ATE342270T1 - Pharmazeutische zusammensetzung enthaltend baicalin, chlorogensäure und forsythiaside in isolierter und gereinigter form und verfahren zur herstellung - Google Patents
Pharmazeutische zusammensetzung enthaltend baicalin, chlorogensäure und forsythiaside in isolierter und gereinigter form und verfahren zur herstellungInfo
- Publication number
- ATE342270T1 ATE342270T1 AT99901358T AT99901358T ATE342270T1 AT E342270 T1 ATE342270 T1 AT E342270T1 AT 99901358 T AT99901358 T AT 99901358T AT 99901358 T AT99901358 T AT 99901358T AT E342270 T1 ATE342270 T1 AT E342270T1
- Authority
- AT
- Austria
- Prior art keywords
- chlorogenic acid
- isolated
- pharmaceutical composition
- baicalin
- present
- Prior art date
Links
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 title abstract 4
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 title abstract 4
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 title abstract 4
- IKIIZLYTISPENI-ZFORQUDYSA-N baicalin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IKIIZLYTISPENI-ZFORQUDYSA-N 0.000 title abstract 4
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 title abstract 4
- 229940074393 chlorogenic acid Drugs 0.000 title abstract 4
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 title abstract 4
- 235000001368 chlorogenic acid Nutrition 0.000 title abstract 4
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 title abstract 4
- IPQKDIRUZHOIOM-UHFFFAOYSA-N Oroxin A Natural products OC1C(O)C(O)C(CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IPQKDIRUZHOIOM-UHFFFAOYSA-N 0.000 title abstract 3
- 229960003321 baicalin Drugs 0.000 title abstract 3
- AQHDANHUMGXSJZ-UHFFFAOYSA-N baicalin Natural products OC1C(O)C(C(O)CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 AQHDANHUMGXSJZ-UHFFFAOYSA-N 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000284 extract Substances 0.000 abstract 6
- DTOUWTJYUCZJQD-UJERWXFOSA-N Forsythiaside Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](OC(=O)\C=C\C=2C=C(O)C(O)=CC=2)[C@H](O)[C@@H](O)[C@H](OCCC=2C=C(O)C(O)=CC=2)O1 DTOUWTJYUCZJQD-UJERWXFOSA-N 0.000 abstract 3
- DTOUWTJYUCZJQD-QJDQKFITSA-N Forsythiaside Natural products C[C@@H]1O[C@H](OC[C@H]2O[C@@H](OCCc3ccc(O)c(O)c3)[C@H](O)[C@@H](O)[C@@H]2OC(=O)C=Cc4ccc(O)c(O)c4)[C@H](O)[C@H](O)[C@H]1O DTOUWTJYUCZJQD-QJDQKFITSA-N 0.000 abstract 3
- 241000196324 Embryophyta Species 0.000 abstract 2
- 241000208828 Caprifoliaceae Species 0.000 abstract 1
- 241000628997 Flos Species 0.000 abstract 1
- 241000207923 Lamiaceae Species 0.000 abstract 1
- 241000245240 Lonicera Species 0.000 abstract 1
- 241000207834 Oleaceae Species 0.000 abstract 1
- 241000207929 Scutellaria Species 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/04—Disaccharides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Botany (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Alternative & Traditional Medicine (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/005,934 US6083921A (en) | 1998-01-12 | 1998-01-12 | Pharmaceutical compositions and method of using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE342270T1 true ATE342270T1 (de) | 2006-11-15 |
Family
ID=21718433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99901358T ATE342270T1 (de) | 1998-01-12 | 1999-01-07 | Pharmazeutische zusammensetzung enthaltend baicalin, chlorogensäure und forsythiaside in isolierter und gereinigter form und verfahren zur herstellung |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6083921A (de) |
| EP (1) | EP1047439B1 (de) |
| AT (1) | ATE342270T1 (de) |
| AU (1) | AU765951B2 (de) |
| CA (1) | CA2317453A1 (de) |
| DE (1) | DE69933539T2 (de) |
| WO (1) | WO1999034812A1 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6290995B1 (en) * | 2000-02-08 | 2001-09-18 | Zhao Xinxian | Plant drug for preventing cancer II |
| US20060143180A1 (en) * | 2000-03-09 | 2006-06-29 | Pkware, Inc. | System and method for manipulating and managing computer archive files |
| CN1309399C (zh) * | 2000-10-25 | 2007-04-11 | 国家中药制药工程技术研究中心 | 复方双黄连制剂及制备方法 |
| US6632459B2 (en) * | 2000-12-11 | 2003-10-14 | Nutricia N.V. | Chlorogenic acid and an analog thereof for immune system stimulation |
| US6455070B1 (en) | 2001-02-15 | 2002-09-24 | East Park Research, Inc. | Composition for treating symptoms of influenza |
| US20030165588A1 (en) | 2002-03-01 | 2003-09-04 | Unigen Pharmaceuticals, Inc. | Identification of free-B-ring flavonoids as potent COX-2 inhibitors |
| US7972632B2 (en) | 2003-02-28 | 2011-07-05 | Unigen Pharmaceuticals, Inc. | Identification of Free-B-Ring flavonoids as potent COX-2 inhibitors |
| US7108868B2 (en) | 2002-03-22 | 2006-09-19 | Unigen Pharmaceuticals, Inc. | Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia |
| US8945518B2 (en) * | 2002-04-30 | 2015-02-03 | Unigen, Inc. | Formulation of dual eicosanoid system and cytokine system inhibitors for use in the prevention and treatment of oral diseases and conditions |
| US8034387B2 (en) * | 2002-04-30 | 2011-10-11 | Unigen, Inc. | Formulation of a mixture of free-B-ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments |
| EP1503778B1 (de) | 2002-04-30 | 2009-08-05 | Unigen Pharmaceuticals, Inc. | Formulierung eines gemisches aus flavonoiden und flavanen mit freiem b ring als therapeutisches mittel |
| WO2003101446A1 (en) * | 2002-05-31 | 2003-12-11 | Council Of Scientific And Industrial Research | A herbal molecule as potential anti-leukemic drug |
| DE10224456A1 (de) * | 2002-06-03 | 2004-01-22 | Beiersdorf Ag | Verwendung von Jelängerjelieber-Blütenextrakt zur Herstellung kosmetischer oder dermatologischer Zubereitungen zur Prophylaxe und Behandlung von entzündlic hen Hautzuständen und/oder zum Hautschutz bei empfindlich determinierter Haut |
| JP2006519231A (ja) * | 2003-02-26 | 2006-08-24 | ユニゲン・ファーマシューティカルス・インコーポレーテッド | 炭水化物誘導性疾患および状態の予防および処置用の製剤 |
| BRPI0409179A (pt) | 2003-04-04 | 2006-05-02 | Unigen Pharmaceuticals Inc | formulação de inibidores duplos de ciclooxigenase (cox) e lipoxigenase (lox) para cuidados com a pele de mamìferos |
| GB2388581A (en) * | 2003-08-22 | 2003-11-19 | Danisco | Coated aqueous beads |
| JP4926707B2 (ja) * | 2003-08-22 | 2012-05-09 | ダニスコ エイ/エス | 封入化抗菌材料 |
| CA2537459A1 (en) * | 2003-09-02 | 2005-03-10 | Unigen Pharmaceuticals, Inc. | Formulation of a mixture of free-b-ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments |
| KR20050037102A (ko) * | 2003-10-17 | 2005-04-21 | 한국 한의학 연구원 | 비만 억제용 조성물 |
| US7605135B2 (en) * | 2003-11-10 | 2009-10-20 | The University Of Hong Kong | Baicalin as a treatment for SARS infection |
| GB2425476A (en) * | 2004-02-27 | 2006-11-01 | Phynova Ltd | Multi-herb medicament for the treatment of SARS |
| GB2425477B (en) * | 2004-02-27 | 2008-04-23 | Phynova Ltd | Extract of Scutellaria for the treatment of RSV |
| US20100311827A1 (en) * | 2006-07-21 | 2010-12-09 | Mohsen Daneshtalab | Chlorogenic acid derivatives and their use as anti-fungal agents |
| KR100761248B1 (ko) | 2006-10-12 | 2007-10-04 | 주식회사 유니젠 | 대나무 및 황금 추출물을 유효성분으로 함유하는 아토피성피부염 치료를 위한 조성물 |
| CN101209255B (zh) * | 2006-12-28 | 2013-04-03 | 山东新时代药业有限公司 | 连翘酯苷注射制剂及其制备方法 |
| MY184667A (en) * | 2007-07-23 | 2021-04-15 | Malaysian Palm Oil Board | An antiviral composition |
| ES2962777T3 (es) | 2007-11-15 | 2024-03-21 | Amgen Inc | Formulación acuosa de anticuerpos estabilizada por antioxidantes para la administración parenteral |
| CA2786169C (en) * | 2009-12-30 | 2018-09-25 | Allan Sik-Yin Lau | Materials and methods for prevention and treatment of viral infections |
| CN102526208A (zh) * | 2010-12-16 | 2012-07-04 | 四川科伦药物研究有限公司 | 一种双黄连泡腾片及其制备方法 |
| CN103102270A (zh) * | 2011-11-09 | 2013-05-15 | 安康市天源植物提取有限公司 | 一种绿原酸的制取方法 |
| KR101182582B1 (ko) * | 2012-04-27 | 2012-09-18 | 주식회사 휴온스 | 활성성분이 증대된 금은화 정제물을 제조하는 제조방법 및 이를 함유한 패혈증 및 패혈성 쇼크의 치료 및 예방용 조성물 |
| KR101438332B1 (ko) | 2013-09-05 | 2014-09-04 | 경희대학교 산학협력단 | 포시티아사이드-에이를 포함하는 탈모방지 또는 발모촉진용 조성물 |
| CN104950063B (zh) * | 2015-06-19 | 2017-03-01 | 广西壮族自治区梧州食品药品检验所 | 银黄颗粒中绿原酸含量测定方法 |
| CN105675784B (zh) * | 2016-01-26 | 2018-08-14 | 中国医学科学院肿瘤医院 | Uplc-ms/ms法测定人血浆和尿液中绿原酸的浓度 |
| CN108452012B (zh) * | 2017-02-20 | 2021-04-06 | 国药集团广东环球制药有限公司 | 三黄片黄芩浸膏粉的制备方法 |
| CN110151821B (zh) * | 2019-05-09 | 2021-08-17 | 中山市恒生药业有限公司 | 一种银黄颗粒及其制备方法 |
| CN110812531B (zh) * | 2019-11-12 | 2022-08-26 | 上海交通大学医学院附属第九人民医院 | 复合材料及其制备方法和在脱钙骨基质支架中的应用 |
| CN113209164B (zh) * | 2020-02-06 | 2023-01-20 | 中国科学院上海药物研究所 | 黄芩、连翘、金银花主要成分及其组合物在抗冠状病毒中的应用 |
| US20210369753A1 (en) * | 2020-05-27 | 2021-12-02 | Brilliant Lab LLC | Nutrient composition able to inhibit quorum sensing |
| CN112946113B (zh) * | 2021-02-01 | 2022-09-30 | 湖北医药学院 | 一种鉴别道地药材十堰连翘基源的方法 |
| CN114586980A (zh) * | 2022-03-11 | 2022-06-07 | 安徽黑娃食品科技有限公司 | 一种金银花提取物的制备方法及其在花生中的应用 |
| CN115990187B (zh) * | 2022-12-07 | 2024-02-06 | 北京中医药大学 | 一种用于改善阿尔茨海默病的中药提取物及其应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US2224807A (en) * | 1936-12-24 | 1940-12-10 | Winthrop Chem Co Inc | Glucosides of polyhydroxy-flavones and polyhydroxy-flavanones |
| US2425291A (en) * | 1944-03-03 | 1947-08-05 | Fruit Growers Exchange Ca | Alkylated chalcone derivatives and methods of preparing the same |
| US2727890A (en) * | 1953-03-02 | 1955-12-20 | Simon H Wender | Synthesis of an aldohexoside of a flavonol |
| US3700775A (en) * | 1970-09-11 | 1972-10-24 | Luigi Turbanti | Choleretic activity |
| US4124724A (en) * | 1975-12-08 | 1978-11-07 | Agoro John W | Crystalline caffeic acid derivatives and compositions and method for treating snakebite |
| IT1098309B (it) * | 1978-06-02 | 1985-09-07 | Snam Progetti | Processo per la preparazione di isolato proteico da farina di girasole |
| JPS5562004A (en) * | 1978-11-02 | 1980-05-10 | Kureha Chem Ind Co Ltd | Control agent against plant viral disease |
| NZ193316A (en) * | 1979-04-10 | 1984-07-31 | Hoffmann La Roche | 3-alkoxyflavone derivatives and pharmaceutical compositions |
| DE3070086D1 (en) * | 1979-12-03 | 1985-03-14 | Kitasato Inst | A process for preparing substances having interferon inducing activity |
| US4465673A (en) * | 1983-01-10 | 1984-08-14 | Yasuo Tanaka | Pentagalloylglucose antiviral composition |
| JPS60243016A (ja) * | 1984-05-17 | 1985-12-03 | Tsumura Juntendo Inc | 抗インフルエンザウイルス剤 |
| DK17885D0 (da) * | 1985-01-14 | 1985-01-14 | Karlsson Karl Anders | Antiviralt middel |
| DE3603574C1 (de) * | 1986-02-06 | 1987-07-23 | Ergo Forschungsgmbh | Verfahren zur Gewinnung von Chlorogensaeure |
| ATE87204T1 (de) * | 1987-12-10 | 1993-04-15 | Tsumura & Co | Anti-retrovirales arzneimittel. |
| JP2974370B2 (ja) * | 1990-05-11 | 1999-11-10 | 社団法人北里研究所 | シアリダーゼ阻害剤 |
| US5178865A (en) * | 1990-06-19 | 1993-01-12 | Cedars-Sinai Medical Center | Chinese herbal extracts in the treatment of hiv related disease in vitro |
| US5380916A (en) * | 1990-11-02 | 1995-01-10 | University Of Florida | Method for the isolation and purification of taxane derivatives |
| US5478579A (en) * | 1991-02-06 | 1995-12-26 | Biodyn Medical Research, Inc. | Method for treatment of osteoporosis |
| US5411733A (en) * | 1992-04-27 | 1995-05-02 | Hozumi; Toyoharu | Antiviral agent containing crude drug |
| CN1089848A (zh) * | 1993-01-15 | 1994-07-27 | 哈尔滨中药四厂 | 双黄连胶囊及其制备方法 |
| CN1090185A (zh) * | 1993-01-20 | 1994-08-03 | 哈尔滨中药四厂 | 双黄连口服液及其制备方法 |
| CN1117851A (zh) * | 1994-01-07 | 1996-03-06 | 山东中医学院 | 银黄含片及其制备工艺 |
| CN1154246A (zh) * | 1996-01-09 | 1997-07-16 | 李宏 | 一种抗菌抗病毒药物的组方 |
-
1998
- 1998-01-12 US US09/005,934 patent/US6083921A/en not_active Expired - Fee Related
-
1999
- 1999-01-07 WO PCT/US1999/000334 patent/WO1999034812A1/en not_active Ceased
- 1999-01-07 AT AT99901358T patent/ATE342270T1/de not_active IP Right Cessation
- 1999-01-07 EP EP99901358A patent/EP1047439B1/de not_active Expired - Lifetime
- 1999-01-07 AU AU21075/99A patent/AU765951B2/en not_active Ceased
- 1999-01-07 CA CA002317453A patent/CA2317453A1/en not_active Abandoned
- 1999-01-07 DE DE69933539T patent/DE69933539T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1047439A1 (de) | 2000-11-02 |
| AU765951B2 (en) | 2003-10-02 |
| DE69933539D1 (de) | 2006-11-23 |
| WO1999034812A1 (en) | 1999-07-15 |
| CA2317453A1 (en) | 1999-07-15 |
| DE69933539T2 (de) | 2007-07-05 |
| EP1047439B1 (de) | 2006-10-11 |
| AU2107599A (en) | 1999-07-26 |
| US6083921A (en) | 2000-07-04 |
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