ATE342920T1 - Methylierte smd homologe peptide, die mit antikörpern aus sera von lebewesen mit systemischer lupus erythematodes reagieren - Google Patents

Methylierte smd homologe peptide, die mit antikörpern aus sera von lebewesen mit systemischer lupus erythematodes reagieren

Info

Publication number
ATE342920T1
ATE342920T1 AT98947487T AT98947487T ATE342920T1 AT E342920 T1 ATE342920 T1 AT E342920T1 AT 98947487 T AT98947487 T AT 98947487T AT 98947487 T AT98947487 T AT 98947487T AT E342920 T1 ATE342920 T1 AT E342920T1
Authority
AT
Austria
Prior art keywords
antibodies
systemic lupus
sera
erythematode
smd
Prior art date
Application number
AT98947487T
Other languages
English (en)
Inventor
Lydie Meheus
Reinhard Georg Luehrmann
Ann Union
Joseph Raymackers
Original Assignee
Innogenetics Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innogenetics Nv filed Critical Innogenetics Nv
Application granted granted Critical
Publication of ATE342920T1 publication Critical patent/ATE342920T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rehabilitation Therapy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT98947487T 1997-08-29 1998-08-31 Methylierte smd homologe peptide, die mit antikörpern aus sera von lebewesen mit systemischer lupus erythematodes reagieren ATE342920T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97870127 1997-08-29

Publications (1)

Publication Number Publication Date
ATE342920T1 true ATE342920T1 (de) 2006-11-15

Family

ID=8231033

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98947487T ATE342920T1 (de) 1997-08-29 1998-08-31 Methylierte smd homologe peptide, die mit antikörpern aus sera von lebewesen mit systemischer lupus erythematodes reagieren

Country Status (9)

Country Link
US (2) US6362007B1 (de)
EP (1) EP0944649B1 (de)
JP (1) JP2001505785A (de)
AT (1) ATE342920T1 (de)
AU (1) AU751784B2 (de)
CA (1) CA2270176C (de)
DE (1) DE69836197T2 (de)
ES (1) ES2276474T3 (de)
WO (1) WO1999011667A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020002270A1 (en) * 1999-06-16 2002-01-03 Raymond P. Zinkowski Purified antigen for alzheimer's disease, and methods of obtaining and using same
US6699673B2 (en) 1999-12-22 2004-03-02 The Research Foundation Of State University Of New York Protein methylarginine-specific antibodies
WO2001094620A1 (en) * 2000-06-09 2001-12-13 Boehringer Ingelheim International Gmbh Screening-method for modulators of methyltransferase-dependent chromosome stability
EP1162274A1 (de) * 2000-06-09 2001-12-12 Boehringer Ingelheim International GmbH Verfahren zur Identifizierung von Verbindungen, die die Methyltransferase-abhängige Chromosomen-Stabilität beeinflussen
EP1162460A1 (de) * 2000-06-09 2001-12-12 Boehringer Ingelheim International GmbH Screeningverfahren für Modulatoren des Suv39h2 Methyltransferases und der männlichen Gametogenese
US7332168B2 (en) 2000-08-22 2008-02-19 Micromet Ag Composition for the elimination of autoreactive B-cells
SE0300958D0 (sv) * 2003-04-02 2003-04-02 Pharmacia Diagnostics Ab Analytical method and kit therof
JPWO2005075414A1 (ja) * 2004-02-04 2007-10-11 公立大学法人横浜市立大学 ペプチジルアルギニンデイミナーゼ４阻害剤
US20050277205A1 (en) * 2004-02-20 2005-12-15 Ki-Bum Lee Multicomponent magnetic nanorods for biomolecular separations
US7422696B2 (en) * 2004-02-20 2008-09-09 Northwestern University Multicomponent nanorods
WO2010005718A1 (en) * 2008-06-16 2010-01-14 University Of Louisville Research Foundation, Inc Systems and methods for diagnosis and prognosis of cancer
US10295547B2 (en) 2013-03-14 2019-05-21 University Of Florida Research Foundation, Incorporated Use and treatment of di-amino acid repeat-containing proteins associated with ALS
US10509045B2 (en) 2015-05-29 2019-12-17 University Of Florida Research Foundation, Incorporated Methods for diagnosing Huntington's disease
US10940161B2 (en) 2016-04-04 2021-03-09 University Of Florida Research Foundation, Incorporated Manipulation of EIF3 to modulate repeat associated non-ATG (RAN) translation
CN106188272A (zh) * 2016-07-27 2016-12-07 朱玫玫 基因工程鼠提高Btg2表达水平的新功能
EP3612190A4 (de) 2017-04-17 2021-01-20 University of Florida Research Foundation, Incorporated Regulierung der ran-translation durch pkr- und eif2a-p-wege
EP3688020A4 (de) 2017-09-25 2021-07-14 University of Florida Research Foundation, Incorporated Immunoassays zum nachweis von ran-proteinen
AU2018342105B2 (en) 2017-09-26 2023-11-16 University Of Florida Research Foundation, Incorporated Use of metformin and analogs thereof to reduce ran protein levels in the treatment of neurological disorders
AU2020348916B2 (en) 2019-09-20 2025-12-18 University Of Florida Research Foundation, Incorporated Detection of antibodies against RAN proteins from serum and tissue lysates
WO2021072187A2 (en) 2019-10-10 2021-04-15 University Of Florida Research Foundation, Incorporated Ran proteins as biomarkers in cag/ctg expansion disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4654419A (en) * 1984-08-08 1987-03-31 Scripps Clinic And Research Foundation Synthetic polypeptides and antibodies related to epstein-barr virus nuclear antigen
FR2663034B1 (fr) 1990-06-06 1995-04-21 Neosystem Sa Peptides de l'antigene sm-d et leur utilisation notamment pour le diagnostic du lupus erythemateux dissemine.
AU1209995A (en) 1993-11-17 1995-06-06 Duke University Medical Center Use of nitric oxide synthase inhibitors in the treatment of autoimmune diseases
EP0776906A3 (de) * 1995-10-19 1998-02-25 Imtec Immundiagnostika Gmbh Peptide des Antigens Sm-D und ihre Verwendung, insbesondere für die Diagnostik des SLE

Also Published As

Publication number Publication date
AU751784B2 (en) 2002-08-29
DE69836197D1 (de) 2006-11-30
AU9438798A (en) 1999-03-22
JP2001505785A (ja) 2001-05-08
US20020165355A1 (en) 2002-11-07
EP0944649A1 (de) 1999-09-29
CA2270176A1 (en) 1999-03-11
ES2276474T3 (es) 2007-06-16
DE69836197T2 (de) 2007-09-06
WO1999011667A1 (en) 1999-03-11
US6362007B1 (en) 2002-03-26
EP0944649B1 (de) 2006-10-18
CA2270176C (en) 2011-08-23

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