ATE342731T1 - Virusimpfstoff charakterisiert durch eine bhv-1- gendeletion - Google Patents

Virusimpfstoff charakterisiert durch eine bhv-1- gendeletion

Info

Publication number: ATE342731T1
Authority: AT; Austria
Prior art keywords: bhv; virus; gene; eletion; deletion
Prior art date: 1999-01-29

Application number

AT00904385T

Other languages

English (en)

Inventor

Shafiqul I Chowdhury

Original Assignee

Univ Kansas State

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-29

Filing date

2000-01-18

Publication date

2006-11-15

2000-01-18 Application filed by Univ Kansas State filed Critical Univ Kansas State

2006-11-15 Application granted granted Critical

2006-11-15 Publication of ATE342731T1 publication Critical patent/ATE342731T1/de

Links

241000700605 Viruses Species 0.000 title abstract 3
229960005486 vaccine Drugs 0.000 title abstract 2
108090000623 proteins and genes Proteins 0.000 title 1
241001465754 Metazoa Species 0.000 abstract 4
241000701083 Bovine alphaherpesvirus 1 Species 0.000 abstract 2
WQZGKKKJIJFFOK-FPRJBGLDSA-N beta-D-galactose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-FPRJBGLDSA-N 0.000 abstract 2
108010005774 beta-Galactosidase Proteins 0.000 abstract 2
230000037430 deletion Effects 0.000 abstract 2
238000012217 deletion Methods 0.000 abstract 2
239000003550 marker Substances 0.000 abstract 2
230000029812 viral genome replication Effects 0.000 abstract 2
108091026890 Coding region Proteins 0.000 abstract 1
101000807236 Human cytomegalovirus (strain AD169) Membrane glycoprotein US3 Proteins 0.000 abstract 1
101150072564 gE gene Proteins 0.000 abstract 1
230000001900 immune effect Effects 0.000 abstract 1
230000037431 insertion Effects 0.000 abstract 1
238000003780 insertion Methods 0.000 abstract 1
239000013612 plasmid Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16741—Use of virus, viral particle or viral elements as a vector
- C12N2710/16743—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16761—Methods of inactivation or attenuation

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Virology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Immunology (AREA)
Microbiology (AREA)
Biophysics (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Physics & Mathematics (AREA)
Gastroenterology & Hepatology (AREA)
Plant Pathology (AREA)
Pulmonology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

AT00904385T 1999-01-29 2000-01-18 Virusimpfstoff charakterisiert durch eine bhv-1- gendeletion ATE342731T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US09/240,173 US6284251B1 (en)	1996-02-26	1999-01-29	BHV-1 gene-deleted virus vaccine

Publications (1)

Publication Number	Publication Date
ATE342731T1 true ATE342731T1 (de)	2006-11-15

Family

ID=22905424

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00904385T ATE342731T1 (de)	1999-01-29	2000-01-18	Virusimpfstoff charakterisiert durch eine bhv-1- gendeletion

Country Status (26)

Country	Link
US (1)	US6284251B1 (de)
EP (1)	EP1155119B1 (de)
JP (2)	JP2002535000A (de)
CN (1)	CN1197961C (de)
AT (1)	ATE342731T1 (de)
AU (1)	AU776261B2 (de)
BG (1)	BG105701A (de)
BR (1)	BR0007855A (de)
CA (1)	CA2359177C (de)
CZ (1)	CZ20012589A3 (de)
DE (1)	DE60031374T2 (de)
DK (1)	DK1155119T3 (de)
EA (1)	EA005736B1 (de)
EE (1)	EE200100396A (de)
ES (1)	ES2269101T3 (de)
HK (1)	HK1042512B (de)
HR (1)	HRP20010476B1 (de)
HU (1)	HUP0200560A2 (de)
NO (1)	NO20013697L (de)
NZ (1)	NZ512125A (de)
PT (1)	PT1155119E (de)
SK (1)	SK10702001A3 (de)
TR (1)	TR200102168T2 (de)
UA (1)	UA75035C2 (de)
WO (1)	WO2000044884A1 (de)
YU (1)	YU45601A (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2193842B1 (es) *	2001-06-28	2005-06-01	Consejo Superior De Investigaciones Cientificas	Virus recombinante de la fiebre aftosa que carece del sitio antigenico a y su utilizacion como vacuna marcada.
CN101353670B (zh) *	2007-07-27	2012-07-04	中国农业科学院哈尔滨兽医研究所	牛传染性鼻气管炎病毒重组毒株、其构建方法及应用
US8877211B2 (en)	2011-06-27	2014-11-04	Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College	Bovine herpes virus vaccine with multiple mutations
CN104640991B (zh) *	2012-07-04	2017-09-19	昆士兰州农渔林业部	重组低毒力1型牛疱疹病毒(BoHV‑1)疫苗载体
PL3194968T3 (pl) *	2014-08-01	2021-04-06	The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College	Wykrywanie i traktowanie bydlęcego wirusa opryszczki
CN107893056B (zh) *	2017-12-13	2019-08-27	江苏省农业科学院	山羊疱疹病毒ⅰ型疫苗株及其应用
CN108690835B (zh) *	2018-05-30	2021-08-31	内蒙古元山生物科技有限公司	一株I型牛疱疹病毒gE缺失毒株及其获取方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8305323D0 (en)	1983-02-25	1983-03-30	Baylor College Medicine	Infectious bovine rhinotracheitis vaccine
JP2559384B2 (ja)	1985-07-29	1996-12-04	ジ・アップジョン・カンパニ−	ウイルスワクチン
US4703011A (en)	1985-11-12	1987-10-27	Novagene, Inc.	Thymidine kinase deletion mutants of bovine herpesvirus-1
US5593873A (en) *	1986-01-27	1997-01-14	Syntro Corporation	Recombinant infectious bovine rhinotracheitis virus
WO1989010965A2 (en)	1988-05-03	1989-11-16	The Upjohn Company	Glycoprotein h of herpes viruses
FR2693472B1 (fr)	1992-06-26	1994-12-23	Rhone Merieux	Mutants du virus de la rhinotrachéite infectieuse bovine, délétés dans l'un des gènes des glycoprotéines mineures, vaccins préparés à partir de ces souches, méthodes de production et méthodes d'utilisation.
NL9100989A (nl) *	1991-06-07	1993-01-04	Stichting Centr Diergeneeskund	Bovine herpesvirus type 1 deletiemutanten, daarop gebaseerde vaccins, diagnostische kits voor detectie van bovine herpesvirus type 1.
US5874279A (en) *	1991-07-18	1999-02-23	Syntro Corporation	Recombinant infectious bovine rhinotracheitis virus
WO1993002104A1 (en)	1991-07-18	1993-02-04	Syntro Corporation	Recombinant infectious bovine rhinotracheitis virus
CA2057387A1 (en)	1991-12-11	1993-06-12	Lorne A. Babiuk	Recombinant bovine herpesvirus type 1 polypeptides and vaccines
ES2074965B1 (es) *	1994-01-31	1996-05-01	Hipra Lab Sa	Virus mutante recombinante de rinotraqueitis infecciosa bovina y vacunas que lo contienen.

1999
- 1999-01-29 US US09/240,173 patent/US6284251B1/en not_active Expired - Fee Related
2000
- 2000-01-18 HR HR20010476A patent/HRP20010476B1/xx not_active IP Right Cessation
- 2000-01-18 CA CA002359177A patent/CA2359177C/en not_active Expired - Fee Related
- 2000-01-18 EP EP00904385A patent/EP1155119B1/de not_active Expired - Lifetime
- 2000-01-18 YU YU45601A patent/YU45601A/sh unknown
- 2000-01-18 NZ NZ512125A patent/NZ512125A/xx unknown
- 2000-01-18 EE EEP200100396A patent/EE200100396A/xx unknown
- 2000-01-18 DE DE60031374T patent/DE60031374T2/de not_active Expired - Fee Related
- 2000-01-18 WO PCT/US2000/001085 patent/WO2000044884A1/en not_active Ceased
- 2000-01-18 BR BR0007855-7A patent/BR0007855A/pt not_active IP Right Cessation
- 2000-01-18 UA UA2001075409A patent/UA75035C2/uk unknown
- 2000-01-18 DK DK00904385T patent/DK1155119T3/da active
- 2000-01-18 PT PT00904385T patent/PT1155119E/pt unknown
- 2000-01-18 TR TR2001/02168T patent/TR200102168T2/xx unknown
- 2000-01-18 JP JP2000596128A patent/JP2002535000A/ja active Pending
- 2000-01-18 HU HU0200560A patent/HUP0200560A2/hu unknown
- 2000-01-18 HK HK02102265.2A patent/HK1042512B/en not_active IP Right Cessation
- 2000-01-18 AT AT00904385T patent/ATE342731T1/de not_active IP Right Cessation
- 2000-01-18 SK SK1070-2001A patent/SK10702001A3/sk unknown
- 2000-01-18 CZ CZ20012589A patent/CZ20012589A3/cs unknown
- 2000-01-18 AU AU26152/00A patent/AU776261B2/en not_active Ceased
- 2000-01-18 EA EA200100720A patent/EA005736B1/ru not_active IP Right Cessation
- 2000-01-18 ES ES00904385T patent/ES2269101T3/es not_active Expired - Lifetime
- 2000-01-18 CN CNB008031363A patent/CN1197961C/zh not_active Expired - Fee Related
2001
- 2001-07-12 BG BG105701A patent/BG105701A/bg unknown
- 2001-07-27 NO NO20013697A patent/NO20013697L/no not_active Application Discontinuation
2006
- 2006-08-23 JP JP2006226616A patent/JP2007020574A/ja active Pending

Also Published As

Publication number	Publication date
DK1155119T3 (da)	2007-02-05
DE60031374D1 (de)	2006-11-30
BR0007855A (pt)	2001-10-23
ES2269101T3 (es)	2007-04-01
YU45601A (sh)	2005-06-10
EE200100396A (et)	2002-10-15
HUP0200560A2 (en)	2002-06-29
EA200100720A1 (ru)	2002-02-28
DE60031374T2 (de)	2007-08-30
CZ20012589A3 (cs)	2002-03-13
AU776261B2 (en)	2004-09-02
JP2002535000A (ja)	2002-10-22
EP1155119A1 (de)	2001-11-21
NO20013697D0 (no)	2001-07-27
UA75035C2 (en)	2006-03-15
WO2000044884A1 (en)	2000-08-03
HK1042512B (en)	2007-05-11
US6284251B1 (en)	2001-09-04
CN1197961C (zh)	2005-04-20
EP1155119B1 (de)	2006-10-18
EA005736B1 (ru)	2005-06-30
CN1364193A (zh)	2002-08-14
NZ512125A (en)	2003-01-31
CA2359177A1 (en)	2000-08-03
NO20013697L (no)	2001-08-27
EP1155119A4 (de)	2003-01-02
HRP20010476A2 (en)	2002-08-31
BG105701A (bg)	2002-03-29
TR200102168T2 (tr)	2001-12-21
HRP20010476B1 (hr)	2007-09-30
HK1042512A1 (en)	2002-08-16
CA2359177C (en)	2007-07-03
PT1155119E (pt)	2006-12-29
AU2615200A (en)	2000-08-18
JP2007020574A (ja)	2007-02-01
SK10702001A3 (sk)	2002-01-07

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2007-03-15

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Publication	Publication Date	Title
EP0232798A3 (de)	1987-10-14	Pseudorabies-Virus-Mutanten, diese enthaltende Vakzine, Verfahren zu deren Herstellung sowie Methoden für deren Anwendung
BR9908267A (pt)	2000-10-24	Plasmìdeo, composição farmacêutica, processos para induzir uma resposta imunológica em um indivìduo contra um imunógeno, para imunizar um indivìduo contra uma infecção por vìrus de herpes simples e para tratar um indivìduo que tem uma doença autoimune, vacina recombinante, e, patógeno atenuado vivo
DE69535359D1 (de)	2007-02-15	Rekombinantes herpesvirus aus trufhähnen und seine verwendungen
DE3786824D1 (de)	1993-09-09	Rekombinante herpes simplex-viren, vakzine und verfahren.
ES2001752A6 (es)	1988-06-16	Procedimiento para producir una vacuna de herpesvirus, y para produciruna vacuna multivalente.
ID24174A (id)	2000-07-13	Vector dari porcine adenovirus
DE50206472D1 (de)	2006-05-24	Attenuierte lebendimpfstoffe
EP1064024A4 (de)	2005-04-06	Impfstoffe gegen circovirus infektionen
RU2003103779A (ru)	2004-08-20	Экспрессионная система
UA40571C2 (uk)	2001-08-15	Мутант коров'ячого вірусу герпесу типу 1 (bhv-1), композиція вакцини для вакцинації тварин для захисту їх від bhv-1, композиція вакцини для вакцинації тварин для захисту їх від патогена
AU3142889A (en)	1989-09-21	A recombinant marek's disease virus and a vaccine
ATE342731T1 (de)	2006-11-15	Virusimpfstoff charakterisiert durch eine bhv-1- gendeletion
WO2003078640A8 (en)	2004-01-29	Recombinant drug-sensitive vaccinia virus as smallpox vaccine
CA2417923A1 (en)	2002-02-14	Vaccination against host cell-associated herpesviruses
AU2403188A (en)	1989-06-01	Infectious bovine rhinotracheitis virus mutants, vaccines containing same, methods for the production of same and methods for the use of same
EP1523333A4 (de)	2007-01-24	Verwendung des vaccinia-virus mit deletion des e3l-gens als vakzine-vektor
WO1994000586A3 (fr)	1994-02-17	Mutants et vaccins du virus de la rhinotracheite infectieuse bovine
IL141443A0 (en)	2002-03-10	Vaccine comprising cytokine-induced heat shock proteins (hsp)
Chowdhury	2001	BHV-1 gene-deleted virus vaccine
MXPA03007862A (es)	2004-05-24	Vacunas de vector basadas en leporipox.
EP0668356A3 (de)	1998-09-02	Rekombinante, infektöse Rinder-Rhinotracheitis-Mutante, Methode zu deren Herstellung, und Vakzine dieselbige enthaltend
BR0101523A (pt)	2001-11-20	Pestivìrus, vacina, e, processos para imunizarcontra doença induzida por pestivìrus e parafabricar uma vacina para a proteção de um animalcontra um pestivìrus
WO2002020041A3 (en)	2003-01-09	Eia vaccine and diagnostic
Zhi et al.	2002	Modification of HPV type 16 E6 and E7 genes, and analysis of stability and immunogenicity of the modified proteins
Audonnet et al.	1998	Avian herpesvirus-based live recombinant avian vaccine, in particular against Gumboro disease