ATE347564T1 - Verfahren zur reinigung von hämoglobin - Google Patents

Verfahren zur reinigung von hämoglobin

Info

Publication number: ATE347564T1
Authority: AT; Austria
Prior art keywords: column; hemoglobin; buffer solution; solution; hydroxymethyl
Prior art date: 1998-07-10

Application number

AT99930467T

Other languages

English (en)

Inventor

Robert A Houtchens

Carl W Rausch

Original Assignee

Biopure Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-10

Filing date

1999-06-21

Publication date

2006-12-15

1999-06-21 Application filed by Biopure Corp filed Critical Biopure Corp

2006-12-15 Application granted granted Critical

2006-12-15 Publication of ATE347564T1 publication Critical patent/ATE347564T1/de

Links

102000001554 Hemoglobins Human genes 0.000 title abstract 5
108010054147 Hemoglobins Proteins 0.000 title abstract 5
239000007853 buffer solution Substances 0.000 abstract 3
239000000243 solution Substances 0.000 abstract 3
PIEPQKCYPFFYMG-UHFFFAOYSA-N tris acetate Chemical compound CC(O)=O.OCC(N)(CO)CO PIEPQKCYPFFYMG-UHFFFAOYSA-N 0.000 abstract 2
239000008351 acetate buffer Substances 0.000 abstract 1
238000005571 anion exchange chromatography Methods 0.000 abstract 1
239000000356 contaminant Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000011800 void material Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Dentistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT99930467T 1998-07-10 1999-06-21 Verfahren zur reinigung von hämoglobin ATE347564T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US09/113,953 US6150507A (en)	1995-03-23	1998-07-10	Method for producing a purified hemoglobin product

Publications (1)

Publication Number	Publication Date
ATE347564T1 true ATE347564T1 (de)	2006-12-15

Family

ID=22352497

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99930467T ATE347564T1 (de)	1998-07-10	1999-06-21	Verfahren zur reinigung von hämoglobin

Country Status (12)

Country	Link
US (1)	US6150507A (de)
EP (1)	EP1097171B1 (de)
JP (1)	JP4581110B2 (de)
CN (1)	CN1166689C (de)
AT (1)	ATE347564T1 (de)
AU (1)	AU755280B2 (de)
CA (1)	CA2336808C (de)
DE (1)	DE69934312T2 (de)
DK (1)	DK1097171T3 (de)
ES (1)	ES2278450T3 (de)
NZ (1)	NZ509257A (de)
WO (1)	WO2000002921A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001076507A2 (en)	2000-04-11	2001-10-18	The University Of Miami	Use of oxygen carriers to improve grafted cell survival in neural transplantation
FR2824568B1 (fr) *	2001-05-11	2004-04-09	Lab Francais Du Fractionnement	Procede de preparation de concentres d'immunoglobulines humaines a usage therapeutique
US7038016B2 (en)	2001-08-21	2006-05-02	Apex Bioscience, Inc.	Methods for purification of an activated PEG solution and for the synthesis of a modified hemoglobin solution
CA2496060C (en) *	2002-09-11	2015-08-04	Genentech, Inc.	Protein purification by ion exchange chromatography
CN1703235A (zh) *	2002-10-03	2005-11-30	北原实验室有限公司	治疗大量失血患者的方法
JP2006516994A (ja) *	2003-01-29	2006-07-13	ノースフィールドラボラトリーズ、インコーポレイテッド	テトラマーの量を低下させた重合ヘモグロビン溶液及び調製するための方法
US20070123698A1 (en) *	2003-12-26	2007-05-31	Oxygenix Co., Ltd.	Process for purification of hemoglobin
US20090117207A1 (en) *	2005-11-29	2009-05-07	Zoltani Csaba K	Methods and compositions for treatment of poison-caused pathology
WO2007087570A2 (en) *	2006-01-24	2007-08-02	Northfield Laboratories, Inc.	Polymerized hemoglobin media and its use in isolation and transplantation of islet cells
US20090004159A1 (en) *	2006-01-24	2009-01-01	The Board Of Trustees Of The University Of Illinoi	Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
EP2054498A1 (de) *	2006-08-15	2009-05-06	Basf Se	Verfahren zur isolierung von proteinen aus produktionszellen
JP2011207853A (ja) *	2010-03-30	2011-10-20	Terumo Corp	人工酸素運搬体製造に用いるヘモグロビン原料中間生成物
JP6786917B2 (ja) *	2016-07-08	2020-11-18	東ソー株式会社	ヘモグロビン調製液及びヘモグロビン類測定液体クロマトグラフィー法
CN111989568B (zh)	2018-04-18	2024-05-28	积水医疗株式会社	血红蛋白分析方法
CN110128531B (zh) *	2019-05-17	2022-03-08	润方（北京）生物医药研究院有限公司	一种无碳酸酐酶血红蛋白的制备方法
CN110563836A (zh) *	2019-09-09	2019-12-13	润方（北京）生物医药研究院有限公司	交联血红蛋白的制备方法及包含该血红蛋白的器官灌注液

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2449885C3 (de) *	1974-10-21	1980-04-30	Biotest-Serum-Institut Gmbh, 6000 Frankfurt	Verfahren zur Herstellung von chemisch modifizierten haltbaren Hämoglobinpräparaten sowie das nach diesem Verfahren hergestellte modifizierte Hämoglobinpräparat
US3959128A (en) *	1974-12-27	1976-05-25	Preventive Systems, Inc	Process for removing endotoxin from biological fluids
US4059512A (en) *	1974-12-27	1977-11-22	Preventive Systems, Inc.	Process for removing endotoxin from biological fluids
DK144800C (da) *	1980-04-21	1982-10-25	Forenede Bryggerier As	Fremgangsmaade til udvinding af enzymer,fortrinsvis cu,zn-superoxid-dismutase (sod),catalase og carbonsyreanhydrase,fra blod
US4381239A (en) *	1981-02-10	1983-04-26	Tanabe Seiyaku Co., Ltd.	Method for reducing the pyrogen content of or removing pyrogens from substances contaminated therewith
US4473647A (en) *	1981-02-27	1984-09-25	Amf Inc.	Tissue culture medium
US4468330A (en) *	1981-04-27	1984-08-28	Sekisui Kagaku Kogyo Kabushiki Kaisha	Filler for liquid chromatography useful for separating a hemoglobin variant in blood
US4584130A (en) *	1985-03-29	1986-04-22	University Of Maryland	Intramolecularly cross-linked hemoglobin and method of preparation
CA1244349A (en) *	1985-06-26	1988-11-08	Jen-Chang Hsia	Purification of hemoglobin and modified hemoglobin by affinity chromatography
GB8600582D0 (en) *	1986-01-10	1986-02-19	Ca Minister Nat Defence	Purifying biological materials
JP2962731B2 (ja) *	1986-11-10	1999-10-12	バイオピュアー、コーポレーション	超純枠半合成代用血液
US5084558A (en) *	1987-10-13	1992-01-28	Biopure Corporation	Extra pure semi-synthetic blood substitute
CA1312009C (en) *	1986-11-10	1992-12-29	Carl W. Rausch	Extra pure semi-synthetic blood substitute
JP2592973B2 (ja) *	1988-06-15	1997-03-19	バクスターインターナショナルインコーポレーテッド	架橋ヘモグロビンの精製方法
CA1338244C (en) *	1988-08-17	1996-04-09	Xiang-Fu Wu	Purification of hemoglobin and methemoglobin by bioselective elution
US5128452A (en) *	1989-04-19	1992-07-07	Baxter International Inc.	Process for the production of crosslinked hemoglobin in the presence of sodium tripolyphosphate
US5234903A (en) *	1989-11-22	1993-08-10	Enzon, Inc.	Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute
DE69108258T2 (de) *	1990-11-29	1995-08-10	Upjohn Co	Mit imidoester quer-vernetzte hämoglobinzusammensetzungen.
US5250665A (en) *	1991-05-31	1993-10-05	The University Of Toronto Innovations Foundation	Specifically β-β cross-linked hemoglobins and method of preparation
US5264555A (en) *	1992-07-14	1993-11-23	Enzon, Inc.	Process for hemoglobin extraction and purification
US5840851A (en) *	1993-07-23	1998-11-24	Plomer; J. Jeffrey	Purification of hemoglobin
US5578564A (en) *	1993-07-23	1996-11-26	Somatogen, Inc.	Nickel-free hemoglobin and methods for producing such hemoglobin
US5665869A (en) *	1993-11-15	1997-09-09	Somatogen, Inc.	Method for the rapid removal of protoporphyrin from protoporphyrin IX-containing solutions of hemoglobin
ATE222926T1 (de) *	1995-03-23	2002-09-15	Biopure Corp	Stabiles polymerisiertes hämoglobin- blutersatzmittel

1998
- 1998-07-10 US US09/113,953 patent/US6150507A/en not_active Expired - Lifetime
1999
- 1999-06-21 ES ES99930467T patent/ES2278450T3/es not_active Expired - Lifetime
- 1999-06-21 AT AT99930467T patent/ATE347564T1/de not_active IP Right Cessation
- 1999-06-21 DK DK99930467T patent/DK1097171T3/da active
- 1999-06-21 CN CNB998082864A patent/CN1166689C/zh not_active Expired - Fee Related
- 1999-06-21 NZ NZ509257A patent/NZ509257A/xx not_active IP Right Cessation
- 1999-06-21 AU AU47003/99A patent/AU755280B2/en not_active Ceased
- 1999-06-21 DE DE69934312T patent/DE69934312T2/de not_active Expired - Lifetime
- 1999-06-21 WO PCT/US1999/013922 patent/WO2000002921A1/en not_active Ceased
- 1999-06-21 CA CA002336808A patent/CA2336808C/en not_active Expired - Fee Related
- 1999-06-21 JP JP2000559150A patent/JP4581110B2/ja not_active Expired - Fee Related
- 1999-06-21 EP EP99930467A patent/EP1097171B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
HK1037643A1 (en)	2002-02-15
CA2336808C (en)	2008-08-19
US6150507A (en)	2000-11-21
AU4700399A (en)	2000-02-01
ES2278450T3 (es)	2007-08-01
CN1166689C (zh)	2004-09-15
NZ509257A (en)	2003-03-28
JP4581110B2 (ja)	2010-11-17
CA2336808A1 (en)	2000-01-20
EP1097171A1 (de)	2001-05-09
WO2000002921A1 (en)	2000-01-20
DK1097171T3 (da)	2007-04-10
DE69934312T2 (de)	2007-07-12
JP2002520338A (ja)	2002-07-09
EP1097171B1 (de)	2006-12-06
DE69934312D1 (de)	2007-01-18
AU755280B2 (en)	2002-12-05
CN1308636A (zh)	2001-08-15

Legal Events

Date	Code	Title	Description
2007-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE347564T1 (de)	2006-12-15	Verfahren zur reinigung von hämoglobin
DE3585147D1 (de)	1992-02-20	Verfahren zur reinigung von proteinen.
DE3484362D1 (de)	1991-05-08	Verfahren zur herstellung von optisch aktiven azetidinonen.
DE3787281D1 (de)	1993-10-07	Verfahren zum nachweis von fremdstoffgehalten in gasen.
ATE206158T1 (de)	2001-10-15	Verfahren zur herstellung von gereinigtem enzym
DE69300600D1 (de)	1995-11-16	Verfahren zum Dotieren von porösen Glasvorformen.
DE3584693D1 (de)	1992-01-02	Verfahren zur herstellung von kohlenstoffasern des pechtyps.
DE3583117D1 (de)	1991-07-11	Verfahren zur herstellung von wirklich poroesen glasgegenstaenden.
ATE79633T1 (de)	1992-09-15	Verfahren zur herstellung des alpha-1-proteinase- inhibitors.
DE3581455D1 (de)	1991-02-28	Verfahren zur herstellung von glas.
DE3578062D1 (de)	1990-07-12	Verfahren zur herstellung von iodbenzol.
DE68907388D1 (de)	1993-08-05	Gereinigte protein a-zusammensetzungen und verfahren zu ihrer herstellung.
DE3882723D1 (de)	1993-09-09	Verfahren zur herstellung von enzymelektroden.
ATE30844T1 (de)	1987-12-15	Verfahren zur herstellung der wichtigsten proteine des haemolysierten bluts in einer nichtdenaturierten form.
ATE218728T1 (de)	2002-06-15	Verfahren zur herstellung von kartenförmigen datenträgern
DK0646594T3 (da)	1997-12-22	Fremgangsmåde til rensning af proteiner
DE3872922D1 (de)	1992-08-27	Verfahren zur herstellung von lanthankuprat-einkristall.
ATE6998T1 (de)	1984-04-15	Verfahren zur herstellung von laengsnahtgeschweissten, gerundeten zargen.
DE3872551D1 (de)	1992-08-13	Verfahren zur herstellung von znse-einkristall.
DE3581248D1 (de)	1991-02-14	Verfahren zur herstellung von optisch aktiven hydantoinen.
DE59004541D1 (de)	1994-03-24	Verfahren zum Vermindern des Alkoholgehaltes alkoholischer Getränke.
DE3577113D1 (de)	1990-05-17	Verfahren zum auswechsein von brueckenlagern.
DE3481320D1 (de)	1990-03-15	Verfahren zur herstellung von protease-inhibitoren.
DE3578455D1 (de)	1990-08-02	Verfahren zur dosierung von uranspuren in loesungen durch zeitgeloeste spektrofluorometrie.
DE3584754D1 (de)	1992-01-09	Verfahren zur herstellung von arylalkylketonen.