ATE346297T1 - Nachweis von molecularbindung durch überwachung von rückkopplung kontrollierten auslegerablenkungen - Google Patents
Nachweis von molecularbindung durch überwachung von rückkopplung kontrollierten auslegerablenkungenInfo
- Publication number
- ATE346297T1 ATE346297T1 AT03770419T AT03770419T ATE346297T1 AT E346297 T1 ATE346297 T1 AT E346297T1 AT 03770419 T AT03770419 T AT 03770419T AT 03770419 T AT03770419 T AT 03770419T AT E346297 T1 ATE346297 T1 AT E346297T1
- Authority
- AT
- Austria
- Prior art keywords
- cantilever
- detection
- counterbalancing force
- analytes
- canomy
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title abstract 4
- 230000009149 molecular binding Effects 0.000 title 1
- 238000012544 monitoring process Methods 0.000 title 1
- 239000000523 sample Substances 0.000 abstract 4
- 239000012491 analyte Substances 0.000 abstract 1
- 230000010365 information processing Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/924—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Length Measuring Devices With Unspecified Measuring Means (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Pressure Sensors (AREA)
- Measurement Of Length, Angles, Or The Like Using Electric Or Magnetic Means (AREA)
- Steering Control In Accordance With Driving Conditions (AREA)
- Control Of Position, Course, Altitude, Or Attitude Of Moving Bodies (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/254,201 US7270952B2 (en) | 2002-09-24 | 2002-09-24 | Detecting molecular binding by monitoring feedback controlled cantilever deflections |
| US10/667,776 US7105301B2 (en) | 2002-09-24 | 2003-09-22 | Detecting molecular binding by monitoring feedback controlled cantilever deflections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE346297T1 true ATE346297T1 (de) | 2006-12-15 |
Family
ID=32829360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03770419T ATE346297T1 (de) | 2002-09-24 | 2003-09-24 | Nachweis von molecularbindung durch überwachung von rückkopplung kontrollierten auslegerablenkungen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7291466B2 (de) |
| EP (1) | EP1543328B1 (de) |
| JP (1) | JP4398375B2 (de) |
| CN (1) | CN100342235C (de) |
| AT (1) | ATE346297T1 (de) |
| AU (1) | AU2003278903A1 (de) |
| DE (1) | DE60309903T2 (de) |
| WO (1) | WO2004029625A2 (de) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090288479A1 (en) * | 2003-11-17 | 2009-11-26 | Woody Shane C | Standing wave fluidic and biological tools |
| US20060157684A1 (en) * | 2004-12-15 | 2006-07-20 | The Regents Of The University Of California | Thin film multilayer with nanolayers addressable from the macroscale |
| CN100458431C (zh) * | 2004-12-30 | 2009-02-04 | 中国科学院电工研究所 | 一种利用微悬臂梁进行生化检测的装置 |
| EP1705486B1 (de) | 2005-02-05 | 2008-03-19 | Samsung Electronics Co., Ltd. | Sensorschalter und seine Verwendung in einem Nachweisverfahren |
| US20070117217A1 (en) * | 2005-06-16 | 2007-05-24 | The Regents Of The University Of California | Large scale parallel immuno-based allergy test and device for evanescent field excitation of fluorescence |
| TWI293682B (en) * | 2006-02-24 | 2008-02-21 | Yuan Jay Wang | Multipurpose micro cantilever sensing sensitivity control device |
| US20080011058A1 (en) * | 2006-03-20 | 2008-01-17 | The Regents Of The University Of California | Piezoresistive cantilever based nanoflow and viscosity sensor for microchannels |
| US7709264B2 (en) * | 2006-09-21 | 2010-05-04 | Philip Morris Usa Inc. | Handheld microcantilever-based sensor for detecting tobacco-specific nitrosamines |
| US7716965B2 (en) * | 2006-10-27 | 2010-05-18 | Ut-Battelle, Llc | Electrochemical sensor having suspended element counter electrode and deflection method for current sensing |
| US8168120B1 (en) | 2007-03-06 | 2012-05-01 | The Research Foundation Of State University Of New York | Reliable switch that is triggered by the detection of a specific gas or substance |
| US8191403B2 (en) * | 2007-03-27 | 2012-06-05 | Richmond Chemical Corporation | Petroleum viscosity measurement and communication system and method |
| EP2053400A1 (de) * | 2007-10-22 | 2009-04-29 | Consejo Superior De Investigaciones Cientificas | Verfahren und System zur Erkennung einer ausgewählten Molekülart in einer Probe |
| US7928343B2 (en) * | 2007-12-04 | 2011-04-19 | The Board Of Trustees Of The University Of Illinois | Microcantilever heater-thermometer with integrated temperature-compensated strain sensor |
| CN101221166B (zh) * | 2008-01-22 | 2011-09-14 | 西北工业大学 | 三维培养条件下细胞应变加载装置 |
| WO2009097487A1 (en) | 2008-01-31 | 2009-08-06 | The Board Of Trustees Of The University Of Illinois | Temperature-dependent nanoscale contact potential measurement technique and device |
| KR100975010B1 (ko) * | 2008-02-29 | 2010-08-09 | 성균관대학교산학협력단 | 다중 크기 압전 마이크로 칸티레버 공진자 어레이를 이용한 물리센서 및 그 제작방법 |
| US20090241681A1 (en) * | 2008-03-27 | 2009-10-01 | Andrew Machauf | Hydrogel-based mems biosensor |
| US8093667B2 (en) * | 2008-06-30 | 2012-01-10 | Intel Corporation | Flexible gate electrode device for bio-sensing |
| US8931950B2 (en) | 2008-08-20 | 2015-01-13 | The Board Of Trustees Of The University Of Illinois | Device for calorimetric measurement |
| US20100099076A1 (en) * | 2008-10-16 | 2010-04-22 | Kent State University | Sensitive and rapid detection of viral particles in early viral infection by laser tweezers |
| US8387443B2 (en) | 2009-09-11 | 2013-03-05 | The Board Of Trustees Of The University Of Illinois | Microcantilever with reduced second harmonic while in contact with a surface and nano scale infrared spectrometer |
| US20110086368A1 (en) * | 2009-10-08 | 2011-04-14 | Drexel University | Method for immune response detection |
| US20110274839A1 (en) | 2010-04-14 | 2011-11-10 | Nanoink, Inc. | Cantilevers for deposition |
| US20110277193A1 (en) | 2010-04-20 | 2011-11-10 | Nanolnk, Inc. | Sensors and biosensors |
| WO2012059828A2 (en) * | 2010-11-01 | 2012-05-10 | Koc Universitesi | Miniaturized integrated micro electo-mechanical systems (mems) optical sensor array |
| CN102252753A (zh) * | 2011-04-18 | 2011-11-23 | 中国科学院半导体研究所 | 基于光压效应的红外光子探测方法 |
| GB2491806B (en) * | 2011-05-25 | 2013-07-10 | Microvisk Ltd | Apparatus and method for measuring properties of a fluid |
| US8533861B2 (en) | 2011-08-15 | 2013-09-10 | The Board Of Trustees Of The University Of Illinois | Magnetic actuation and thermal cantilevers for temperature and frequency dependent atomic force microscopy |
| US8914911B2 (en) | 2011-08-15 | 2014-12-16 | The Board Of Trustees Of The University Of Illinois | Magnetic actuation and thermal cantilevers for temperature and frequency dependent atomic force microscopy |
| GB2508358B (en) | 2012-11-28 | 2014-10-29 | Microvisk Ltd | Apparatus and method for monitoring a sedimentation parameter in a fluid medium sample |
| CN103207035B (zh) * | 2013-05-14 | 2015-07-15 | 南京因艾生生物科技有限公司 | 一种用于测量分子间作用力的力谱仪 |
| US9366651B2 (en) * | 2013-07-03 | 2016-06-14 | Matrix Sensors, Inc. | Array of sensors with surface modifications |
| KR102316324B1 (ko) * | 2015-03-24 | 2021-10-22 | 엘지전자 주식회사 | 인플루엔자 검출용 센서 |
| CN106124105A (zh) * | 2016-06-13 | 2016-11-16 | 常州大学 | 利用弯曲变形测量dna分子间作用力的方法 |
| CN106124104A (zh) * | 2016-06-13 | 2016-11-16 | 常州大学 | 一种测量基因片段作用力的微悬臂梁装置 |
| CN105950461B (zh) * | 2016-07-20 | 2017-10-24 | 江苏瑞明生物科技有限公司 | 单细胞纳米精准给药系统 |
| FR3060803B1 (fr) | 2016-12-20 | 2021-12-10 | Ondilo | Procede pour maintenir un equilibre d'un parametre physico-chimique d'un milieu, produit programme d'ordinateur et moyen electronique associes |
| CN106501349B (zh) * | 2017-01-05 | 2019-05-14 | 中国科学院化学研究所 | 一种基于光学原子磁力仪的原位力谱方法 |
| CN108469399A (zh) * | 2018-05-09 | 2018-08-31 | 南京煦源生物科技有限公司 | 固相表面与溶液的运动方式及运动装置 |
| ES2776702B2 (es) | 2019-01-31 | 2020-12-22 | Consejo Superior Investigacion | Metodo y sistema para la identificacion de particulas basado en mediciones multifrecuencia de placas resonantes |
| US11209369B2 (en) * | 2019-09-30 | 2021-12-28 | United States Of America, As Represented By The Secretary Of The Army | Measuring deflection to determine a characteristic of a cantilever |
| DE102021107255B4 (de) * | 2021-03-23 | 2024-06-27 | digid GmbH | Digitaler Sensor mit Referenzkantilever zur Umwandlung chemischer und/oder biochemischer Information |
| DE102021107254B4 (de) * | 2021-03-23 | 2024-06-27 | digid GmbH | Digitale Sensorvorrichtung zur Detektion eines Analyten in einer Probe |
| DE102022121187B3 (de) * | 2022-08-22 | 2024-01-18 | digid GmbH | Digitale Sensorvorrichtung zur Detektion von Analyten in einer Probe |
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| US4196265A (en) * | 1977-06-15 | 1980-04-01 | The Wistar Institute | Method of producing antibodies |
| US6379895B1 (en) * | 1989-06-07 | 2002-04-30 | Affymetrix, Inc. | Photolithographic and other means for manufacturing arrays |
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| US5106729A (en) * | 1989-07-24 | 1992-04-21 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Method for visualizing the base sequence of nucleic acid polymers |
| JP3407072B2 (ja) * | 1991-02-14 | 2003-05-19 | バクスター、インターナショナル、インコーポレイテッド | リポソームへの認識物質の結合 |
| US5603872A (en) * | 1991-02-14 | 1997-02-18 | Baxter International Inc. | Method of binding recognizing substances to liposomes |
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| FR2703693B1 (fr) * | 1993-04-06 | 1995-07-13 | Pasteur Institut | Procédé rapide de détermination d'une séquence d'ADN et application au séquençage et au diagnostic. |
| US5515719A (en) * | 1994-05-19 | 1996-05-14 | Molecular Imaging Corporation | Controlled force microscope for operation in liquids |
| US5607568A (en) * | 1995-03-16 | 1997-03-04 | International Business Machines Corporation | Assembly suitable for identifying a code sequence of a biomolecule in a free-solution embodiment |
| US5824470A (en) * | 1995-05-30 | 1998-10-20 | California Institute Of Technology | Method of preparing probes for sensing and manipulating microscopic environments and structures |
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| WO1997004283A2 (en) * | 1995-07-20 | 1997-02-06 | Cornell Research Foundation, Inc. | Microfabricated torsional cantilevers for sensitive force detection |
| US5807758A (en) * | 1995-07-21 | 1998-09-15 | Lee; Gil U. | Chemical and biological sensor using an ultra-sensitive force transducer |
| JP2940643B2 (ja) * | 1995-09-01 | 1999-08-25 | インターナシヨナル・ビジネス・マシーンズ・コーポレーシヨン | 振れセンサを組み込んだカンチレバー |
| EP0852708B1 (de) * | 1995-09-29 | 2001-09-12 | International Business Machines Corporation | Mechanischer signalprozessor auf basis von mikromechanischen oszillatoren und intelligenten akustischen detektoren und darauf aufgebaute systeme |
| DE69618627T2 (de) * | 1996-03-13 | 2002-09-12 | International Business Machines Corp., Armonk | Auslegerstrukturen |
| US6033852A (en) * | 1996-09-27 | 2000-03-07 | University Of Maine | Monolithic piezoelectric sensor (MPS) for sensing chemical, biochemical and physical measurands |
| JP4532608B2 (ja) * | 1997-02-07 | 2010-08-25 | オリンパス株式会社 | 走査型プローブ顕微鏡を用いた核酸検出方法 |
| US6203983B1 (en) * | 1997-06-16 | 2001-03-20 | Affymetrix, Inc. | Method for detecting chemical interactions between naturally occurring bio-polymers which are non-identical binding partners |
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| US6280939B1 (en) * | 1998-09-01 | 2001-08-28 | Veeco Instruments, Inc. | Method and apparatus for DNA sequencing using a local sensitive force detector |
| GB9819319D0 (en) * | 1998-09-05 | 1998-10-28 | Aea Technology Plc | Assay of chemical binding |
| US6146227A (en) * | 1998-09-28 | 2000-11-14 | Xidex Corporation | Method for manufacturing carbon nanotubes as functional elements of MEMS devices |
| US6289717B1 (en) * | 1999-03-30 | 2001-09-18 | U. T. Battelle, Llc | Micromechanical antibody sensor |
| EP1204842A4 (de) * | 1999-08-19 | 2003-04-02 | Univ California | Apparat und verfahren zur visuellen identifikation von mikrokräften mittels einer palette von auslegerblöcken |
| AU7549700A (en) * | 1999-11-03 | 2001-05-14 | International Business Machines Corporation | Cantilever sensors and transducers |
-
2003
- 2003-09-24 AT AT03770419T patent/ATE346297T1/de not_active IP Right Cessation
- 2003-09-24 EP EP03770419A patent/EP1543328B1/de not_active Expired - Lifetime
- 2003-09-24 WO PCT/US2003/030192 patent/WO2004029625A2/en not_active Ceased
- 2003-09-24 JP JP2004539886A patent/JP4398375B2/ja not_active Expired - Fee Related
- 2003-09-24 AU AU2003278903A patent/AU2003278903A1/en not_active Abandoned
- 2003-09-24 DE DE60309903T patent/DE60309903T2/de not_active Expired - Lifetime
- 2003-09-24 CN CNB038226898A patent/CN100342235C/zh not_active Expired - Fee Related
-
2005
- 2005-04-20 US US11/111,308 patent/US7291466B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US7291466B2 (en) | 2007-11-06 |
| EP1543328A2 (de) | 2005-06-22 |
| WO2004029625A3 (en) | 2004-08-12 |
| CN1685233A (zh) | 2005-10-19 |
| US20050244820A1 (en) | 2005-11-03 |
| AU2003278903A1 (en) | 2004-04-19 |
| WO2004029625A2 (en) | 2004-04-08 |
| EP1543328B1 (de) | 2006-11-22 |
| DE60309903D1 (de) | 2007-01-04 |
| JP2006500587A (ja) | 2006-01-05 |
| CN100342235C (zh) | 2007-10-10 |
| JP4398375B2 (ja) | 2010-01-13 |
| DE60309903T2 (de) | 2007-10-18 |
| AU2003278903A8 (en) | 2004-04-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |