ATE344035T1 - Topische zusammensetzung enthaltend ein opioid- analgetikum und einen nmda-antagonisten - Google Patents

Topische zusammensetzung enthaltend ein opioid- analgetikum und einen nmda-antagonisten

Info

Publication number: ATE344035T1
Authority: AT; Austria
Prior art keywords: morphine; topical; tolerance; nmda; peripheral
Prior art date: 1998-07-16

Application number

AT99934071T

Other languages

English (en)

Inventor

Yuri Kolesnikov

Gavril W Pasternak

Original Assignee

Memorial Sloan Kettering Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-16

Filing date

1999-07-15

Publication date

2006-11-15

1999-07-15 Application filed by Memorial Sloan Kettering Inst filed Critical Memorial Sloan Kettering Inst

2006-11-15 Application granted granted Critical

2006-11-15 Publication of ATE344035T1 publication Critical patent/ATE344035T1/de

Links

230000000699 topical effect Effects 0.000 title abstract 7
239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 title abstract 2
239000000014 opioid analgesic Substances 0.000 title 1
BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 abstract 16
229960005181 morphine Drugs 0.000 abstract 8
HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 3
230000002093 peripheral effect Effects 0.000 abstract 3
HPZJMUBDEAMBFI-WTNAPCKOSA-N (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin Chemical compound C([C@H](N)C(=O)N[C@H](C)C(=O)NCC(=O)N(C)[C@@H](CC=1C=CC=CC=1)C(=O)NCCO)C1=CC=C(O)C=C1 HPZJMUBDEAMBFI-WTNAPCKOSA-N 0.000 abstract 2
108700022183 Ala(2)-MePhe(4)-Gly(5)- Enkephalin Proteins 0.000 abstract 2
108010092674 Enkephalins Proteins 0.000 abstract 2
URLZCHNOLZSCCA-VABKMULXSA-N Leu-enkephalin Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 URLZCHNOLZSCCA-VABKMULXSA-N 0.000 abstract 2
230000036592 analgesia Effects 0.000 abstract 2
230000000202 analgesic effect Effects 0.000 abstract 2
239000005557 antagonist Substances 0.000 abstract 2
YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 abstract 1
102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 abstract 1
108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 abstract 1
229940127523 NMDA Receptor Antagonists Drugs 0.000 abstract 1
229940099433 NMDA receptor antagonist Drugs 0.000 abstract 1
102000003840 Opioid Receptors Human genes 0.000 abstract 1
108090000137 Opioid Receptors Proteins 0.000 abstract 1
-1 [D-Ala2 Chemical compound 0.000 abstract 1
238000003556 assay Methods 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
231100000673 dose–response relationship Toxicity 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
229960003299 ketamine Drugs 0.000 abstract 1
230000007246 mechanism Effects 0.000 abstract 1
229940005483 opioid analgesics Drugs 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
102000005962 receptors Human genes 0.000 abstract 1
108020003175 receptors Proteins 0.000 abstract 1
230000009885 systemic effect Effects 0.000 abstract 1
231100000936 topical exposure Toxicity 0.000 abstract 1
239000012049 topical pharmaceutical composition Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Anesthesiology (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT99934071T 1998-07-16 1999-07-15 Topische zusammensetzung enthaltend ein opioid- analgetikum und einen nmda-antagonisten ATE344035T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US9298298P	1998-07-16	1998-07-16

Publications (1)

Publication Number	Publication Date
ATE344035T1 true ATE344035T1 (de)	2006-11-15

Family

ID=22236108

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99934071T ATE344035T1 (de)	1998-07-16	1999-07-15	Topische zusammensetzung enthaltend ein opioid- analgetikum und einen nmda-antagonisten

Country Status (15)

Country	Link
US (1)	US7700122B1 (de)
EP (1)	EP1102589B1 (de)
JP (2)	JP2002520363A (de)
KR (1)	KR100762018B1 (de)
CN (1)	CN1309562A (de)
AT (1)	ATE344035T1 (de)
AU (1)	AU758448B2 (de)
BR (1)	BR9912827A (de)
CA (1)	CA2336902C (de)
DE (1)	DE69933874T2 (de)
DK (1)	DK1102589T3 (de)
ES (1)	ES2198196B2 (de)
IL (2)	IL140834A0 (de)
PT (1)	PT1102589E (de)
WO (1)	WO2000003716A1 (de)

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DE10025946A1 (de) *	2000-05-26	2001-11-29	Gruenenthal Gmbh	Wirkstoffkombination
US20020013331A1 (en)	2000-06-26	2002-01-31	Williams Robert O.	Methods and compositions for treating pain of the mucous membrane
US7820688B2 (en)	2001-04-27	2010-10-26	Memorial Sloan-Kettering Cancer Center	Topical anesthetic/opioid formulations and uses thereof
DE60143671D1 (de)	2001-06-07	2011-01-27	Sang Christine	Behandlung von neuropathischen schmerzen mittels eines n-methyl-d-aspartate (nmda)-rezeptor-antagonists
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JP2006500395A (ja) *	2002-09-09	2006-01-05	エンドファーマシューティカルズインコーポレーテッド	組み合わされた即時放出及び徐放の鎮痛組成物
CA2551169A1 (en) *	2002-12-23	2004-07-08	Global Cardiac Solutions Pty Ltd	Organ preconditioning, arrest, protection, preservation and recovery
DE10340428B4 (de) *	2003-09-02	2015-02-12	Acino Ag	Opioides Analgetikum enthaltende transdermale Formulierung
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CN101317844B (zh) *	2007-06-08	2010-11-17	章劲夫	化合物(+)-5-甲基-10，11-二氢-5H-二苯并〔a，d〕环庚烯-5，10-亚胺在制备避孕药物中的应用
TWI380992B (zh)	2010-03-11	2013-01-01	Univ Ishou	一種抑制ｎｍｄａ受體ｎｒ１之小段干擾ｒｎａ、該小段干擾ｒｎａ用以抑制皮下組織ｎｍｄａ受體ｎｒ１之方法、該小段干擾ｒｎａ之用途以及一種減緩皮膚炎症性疼痛之藥物化合物
AU2011267474B2 (en)	2010-06-15	2016-05-26	Grünenthal GmbH	Pharmaceutical combination for the treatment of pain
DE102010024105A1 (de)	2010-06-17	2011-12-22	Grünenthal GmbH	Transdermale Verabreichung von Memantin
TWI417109B (zh)	2010-12-30	2013-12-01	Univ Ishou	一種用以抑制ｎｍｄａ受體ｎｒ１之短夾ｒｎａ、一種以短夾rna製備用以抑制ｎｍｄａ受體ｎｒ１之試劑之用途以及一種減緩皮膚炎症性疼痛之藥物
FR2998892B1 (fr)	2012-12-04	2015-01-02	Pf Medicament	Derives d'aminocyclobutane, leur procede de preparation et leur utilisation a titre de medicaments
AU2014292827A1 (en)	2013-07-17	2016-02-04	Hibernation Therapeutics, A Kf Llc	A method for organ arrest, protection and preservation and reducing tissue injury
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1999
- 1999-07-15 EP EP99934071A patent/EP1102589B1/de not_active Expired - Lifetime
- 1999-07-15 AU AU49987/99A patent/AU758448B2/en not_active Ceased
- 1999-07-15 WO PCT/US1999/016049 patent/WO2000003716A1/en not_active Ceased
- 1999-07-15 ES ES200150003A patent/ES2198196B2/es not_active Expired - Fee Related
- 1999-07-15 US US09/806,645 patent/US7700122B1/en not_active Expired - Fee Related
- 1999-07-15 JP JP2000559851A patent/JP2002520363A/ja active Pending
- 1999-07-15 PT PT99934071T patent/PT1102589E/pt unknown
- 1999-07-15 DK DK99934071T patent/DK1102589T3/da active
- 1999-07-15 IL IL14083499A patent/IL140834A0/xx active IP Right Grant
- 1999-07-15 DE DE69933874T patent/DE69933874T2/de not_active Expired - Fee Related
- 1999-07-15 CN CN99808693A patent/CN1309562A/zh active Pending
- 1999-07-15 AT AT99934071T patent/ATE344035T1/de not_active IP Right Cessation
- 1999-07-15 KR KR1020017000660A patent/KR100762018B1/ko not_active Expired - Fee Related
- 1999-07-15 BR BR9912827-6A patent/BR9912827A/pt not_active IP Right Cessation
- 1999-07-15 CA CA002336902A patent/CA2336902C/en not_active Expired - Fee Related
2001
- 2001-01-10 IL IL140834A patent/IL140834A/en not_active IP Right Cessation
2007
- 2007-07-02 JP JP2007174667A patent/JP2007246546A/ja active Pending

Also Published As

Publication number	Publication date
CN1309562A (zh)	2001-08-22
EP1102589A1 (de)	2001-05-30
DK1102589T3 (da)	2006-12-04
EP1102589B1 (de)	2006-11-02
CA2336902A1 (en)	2000-01-27
IL140834A0 (en)	2002-02-10
AU758448B2 (en)	2003-03-20
JP2007246546A (ja)	2007-09-27
ES2198196A1 (es)	2004-01-16
WO2000003716A1 (en)	2000-01-27
DE69933874D1 (de)	2006-12-14
KR20010070969A (ko)	2001-07-28
AU4998799A (en)	2000-02-07
PT1102589E (pt)	2006-12-29
IL140834A (en)	2009-02-11
US7700122B1 (en)	2010-04-20
KR100762018B1 (ko)	2007-10-04
BR9912827A (pt)	2001-05-02
CA2336902C (en)	2009-04-21
ES2198196B2 (es)	2006-04-01
JP2002520363A (ja)	2002-07-09
DE69933874T2 (de)	2007-10-04

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Publication	Publication Date	Title
DE69933874D1 (de)	2006-12-14	Topische zusammensetzung enthaltend ein opioid-analgetikum und einen nmda-antagonisten
Sacerdote et al.	1997	Antinociceptive and immunosuppressive effects of opiate drugs: a structure‐related activity study
ATE220907T1 (de)	2002-08-15	Opioidantagonisthaltige galenische formulierung
CR6767A (es)	2004-06-09	Una composicion farmaceutica para el tratamiento del dolor agudo, cronico y/o el dolor neuropatico y las migranas
WO2003090697A3 (en)	2004-10-07	Chimeric hybrid analgesics
AU2003275357A1 (en)	2004-04-19	Analgesic compositions comprising nmda receptor antagonists and benzalkonium chloride
SI1041987T1 (sl)	2006-10-31	Farmacevtska oralna dozirna oblika, ki obsega kombinacijo opioidnega agonista in naltreksona
ATE407125T1 (de)	2008-09-15	Pharmazeutische zusammenstellungen aus tachykinin antagonisten und einen serotonin-wiederaufname hemmer
ATE296629T1 (de)	2005-06-15	Pharmazeutische zusammensetzungen mit nmda- rezeptor-agonist
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DE69619832D1 (de)	2002-04-18	Schmerzlindernde arzneistoffzusammensetzung
CA2325739A1 (en)	1999-09-30	Combination for the treatment of alcohol and drug dependence containing an opioid antagonist and a nmda receptor complex modulator
LT2001119A (en)	2002-07-25	Pharmaceutical formulations comprising intranasal morphine and use thereof
AU2161599A (en)	1999-06-28	Pharmaceutical combination with analgesic activity, containing an adenosinergic agonist and a compound selected from opiates, benzodiazepines and nmda antagonists
ATE252377T1 (de)	2003-11-15	Kontrolliert freisetzende pharmazeutische zusammensetzung mit tilidinmesylat als wirkstoff
DE69810146D1 (de)	2003-01-23	Analgetika, einen cholezystokinin antagonisten und ein opioid enthaltend
IS8396A (is)	2006-04-03	Lyfjablanda sem felur í sér P2X7 viðtakamótlyf ogbólgueyðandi lyf án stera
SE9702651D0 (sv)	1997-07-09	Novel compounds
Allen et al.	1999	The competitive NMDA receptor antagonist LY235959 modulates the progression of morphine tolerance in rats
DE60236077D1 (de)	2010-06-02	Analgetische zusammensetzung enthaltend ein opioid und einen natriumkanalblocker
TNSN05233A1 (en)	2007-06-11	Oral pharmaceutical preparation comprising a proton pump antagonist and a basic exipient
Benthuysen et al.	1989	Synthetic opioids compared with morphine and ketamine: catalepsy, cross-tolerance and interactions in the rat
EP1164994A4 (de)	2004-05-26	Opioid-agonist in schnell dispergierender darreichungsform