ATE347596T1 - Dna kodierend für einen humanen protonenabhängigen ionenkanal und deren verwendungen - Google Patents
Dna kodierend für einen humanen protonenabhängigen ionenkanal und deren verwendungenInfo
- Publication number
- ATE347596T1 ATE347596T1 AT98951141T AT98951141T ATE347596T1 AT E347596 T1 ATE347596 T1 AT E347596T1 AT 98951141 T AT98951141 T AT 98951141T AT 98951141 T AT98951141 T AT 98951141T AT E347596 T1 ATE347596 T1 AT E347596T1
- Authority
- AT
- Austria
- Prior art keywords
- hasic3
- proton
- neurons
- sensory
- gated
- Prior art date
Links
- 230000001419 dependent effect Effects 0.000 title 1
- 102100022097 Acid-sensing ion channel 3 Human genes 0.000 abstract 5
- 101000901082 Homo sapiens Acid-sensing ion channel 3 Proteins 0.000 abstract 5
- 230000014509 gene expression Effects 0.000 abstract 2
- 108020004999 messenger RNA Proteins 0.000 abstract 2
- 230000035945 sensitivity Effects 0.000 abstract 2
- 101710099898 Acid-sensing ion channel 3 Proteins 0.000 abstract 1
- 108091005462 Cation channels Proteins 0.000 abstract 1
- 108091006146 Channels Proteins 0.000 abstract 1
- 108010033806 Degenerin Sodium Channels Proteins 0.000 abstract 1
- 108090000140 Epithelial Sodium Channels Proteins 0.000 abstract 1
- 102000003837 Epithelial Sodium Channels Human genes 0.000 abstract 1
- 101710099641 Proton-gated ion channel Proteins 0.000 abstract 1
- 101000901078 Rattus norvegicus Acid-sensing ion channel 3 Proteins 0.000 abstract 1
- 241000269370 Xenopus <genus> Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- XSDQTOBWRPYKKA-UHFFFAOYSA-N amiloride Chemical compound NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N XSDQTOBWRPYKKA-UHFFFAOYSA-N 0.000 abstract 1
- 229960002576 amiloride Drugs 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000002051 biphasic effect Effects 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 230000002999 depolarising effect Effects 0.000 abstract 1
- 238000009396 hybridization Methods 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000010369 molecular cloning Methods 0.000 abstract 1
- 210000002569 neuron Anatomy 0.000 abstract 1
- 210000000929 nociceptor Anatomy 0.000 abstract 1
- 210000000287 oocyte Anatomy 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 210000005223 peripheral sensory neuron Anatomy 0.000 abstract 1
- 230000002085 persistent effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000003757 reverse transcription PCR Methods 0.000 abstract 1
- 230000001953 sensory effect Effects 0.000 abstract 1
- 210000000413 sensory ganglia Anatomy 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
- 210000001550 testis Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2219713 | 1997-10-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE347596T1 true ATE347596T1 (de) | 2006-12-15 |
Family
ID=4161708
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98951141T ATE347596T1 (de) | 1997-10-29 | 1998-10-29 | Dna kodierend für einen humanen protonenabhängigen ionenkanal und deren verwendungen |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1025226B1 (de) |
| AT (1) | ATE347596T1 (de) |
| AU (1) | AU9732498A (de) |
| CA (1) | CA2308014A1 (de) |
| DE (1) | DE69836591T2 (de) |
| ES (1) | ES2279583T3 (de) |
| WO (1) | WO1999021981A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6287859B1 (en) * | 1998-08-05 | 2001-09-11 | Centre National De La Recherche | Identification, functional expression and chromosal localization of a sustained human proton-gated cation channel |
| DK1183025T3 (da) | 1999-05-19 | 2009-05-04 | Painceptor Pharma Corp | Hæmmere af proton-styrede kationskanaler og deres anvendelse til behandling af iskæmiske lidelser |
| US6548270B1 (en) | 2000-03-03 | 2003-04-15 | Ortho-Mcneil Pharmaceutical, Inc. | DNA encoding human acid-sensing ion channel BNaC4 (ASIC4) |
| CA2304494A1 (en) | 2000-04-20 | 2001-10-20 | Philippe Seguela | A novel heteromultimeric ion channel receptor and uses thereof |
| NZ626242A (en) | 2012-01-31 | 2017-02-24 | Regeneron Pharma | Anti-asic1 antibodies and uses thereof |
| US9371383B2 (en) | 2012-01-31 | 2016-06-21 | Regeneron Pharmaceuticals, Inc. | Anti-ASIC1 antibodies and uses thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9513180D0 (en) * | 1995-06-28 | 1995-08-30 | Univ London | Ion channel |
| FR2759373B1 (fr) * | 1997-02-11 | 2001-05-04 | Centre Nat Rech Scient | Nouveau canal cationique neuronal de mammifere sensible a l'acidite, son clonage et ses applications |
| EP0884386A1 (de) * | 1997-05-30 | 1998-12-16 | Synthelabo | Natrium-Ionenkanäle Rezeptor |
-
1998
- 1998-10-29 AT AT98951141T patent/ATE347596T1/de not_active IP Right Cessation
- 1998-10-29 EP EP98951141A patent/EP1025226B1/de not_active Expired - Lifetime
- 1998-10-29 WO PCT/CA1998/001016 patent/WO1999021981A1/en not_active Ceased
- 1998-10-29 ES ES98951141T patent/ES2279583T3/es not_active Expired - Lifetime
- 1998-10-29 DE DE69836591T patent/DE69836591T2/de not_active Expired - Lifetime
- 1998-10-29 AU AU97324/98A patent/AU9732498A/en not_active Abandoned
- 1998-10-29 CA CA002308014A patent/CA2308014A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1025226B1 (de) | 2006-12-06 |
| ES2279583T3 (es) | 2007-08-16 |
| EP1025226A1 (de) | 2000-08-09 |
| DE69836591T2 (de) | 2007-09-20 |
| AU9732498A (en) | 1999-05-17 |
| DE69836591D1 (de) | 2007-01-18 |
| CA2308014A1 (en) | 1999-05-06 |
| WO1999021981A1 (en) | 1999-05-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |