Llc. Method and device for securing body tissue
US9271766B2 (en) 2004-10-26 2016-03-01 P Tech, Llc Devices and methods for stabilizing tissue and implants
US9173647B2 (en) 2004-10-26 2015-11-03 P Tech, Llc Tissue fixation system
US20060089646A1 (en) * 2004-10-26 2006-04-27 Bonutti Peter M Devices and methods for stabilizing tissue and implants
US9463012B2 (en) 2004-10-26 2016-10-11 P Tech, Llc Apparatus for guiding and positioning an implant
US9089323B2 (en) 2005-02-22 2015-07-28 P Tech, Llc Device and method for securing body tissue
US8021432B2 (en) * 2005-12-05 2011-09-20 Biomet Manufacturing Corp. Apparatus for use of porous implants
US8266780B2 (en) * 2005-04-21 2012-09-18 Biomet Manufacturing Corp. Method and apparatus for use of porous implants
US8292967B2 (en) * 2005-04-21 2012-10-23 Biomet Manufacturing Corp. Method and apparatus for use of porous implants
US8066778B2 (en) * 2005-04-21 2011-11-29 Biomet Manufacturing Corp. Porous metal cup with cobalt bearing surface
US20070158446A1 (en) * 2006-01-05 2007-07-12 Howmedica Osteonics Corp. Method for fabricating a medical implant component and such component
US8187660B2 (en) * 2006-01-05 2012-05-29 Howmedica Osteonics Corp. Method for fabricating a medical implant component and such component
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US20070179615A1 (en) * 2006-01-31 2007-08-02 Sdgi Holdings, Inc. Intervertebral prosthetic disc
US20070179618A1 (en) * 2006-01-31 2007-08-02 Sdgi Holdings, Inc. Intervertebral prosthetic disc
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US11253296B2 (en) 2006-02-07 2022-02-22 P Tech, Llc Methods and devices for intracorporeal bonding of implants with thermal energy
US11278331B2 (en) 2006-02-07 2022-03-22 P Tech Llc Method and devices for intracorporeal bonding of implants with thermal energy
US7967820B2 (en) 2006-02-07 2011-06-28 P Tech, Llc. Methods and devices for trauma welding
US8496657B2 (en) * 2006-02-07 2013-07-30 P Tech, Llc. Methods for utilizing vibratory energy to weld, stake and/or remove implants
US20070196642A1 (en) * 2006-02-17 2007-08-23 Feldstein Michael D Coating for biological rejuvenation
US7635447B2 (en) * 2006-02-17 2009-12-22 Biomet Manufacturing Corp. Method and apparatus for forming porous metal implants
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US11246638B2 (en) 2006-05-03 2022-02-15 P Tech, Llc Methods and devices for utilizing bondable materials
EP2054537A2 (en) 2006-08-02 2009-05-06 Boston Scientific Scimed, Inc. Endoprosthesis with three-dimensional disintegration control
US8043377B2 (en) * 2006-09-02 2011-10-25 Osprey Biomedical, Inc. Implantable intervertebral fusion device
ES2357661T3 (en) 2006-09-15 2011-04-28 Boston Scientific Scimed, Inc. BIOEROSIONABLE ENDOPROOTHESIS WITH BIOESTABLE INORGANIC LAYERS.
WO2008034047A2 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Endoprosthesis with adjustable surface features
CA2663220A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Medical devices and methods of making the same
ATE517590T1 (en) 2006-09-15 2011-08-15 Boston Scient Ltd BIOLOGICALLY ERODABLE ENDOPROTHESES
WO2008034031A2 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
JP2010503482A (en) 2006-09-18 2010-02-04 ボストン サイエンティフィック リミテッド Endoprosthesis
WO2008064672A2 (en) * 2006-11-27 2008-06-05 Berthold Nies Bone implant, and set for the production of bone implants
JP5355418B2 (en) 2006-12-28 2013-11-27 ボストン サイエンティフィック リミテッド Bioerodible endoprosthesis and method for manufacturing the bioerodible endoprosthesis
US8617185B2 (en) 2007-02-13 2013-12-31 P Tech, Llc. Fixation device
US8066770B2 (en) * 2007-05-31 2011-11-29 Depuy Products, Inc. Sintered coatings for implantable prostheses
US20090012620A1 (en) * 2007-07-06 2009-01-08 Jim Youssef Implantable Cervical Fusion Device
US20090008365A1 (en) 2007-07-06 2009-01-08 Depuy Products, Inc. Microtextured Implants and Methods of Making Same
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
CN101842062B (en) * 2007-09-25 2013-04-03 拜欧米特制造公司 Method for manufacturing cementless tibial tray
US9295564B2 (en) * 2007-10-19 2016-03-29 Spinesmith Partners, L.P. Fusion methods using autologous stem cells
US20090105824A1 (en) * 2007-10-19 2009-04-23 Jones Robert J Spinal fusion device and associated methods
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
CA2753592A1 (en) * 2009-02-24 2010-09-02 P Tech, Llc Methods and devices for utilizing bondable materials
EP2403546A2 (en) 2009-03-02 2012-01-11 Boston Scientific Scimed, Inc. Self-buffering medical implants
AU2010201402C1 (en) 2009-04-15 2014-10-16 Depuy Products, Inc. Nanotextured cobalt-chromium alloy articles having high wettability and method of producing same
US8696759B2 (en) * 2009-04-15 2014-04-15 DePuy Synthes Products, LLC Methods and devices for implants with calcium phosphate
US8303830B2 (en) 2009-04-15 2012-11-06 Depuy Products, Inc. Micro and NANO scale surface textured titanium-containing articles and methods of producing same
US20100268227A1 (en) * 2009-04-15 2010-10-21 Depuy Products, Inc. Methods and Devices for Bone Attachment
US8383033B2 (en) 2009-10-08 2013-02-26 Biomet Manufacturing Corp. Method of bonding porous metal to metal substrates
US8475536B2 (en) * 2010-01-29 2013-07-02 DePuy Synthes Products, LLC Methods and devices for implants with improved cement adhesion
WO2011119573A1 (en) 2010-03-23 2011-09-29 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
US10076377B2 (en) 2013-01-05 2018-09-18 P Tech, Llc Fixation systems and methods
DE102015209007A1 (en) 2015-05-15 2016-11-17 Aesculap Ag Bone replacement materials, methods of making bone replacement material, and medical kits for treating bone defects
US10058393B2 (en) 2015-10-21 2018-08-28 P Tech, Llc Systems and methods for navigation and visualization
DE102016110622A1 (en) 2016-06-09 2017-12-14 Michael Gahlert Bone substitute made of zirconia ceramic
DE202016103296U1 (en) 2016-06-09 2017-09-18 Michael Gahlert Bone substitute made of zirconia ceramic
EP3578508B1 (en) * 2018-06-05 2022-09-14 CSEM Centre Suisse D'electronique Et De Microtechnique SA Methods for manufacturing micromechanical components and method for manufacturing a mould insert component

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2008010C3 (en) * 1970-02-20 1980-07-10 Schneider Gmbh & Co, 5020 Frechen Process for the manufacture of dental implants
CA962806A (en) * 1970-06-04 1975-02-18 Ontario Research Foundation Surgical prosthetic device
DE2306552B2 (en) * 1973-02-10 1975-07-03 Friedrichsfeld Gmbh Steinzeug- Und Kunststoffwerke, 6800 Mannheim Joint endoprosthesis
DE2546824C2 (en) * 1975-10-18 1986-05-07 Ernst Leitz Wetzlar Gmbh, 6330 Wetzlar Coated endoprosthesis and process for their manufacture
DE2620907C3 (en) * 1976-05-12 1984-09-20 Battelle-Institut E.V., 6000 Frankfurt Anchoring for highly stressed endoprostheses
DE2620891C3 (en) * 1976-05-12 1989-06-29 Battelle-Institut eV, 6000 Frankfurt Solid, resorbable bone substitute, bone composite or prosthesis anchoring material
NL7704659A (en) * 1976-05-12 1977-11-15 Battelle Institut E V BONE REPLACEMENT, BONE JOINT, OR PROSTHESIS ANCHORING MATERIAL.
DE2620890C3 (en) * 1976-05-12 1987-09-10 Battelle-Institut eV, 6000 Frankfurt Plastic mass based on sintered calcium phosphates for implantable bone replacement, bone composite or prosthesis anchoring materials
DE2659916A1 (en) * 1976-05-14 1977-11-24 Pfaudler Werke Ag Surgical prosthetic fixing with self cutting screw threads - having abrasive coating to facilitate insertion and improve screw grip
JPS59219B2 (en) * 1976-06-07 1984-01-05 旭光学工業株式会社 Artificial teeth, artificial bones and their manufacturing method
GB1550010A (en) * 1976-12-15 1979-08-08 Ontario Research Foundation Surgical prosthetic device or implant having pure metal porous coating
DE2733394C3 (en) * 1977-07-23 1984-10-25 Riess, Guido, Prof. Dr.med.dent., 8100 Garmisch-Partenkirchen Artificial tooth with implantable tooth root
US4156943A (en) * 1977-08-24 1979-06-05 Collier John P High-strength porous prosthetic device and process for making the same
US4195366A (en) * 1977-12-23 1980-04-01 Sterling Drug Inc. Whitlockite ceramic

Also Published As

Publication number Publication date
DE2827529A1 (en) 1980-01-03
EP0006544A1 (en) 1980-01-09
US4309488A (en) 1982-01-05
JPS558797A (en) 1980-01-22
DE2827529C2 (en) 1982-09-30
EP0006544B1 (en) 1981-11-04
CA1121102A (en) 1982-04-06

Similar Documents

Publication Publication Date Title
ATE341T1 (en) IMPLANTABLE BONE REPLACEMENT MATERIALS BASED ON CALCIUM PHOSPHATE CERAMIC IN A MATRIX MATERIAL AND PROCESS FOR THEIR MANUFACTURE.
DE3886493D1 (en) Osteoinductive collagen composition to fight bone defects.
HUT42329A (en) Process for producing compositions for curing wounds
RU94045951A (en) Covering material and method of its preparing, implant for biomedicinal use
JPS5618866A (en) Transplantation material piece which can be used as bonding material for bone and can biologically be decomposed
SE7705418L (en) ANCHORING FOR HIGH-LOADED END PROSTHESES
DE69029735D1 (en) SYNTHETIC MATERIAL THAT PROMOTES THE ADDITION, GROWTH AND FASTENING OF EPITHELIC CELLS, PROSTHETIC DEVICE FOR SUBEPITHELIAL IMPLANTATION AND TREATED LENS
FI834150A0 (en) POLYMER ACRYLIC PROCESSORS
GB1455360A (en) Porous synthetic materials
JPS51106114A (en)
GB2169914B (en) Implant material for replacing hard tissue of living bodies
HUT47977A (en) Polipeptides, process for their production and process for production of medical compositions containing such active substances
ATE225192T1 (en) MATERIAL FOR BONE PROSTHESIS CONTAINING CALCIUM CARBONATE PARTICLES DISPERSED IN A BIORESORBABLE POLYMER MATRIX
IT1125451B (en) ARTIFICIAL DENTAL ROOT
ATE79763T1 (en) USE OF AT LEAST ONE CYTOKINE IN THE MANUFACTURE OF A MEDICATION FOR THE SYSTEMIC TREATMENT OF PRAENEOPLASTIC LESIONS.
BR8501365A (en) SEALED COVER, ARTICLE USABLE TO TREAT FABRICS, WATERPROOF POLYMER COMPOSITION, MODELABLE AS A SELF-SUPPORT FILM, FINE, SELF-SUPPORT FILM AND PROCESS TO INCREASE THE STRENGTH OF POLLINKING ALCOHOL FILTERS
PT82788B (en) A process for the preparation of an anti-corrosive coating composition comprising metal-bearing particles and phosphorus material
JPS5543119A (en) Titanium ester contained vulcanizable organopolysiloxane composition and its manufacture
Brook et al. In vitro interaction between primary bone organ cultures, glass-ionomer cements and hydroxyapatite/tricalcium phosphate ceramics
FR2230598B1 (en)
ATE77239T1 (en) PREPARATION FOR STIMULATION OF CHONDROCYTES AND OSTEOBLAST (OSSEIN HYDROXYAPATITE COMPOUND), METHOD OF MANUFACTURE AND PHARMACEUTICAL PRODUCTS CONTAINING THEM.
FR2563108B1 (en) ANTIACID PHARMACEUTICAL COMPOSITION AND AQUEOUS SUSPENSION CONTAINING THE SAME
FR2702649B1 (en) PROCESS AND KIT FOR MAKING A CERAMIC CUP TO PREPARE A DENTAL RECONSTRUCTION.
ATE76759T1 (en) CALCIUM PHOSPHATE-CONTAINING, BIOCOMPATIBLE LAYERED BODY AND PROCESS FOR ITS PRODUCTION.
ATE37142T1 (en) USE OF THE HETEROPOLYANION (NASB9W21O86)18- IN THE MANUFACTURE OF A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF AIDS AND ANALOGUE SYNDROMES.

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee