ATE342347T1 - Mikrofabrizierte vorrichtung zur analyse von zellen - Google Patents

Mikrofabrizierte vorrichtung zur analyse von zellen

Info

Publication number
ATE342347T1
ATE342347T1 AT02022306T AT02022306T ATE342347T1 AT E342347 T1 ATE342347 T1 AT E342347T1 AT 02022306 T AT02022306 T AT 02022306T AT 02022306 T AT02022306 T AT 02022306T AT E342347 T1 ATE342347 T1 AT E342347T1
Authority
AT
Austria
Prior art keywords
cell growth
cell
channel
cells
micro
Prior art date
Application number
AT02022306T
Other languages
English (en)
Inventor
Nicholas Thomas
Original Assignee
Gyros Patent Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gyros Patent Ab filed Critical Gyros Patent Ab
Application granted granted Critical
Publication of ATE342347T1 publication Critical patent/ATE342347T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/38—Caps; Covers; Plugs; Pouring means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/16—Particles; Beads; Granular material; Encapsulation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B01L2300/0806—Standardised forms, e.g. compact disc [CD] format
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/10—Means to control humidity and/or other gases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Clinical Laboratory Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Immunology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT02022306T 1998-04-27 1999-03-17 Mikrofabrizierte vorrichtung zur analyse von zellen ATE342347T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9808836.2A GB9808836D0 (en) 1998-04-27 1998-04-27 Microfabricated apparatus for cell based assays

Publications (1)

Publication Number Publication Date
ATE342347T1 true ATE342347T1 (de) 2006-11-15

Family

ID=10830968

Family Applications (2)

Application Number Title Priority Date Filing Date
AT99913456T ATE244755T1 (de) 1998-04-27 1999-03-17 Mikrofabrizierte vorrichtung für analyse von zellen
AT02022306T ATE342347T1 (de) 1998-04-27 1999-03-17 Mikrofabrizierte vorrichtung zur analyse von zellen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT99913456T ATE244755T1 (de) 1998-04-27 1999-03-17 Mikrofabrizierte vorrichtung für analyse von zellen

Country Status (10)

Country Link
US (5) US6632656B1 (de)
EP (2) EP1073709B1 (de)
JP (1) JP4064631B2 (de)
AT (2) ATE244755T1 (de)
CA (1) CA2330034A1 (de)
DE (2) DE69933588T2 (de)
DK (1) DK1073709T3 (de)
ES (1) ES2203098T3 (de)
GB (1) GB9808836D0 (de)
WO (1) WO1999055827A1 (de)

Families Citing this family (201)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9808836D0 (en) 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
GB9809943D0 (en) * 1998-05-08 1998-07-08 Amersham Pharm Biotech Ab Microfluidic device
GB9912641D0 (en) * 1999-05-28 1999-07-28 Ashby Scient Ltd Textured and porous silicone rubber
US7261859B2 (en) * 1998-12-30 2007-08-28 Gyros Ab Microanalysis device
SE9901100D0 (sv) 1999-03-24 1999-03-24 Amersham Pharm Biotech Ab Surface and tis manufacture and uses
US7560274B1 (en) 1999-05-28 2009-07-14 Cellon S.A. Culture chamber
SE9902474D0 (sv) 1999-06-30 1999-06-30 Amersham Pharm Biotech Ab Polymer valves
GB2355717A (en) 1999-10-28 2001-05-02 Amersham Pharm Biotech Uk Ltd DNA isolation method
SE9904802D0 (sv) * 1999-12-23 1999-12-23 Amersham Pharm Biotech Ab Microfluidic surfaces
SE0000300D0 (sv) 2000-01-30 2000-01-30 Amersham Pharm Biotech Ab Microfluidic assembly, covering method for the manufacture of the assembly and the use of the assembly
US7485454B1 (en) 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
SE0001790D0 (sv) * 2000-05-12 2000-05-12 Aamic Ab Hydrophobic barrier
WO2001087487A2 (en) 2000-05-15 2001-11-22 Tecan Trading Ag Bidirectional flow centrifugal microfluidic devices
US6627159B1 (en) 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
US6720187B2 (en) 2000-06-28 2004-04-13 3M Innovative Properties Company Multi-format sample processing devices
US6734401B2 (en) 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
SE0004296D0 (sv) * 2000-11-23 2000-11-23 Gyros Ab Device and method for the controlled heating in micro channel systems
US6653625B2 (en) * 2001-03-19 2003-11-25 Gyros Ab Microfluidic system (MS)
US7759067B2 (en) 2001-03-19 2010-07-20 Gyros Patent Ab Method for determining the amount of an analyte with a disc-shaped microfluidic device
US7429354B2 (en) 2001-03-19 2008-09-30 Gyros Patent Ab Structural units that define fluidic functions
US20040058437A1 (en) * 2001-04-10 2004-03-25 Rodgers Seth T. Materials and reactor systems having humidity and gas control
US20040058407A1 (en) * 2001-04-10 2004-03-25 Miller Scott E. Reactor systems having a light-interacting component
US20050032204A1 (en) * 2001-04-10 2005-02-10 Bioprocessors Corp. Microreactor architecture and methods
US20040132166A1 (en) * 2001-04-10 2004-07-08 Bioprocessors Corp. Determination and/or control of reactor environmental conditions
CA2440785A1 (en) * 2001-04-10 2002-10-24 Bioprocessors Corporation Microfermentor device and cell based screening method
WO2002092783A2 (en) * 2001-05-15 2002-11-21 Children's Medical Center Corporation Methods and apparatus for application of micro-mechanical forces to tissues
ES2261669T3 (es) 2001-05-30 2006-11-16 Biolex, Inc. Placa y metodo de cribado de alto rendimiento.
EP2269736B1 (de) 2001-08-28 2013-04-24 Gyros Patent Ab Mikrokammern und mikrofluidische Strukturen zur Handhabung kleiner Flüssigkeitsmengen
US6919058B2 (en) 2001-08-28 2005-07-19 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
US7189368B2 (en) 2001-09-17 2007-03-13 Gyros Patent Ab Functional unit enabling controlled flow in a microfluidic device
KR100442836B1 (ko) * 2001-11-10 2004-08-02 삼성전자주식회사 생화학 유체를 온도가 다른 폐쇄된 챔버 구간을 따라 회전이동시키는 폐쇄 유체 회로 시스템
US20050214442A1 (en) * 2001-11-27 2005-09-29 Anders Larsson Surface and its manufacture and uses
US6889468B2 (en) 2001-12-28 2005-05-10 3M Innovative Properties Company Modular systems and methods for using sample processing devices
US7238255B2 (en) * 2001-12-31 2007-07-03 Gyros Patent Ab Microfluidic device and its manufacture
US7221783B2 (en) * 2001-12-31 2007-05-22 Gyros Patent Ab Method and arrangement for reducing noise
JP2003225083A (ja) * 2002-02-05 2003-08-12 Sony Corp 円盤状培養媒体
GB0206117D0 (en) * 2002-03-15 2002-04-24 Imaging Res Solutions Ltd Use of microfabricated devices
WO2003082730A1 (en) * 2002-03-31 2003-10-09 Gyros Ab Efficient mmicrofluidic devices
AU2003224817B2 (en) * 2002-04-01 2008-11-06 Fluidigm Corporation Microfluidic particle-analysis systems
US6955738B2 (en) * 2002-04-09 2005-10-18 Gyros Ab Microfluidic devices with new inner surfaces
US20050026134A1 (en) * 2002-04-10 2005-02-03 Bioprocessors Corp. Systems and methods for control of pH and other reactor environment conditions
US20050277195A1 (en) * 2002-04-30 2005-12-15 Gyros Ab Integrated microfluidic device (ea)
EP1509760A1 (de) * 2002-05-31 2005-03-02 Gyros AB Detektoranordnung auf grundlage der oberflächenplasmonresonanz
US20050106714A1 (en) * 2002-06-05 2005-05-19 Zarur Andrey J. Rotatable reactor systems and methods
FR2842747B1 (fr) * 2002-07-23 2004-10-15 Commissariat Energie Atomique Procede et dispositif pour le criblage de molecules dans des cellules
CN1678731A (zh) * 2002-08-27 2005-10-05 范德比尔特大学 多室生物反应器
US7332129B2 (en) 2003-01-09 2008-02-19 3M Innovative Properties Company Sample processing device having process chambers with bypass slots
WO2004065618A2 (en) * 2003-01-16 2004-08-05 Thermogenic Imaging Methods and devices for monitoring cellular metabolism in microfluidic cell-retaining chambers
JP4519124B2 (ja) * 2003-01-30 2010-08-04 ユィロス・パテント・アクチボラグ 微小流動性デバイスの内部の壁
SE0300823D0 (sv) 2003-03-23 2003-03-23 Gyros Ab Preloaded Microscale Devices
SE0300822D0 (sv) * 2003-03-23 2003-03-23 Gyros Ab A collection of Micro Scale Devices
WO2004098741A2 (en) * 2003-04-30 2004-11-18 Biovitesse Apparatus and method for detecting live cells with an integrated filter and growth detection device
GB2401612A (en) * 2003-05-13 2004-11-17 Univ Manchester Method and device for culturing tissue
KR100737295B1 (ko) * 2003-05-19 2007-07-09 도꾸리쯔교세이호징 가가꾸 기쥬쯔 신꼬 기꼬 세포배양용 마이크로 챔버
JP2007502218A (ja) 2003-05-23 2007-02-08 ユィロス・パテント・アクチボラグ 親水性／疎水性表面
US20050042770A1 (en) * 2003-05-23 2005-02-24 Gyros Ab Fluidic functions based on non-wettable surfaces
US20060246526A1 (en) * 2003-06-02 2006-11-02 Gyros Patent Ab Microfluidic affinity assays with improved performance
EP1628748A2 (de) * 2003-06-05 2006-03-01 Bioprocessors Corporation Reaktor mit speicherkomponente
US20090137018A1 (en) 2003-06-30 2009-05-28 University Of South Florida Magnetic three-dimensional cell culture apparatus and method
FR2857451B1 (fr) * 2003-07-11 2005-09-30 Commissariat Energie Atomique Procede et dispositif pour l'analyse de milieux reactionnels vivants
CA2532754A1 (en) * 2003-07-17 2005-02-03 Global Cell Solutions, Llc Automated cell culture system and process
WO2005010139A2 (en) 2003-07-23 2005-02-03 University Of South Florida Ferromagnetic cell and tissue culture microcarriers
EP1508373A3 (de) * 2003-08-19 2005-08-03 Herbener, Heinz-Gerd Probenträger mit Flüssigkeitskanal
US20050046848A1 (en) * 2003-08-26 2005-03-03 Blueshift Biotechnologies, Inc. Time dependent fluorescence measurements
US7582472B2 (en) * 2003-08-26 2009-09-01 Smith Kenneth E Apparatus and method for liquid sample testing
US7276351B2 (en) 2003-09-10 2007-10-02 Seahorse Bioscience Method and device for measuring multiple physiological properties of cells
US7776272B2 (en) * 2003-10-03 2010-08-17 Gyros Patent Ab Liquid router
US8658349B2 (en) 2006-07-13 2014-02-25 Seahorse Bioscience Cell analysis apparatus and method
SE0400007D0 (sv) * 2004-01-02 2004-01-02 Gyros Ab Large scale surface modifiv´cation of microfluidic devices
JP2007524849A (ja) * 2004-01-06 2007-08-30 ユィロス・パテント・アクチボラグ 接触加熱アレンジメント
US7407799B2 (en) * 2004-01-16 2008-08-05 California Institute Of Technology Microfluidic chemostat
US8592219B2 (en) 2005-01-17 2013-11-26 Gyros Patent Ab Protecting agent
US20090010819A1 (en) * 2004-01-17 2009-01-08 Gyros Patent Ab Versatile flow path
US20050164373A1 (en) * 2004-01-22 2005-07-28 Oldham Mark F. Diffusion-aided loading system for microfluidic devices
SE0400181D0 (sv) * 2004-01-29 2004-01-29 Gyros Ab Segmented porous and preloaded microscale devices
WO2005081801A2 (en) * 2004-02-09 2005-09-09 Blueshift Biotechnologies, Inc. Methods and apparatus for scanning small sample volumes
JP2005257337A (ja) * 2004-03-09 2005-09-22 Brother Ind Ltd 検査対象受体、検査装置、及び検査方法
US8058056B2 (en) 2004-03-12 2011-11-15 The Regents Of The University Of California Method and apparatus for integrated cell handling and measurements
US20050227350A1 (en) * 2004-04-13 2005-10-13 Agency For Science, Technology And Research Device and method for studying cell migration and deformation
EP1758674A2 (de) * 2004-06-07 2007-03-07 Bioprocessors Corporation Schuberzeugung in einem reaktor
EP1765487A1 (de) * 2004-06-07 2007-03-28 Bioprocessors Corporation Mischen im reaktor
EP1761331A2 (de) * 2004-06-07 2007-03-14 Bioprocessors Corporation Steuerung von reaktorumgebungsbedingungen
US20050271560A1 (en) * 2004-06-07 2005-12-08 Bioprocessors Corp. Gas control in a reactor
US7141378B2 (en) 2004-07-02 2006-11-28 Blueshift Biotechnologies, Inc. Exploring fluorophore microenvironments
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
EP1815244A4 (de) * 2004-11-11 2009-07-22 Agency Science Tech & Res Zellkulturvorrichtung
EP1849005A1 (de) * 2005-01-17 2007-10-31 Gyros Patent Ab Verfahren zum nachweis eines wenigstens bivalenten analyten unter verwendung von zwei affinitätsreaktanden
GB0505379D0 (en) * 2005-03-16 2005-04-20 Robio Systems Ltd Cellular entity maturation and transportation systems
WO2006110095A1 (en) 2005-04-14 2006-10-19 Gyros Patent Ab A microfluidic device with finger valves
EP1874677B1 (de) 2005-04-14 2013-03-20 Gyros Patent Ab Mikrofluidische Vorrichtung mit Mäander
EP1885839B1 (de) 2005-04-26 2018-08-08 Life Technologies Corporation Systeme und verfahren zum nachweis mehrerer analyte
US7668069B2 (en) 2005-05-09 2010-02-23 Searete Llc Limited use memory device with associated information
US8159925B2 (en) 2005-08-05 2012-04-17 The Invention Science Fund I, Llc Limited use memory device with associated information
US8218262B2 (en) 2005-05-09 2012-07-10 The Invention Science Fund I, Llc Method of manufacturing a limited use data storing device including structured data and primary and secondary read-support information
US7565596B2 (en) 2005-09-09 2009-07-21 Searete Llc Data recovery systems
US8462605B2 (en) 2005-05-09 2013-06-11 The Invention Science Fund I, Llc Method of manufacturing a limited use data storing device
US8099608B2 (en) 2005-05-09 2012-01-17 The Invention Science Fund I, Llc Limited use data storing device
US7916615B2 (en) 2005-06-09 2011-03-29 The Invention Science Fund I, Llc Method and system for rotational control of data storage devices
US8140745B2 (en) 2005-09-09 2012-03-20 The Invention Science Fund I, Llc Data retrieval methods
US7770028B2 (en) 2005-09-09 2010-08-03 Invention Science Fund 1, Llc Limited use data storing device
US7519980B2 (en) * 2005-05-09 2009-04-14 Searete Llc Fluid mediated disk activation and deactivation mechanisms
US7596073B2 (en) 2005-05-09 2009-09-29 Searete Llc Method and system for fluid mediated disk activation and deactivation
US7907486B2 (en) 2006-06-20 2011-03-15 The Invention Science Fund I, Llc Rotation responsive disk activation and deactivation mechanisms
US7668068B2 (en) 2005-06-09 2010-02-23 Searete Llc Rotation responsive disk activation and deactivation mechanisms
US9396752B2 (en) 2005-08-05 2016-07-19 Searete Llc Memory device activation and deactivation
US7748012B2 (en) * 2005-05-09 2010-06-29 Searete Llc Method of manufacturing a limited use data storing device
US8121016B2 (en) 2005-05-09 2012-02-21 The Invention Science Fund I, Llc Rotation responsive disk activation and deactivation mechanisms
US8220014B2 (en) 2005-05-09 2012-07-10 The Invention Science Fund I, Llc Modifiable memory devices having limited expected lifetime
US7512959B2 (en) * 2005-05-09 2009-03-31 Searete Llc Rotation responsive disk activation and deactivation mechanisms
US7916592B2 (en) 2005-05-09 2011-03-29 The Invention Science Fund I, Llc Fluid mediated disk activation and deactivation mechanisms
US7694316B2 (en) 2005-05-09 2010-04-06 The Invention Science Fund I, Llc Fluid mediated disk activation and deactivation mechanisms
US7323660B2 (en) 2005-07-05 2008-01-29 3M Innovative Properties Company Modular sample processing apparatus kits and modules
USD564667S1 (en) 2005-07-05 2008-03-18 3M Innovative Properties Company Rotatable sample processing disk
US7754474B2 (en) 2005-07-05 2010-07-13 3M Innovative Properties Company Sample processing device compression systems and methods
US7763210B2 (en) 2005-07-05 2010-07-27 3M Innovative Properties Company Compliant microfluidic sample processing disks
US20090035793A1 (en) * 2005-08-31 2009-02-05 Nissan Chemical Industries, Ltd. Microchip for cell response evaluation
WO2007044888A2 (en) * 2005-10-11 2007-04-19 The Johns Hopkins Univerisity Microfluidic device and method for high-throughput cellular gradient and dose response studies
US8822206B2 (en) * 2005-10-11 2014-09-02 The Johns Hopkins University Device for high-throughput stimulation, immunostaining, and visualization of single cells
US20070134739A1 (en) * 2005-12-12 2007-06-14 Gyros Patent Ab Microfluidic assays and microfluidic devices
US8293524B2 (en) 2006-03-31 2012-10-23 Fluxion Biosciences Inc. Methods and apparatus for the manipulation of particle suspensions and testing thereof
HUE059011T2 (hu) * 2006-05-31 2022-09-28 Childrens Medical Center Immunmodulátorként szolgáló ABC5-pozitív mezenchimális õssejtek
US7641860B2 (en) 2006-06-01 2010-01-05 Nanotek, Llc Modular and reconfigurable multi-stage microreactor cartridge apparatus
US7998418B1 (en) 2006-06-01 2011-08-16 Nanotek, Llc Evaporator and concentrator in reactor and loading system
US8432777B2 (en) * 2006-06-19 2013-04-30 The Invention Science Fund I, Llc Method and system for fluid mediated disk activation and deactivation
US8264928B2 (en) 2006-06-19 2012-09-11 The Invention Science Fund I, Llc Method and system for fluid mediated disk activation and deactivation
KR101335920B1 (ko) * 2006-08-02 2013-12-03 삼성전자주식회사 박막화학분석장치 및 이를 이용한 분석방법
US7854902B2 (en) * 2006-08-23 2010-12-21 Nanotek, Llc Modular and reconfigurable multi-stage high temperature microreactor cartridge apparatus and system for using same
US7797988B2 (en) 2007-03-23 2010-09-21 Advion Biosystems, Inc. Liquid chromatography-mass spectrometry
DK2155248T3 (en) 2007-04-12 2015-09-14 Brigham & Womens Hospital Targeting abcb5 for cancer therapy
EP2152196A1 (de) * 2007-05-01 2010-02-17 The Brigham and Women's Hospital, Inc. Wundheilungsvorrichtung
JP4932656B2 (ja) * 2007-09-28 2012-05-16 富士フイルム株式会社 マイクロ化学装置
WO2009048642A1 (en) * 2007-10-11 2009-04-16 Accelbeam Devices Llc Microwave reactor
EP2203548A4 (de) * 2007-10-11 2014-01-15 Agency Science Tech & Res Bildung einer zellstruktur mit transientem linker in einem käfig
JP2009106169A (ja) * 2007-10-26 2009-05-21 Univ Soka マイクロチャンバーアレイを用いた細胞培養方法及び該方法に用いられる細胞培養装置
CN101873885B (zh) * 2007-11-22 2013-07-31 三星电子株式会社 薄膜阀器件及其控制装置
DE102008010436A1 (de) * 2008-02-21 2009-09-03 Berthold Technologies Gmbh & Co. Kg Vorrichtung und Verfahren zur Messung von Lumineszenz und Fluoreszenz von transfizierten Zellen oder Organteilen
WO2009146911A2 (en) * 2008-06-04 2009-12-10 Uwe Marx Organ-on-a-chip-device
FR2937050A1 (fr) * 2008-10-10 2010-04-16 Inst Curie Dispositif de culture cellulaire
US8202702B2 (en) 2008-10-14 2012-06-19 Seahorse Bioscience Method and device for measuring extracellular acidification and oxygen consumption rate with higher precision
BRPI0918357A2 (pt) 2008-12-19 2016-07-26 3M Innovative Properties Co sistema e método para processamento de amostras
BRPI0918358A2 (pt) 2008-12-19 2015-12-15 3M Innovative Properties Co sistema e método para a concentração de amostras
IT1392842B1 (it) * 2008-12-29 2012-03-23 St Microelectronics Rousset Microreattore con canali di sfiato per rimuovere aria da una camera di reazione
WO2010078623A1 (en) * 2009-01-07 2010-07-15 The University Of Queensland Cell migration
DE102009039956A1 (de) * 2009-08-27 2011-03-10 NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen Mikrofluidisches System und Verfahren zu dessen Herstellung
US8834792B2 (en) 2009-11-13 2014-09-16 3M Innovative Properties Company Systems for processing sample processing devices
MX2012007479A (es) * 2009-12-28 2012-11-29 Achira Labs Pvt Ltd Elemento de diagnostico y un dispositivo de diagnostico que comprende el elemento de diagnostico.
US20110195488A1 (en) * 2010-02-10 2011-08-11 Selinfreund Richard H Devices for collection and stabilization of biomarkers in liquid samples
CA2805720A1 (en) 2010-06-17 2011-12-22 Abaxis, Inc. Rotors for immunoassays
EP2404867A1 (de) * 2010-07-09 2012-01-11 Trinean NV Verfahren zur Herstellung mikrofluidischer Vorrichtungen
CN103140755B (zh) 2010-07-22 2016-03-16 哈希公司 用于碱度分析的芯片上实验室
US20130287613A1 (en) 2010-10-07 2013-10-31 Vanderbilt University Peristaltic micropump and related systems and methods
WO2014081840A1 (en) * 2012-11-21 2014-05-30 Vanderbilt University Organ on chip integration and applications of the same
CN103501908B (zh) 2011-05-18 2016-03-16 3M创新有限公司 用于样品处理装置上阀调的系统和方法
US9168523B2 (en) 2011-05-18 2015-10-27 3M Innovative Properties Company Systems and methods for detecting the presence of a selected volume of material in a sample processing device
AU2012255144B2 (en) 2011-05-18 2015-01-29 Diasorin Italia S.P.A. Systems and methods for volumetric metering on a sample processing device
DE102011076543B4 (de) * 2011-05-26 2014-04-10 Siemens Aktiengesellschaft CT-System mit einem quantenzählenden Röntgendetektor
JP2014518394A (ja) 2011-06-30 2014-07-28 スリーエム イノベイティブ プロパティズ カンパニー 微細構造化表面を使用して、サンプル内の目的の検体を検出するためのシステム及び方法
CN103620373B (zh) 2011-06-30 2017-07-07 3M创新有限公司 利用过滤器和微结构化表面检测样品中所关注分析物的方法
US10209241B2 (en) * 2011-08-12 2019-02-19 Rutgers, The State University Of New Jersey High throughput sensitization detection devices and methods
KR101257700B1 (ko) * 2011-12-05 2013-04-24 삼성전자주식회사 미세유동장치 및 이를 포함하는 미세유동시스템
GB201121959D0 (en) * 2011-12-21 2012-02-01 Univ Leeds Assay of functional cell viability
TWI456196B (zh) 2012-04-24 2014-10-11 Ind Tech Res Inst 檢體免疫分析檢測裝置
US9180449B2 (en) 2012-06-12 2015-11-10 Hach Company Mobile water analysis
JP2015521863A (ja) * 2012-07-13 2015-08-03 エル． ホルツマン，ジョーダン アルツハイマー病の治療のための治療薬剤をスクリーニングするための細胞モデルと動物モデル
TWI475226B (zh) * 2012-08-01 2015-03-01 Univ Feng Chia 利用分流結構進行生化檢測之裝置及其運作方法
US9573128B1 (en) * 2012-09-06 2017-02-21 SciKon Innovation, Inc. Fluidics device allowing fluid flow between a plurality of wells
US9518977B2 (en) 2012-10-19 2016-12-13 University Of Washington Through Its Center For Commercialization Microfluidic assay apparatus and methods of use
CN102921480B (zh) * 2012-10-26 2014-10-01 北京理工大学 一种利用紫外固化光胶制作微流控芯片的方法
CN104471052B (zh) 2012-11-13 2017-06-13 海马生物科学公司 用于基于控制介质流动的三维组织测量的装置和方法
USD768872S1 (en) 2012-12-12 2016-10-11 Hach Company Cuvette for a water analysis instrument
WO2014131079A1 (en) * 2013-02-26 2014-09-04 Ddnt Consultants Australia Pty Ltd Structure for culturing cells
ES2716568T3 (es) * 2013-03-11 2019-06-13 Becton Dickinson Co Cartucho de detección bacteriana
CN103323605B (zh) * 2013-06-18 2017-06-30 杭州普施康生物科技有限公司 一种糖化血红蛋白免疫检测的微流控芯片
WO2015009688A1 (en) 2013-07-17 2015-01-22 The Johns Hopkins University Microfluidic chip for analysis of cell motility and methods for using same
EP3689467B1 (de) 2014-06-02 2025-04-09 Agilent Technologies, Inc. Mikroplattenträger zur analyse biologischer proben
JP5994116B2 (ja) * 2014-08-26 2016-09-21 ローム株式会社 回転式分析チップおよび測定システム
WO2016077735A1 (en) * 2014-11-14 2016-05-19 Yale University Novel methods and devices for high-throughput quantification, detection and temporal profiling of cellular secretions, and compositions identified using same
US10035145B2 (en) 2014-12-02 2018-07-31 SciKon Innovation, Inc. Piston assembly and related systems for use with a fluidics device
CN104502617A (zh) * 2014-12-24 2015-04-08 杭州霆科生物科技有限公司 一种全自动、高通量农药残留检测的微流控芯片系统及方法
US9993819B2 (en) 2014-12-30 2018-06-12 Stmicroelectronics S.R.L. Apparatus for actuating and reading a centrifugal microfluidic disk for biological and biochemical analyses, and use of the apparatus
WO2016109905A1 (es) * 2015-01-06 2016-07-14 Droguett Bizet Sara Aparato para la instalacion de un sistema tipo lab-on chip para identificar la sensibilidad antibiotica en el punto de atencion de los pacientes
JP2018512171A (ja) 2015-03-23 2018-05-17 シコン イノベーション，インク． 流体装置と共に使用するための方法および関連システム
WO2016161090A1 (en) * 2015-04-01 2016-10-06 President And Fellows Of Harvard College Respiration device for analysis of a response to shear stress and foreign agents on cells
WO2016161081A1 (en) 2015-04-03 2016-10-06 Fluxion Biosciences, Inc. Molecular characterization of single cells and cell populations for non-invasive diagnostics
CN114540192A (zh) 2015-08-26 2022-05-27 仿真股份有限公司 灌注歧管组件
US9757728B2 (en) * 2016-01-26 2017-09-12 Lidong Qin Microfluidic aliquoting for single-cell isolation
SE540775C2 (en) * 2016-03-21 2018-11-06 Microfluidic device for culturing cells
US11287358B1 (en) 2016-04-14 2022-03-29 Triad National Security, Llc Microfluidic aspirator and multi-purpose flow sensor and methods of making and using the same
US10408821B2 (en) * 2016-04-14 2019-09-10 Triad National Security, Llc Microfluidic aspirator and methods of making and using the same
CN108732339B (zh) * 2017-04-19 2021-04-13 光宝电子(广州)有限公司 用于多重反应生物检测的流道装置及其检测方法
DE102017209942B4 (de) 2017-06-13 2019-05-09 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein Vorrichtung und Verfahren für die Kultivierung von Zellen
CN108043478A (zh) * 2017-12-04 2018-05-18 国家纳米科学中心 一种微流控芯片、手动离心装置及核酸检测方法
CN112119153B (zh) 2018-05-29 2024-03-19 株式会社日立高新技术 细胞检测装置和细胞检测方法
KR102401909B1 (ko) 2018-08-30 2022-05-24 주식회사 엘지화학 반응 최적화를 위한 고속 스크리닝 분석 시스템
EP3870366A1 (de) * 2018-10-24 2021-09-01 Danmarks Tekniske Universitet Multifunktionale spinnplattform
US20230038829A1 (en) 2019-08-29 2023-02-09 Fanuc Corporation Cell production device and cell production method
KR20210053010A (ko) * 2019-11-01 2021-05-11 주식회사라이브셀인스트루먼트 세포 분주 및 배양용 디스크, 실시간 모니터링 시스템 및 세포 분주 및 배양 방법
WO2022025044A1 (ja) * 2020-07-29 2022-02-03 京セラ株式会社 流路デバイス
CN113155588A (zh) * 2021-05-13 2021-07-23 武汉新烽光电股份有限公司 一种基于微流控的快速自动化水质检测系统及方法
DE102022201938A1 (de) 2022-02-24 2023-08-24 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Flüssigkeitstransfer zwischen rotierenden Modulen
WO2025230778A2 (en) * 2024-04-30 2025-11-06 Gram Medical Inc. Method for processing biological samples

Family Cites Families (141)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2005A (en) * 1841-03-16 Improvement in the manner of constructing molds for casting butt-hinges
US2006A (en) * 1841-03-16 Clamp for crimping leather
US2002A (en) * 1841-03-12 Tor and planter for plowing
US2003A (en) * 1841-03-12 Improvement in horizontal windivhlls
US3679367A (en) 1970-09-14 1972-07-25 Technicon Instr Apparatus for determining the pack volume of particulates in liquid mixtures
US3728644A (en) * 1971-11-01 1973-04-17 Bell Telephone Labor Inc Polarization transformation apparatus
US3899296A (en) * 1974-07-17 1975-08-12 Us Energy Whole blood analysis rotor for a multistation dynamic photometer
US4006749A (en) * 1975-01-31 1977-02-08 Consolidated Cigar Corporation Removal of harmful components from tobacco smoke
US4018652A (en) * 1976-01-09 1977-04-19 Mcdonnell Douglas Corporation Process and apparatus for ascertaining the concentration of microorganism in a water specimen
US4077845A (en) 1977-04-20 1978-03-07 Miles Laboratories, Inc. Disposable inoculation device and process of using same
FR2400700A1 (fr) 1977-08-18 1979-03-16 Guigan Jean Dispositif de conditionnement d'un echantillon de liquide en vue de son analyse
US4381291A (en) 1979-02-23 1983-04-26 Ab Fortia Measurement of free ligands
US4318994A (en) * 1979-08-30 1982-03-09 Mcdonnell Douglas Corporation Enterobacteriaceae species biochemical test card
DE3044385A1 (de) 1980-11-25 1982-06-24 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur durchfuehrung analytischer bestimmungen und hierfuer geeignetes rotoreinsatzelement
US4426451A (en) 1981-01-28 1984-01-17 Eastman Kodak Company Multi-zoned reaction vessel having pressure-actuatable control means between zones
US4729862A (en) 1981-04-24 1988-03-08 Allied-Signal Inc. Nylon composition for use in rotational molding
US4440638A (en) * 1982-02-16 1984-04-03 U.T. Board Of Regents Surface field-effect device for manipulation of charged species
DE3314961A1 (de) 1983-04-25 1984-10-25 Boehringer Mannheim Gmbh, 6800 Mannheim Analysegeraet zur photometrischen bestimmung eines parameters einer fluessigkeit
GB8317124D0 (en) 1983-06-23 1983-07-27 Ekins R P Free ligand assay
US4661451A (en) * 1984-02-06 1987-04-28 Ortho Diagnostic Systems, Inc. Methods for immobilizing and translocating biological cells
US4676274A (en) 1985-02-28 1987-06-30 Brown James F Capillary flow control
US4756884A (en) 1985-08-05 1988-07-12 Biotrack, Inc. Capillary flow device
DK112986D0 (da) 1986-03-11 1986-03-11 Svenska Sockerfabriks Ab Fremgangsmaade til detektion af komponenter i en proeve
AU614935B2 (en) 1986-08-06 1991-09-19 Multilyte Limited Determination of analyte concentration using two labelling markers
US4935346A (en) 1986-08-13 1990-06-19 Lifescan, Inc. Minimum procedure system for the determination of analytes
US4762683A (en) 1986-09-16 1988-08-09 E. I. Du Pont De Nemours And Company Analysis device
US4806316A (en) * 1987-03-17 1989-02-21 Becton, Dickinson And Company Disposable device for use in chemical, immunochemical and microorganism analysis
US4940527A (en) 1987-06-01 1990-07-10 Abbott Laboratories Two-part test cartridge for centrifuge
US5242803A (en) 1987-07-17 1993-09-07 Martin Marietta Energy Systems, Inc. Rotor assembly and assay method
US5173262A (en) 1987-07-17 1992-12-22 Martin Marietta Energy Systems, Inc. Rotor assembly and method for automatically processing liquids
US4868129A (en) * 1987-08-27 1989-09-19 Biotrack Inc. Apparatus and method for dilution and mixing of liquid samples
US4946795A (en) * 1987-08-27 1990-08-07 Biotrack, Inc. Apparatus and method for dilution and mixing of liquid samples
US4839292B1 (en) * 1987-09-11 1994-09-13 Joseph G Cremonese Cell culture flask utilizing membrane barrier
US5252294A (en) 1988-06-01 1993-10-12 Messerschmitt-Bolkow-Blohm Gmbh Micromechanical structure
US5160702A (en) 1989-01-17 1992-11-03 Molecular Devices Corporation Analyzer with improved rotor structure
US5006749A (en) 1989-10-03 1991-04-09 Regents Of The University Of California Method and apparatus for using ultrasonic energy for moving microminiature elements
FR2657879B1 (fr) * 1990-02-02 1994-09-02 Imedex Plaque de culture cellulaire.
US5190879A (en) * 1990-05-08 1993-03-02 Bowolfe, Inc. Controlled environment animal isolation systems
SE470347B (sv) 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system
US5122284A (en) 1990-06-04 1992-06-16 Abaxis, Inc. Apparatus and method for optically analyzing biological fluids
US5230866A (en) * 1991-03-01 1993-07-27 Biotrack, Inc. Capillary stop-flow junction having improved stability against accidental fluid flow
US5413732A (en) 1991-08-19 1995-05-09 Abaxis, Inc. Reagent compositions for analytical testing
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
AU4047493A (en) 1992-04-02 1993-11-08 Abaxis, Inc. Analytical rotor with dye mixing chamber
US5637469A (en) * 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5744366A (en) * 1992-05-01 1998-04-28 Trustees Of The University Of Pennsylvania Mesoscale devices and methods for analysis of motile cells
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5296375A (en) * 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
CA2134474C (en) * 1992-05-01 1999-07-06 The Trustees Of The University Of Pennsylvania Microfabricated sperm handling devices
US6156270A (en) 1992-05-21 2000-12-05 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US5503985A (en) * 1993-02-18 1996-04-02 Cathey; Cheryl A. Disposable device for diagnostic assays
US5798215A (en) 1993-02-18 1998-08-25 Biocircuits Corporation Device for use in analyte detection assays
SE508435C2 (sv) 1993-02-23 1998-10-05 Erik Stemme Förträngningspump av membranpumptyp
US5665562A (en) * 1993-05-17 1997-09-09 Amersham International Plc Devices and methods for the measurement of cellular biochemical processes
SE501380C2 (sv) 1993-06-15 1995-01-30 Pharmacia Lkb Biotech Sätt att tillverka mikrokanal/mikrokavitetsstrukturer
EP0629492B1 (de) 1993-06-17 1998-11-11 Sekisui Kagaku Kogyo Kabushiki Kaisha Film für Haftpflaster
US5368704A (en) 1993-08-06 1994-11-29 Teknekron Corporation Micro-electrochemical valves and method
US5409665A (en) 1993-09-01 1995-04-25 Abaxis, Inc. Simultaneous cuvette filling with means to isolate cuvettes
SE9304145D0 (sv) 1993-12-10 1993-12-10 Pharmacia Lkb Biotech Sätt att tillverka hålrumsstrukturer
DE4400955C2 (de) 1993-12-23 1999-04-01 Fraunhofer Ges Forschung Adhäsionssteuerbare Oberflächenstruktur
SE9401327D0 (sv) 1994-04-20 1994-04-20 Pharmacia Lkb Biotech Hydrofilisering av hydrofob polymer
US5627041A (en) 1994-09-02 1997-05-06 Biometric Imaging, Inc. Disposable cartridge for an assay of a biological sample
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
DE29500587U1 (de) * 1995-01-17 1996-05-15 Schreiber, Hans, Dr. Dr., 69469 Weinheim Bausatz insbesondere zur Blutgruppenbestimmung
EP0823054A1 (de) 1995-04-27 1998-02-11 Pharmacia Biotech AB Vorrichtung zur kontinuierlichen messung von physikalischen und chemischen parametern in einer strömung
US5609828A (en) * 1995-05-31 1997-03-11 bio M erieux Vitek, Inc. Sample card
US5800778A (en) * 1995-05-31 1998-09-01 Biomerieux Vitek, Inc. Sealant for sample holder
SE9502251D0 (sv) 1995-06-21 1995-06-21 Pharmacia Ab Flow-through sampling cell and use thereof
SE9502258D0 (sv) 1995-06-21 1995-06-21 Pharmacia Biotech Ab Method for the manufacture of a membrane-containing microstructure
US6143247A (en) 1996-12-20 2000-11-07 Gamera Bioscience Inc. Affinity binding-based system for detecting particulates in a fluid
US20020025583A1 (en) 1995-08-31 2002-02-28 Stoughton L. Ellsworth Analytical rotor and method for detecting analytes in liquid samples
US6299839B1 (en) * 1995-08-31 2001-10-09 First Medical, Inc. System and methods for performing rotor assays
US5650334A (en) * 1995-08-31 1997-07-22 First Medical, Inc. Fluorescent labelling compositions and methods for their use
US6130098A (en) 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
US20010055812A1 (en) 1995-12-05 2001-12-27 Alec Mian Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
AU702403B2 (en) 1995-12-05 1999-02-18 Gamera Bioscience Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
US5698162A (en) 1996-02-27 1997-12-16 Johnson & Johnson Clinical Diagnostics Apparatus for staining of cells and tissues
US6144447A (en) 1996-04-25 2000-11-07 Pharmacia Biotech Ab Apparatus for continuously measuring physical and chemical parameters in a fluid flow
SE9602638D0 (sv) 1996-07-03 1996-07-03 Pharmacia Biotech Ab An improved method for the capillary electrophoresis of nucleic acids, proteins and low molecular charged compounds
US6074827A (en) 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
US6143248A (en) 1996-08-12 2000-11-07 Gamera Bioscience Corp. Capillary microvalve
CA2276251A1 (en) 1996-11-20 1998-05-28 The Regents Of The University Of Michigan Microfabricated isothermal nucleic acid amplification devices and methods
WO1998040735A1 (en) 1997-03-12 1998-09-17 Kyoto Daiichi Kagaku Co., Ltd. Testing instrument for analyzing liquid sample
DE69823347T2 (de) 1997-05-16 2005-05-12 Alberta Research Council, Edmonton Mikrofluidisches system und verfahren zu dessen betrieb
US6375871B1 (en) 1998-06-18 2002-04-23 3M Innovative Properties Company Methods of manufacturing microfluidic articles
US5992820A (en) 1997-11-19 1999-11-30 Sarnoff Corporation Flow control in microfluidics devices by controlled bubble formation
GB9808836D0 (en) 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
US20040202579A1 (en) 1998-05-08 2004-10-14 Anders Larsson Microfluidic device
EP1125129A1 (de) * 1998-10-13 2001-08-22 Biomicro Systems, Inc. Komponenten eines flüssigkeitskreislaufes, basierend auf passiven flüssigkeitsdynamiken
US6591852B1 (en) * 1998-10-13 2003-07-15 Biomicro Systems, Inc. Fluid circuit components based upon passive fluid dynamics
EP1358987A3 (de) 1998-10-14 2004-03-03 Gyros AB Abformungsmatrix
SE9803734D0 (sv) * 1998-10-30 1998-10-30 Amersham Pharm Biotech Ab Liquid handling system
US7261859B2 (en) 1998-12-30 2007-08-28 Gyros Ab Microanalysis device
SE9901100D0 (sv) * 1999-03-24 1999-03-24 Amersham Pharm Biotech Ab Surface and tis manufacture and uses
SE9902474D0 (sv) 1999-06-30 1999-06-30 Amersham Pharm Biotech Ab Polymer valves
SE9903011D0 (sv) 1999-08-26 1999-08-26 Aamic Ab Sätt att framställa en plastprodukt och ett härför utnyttjat plastproduktformande arrangemang
SE9903255L (sv) 1999-09-13 2001-03-14 Aamic Ab Förfarande för att framställa en matris samt en matris sålunda framställd.(Hybridtillämpningen)
GB2355717A (en) 1999-10-28 2001-05-02 Amersham Pharm Biotech Uk Ltd DNA isolation method
SE9904802D0 (sv) 1999-12-23 1999-12-23 Amersham Pharm Biotech Ab Microfluidic surfaces
US6884395B2 (en) 2000-05-12 2005-04-26 Gyros Ab Integrated microfluidic disc
SE0000300D0 (sv) 2000-01-30 2000-01-30 Amersham Pharm Biotech Ab Microfluidic assembly, covering method for the manufacture of the assembly and the use of the assembly
JP2001293643A (ja) * 2000-04-17 2001-10-23 Hirata Corp 生産システム
SE0001790D0 (sv) 2000-05-12 2000-05-12 Aamic Ab Hydrophobic barrier
US6699665B1 (en) * 2000-11-08 2004-03-02 Surface Logix, Inc. Multiple array system for integrating bioarrays
SE0004296D0 (sv) * 2000-11-23 2000-11-23 Gyros Ab Device and method for the controlled heating in micro channel systems
SE0004297D0 (sv) 2000-11-23 2000-11-23 Gyros Ab Device for thermal cycling
SE0004594D0 (sv) 2000-12-12 2000-12-12 Gyros Ab Microscale nozzie
US20040099310A1 (en) 2001-01-05 2004-05-27 Per Andersson Microfluidic device
US6653625B2 (en) 2001-03-19 2003-11-25 Gyros Ab Microfluidic system (MS)
US6717136B2 (en) 2001-03-19 2004-04-06 Gyros Ab Microfludic system (EDI)
US7759067B2 (en) 2001-03-19 2010-07-20 Gyros Patent Ab Method for determining the amount of an analyte with a disc-shaped microfluidic device
SE0100952D0 (sv) 2001-03-19 2001-03-19 Gyros Ab A microfluidic system (MS)
CA2442342A1 (en) 2001-03-19 2002-09-26 Gyros Ab A microfluidic system (edi)
US7429354B2 (en) 2001-03-19 2008-09-30 Gyros Patent Ab Structural units that define fluidic functions
US6418968B1 (en) * 2001-04-20 2002-07-16 Nanostream, Inc. Porous microfluidic valves
US20030013120A1 (en) 2001-07-12 2003-01-16 Patz Edward F. System and method for differential protein expression and a diagnostic biomarker discovery system and method using same
SE0104077D0 (sv) 2001-10-21 2001-12-05 Gyros Ab A method and instrumentation for micro dispensation of droplets
US6919058B2 (en) 2001-08-28 2005-07-19 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
US7189368B2 (en) 2001-09-17 2007-03-13 Gyros Patent Ab Functional unit enabling controlled flow in a microfluidic device
US6728644B2 (en) 2001-09-17 2004-04-27 Gyros Ab Method editor
SE0103109D0 (sv) 2001-09-17 2001-09-17 Gyros Microlabs Ab Detector arrangement with rotary drive in an instrument for analysis of microscale liquid sample volumes
US20030054563A1 (en) 2001-09-17 2003-03-20 Gyros Ab Detector arrangement for microfluidic devices
SE0103108D0 (sv) 2001-09-17 2001-09-17 Gyros Microlabs Ab Rotary drive in an instrument for analysis of microscale liquid sample volumes
US20050214442A1 (en) 2001-11-27 2005-09-29 Anders Larsson Surface and its manufacture and uses
US7238255B2 (en) 2001-12-31 2007-07-03 Gyros Patent Ab Microfluidic device and its manufacture
US7221783B2 (en) 2001-12-31 2007-05-22 Gyros Patent Ab Method and arrangement for reducing noise
US6637469B2 (en) * 2002-03-19 2003-10-28 Air Products And Chemicals, Inc. Product delivery system for stationary or portable bulk containers
WO2003082730A1 (en) 2002-03-31 2003-10-09 Gyros Ab Efficient mmicrofluidic devices
JP4338529B2 (ja) 2002-04-08 2009-10-07 ユロス・パテント・アクチボラゲット ホーミングプロセス
US6955738B2 (en) 2002-04-09 2005-10-18 Gyros Ab Microfluidic devices with new inner surfaces
US20050277195A1 (en) 2002-04-30 2005-12-15 Gyros Ab Integrated microfluidic device (ea)
EP1509760A1 (de) 2002-05-31 2005-03-02 Gyros AB Detektoranordnung auf grundlage der oberflächenplasmonresonanz
JP4519124B2 (ja) 2003-01-30 2010-08-04 ユィロス・パテント・アクチボラグ 微小流動性デバイスの内部の壁
SE0300822D0 (sv) 2003-03-23 2003-03-23 Gyros Ab A collection of Micro Scale Devices
JP5171034B2 (ja) 2003-03-23 2013-03-27 ユィロス・パテント・アクチボラグ 充填済みのマイクロスケール装置
JP2007502218A (ja) 2003-05-23 2007-02-08 ユィロス・パテント・アクチボラグ 親水性／疎水性表面
US20050042770A1 (en) 2003-05-23 2005-02-24 Gyros Ab Fluidic functions based on non-wettable surfaces
WO2004106926A1 (en) 2003-06-02 2004-12-09 Gyros Patent Ab Microfluidic affinity assays with improved performance
US7776272B2 (en) 2003-10-03 2010-08-17 Gyros Patent Ab Liquid router
US8592219B2 (en) 2005-01-17 2013-11-26 Gyros Patent Ab Protecting agent

Also Published As

Publication number Publication date
US20060194273A1 (en) 2006-08-31
ES2203098T3 (es) 2004-04-01
JP2002512783A (ja) 2002-05-08
EP1073709B1 (de) 2003-07-09
US20040058408A1 (en) 2004-03-25
DE69909462T2 (de) 2004-04-15
EP1073709A1 (de) 2001-02-07
DE69933588T2 (de) 2007-08-16
WO1999055827A1 (en) 1999-11-04
US20120003682A1 (en) 2012-01-05
DE69909462D1 (de) 2003-08-14
EP1298198A2 (de) 2003-04-02
ATE244755T1 (de) 2003-07-15
EP1298198B1 (de) 2006-10-11
US7935522B2 (en) 2011-05-03
US20090239292A1 (en) 2009-09-24
JP4064631B2 (ja) 2008-03-19
US8030062B2 (en) 2011-10-04
EP1298198A3 (de) 2004-02-11
DE69933588D1 (de) 2006-11-23
GB9808836D0 (en) 1998-06-24
DK1073709T3 (da) 2003-11-03
CA2330034A1 (en) 1999-11-04
US6632656B1 (en) 2003-10-14

Similar Documents

Publication Publication Date Title
ATE342347T1 (de) Mikrofabrizierte vorrichtung zur analyse von zellen
NZ335863A (en) Apparatus and method for conducting assays such as blood screening
US7122104B2 (en) Electrophoresis apparatus for simultaneous loading of multiple samples
US5962250A (en) Split multi-well plate and methods
DE68917879D1 (de) Verfahren und Vorrichtung zur Analyse von Polynucleotid-Sequenzen.
DE69526364D1 (de) Patch-clamp-vorrichtung und -technik mit hohem durchfluss und niedrigen flüssigkeitsvolumenanforderungen
DE69429783D1 (de) Vorrichtung und verfahren zur sammlung von zellen aus einer flüssigen probe
DK0817679T3 (da) Forbedringer af behandlingen af prøver
WO2000049385A3 (en) Method and apparatus for analyzing cells in a whole blood sample
DE69841255D1 (de) Arbeitsgerät zur Analyse
NZ504112A (en) Continuous format high throughput screening for testing compound for biological activity
US6783928B2 (en) Microstructures for cell proliferation assays and semen analysis
US4978507A (en) Fluid flow manifold for blot type screening apparatus
US20190314812A1 (en) Skin sample culture and membrane test device
JP2006506646A (ja) 粒子の処理方法
TW200730812A (en) Dissolution test equipment and methods for testing
DK165859C (da) Apparat til bestemmelse af en analyt i en biologisk vaeske
JP7619773B2 (ja) 増幅反応チャンバーを含むマイクロ流体デバイス
US20070269347A1 (en) Microscope slide incubation and processing system
EP0486514A1 (de) Gerät für mikrobiologische versuche
JPWO2003029820A1 (ja) 電気泳動用デバイス、電気泳動装置、電気泳動法及び検体検出法
IL154643A (en) Electrophoresis apparatus for simultaneous loading of multiple samples

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties