ATE342270T1 - Pharmazeutische zusammensetzung enthaltend baicalin, chlorogensäure und forsythiaside in isolierter und gereinigter form und verfahren zur herstellung - Google Patents

Pharmazeutische zusammensetzung enthaltend baicalin, chlorogensäure und forsythiaside in isolierter und gereinigter form und verfahren zur herstellung

Info

Publication number: ATE342270T1
Authority: AT; Austria
Prior art keywords: chlorogenic acid; isolated; pharmaceutical composition; baicalin; present
Prior art date: 1998-01-12

Application number

AT99901358T

Other languages

English (en)

Inventor

Kai Jian Xu

Original Assignee

Kai Jian Xu

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-01-12

Filing date

1999-01-07

Publication date

2006-11-15

1999-01-07 Application filed by Kai Jian Xu filed Critical Kai Jian Xu

2006-11-15 Application granted granted Critical

2006-11-15 Publication of ATE342270T1 publication Critical patent/ATE342270T1/de

Links

CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 title abstract 4
PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 title abstract 4
CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 title abstract 4
IKIIZLYTISPENI-ZFORQUDYSA-N baicalin Chemical compound O1[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IKIIZLYTISPENI-ZFORQUDYSA-N 0.000 title abstract 4
CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 title abstract 4
229940074393 chlorogenic acid Drugs 0.000 title abstract 4
FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 title abstract 4
235000001368 chlorogenic acid Nutrition 0.000 title abstract 4
BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 title abstract 4
IPQKDIRUZHOIOM-UHFFFAOYSA-N Oroxin A Natural products OC1C(O)C(O)C(CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 IPQKDIRUZHOIOM-UHFFFAOYSA-N 0.000 title abstract 3
229960003321 baicalin Drugs 0.000 title abstract 3
AQHDANHUMGXSJZ-UHFFFAOYSA-N baicalin Natural products OC1C(O)C(C(O)CO)OC1OC(C(=C1O)O)=CC2=C1C(=O)C=C(C=1C=CC=CC=1)O2 AQHDANHUMGXSJZ-UHFFFAOYSA-N 0.000 title abstract 3
239000008194 pharmaceutical composition Substances 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title 1
239000000284 extract Substances 0.000 abstract 6
DTOUWTJYUCZJQD-UJERWXFOSA-N Forsythiaside Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](OC(=O)\C=C\C=2C=C(O)C(O)=CC=2)[C@H](O)[C@@H](O)[C@H](OCCC=2C=C(O)C(O)=CC=2)O1 DTOUWTJYUCZJQD-UJERWXFOSA-N 0.000 abstract 3
DTOUWTJYUCZJQD-QJDQKFITSA-N Forsythiaside Natural products C[C@@H]1O[C@H](OC[C@H]2O[C@@H](OCCc3ccc(O)c(O)c3)[C@H](O)[C@@H](O)[C@@H]2OC(=O)C=Cc4ccc(O)c(O)c4)[C@H](O)[C@H](O)[C@H]1O DTOUWTJYUCZJQD-QJDQKFITSA-N 0.000 abstract 3
241000196324 Embryophyta Species 0.000 abstract 2
241000208828 Caprifoliaceae Species 0.000 abstract 1
241000628997 Flos Species 0.000 abstract 1
241000207923 Lamiaceae Species 0.000 abstract 1
241000245240 Lonicera Species 0.000 abstract 1
241000207834 Oleaceae Species 0.000 abstract 1
241000207929 Scutellaria Species 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
230000000840 anti-viral effect Effects 0.000 abstract 1
230000002519 immonomodulatory effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/04—Disaccharides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Natural Medicines & Medicinal Plants (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Microbiology (AREA)
Mycology (AREA)
Medical Informatics (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Botany (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Alternative & Traditional Medicine (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Neurosurgery (AREA)
Medicines Containing Plant Substances (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT99901358T 1998-01-12 1999-01-07 Pharmazeutische zusammensetzung enthaltend baicalin, chlorogensäure und forsythiaside in isolierter und gereinigter form und verfahren zur herstellung ATE342270T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US09/005,934 US6083921A (en)	1998-01-12	1998-01-12	Pharmaceutical compositions and method of using same

Publications (1)

Publication Number	Publication Date
ATE342270T1 true ATE342270T1 (de)	2006-11-15

Family

ID=21718433

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99901358T ATE342270T1 (de)	1998-01-12	1999-01-07	Pharmazeutische zusammensetzung enthaltend baicalin, chlorogensäure und forsythiaside in isolierter und gereinigter form und verfahren zur herstellung

Country Status (7)

Country	Link
US (1)	US6083921A (de)
EP (1)	EP1047439B1 (de)
AT (1)	ATE342270T1 (de)
AU (1)	AU765951B2 (de)
CA (1)	CA2317453A1 (de)
DE (1)	DE69933539T2 (de)
WO (1)	WO1999034812A1 (de)

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KR20050037102A (ko) *	2003-10-17	2005-04-21	한국 한의학 연구원	비만 억제용 조성물
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US20100311827A1 (en) *	2006-07-21	2010-12-09	Mohsen Daneshtalab	Chlorogenic acid derivatives and their use as anti-fungal agents
KR100761248B1 (ko)	2006-10-12	2007-10-04	주식회사 유니젠	대나무 및 황금 추출물을 유효성분으로 함유하는 아토피성피부염 치료를 위한 조성물
CN101209255B (zh) *	2006-12-28	2013-04-03	山东新时代药业有限公司	连翘酯苷注射制剂及其制备方法
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CN102526208A (zh) *	2010-12-16	2012-07-04	四川科伦药物研究有限公司	一种双黄连泡腾片及其制备方法
CN103102270A (zh) *	2011-11-09	2013-05-15	安康市天源植物提取有限公司	一种绿原酸的制取方法
KR101182582B1 (ko) *	2012-04-27	2012-09-18	주식회사 휴온스	활성성분이 증대된 금은화 정제물을 제조하는 제조방법 및 이를 함유한 패혈증 및 패혈성 쇼크의 치료 및 예방용 조성물
KR101438332B1 (ko)	2013-09-05	2014-09-04	경희대학교 산학협력단	포시티아사이드-에이를 포함하는 탈모방지 또는 발모촉진용 조성물
CN104950063B (zh) *	2015-06-19	2017-03-01	广西壮族自治区梧州食品药品检验所	银黄颗粒中绿原酸含量测定方法
CN105675784B (zh) *	2016-01-26	2018-08-14	中国医学科学院肿瘤医院	Uplc-ms/ms法测定人血浆和尿液中绿原酸的浓度
CN108452012B (zh) *	2017-02-20	2021-04-06	国药集团广东环球制药有限公司	三黄片黄芩浸膏粉的制备方法
CN110151821B (zh) *	2019-05-09	2021-08-17	中山市恒生药业有限公司	一种银黄颗粒及其制备方法
CN110812531B (zh) *	2019-11-12	2022-08-26	上海交通大学医学院附属第九人民医院	复合材料及其制备方法和在脱钙骨基质支架中的应用
CN113209164B (zh) *	2020-02-06	2023-01-20	中国科学院上海药物研究所	黄芩、连翘、金银花主要成分及其组合物在抗冠状病毒中的应用
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1998
- 1998-01-12 US US09/005,934 patent/US6083921A/en not_active Expired - Fee Related
1999
- 1999-01-07 EP EP99901358A patent/EP1047439B1/de not_active Expired - Lifetime
- 1999-01-07 CA CA002317453A patent/CA2317453A1/en not_active Abandoned
- 1999-01-07 WO PCT/US1999/000334 patent/WO1999034812A1/en not_active Ceased
- 1999-01-07 DE DE69933539T patent/DE69933539T2/de not_active Expired - Fee Related
- 1999-01-07 AU AU21075/99A patent/AU765951B2/en not_active Ceased
- 1999-01-07 AT AT99901358T patent/ATE342270T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO1999034812A1 (en)	1999-07-15
DE69933539D1 (de)	2006-11-23
AU765951B2 (en)	2003-10-02
US6083921A (en)	2000-07-04
AU2107599A (en)	1999-07-26
CA2317453A1 (en)	1999-07-15
DE69933539T2 (de)	2007-07-05
EP1047439A1 (de)	2000-11-02
EP1047439B1 (de)	2006-10-11

Legal Events

Date	Code	Title	Description
2007-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69933539D1 (de)	2006-11-23	Pharmazeutische zusammensetzung enthaltend baicalin, chlorogensäure und forsythiaside in isolierter und gereinigter form und verfahren zur herstellung
DE60206474D1 (de)	2005-11-10	Prozess zur herstellung eines matrin enthaltenden pflanzenextrakts
Kuppusamy et al.	1990	Structure-activity studies of flavonoids as inhibitors of hyaluronidase
WO2002060379A3 (en)	2003-03-13	Composition comprising extracts of flos lonicerae, fructus forsythiae and radix scutellariae, uses and preparation thereof
WO2002007743A3 (de)	2003-04-03	Piper methysticum pflanzenextrakt
EP0813875A3 (de)	1998-12-16	Hemmung der abnormalen Anhäufung von extrazellulärer Matrix
PT906761E (pt)	2004-11-30	Metodo de preparacao e utilizacao de produtos fitoquimicos
ID25661A (id)	2000-10-19	Komposisi ekstrak herbal dan metode pembuatannya yang memiliki kemampuan meningkatkan kekebalan
MX212260B (es)	2002-12-18	Composiciones de carbohidratos de planta como complementos dieteticos
AU2000246679A1 (en)	2001-11-12	Oral compositions comprising polyphenol herbal extracts
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