ATE343393T1 - Verfahren zur isolierung von terpentrilactonen (ginkgoliden, bilobaliden) aus blättern und pharmazeutische pulver aus ginkgo biloba - Google Patents

Verfahren zur isolierung von terpentrilactonen (ginkgoliden, bilobaliden) aus blättern und pharmazeutische pulver aus ginkgo biloba

Info

Publication number
ATE343393T1
ATE343393T1 AT02748132T AT02748132T ATE343393T1 AT E343393 T1 ATE343393 T1 AT E343393T1 AT 02748132 T AT02748132 T AT 02748132T AT 02748132 T AT02748132 T AT 02748132T AT E343393 T1 ATE343393 T1 AT E343393T1
Authority
AT
Austria
Prior art keywords
acceptable
organic layer
terpene trilactones
ginkgo biloba
extract
Prior art date
Application number
AT02748132T
Other languages
English (en)
Inventor
Dirk Andreas Litchblau
John Berger
Nina Berova
Koji Nakanishi
Original Assignee
Univ Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia filed Critical Univ Columbia
Application granted granted Critical
Publication of ATE343393T1 publication Critical patent/ATE343393T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT02748132T 2001-07-11 2002-07-11 Verfahren zur isolierung von terpentrilactonen (ginkgoliden, bilobaliden) aus blättern und pharmazeutische pulver aus ginkgo biloba ATE343393T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90304901A 2001-07-11 2001-07-11

Publications (1)

Publication Number Publication Date
ATE343393T1 true ATE343393T1 (de) 2006-11-15

Family

ID=25416854

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02748132T ATE343393T1 (de) 2001-07-11 2002-07-11 Verfahren zur isolierung von terpentrilactonen (ginkgoliden, bilobaliden) aus blättern und pharmazeutische pulver aus ginkgo biloba

Country Status (7)

Country Link
US (3) US6590109B2 (de)
EP (1) EP1416949B1 (de)
KR (1) KR20040031772A (de)
AT (1) ATE343393T1 (de)
CA (1) CA2453467A1 (de)
DE (1) DE60215671T2 (de)
WO (1) WO2003006040A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2823116B1 (fr) * 2001-04-10 2004-11-19 Sod Conseils Rech Applic Procede de preparation d'une extrait de feuilles de ginkgo biloba hautement enrichi en principes actifs
WO2003006040A1 (en) * 2001-07-11 2003-01-23 The Trustees Of Columbia University In The City Of New York Method for isolating terpene trilactones (ginkgolides, bilobalide) from leaves and pharmaceutical powders of ginkgo biloba
WO2003082185A2 (en) * 2002-03-29 2003-10-09 The Trustees Of Columbia University In The City Of New York Analogs of terpene trilactones from ginkgo biloba and related compounds and uses thereof
ITMI20031390A1 (it) * 2003-07-08 2005-01-09 Turispharma S R L Metodo di estrazione di strutture molecolari attive da resine naturali e/o da oli essenziali.
US7429670B2 (en) 2003-08-27 2008-09-30 The Trustees Of Columbia University In The City Of New York Synthesis of derivatives of ginkgolide C
KR100579710B1 (ko) * 2003-09-16 2006-05-15 학교법인조선대학교 은행잎에서 분리한 비듬치료 및 탈모방지용 샴푸 조성물
WO2005046829A2 (en) 2003-11-12 2005-05-26 The Trustees Of Columbia University In The City Of New York Separation of ginkgolides and bilobalide from g. biloba
US20090156668A1 (en) * 2004-03-19 2009-06-18 The Trustees Of Columbia University In The City Of New York Ginkgolide Compounds, Compositions, And Extracts, And Uses Thereof
KR100623164B1 (ko) * 2004-07-22 2006-09-19 재단법인서울대학교산학협력재단 뇌신경 보호효과를 갖는 신규한 은행잎 엑스를 정제하는방법 및 이를 함유하는 조성물
US20080306145A1 (en) * 2004-11-23 2008-12-11 The Trustees Of Columbia University In The City Of New York Preparation Of Ginkgolide And F-Seco-Ginkgolide Lactols
US20090221019A1 (en) * 2005-06-22 2009-09-03 Koji Nakanishi Core-Modified Terpene Trilactones From Ginkgo Biloba Extract and Biological Evaluation Thereof
CN100462006C (zh) * 2006-02-21 2009-02-18 复旦大学 银杏酸在制备杀灭钉螺、防止血吸虫病的生物农药中的用途
CN102199159B (zh) * 2011-03-21 2013-07-03 贵州大学 从银杏根皮中分离、纯化银杏内酯c的方法
JP5461614B2 (ja) 2011-05-31 2014-04-02 株式会社Ｔｂｍ 無機物質粉末高配合薄膜シートの製造方法
CN103396421B (zh) * 2013-08-21 2016-03-30 上海信谊百路达药业有限公司 一种银杏内酯c的分离纯化方法
CN103524526B (zh) * 2013-10-15 2016-05-25 上海信谊百路达药业有限公司 一种白果内酯的分离纯化方法
CN104034826B (zh) * 2014-07-08 2015-12-02 上海信谊百路达药业有限公司 一种银杏叶提取物中萜类内酯的检测方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117429C3 (de) * 1971-04-08 1982-04-01 Fa. Dr. Willmar Schwabe, 7500 Karlsruhe Verfahren zur Herstellung eines Injektions- bzw. Infusionspräparates mit einem Gehalt an einem Wirkstoffgemisch aus den Blättern von Ginkgo biloba
FR2627387B1 (fr) 1988-02-24 1992-06-05 Fabre Sa Pierre Procede d'obtention d'un extrait de feuilles de ginkgo biloba
DE3940091A1 (de) 1989-12-04 1991-06-06 Schwabe Willmar Gmbh & Co Extrakt aus blaettern von ginkgo biloba, verfahren zu seiner herstellung und den extrakt enthaltende arzneimittel
DE3940094A1 (de) * 1989-12-04 1991-06-06 Montana Ltd Wirkstoffkonzentrate und neue wirkstoff-kombinationen aus blaettern von ginkgo biloba, ein verfahren zu ihrer herstellung und die wirkstoff-konzentrate bzw. die wirkstoff-kombinationen enthaltenden arzneimittel
DE4030758A1 (de) 1990-09-28 1992-04-02 Schwabe Willmar Gmbh & Co Extrakt aus blaettern von ginkgo biloba, insbesondere zur intravenoesen injektion oder infusion, verfahren zu seiner herstellung und den extrakt enthaltende ampullenpraeparate
KR930002507A (ko) * 1991-07-18 1993-02-23 김영중 식물세포 배양법에 의한 징콜라이드류의 제조방법
US6274621B1 (en) * 1995-11-09 2001-08-14 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Ginkgolides for inhibition of membrane expression of benzodiazepine receptors
US6221356B1 (en) 1996-12-13 2001-04-24 Viva America Marketing, Inc. Method of preparation of biologically active Ginkgo biloba product
FR2763592B1 (fr) 1997-05-20 1999-07-16 Sod Conseils Rech Applic Nouveaux derives glycosyles des ginkgolides, leur application en tant que medicaments et compositions pharmaceutiques les contenant
WO1999026643A1 (en) 1997-11-25 1999-06-03 Pharmanex, Inc. Methods of preparation of bioginkgo
DE19756848C2 (de) * 1997-12-19 2003-01-16 Schwabe Willmar Gmbh & Co Extrakte aus Blättern von Ginkgo biloba mit vermindertem Gehalt an 4'-O-Methylpyridoxin und Biflavonen
US6030621A (en) 1998-03-19 2000-02-29 De Long; Xie Ginkgo biloba composition, method to prepare the same and uses thereof
US6117431A (en) 1999-12-03 2000-09-12 Pharmline Inc. Method for obtaining an extract from ginkgo biloba leaves
FR2823116B1 (fr) 2001-04-10 2004-11-19 Sod Conseils Rech Applic Procede de preparation d'une extrait de feuilles de ginkgo biloba hautement enrichi en principes actifs
WO2003006040A1 (en) 2001-07-11 2003-01-23 The Trustees Of Columbia University In The City Of New York Method for isolating terpene trilactones (ginkgolides, bilobalide) from leaves and pharmaceutical powders of ginkgo biloba
US6693091B2 (en) * 2002-03-29 2004-02-17 The Trustees Of Columbia University In The City Of New York Analogs of terpene trilactones from Ginkgo biloba for bioorganic and imaging studies

Also Published As

Publication number Publication date
EP1416949A1 (de) 2004-05-12
HK1065939A1 (en) 2005-03-11
DE60215671T2 (de) 2007-09-06
US20030031736A1 (en) 2003-02-13
KR20040031772A (ko) 2004-04-13
EP1416949A4 (de) 2005-11-16
EP1416949B1 (de) 2006-10-25
WO2003006040A1 (en) 2003-01-23
DE60215671D1 (de) 2006-12-07
US20040077883A1 (en) 2004-04-22
US6844451B2 (en) 2005-01-18
US20050136136A1 (en) 2005-06-23
US6590109B2 (en) 2003-07-08
CA2453467A1 (en) 2003-01-23

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