ATE345129T1 - Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer - Google Patents
Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmerInfo
- Publication number
- ATE345129T1 ATE345129T1 AT01994068T AT01994068T ATE345129T1 AT E345129 T1 ATE345129 T1 AT E345129T1 AT 01994068 T AT01994068 T AT 01994068T AT 01994068 T AT01994068 T AT 01994068T AT E345129 T1 ATE345129 T1 AT E345129T1
- Authority
- AT
- Austria
- Prior art keywords
- polyaza
- naphthalenyl
- aza
- hiv
- carbonic acid
- Prior art date
Links
- 229940099797 HIV integrase inhibitor Drugs 0.000 title 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 title 1
- 239000003084 hiv integrase inhibitor Substances 0.000 title 1
- 208000030507 AIDS Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- JKNBCQYLFYHBHU-UHFFFAOYSA-N 1,8-naphthyridine-2-carboxamide Chemical class C1=CC=NC2=NC(C(=O)N)=CC=C21 JKNBCQYLFYHBHU-UHFFFAOYSA-N 0.000 abstract 1
- 108010002459 HIV Integrase Proteins 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 229940053202 antiepileptics carboxamide derivative Drugs 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- 229940121354 immunomodulator Drugs 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 229940042443 other antivirals in atc Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- ZEXKKIXCRDTKBF-UHFFFAOYSA-N quinoline-2-carboxamide Chemical compound C1=CC=CC2=NC(C(=O)N)=CC=C21 ZEXKKIXCRDTKBF-UHFFFAOYSA-N 0.000 abstract 1
- 230000010076 replication Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Compression Or Coding Systems Of Tv Signals (AREA)
- Pyrrole Compounds (AREA)
- Decoration By Transfer Pictures (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23967900P | 2000-10-12 | 2000-10-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE345129T1 true ATE345129T1 (de) | 2006-12-15 |
Family
ID=22903252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01994068T ATE345129T1 (de) | 2000-10-12 | 2001-10-09 | Aza- und polyaza-naphthalenylcarbonsäureamide als hiv-integrase-hemmer |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6841558B2 (de) |
| EP (1) | EP1326610B1 (de) |
| JP (1) | JP2004517860A (de) |
| AT (1) | ATE345129T1 (de) |
| AU (1) | AU2002246499B2 (de) |
| CA (1) | CA2425625A1 (de) |
| DE (1) | DE60124577T2 (de) |
| ES (1) | ES2274913T3 (de) |
| WO (1) | WO2002055079A2 (de) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL157638A0 (en) | 2001-03-01 | 2004-03-28 | Shionogi & Co | Nitrogen-containing heteroaryl compounds having hiv integrase inhibitory activity |
| DE60209381T2 (de) | 2001-10-26 | 2006-10-05 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | N-substituierte hydroxypyrimidinoncarboxamid-hemmer der hiv-integrase |
| SI1441734T1 (sl) * | 2001-10-26 | 2007-08-31 | Angeletti P Ist Richerche Bio | Dihidropirimidin karboksamidni inhibitorji HIV-integraze |
| AU2003218130A1 (en) * | 2002-03-15 | 2003-09-29 | Merck And Co., Inc. | N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors |
| DE60322920D1 (de) | 2002-08-13 | 2008-09-25 | Shionogi & Co | Heterocyclische verbindungen mit hiv-integrase-hemmender wirkung |
| US7399763B2 (en) | 2002-09-11 | 2008-07-15 | Merck & Co., Inc. | 8-hydroxy-1-oxo-tetrahydropyrrolopyrazine compounds useful as HIV integrase inhibitors |
| US7517532B2 (en) | 2002-09-11 | 2009-04-14 | Merck & Co., Inc. | Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors |
| WO2004035577A2 (en) | 2002-10-16 | 2004-04-29 | Gilead Sciences, Inc. | Pre-organized tricyclic integrase inhibitor compounds |
| WO2004046115A1 (ja) | 2002-11-20 | 2004-06-03 | Japan Tobacco Inc. | ４−オキソキノリン化合物及びそのｈｉｖインテグラーゼ阻害剤としての利用 |
| BR0317749A (pt) | 2002-12-27 | 2005-11-22 | Angeletti P Ist Richerche Bio | Composto, composição farmacêutica, e, uso de um composto |
| US20060211724A1 (en) * | 2003-04-28 | 2006-09-21 | Verschueren Gaston W | Hiv integrase inhibitors |
| WO2004101512A2 (en) | 2003-05-13 | 2004-11-25 | Smithkline Beecham Corporation | Naphthyridine integrase inhibitors |
| TW200510425A (en) | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| WO2005028478A1 (en) * | 2003-09-19 | 2005-03-31 | Gilead Sciences, Inc. | Aza-quinolinol phosphonate integrase inhibitor compounds |
| JP2007509149A (ja) | 2003-10-20 | 2007-04-12 | メルク エンド カムパニー インコーポレーテッド | Ｈｉｖインテグラーゼ阻害薬として有用なヒドロキシピリドピロロピラジンジオン化合物 |
| EP1714966A4 (de) * | 2004-02-04 | 2008-01-02 | Shionogi & Co | Naphthylidinderivat mit einer hiv-integrase-hemmenden wirkung |
| EP1720856B1 (de) | 2004-02-11 | 2013-08-14 | GlaxoSmithKline LLC | Hiv-integrasehemmer |
| CA2557926A1 (en) | 2004-03-09 | 2005-09-22 | Monica Donghi | Hiv integrase inhibitors |
| EP1725556A1 (de) | 2004-03-09 | 2006-11-29 | Merck & Co., Inc. | Hiv-integrasehemmer |
| JP2007528396A (ja) * | 2004-03-09 | 2007-10-11 | メルク エンド カムパニー インコーポレーテッド | Ｈｉｖインテグラーゼ阻害薬 |
| JP2007528394A (ja) * | 2004-03-09 | 2007-10-11 | メルク エンド カムパニー インコーポレーテッド | Ｈｉｖインテグラーゼ阻害薬 |
| EP1756114B1 (de) * | 2004-05-07 | 2014-11-19 | Merck Sharp & Dohme Corp. | Hiv-integrasehemmer |
| MY134672A (en) | 2004-05-20 | 2007-12-31 | Japan Tobacco Inc | Stable crystal of 4-oxoquinoline compound |
| WO2005113509A1 (en) | 2004-05-20 | 2005-12-01 | Japan Tobacco Inc. | Novel 4-oxoquinoline compound and use thereof as hiv integrase inhibitor |
| EP2229945A1 (de) | 2004-05-21 | 2010-09-22 | Japan Tobacco, Inc. | Kombinationen aus einem 4-Isochinolon-Derivat und Anti-HIV-Mitteln |
| WO2005120516A2 (en) | 2004-06-09 | 2005-12-22 | Merck & Co., Inc. | Hiv integrase inhibitors |
| AU2006228278C1 (en) * | 2005-03-31 | 2011-06-23 | Msd Italia S.R.L. | HIV integrase inhibitors |
| CA2607151C (en) * | 2005-05-10 | 2012-06-19 | Merck & Co., Inc. | Hiv integrase inhibitors |
| CA2622639C (en) * | 2005-10-04 | 2012-01-03 | Istituto Di Recerche Di Biologia Molecolare P. Angeletti S.P.A. | Hiv integrase inhibitors |
| AU2006306355A1 (en) * | 2005-10-27 | 2007-05-03 | Merck & Co., Inc. | HIV integrase inhibitors |
| EP1790342A1 (de) | 2005-11-11 | 2007-05-30 | Zentaris GmbH | Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege |
| US8217042B2 (en) | 2005-11-11 | 2012-07-10 | Zentaris Gmbh | Pyridopyrazines and their use as modulators of kinases |
| US7902182B2 (en) * | 2005-11-16 | 2011-03-08 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| KR101023635B1 (ko) | 2006-03-06 | 2011-03-22 | 니뽄 다바코 산교 가부시키가이샤 | 4-옥소퀴놀린 화합물 제조 방법 |
| WO2007136714A2 (en) | 2006-05-16 | 2007-11-29 | Gilead Sciences, Inc. | Integrase inhibitors |
| CA2657287A1 (en) * | 2006-07-17 | 2008-01-24 | Merck & Co., Inc. | 1-hydroxy naphthyridine compounds as anti-hiv agents |
| ES2488922T3 (es) | 2006-09-29 | 2014-09-01 | Idenix Pharmaceuticals, Inc. | Fosfoindoles enantiómeramente puros como inhibidores del HIV |
| AU2007313293A1 (en) * | 2006-10-18 | 2008-04-24 | Merck & Co., Inc. | HIV integrase inhibitors |
| US8513420B2 (en) * | 2007-03-19 | 2013-08-20 | Monika Mazik | Amino-naphthyridine derivatives |
| EP1972627A1 (de) * | 2007-03-19 | 2008-09-24 | Technische Universität Carolo-Wilhelmina zu Braunschweig | Aminonaphthyridin-Derivate |
| CN101977610B (zh) | 2008-01-25 | 2012-05-16 | 奇默里克斯公司 | 治疗病毒感染的方法 |
| DE102009038123A1 (de) | 2009-08-17 | 2011-02-24 | Aicuris Gmbh & Co. Kg | Substituierte (Thiazolyl-carbonyl)imidazolidinone und ihre Verwendung |
| JP5624148B2 (ja) | 2009-10-13 | 2014-11-12 | エランコ・アニマル・ヘルス・アイルランド・リミテッド | 大環状インテグラーゼ阻害剤 |
| PT2534150T (pt) | 2010-02-12 | 2017-05-02 | Chimerix Inc | Métodos para tratar uma infecção viral |
| RU2567385C2 (ru) | 2010-04-02 | 2015-11-10 | ЯНССЕН Ар ЭНД Ди АЙРЛЭНД | Макроциклические ингибиторы интегразы |
| US9029391B2 (en) | 2011-01-24 | 2015-05-12 | Viiv Healthcare Uk Limited | Isoquinoline compounds and methods for treating HIV |
| BR112015028760A2 (pt) | 2013-05-16 | 2017-07-25 | Us Health | compostos para inibição de cepas de integrase do hiv-1 resistentes a drogas |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5751837B2 (de) * | 1973-04-05 | 1982-11-04 | ||
| US4416884A (en) * | 1978-04-12 | 1983-11-22 | Otsuka Pharmaceutical Co., Ltd. | Piperazinylbenzoheterocyclic compounds |
| FR2632639B1 (fr) | 1988-06-09 | 1990-10-05 | Sanofi Sa | Derives d'amino-4 carboxy-3 naphtyridines, leur preparation et compositions pharmaceutiques qui les contiennent |
| IL101860A0 (en) | 1991-05-31 | 1992-12-30 | Ici Plc | Heterocyclic derivatives |
| US5681832A (en) | 1995-02-17 | 1997-10-28 | The United States Of America As Represented By The Department Of Health And Human Services | Aroylaniline compounds, pharmaceutical compositions, and methods of using same to inhibit viral activity |
| ES2211965T3 (es) | 1995-08-02 | 2004-07-16 | Darwin Discovery Limited | Quinolonas y su utilizacion terapeutica. |
| US5945431A (en) | 1996-03-15 | 1999-08-31 | Biochem Therapeutics Incorporated | Cytomegalovirus inhibiting compounds |
| US6310211B1 (en) * | 1996-09-10 | 2001-10-30 | Pharmacia & Upjohn Company | 8-hydroxy-7-substituted quinolines as anti-viral agents |
| AU733551B2 (en) | 1996-09-25 | 2001-05-17 | Astrazeneca Ab | Qinoline derivatives inhibiting the effect of growth factors such as VEGF |
| CA2295309A1 (en) | 1997-06-30 | 1999-01-07 | Nippon Kayaku Kabushiki Kaisha | Novel naphthyridine derivatives or salts thereof |
| US6143760A (en) | 1997-08-25 | 2000-11-07 | Neurogen Corporation | Substituted 4-oxo-napthyridine-3-carboxamides: GABA brain receptor ligands |
| YU10500A (sh) | 1997-08-25 | 2002-10-18 | Neurogen Corporation | Supstituisani 4-okso-naptiridin-3-karboksamidi kao gaba moždani receptorski liganidi |
| GB9720052D0 (en) * | 1997-09-19 | 1997-11-19 | Smithkline Beecham Plc | Novel compounds |
| US6525042B1 (en) * | 1997-09-30 | 2003-02-25 | Daiichi Pharmaceutical Co., Ltd. | Sulfonyl derivatives |
| RU2220960C2 (ru) | 1997-12-22 | 2004-01-10 | Фармация Энд Апджон Компани | 4-гидрокси-3-хинолинкарбоксамиды и гидразиды, фармацевтическая композиция и способ лечения на их основе |
| US6262055B1 (en) | 1998-06-03 | 2001-07-17 | Merck & Co., Inc. | HIV integrase inhibitors |
| US6306891B1 (en) | 1998-06-03 | 2001-10-23 | Merck & Co., Inc. | HIV integrase inhibitors |
| US6380249B1 (en) | 1998-06-03 | 2002-04-30 | Merck & Co., Inc. | HIV integrase inhibitors |
| JP2003503386A (ja) | 1999-06-25 | 2003-01-28 | メルク エンド カムパニー インコーポレーテッド | １−（芳香族またはヘテロ芳香族置換）−３−（ヘテロ芳香族置換）−１，３−プロパンジオン類およびそれの使用 |
| US6730682B2 (en) | 2000-07-12 | 2004-05-04 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
| GB0017676D0 (en) | 2000-07-19 | 2000-09-06 | Angeletti P Ist Richerche Bio | Inhibitors of viral polymerase |
| SI1441734T1 (sl) | 2001-10-26 | 2007-08-31 | Angeletti P Ist Richerche Bio | Dihidropirimidin karboksamidni inhibitorji HIV-integraze |
| DE60209381T2 (de) | 2001-10-26 | 2006-10-05 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | N-substituierte hydroxypyrimidinoncarboxamid-hemmer der hiv-integrase |
-
2001
- 2001-10-09 DE DE60124577T patent/DE60124577T2/de not_active Expired - Fee Related
- 2001-10-09 WO PCT/US2001/042565 patent/WO2002055079A2/en not_active Ceased
- 2001-10-09 JP JP2002555813A patent/JP2004517860A/ja not_active Withdrawn
- 2001-10-09 CA CA002425625A patent/CA2425625A1/en not_active Abandoned
- 2001-10-09 ES ES01994068T patent/ES2274913T3/es not_active Expired - Lifetime
- 2001-10-09 AT AT01994068T patent/ATE345129T1/de not_active IP Right Cessation
- 2001-10-09 US US10/398,988 patent/US6841558B2/en not_active Expired - Fee Related
- 2001-10-09 EP EP01994068A patent/EP1326610B1/de not_active Expired - Lifetime
- 2001-10-09 AU AU2002246499A patent/AU2002246499B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE60124577T2 (de) | 2007-09-27 |
| DE60124577D1 (en) | 2006-12-28 |
| AU2002246499B2 (en) | 2005-12-22 |
| EP1326610B1 (de) | 2006-11-15 |
| CA2425625A1 (en) | 2002-07-18 |
| ES2274913T3 (es) | 2007-06-01 |
| WO2002055079A3 (en) | 2002-09-06 |
| EP1326610A2 (de) | 2003-07-16 |
| WO2002055079A2 (en) | 2002-07-18 |
| US6841558B2 (en) | 2005-01-11 |
| JP2004517860A (ja) | 2004-06-17 |
| US20040044207A1 (en) | 2004-03-04 |
| EP1326610A4 (de) | 2004-06-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |