ATE349460T1 - Rückfaltung von protein-aggregaten und einschlussteilchen durch hohen druck - Google Patents

Rückfaltung von protein-aggregaten und einschlussteilchen durch hohen druck

Info

Publication number
ATE349460T1
ATE349460T1 AT99933769T AT99933769T ATE349460T1 AT E349460 T1 ATE349460 T1 AT E349460T1 AT 99933769 T AT99933769 T AT 99933769T AT 99933769 T AT99933769 T AT 99933769T AT E349460 T1 ATE349460 T1 AT E349460T1
Authority
AT
Austria
Prior art keywords
refolding
kbar
solution
aggregates
protein
Prior art date
Application number
AT99933769T
Other languages
English (en)
Inventor
Theodore W Randolph
John F Carpenter
John Richard St
Original Assignee
Barofold Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22232166&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE349460(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Barofold Inc filed Critical Barofold Inc
Application granted granted Critical
Publication of ATE349460T1 publication Critical patent/ATE349460T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Peptides Or Proteins (AREA)
AT99933769T 1998-07-09 1999-07-09 Rückfaltung von protein-aggregaten und einschlussteilchen durch hohen druck ATE349460T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9220898P 1998-07-09 1998-07-09

Publications (1)

Publication Number Publication Date
ATE349460T1 true ATE349460T1 (de) 2007-01-15

Family

ID=22232166

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99933769T ATE349460T1 (de) 1998-07-09 1999-07-09 Rückfaltung von protein-aggregaten und einschlussteilchen durch hohen druck

Country Status (7)

Country Link
US (5) US6489450B2 (de)
EP (1) EP1095056B1 (de)
AT (1) ATE349460T1 (de)
AU (1) AU4975699A (de)
DE (1) DE69934585T2 (de)
DK (1) DK1095056T3 (de)
WO (1) WO2000002901A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1095056B1 (de) * 1998-07-09 2006-12-27 BaroFold, Inc. Rückfaltung von protein-aggregaten und einschlussteilchen durch hohen druck
US6395538B1 (en) * 1999-07-16 2002-05-28 Human Genome Sciences, Inc. Method and system for providing real-time, in situ biomanufacturing process monitoring and control in response to IR spectroscopy
US7615617B2 (en) * 1999-10-25 2009-11-10 University Of Delaware Use of hydrostatic pressure to inhibit and reverse protein aggregation and facilitate protein refolding
CA2434045A1 (en) * 2000-10-31 2002-08-15 The Regents Of The University Of Colorado, A Body Corporate Improved protein disaggregation and refolding using high pressure
WO2007008697A2 (en) 2005-07-08 2007-01-18 University Of Chicago Compositions and methods for refolding of denatured proteins
US20070141341A1 (en) * 2005-12-15 2007-06-21 Dewald Aaron Coating containing denatured aloe vera, for covering either chlorine-generating compositions or other hazardous chemicals and method for making
GB0605684D0 (en) * 2006-03-21 2006-05-03 Sicor Biotech Uab Method For Purifying Granulocyte-Colony Stimulating Factor
CA2663416A1 (en) * 2006-09-15 2008-03-20 Barofold, Inc. High pressure treatment of proteins for reduced immunogenicity
WO2008033555A2 (en) * 2006-09-15 2008-03-20 Barofold, Inc. High-pressure refolding of difficult-to-fold proteins
WO2008124134A2 (en) * 2007-04-05 2008-10-16 Barofold, Inc. High-pressure refolding of proteins in the presence of binding partners
WO2008124139A1 (en) * 2007-04-05 2008-10-16 Barofold, Inc. High pressure inclusion body solubilization in the presence of a protease
CN106267902B (zh) * 2007-06-04 2019-08-20 高压生物科学公司 分子的压力提高的提取和分配
EP2205622A1 (de) * 2007-09-10 2010-07-14 BaroFold, Inc. Umfaltung monoklonaler antikörperaggregate unter hohem druck
EP2207890A4 (de) * 2007-10-05 2010-12-15 Barofold Inc Hochdruckbehandlung aggregierter interferone
AU2009244213A1 (en) * 2008-05-07 2009-11-12 Pressure Biosciences Inc. Extraction of biomolecular complexes assisted by alternating hydrostatic pressure
WO2009155102A2 (en) * 2008-05-30 2009-12-23 Barofold, Inc. Method for derivatization of proteins using hydrostatic pressure
EP2600843B9 (de) 2010-07-19 2020-03-11 Pressure BioSciences, Inc. Therapeutische proteinzusammensetzungen mit reduzierter immunogenität und/oder verbesserter wirksamkeit
US9995661B2 (en) 2010-08-18 2018-06-12 Pressure Biosciences, Inc. Flow-through high hydrostatic pressure microfluidic sample preparation device and related methods therefor
EP2632594A1 (de) 2010-10-28 2013-09-04 Edmund Y. Ting System und verfahren zur unterdrucksetzung von mikroplatten
CA2857307A1 (en) * 2011-12-01 2013-06-06 Barofold, Inc. Methods and systems for protein refolding
HUP1200172A2 (en) 2012-03-19 2013-10-28 Richter Gedeon Nyrt Methods for refolding g-csf from inclusion bodies
HUP1200171A1 (hu) 2012-03-19 2013-09-30 Richter Gedeon Nyrt Módszerek polipeptidek elõállítására
EP2890393A2 (de) 2012-08-30 2015-07-08 Merial, Inc. Hyperbarische vorrichtung und verfahren zur herstellung inaktivierter impfstoffe sowie zur rückfaltung/solubilisierung rekombinanter proteine
ZA201501696B (en) 2012-08-30 2016-01-27 Merial Ltd Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins
WO2021050009A2 (en) * 2019-09-13 2021-03-18 National Science And Technology Development Agency Composition of renaturation buffer solution for dimeric proteins and method of renaturation dimeric proteins using the composition thereof
ES3040791T3 (en) 2020-12-18 2025-11-05 Richter Gedeon Nyrt Methods for the purification of refolded fc-peptide fusion protein
CN113683676A (zh) * 2021-08-27 2021-11-23 恒敬合创生物医药(上海)有限公司 一种环保的可逆的蛋白变性工艺

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US4234620A (en) 1978-12-26 1980-11-18 A. E. Staley Manufacturing Company Water-soluble vegetable protein aggregates
US4652630A (en) 1985-02-22 1987-03-24 Monsanto Company Method of somatotropin naturation
US4659568A (en) 1985-02-27 1987-04-21 American Cyanamid Company Process for solubilization, purification and characterization of protein from insoluble protein aggregates or complexes and compositions of matter therefrom
US4766224A (en) 1985-08-19 1988-08-23 International Minerals & Chemical Corp. Purification and activation of proteins from insoluble inclusion bodies
US4677196A (en) 1985-09-06 1987-06-30 International Minerals & Chemical Corp. Purification and activation of proteins from insoluble inclusion bodies
US5453363A (en) 1985-10-23 1995-09-26 Boehringer Mannheim Gmbh Process for the activation of t-PA or Ing after genetic expression in prokaryotes
US4929700A (en) 1987-04-16 1990-05-29 Cetus Corporation Production of purified, biologically active, bacterially produced recombinant human CSF-1
US5162507A (en) 1987-05-11 1992-11-10 Cetus Corporation Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
US4985544A (en) 1987-08-04 1991-01-15 Kyowa Hakko Kogyo Co., Ltd. Process for renaturing fish growth hormone
US4923967A (en) 1988-09-26 1990-05-08 Eli Lilly And Company Purification and refolding of recombinant proteins
DE3835350A1 (de) * 1988-10-17 1990-04-19 Boehringer Mannheim Gmbh Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern
US5064943A (en) 1988-12-16 1991-11-12 American Cyanamid Company Method for solubilization and naturation of somatotropin
GB8927008D0 (en) 1989-11-29 1990-01-17 Ciba Geigy Novel process for the production of unfused protein in e.coli
US5109117A (en) 1990-06-26 1992-04-28 Monsanto Company Method of somatotropin naturation using urea and a soluble organic alcohol
US5023323A (en) 1990-09-12 1991-06-11 Monsanto Company Method of somatotropin naturation
US5288931A (en) 1991-12-06 1994-02-22 Genentech, Inc. Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
US5288462A (en) 1992-05-18 1994-02-22 Stephen D. Carter Sterilization apparatus and method
AU679920B2 (en) * 1992-06-29 1997-07-17 United Technologies Corporation Beneficial use of energy-containing wastes
US5605691A (en) 1992-09-17 1997-02-25 Ophidian Pharmaceuticals, Inc. Immunologically active proteins from inclusion bodies
US5714371A (en) 1995-05-12 1998-02-03 Schering Corporation Method for refolding insoluble aggregates of hepatitis C virus protease
US5728804A (en) 1995-06-02 1998-03-17 Research Corporation Technologies, Inc. Use of cyclodextrins for protein renaturation
US5800811A (en) * 1995-06-06 1998-09-01 Hall; Frederick L. Artificial skin prepared from coclagen matrix containing transforming growth factor-β having a collagen binding site
PT924991E (pt) * 1996-07-02 2002-02-28 Bbi Bioseq Inc Ligacao mediada por pressao de complexos biomoleculares
EP1095056B1 (de) 1998-07-09 2006-12-27 BaroFold, Inc. Rückfaltung von protein-aggregaten und einschlussteilchen durch hohen druck
US7615617B2 (en) 1999-10-25 2009-11-10 University Of Delaware Use of hydrostatic pressure to inhibit and reverse protein aggregation and facilitate protein refolding
CA2434045A1 (en) 2000-10-31 2002-08-15 The Regents Of The University Of Colorado, A Body Corporate Improved protein disaggregation and refolding using high pressure

Also Published As

Publication number Publication date
EP1095056B1 (de) 2006-12-27
US20100255536A1 (en) 2010-10-07
WO2000002901A1 (en) 2000-01-20
US7767795B2 (en) 2010-08-03
EP1095056A1 (de) 2001-05-02
US7064192B2 (en) 2006-06-20
AU4975699A (en) 2000-02-01
US20020137157A1 (en) 2002-09-26
DK1095056T3 (da) 2007-04-23
US20110046357A1 (en) 2011-02-24
US6489450B2 (en) 2002-12-03
US20060188970A1 (en) 2006-08-24
DE69934585D1 (de) 2007-02-08
US8710197B2 (en) 2014-04-29
US20030083475A1 (en) 2003-05-01
DE69934585T2 (de) 2007-10-25

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