ATE349420T1 - Azulenylnitrone als radikal fanger (spin trapping agents), verfahren zu ihrer herstellung und ihre anwendung - Google Patents

Azulenylnitrone als radikal fanger (spin trapping agents), verfahren zu ihrer herstellung und ihre anwendung

Info

Publication number: ATE349420T1
Authority: AT; Austria
Prior art keywords: agents; radical species; present; azulenyl nitrones; production
Prior art date: 1995-11-17

Application number

AT96940538T

Other languages

English (en)

Inventor

David A Becker

Original Assignee

Florida Internat University

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-17

Filing date

1996-11-15

Publication date

2007-01-15

1996-11-15 Application filed by Florida Internat University filed Critical Florida Internat University

2007-01-15 Application granted granted Critical

2007-01-15 Publication of ATE349420T1 publication Critical patent/ATE349420T1/de

Links

238000000034 method Methods 0.000 title abstract 3
238000013319 spin trapping Methods 0.000 title abstract 2
-1 AZULENYL Chemical class 0.000 title 1
150000003254 radicals Chemical class 0.000 abstract 4
239000003795 chemical substances by application Substances 0.000 abstract 3
LHPJANNUQBDRNT-UHFFFAOYSA-N N-(azulen-1-ylmethylidene)hydroxylamine Chemical class C1=CC=CC=C2C(C=NO)=CC=C21 LHPJANNUQBDRNT-UHFFFAOYSA-N 0.000 abstract 2
239000003963 antioxidant agent Substances 0.000 abstract 1
238000003556 assay Methods 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
SQDFHQJTAWCFIB-UHFFFAOYSA-N n-methylidenehydroxylamine Chemical compound ON=C SQDFHQJTAWCFIB-UHFFFAOYSA-N 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
230000000069 prophylactic effect Effects 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
- C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/30—Azulenes; Hydrogenated azulenes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Cephalosporin Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT96940538T 1995-11-17 1996-11-15 Azulenylnitrone als radikal fanger (spin trapping agents), verfahren zu ihrer herstellung und ihre anwendung ATE349420T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US694995P	1995-11-17	1995-11-17
US2463196P	1996-08-27	1996-08-27

Publications (1)

Publication Number	Publication Date
ATE349420T1 true ATE349420T1 (de)	2007-01-15

Family

ID=26676282

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96940538T ATE349420T1 (de)	1995-11-17	1996-11-15	Azulenylnitrone als radikal fanger (spin trapping agents), verfahren zu ihrer herstellung und ihre anwendung

Country Status (8)

Country	Link
US (3)	US6083988A (de)
EP (1)	EP0888290B1 (de)
JP (1)	JP3887020B2 (de)
AT (1)	ATE349420T1 (de)
AU (1)	AU7739796A (de)
CA (1)	CA2235765C (de)
DE (1)	DE69636795D1 (de)
WO (1)	WO1997019054A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1021430A1 (de) *	1996-07-19	2000-07-26	Centaur Pharmaceuticals, Inc.	Furan-nitronverbindungen
TW429241B (en) *	1996-09-26	2001-04-11	Sumitomo Pharma	Nitrone derivatives
MA26553A1 (fr) *	1997-10-17	2004-12-20	Centaur Pharmaceuticals Inc	Alpha-aryl-n-alkylnitrones et compositions pharmaceutiques contenant ceux-la
JP2002509147A (ja) *	1998-01-16	2002-03-26	センターファーマシューティカルズ，インコーポレイテッド	チオフェンニトロン化合物
NZ505757A (en) *	1998-01-16	2002-09-27	Centaur Pharmaceuticals Inc	Thioether furan nitrone compounds and pharmaceuticals thereof; useful for the treatment or prophylaxis of neurodegenerative, autoimmune and inflammatory conditions
FR2780404B1 (fr) *	1998-06-26	2001-04-13	Adir	Nouveaux derives de nitrone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6569826B1 (en)	1999-10-19	2003-05-27	The Procter & Gamble Company	Radical scavenger
US6566320B1 (en)	1999-10-19	2003-05-20	The Procter & Gamble Company	Bleaching composition containing chromotropic compound
EP1094106A1 (de) *	1999-10-19	2001-04-25	The Procter & Gamble Company	Reinigungsmittelzusammensetzung
GB0024938D0 (en) *	2000-10-11	2000-11-29	Queen Mary & Westfield College	Method of diagnosis
WO2002065993A2 (en)	2001-01-08	2002-08-29	Centaur Pharmaceuticals, Inc.	Use of aryl nitrone compounds in methods for treating neuropathic pain
US6746808B2 (en)	2001-08-29	2004-06-08	Fuji Xerox Co., Ltd.	Image forming color toner, color image forming method and color image forming apparatus
US6762322B1 (en) *	2002-12-20	2004-07-13	Goodyear Tire & Rubber Company	Preparation of nitrone derivatives
US20050182060A1 (en) *	2004-02-13	2005-08-18	Kelly Michael G.	2-Substituted and 4-substituted aryl nitrone compounds
US7910729B2 (en)	2004-09-22	2011-03-22	The Florida International University Board Of Trustees	Azulenyl nitrone spin trapping agents, methods of making and using same
GB0518890D0 (en) *	2005-09-15	2005-10-26	Ucl Biomedica Plc	Method of determining damage to skin
WO2008002614A2 (en) *	2006-06-28	2008-01-03	The Florida International University Board Of Trustees	Pseudoazulenyl nitrones
GB0623758D0 (en) *	2006-11-25	2007-01-10	Univ Salford The	Free radical trapping
EP2242360B1 (de) *	2008-02-12	2015-04-08	Tosk, Inc.	Doxorubicin-hilfsstoffe zur toxizitätsminderung und anwendungsverfahren dafür
US8313456B2 (en) *	2009-06-30	2012-11-20	Palo Alto Research Center Incorporated	Drug-transfer device, drug-delivery system incorporating the same, methods of fabricating the same, and methods of enabling administration of a drug
US9034926B2 (en)	2010-12-30	2015-05-19	Nicholas V. Perricone	Topical nitrone spin trap compositions for psoriasis
US9156862B2 (en) *	2011-11-01	2015-10-13	The Florida International University Board Of Trustees	Silylated azulenyl nitrone spin traps as chromotropic superoxide detectors
GB201217228D0 (en) *	2012-09-26	2012-11-07	Pepric Nv	Methods and systems for determining a particle distribution
WO2014151486A1 (en) *	2013-03-15	2014-09-25	The Florida International University Board Of Trustees	Chromotropic detection of ionizing radiation
US10323147B1 (en)	2016-05-26	2019-06-18	Marathon Petroleum Company Lp	Asphalt composition containing ester bottoms
US11814506B2 (en)	2019-07-02	2023-11-14	Marathon Petroleum Company Lp	Modified asphalts with enhanced rheological properties and associated methods
CA3088894C (en)	2020-05-21	2024-04-30	Marathon Petroleum Company Lp	Systems and methods for venting asphalt transport tanks

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US35112A (en) *		1862-04-29		Improvement in head-rests for car-seats
US35213A (en) *		1862-05-13		Improved hydrant
US3509215A (en) *	1967-06-15	1970-04-28	Givaudan Corp	Acyl indan compounds
US4141995A (en) *	1975-04-17	1979-02-27	Lilly Industries Limited	Ketone derivatives
JPS5916867A (ja) *	1982-07-21	1984-01-28	Nippon Chemiphar Co Ltd	新規アズレン誘導体およびその製造法
US4990665A (en) *	1982-11-01	1991-02-05	Microsi, Inc.	Diarylnitrones
JPS6197238A (ja) *	1984-10-17	1986-05-15	Ajinomoto Co Inc	新規アズレン誘導体およびその用途
JPS63239248A (ja) *	1986-11-07	1988-10-05	Ajinomoto Co Inc	抗脂血剤
US5025032A (en)	1989-10-17	1991-06-18	Oklahoma Medical Research Foundation	Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage
EP0496796B1 (de) *	1989-10-17	1994-08-31	Oklahoma Medical Research Foundation	Verfahren und zubereitungen zur hemmung von mit oxidativer schädigung assoziierten krankheiten
USRE35213E (en)	1989-10-17	1996-04-16	Oklahoma Medical Research Foundation	Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration
US5235076A (en) *	1991-05-28	1993-08-10	University Of Hawaii	Azulenic retinoid compounds, compositions and methods
US5292746A (en) *	1991-09-12	1994-03-08	Merrell Dow Pharmaceuticals Inc.	Cyclic nitrones, pharmaceutical compositions thereof and their use in treating shock
US5488145A (en) *	1993-12-23	1996-01-30	Oklahoma Medical Research Foundation	2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps

1996
- 1996-11-15 WO PCT/US1996/018570 patent/WO1997019054A1/en not_active Ceased
- 1996-11-15 AU AU77397/96A patent/AU7739796A/en not_active Abandoned
- 1996-11-15 EP EP96940538A patent/EP0888290B1/de not_active Expired - Lifetime
- 1996-11-15 CA CA002235765A patent/CA2235765C/en not_active Expired - Fee Related
- 1996-11-15 JP JP51985097A patent/JP3887020B2/ja not_active Expired - Fee Related
- 1996-11-15 DE DE69636795T patent/DE69636795D1/de not_active Expired - Lifetime
- 1996-11-15 AT AT96940538T patent/ATE349420T1/de not_active IP Right Cessation
1997
- 1997-09-04 US US08/944,042 patent/US6083988A/en not_active Expired - Lifetime
1998
- 1998-05-28 US US09/085,170 patent/US6197825B1/en not_active Expired - Lifetime
2000
- 2000-02-08 US US09/500,228 patent/US6291702B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP3887020B2 (ja)	2007-02-28
EP0888290A4 (de)	2004-08-18
WO1997019054A1 (en)	1997-05-29
US6083988A (en)	2000-07-04
US6197825B1 (en)	2001-03-06
US6291702B1 (en)	2001-09-18
AU7739796A (en)	1997-06-11
EP0888290B1 (de)	2006-12-27
JP2000501081A (ja)	2000-02-02
EP0888290A1 (de)	1999-01-07
CA2235765C (en)	2006-04-04
DE69636795D1 (de)	2007-02-08
CA2235765A1 (en)	1997-05-29

Legal Events

Date	Code	Title	Description
2007-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69636795D1 (de)	2007-02-08	Azulenylnitrone als radikal fanger (spin trapping agents), verfahren zu ihrer herstellung und ihre anwendung
DE69832209D1 (de)	2005-12-08	Verfahren zur Herstellung von 3,3-Dimethylbutyraldehyd durch Oxidation von 3,3-Dimethylbutanol
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