ATE350470T1 - Durch thrombin spaltbare chimäre proteine - Google Patents

Durch thrombin spaltbare chimäre proteine

Info

Publication number: ATE350470T1
Authority: AT; Austria
Prior art keywords: chimeric proteins; thrombin; clipable; fibrinopeptide; zymogen
Prior art date: 2001-10-19

Application number

AT02801919T

Other languages

English (en)

Inventor

Bonniec Bernard Le

Pierre-Emmanuel Marque

Virginie Louvain

Claire Calmel

Elsa Bianchini

Martine Aiach

Original Assignee

Inst Nat Sante Rech Med

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-19

Filing date

2002-10-18

Publication date

2007-01-15

2002-10-18 Application filed by Inst Nat Sante Rech Med filed Critical Inst Nat Sante Rech Med

2007-01-15 Application granted granted Critical

2007-01-15 Publication of ATE350470T1 publication Critical patent/ATE350470T1/de

Links

102000037865 fusion proteins Human genes 0.000 title abstract 3
108020001507 fusion proteins Proteins 0.000 title abstract 3
108090000190 Thrombin Proteins 0.000 title abstract 2
229960004072 thrombin Drugs 0.000 title abstract 2
JWICNZAGYSIBAR-LEEGLKINSA-N (4s)-4-[[2-[[(2s)-2-[[(2s)-2-[[(2s)-2-aminopropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]-5-[[2-[[(2s)-3-carboxy-1-[[(2s)-1-[[1-[[(2s)-1-[[(2s)-4-carboxy-1-[[2-[[2-[[2-[[(2s)-1-[[(1s)-1-carboxy-4-(diaminomethylideneamino Chemical group NC(N)=NCCC[C@@H](C(O)=O)NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)C(CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)N)CC1=CC=CC=C1 JWICNZAGYSIBAR-LEEGLKINSA-N 0.000 abstract 2
101800001401 Activation peptide Proteins 0.000 abstract 2
102400000069 Activation peptide Human genes 0.000 abstract 2
102000010911 Enzyme Precursors Human genes 0.000 abstract 2
108010062466 Enzyme Precursors Proteins 0.000 abstract 2
101800000974 Fibrinopeptide A Proteins 0.000 abstract 2
102400000525 Fibrinopeptide A Human genes 0.000 abstract 2
108010022999 Serine Proteases Proteins 0.000 abstract 1
102000012479 Serine Proteases Human genes 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
238000003776 cleavage reaction Methods 0.000 abstract 1
239000002350 fibrinopeptide Substances 0.000 abstract 1
230000007017 scission Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Medicinal Chemistry (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biotechnology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Microbiology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Enzymes And Modification Thereof (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

AT02801919T 2001-10-19 2002-10-18 Durch thrombin spaltbare chimäre proteine ATE350470T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0113492A FR2831170B1 (fr)	2001-10-19	2001-10-19	Proteines c modifiees activables directement par la thrombine

Publications (1)

Publication Number	Publication Date
ATE350470T1 true ATE350470T1 (de)	2007-01-15

Family

ID=8868473

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02801919T ATE350470T1 (de)	2001-10-19	2002-10-18	Durch thrombin spaltbare chimäre proteine

Country Status (10)

Country	Link
US (1)	US7589178B2 (de)
EP (1)	EP1436389B1 (de)
JP (1)	JP4355924B2 (de)
AT (1)	ATE350470T1 (de)
AU (1)	AU2002357479B2 (de)
CA (1)	CA2463772C (de)
DE (1)	DE60217377T2 (de)
ES (1)	ES2279010T3 (de)
FR (1)	FR2831170B1 (de)
WO (1)	WO2003035861A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI353991B (en)	2003-05-06	2011-12-11	Syntonix Pharmaceuticals Inc	Immunoglobulin chimeric monomer-dimer hybrids
CA2527361A1 (en) *	2003-06-11	2004-12-23	Schering Aktiengesellschaft	Novel modified corin molecules having substitute activation sequences and uses thereof
WO2004113385A1 (en) *	2003-06-20	2004-12-29	Maxygen Holdings Ltd.	Protein c propeptide variants
WO2006018204A1 (en) *	2004-08-17	2006-02-23	Zlb Behring Gmbh	Modified vitamin k dependent polypeptides
US7585943B2 (en) *	2005-04-20	2009-09-08	Viromed Co., Ltd.	Compositions and methods for fusion protein separation
EP1728798A1 (de)	2005-06-01	2006-12-06	ZLB Behring GmbH	Blutgerinnungsfaktor X Polypeptide mit veränderten Aktivierungseigenschaften
WO2007015782A1 (en) *	2005-07-29	2007-02-08	Ecole Polytechnique Federale De Lausanne	Molecular variant fibrinogen fusion proteins
MX2008006313A (es) *	2005-11-15	2008-11-06	Philadelphia Children Hospital	Metodos y composiciones para modular la hemostasia.
EP1820508A1 (de) *	2006-02-21	2007-08-22	CSL Behring GmbH	Polypeptide des Gerinnfaktors X mit geänderten Aktivierungseigenschaften
JP5833448B2 (ja) *	2008-12-19	2015-12-16	アンスティチュナショナルドゥラサンテエドゥラルシェルシュメディカル	セリンプロテアーゼ誘導体および血液凝固疾患の予防または処置における使用
EP2199387A1 (de)	2008-12-19	2010-06-23	INSERM (Institut National de la Santé et de la Recherche Médicale)	Serinproteasederivate und deren Verwendung zur Vorbeugung und/oder Behandlung von Blutgerinnungsstörungen
TW201217527A (en)	2010-07-09	2012-05-01	Biogen Idec Hemophilia Inc	Processable single chain molecules and polypeptides made using same
US9486507B2 (en)	2011-06-10	2016-11-08	Biogen Ma Inc.	Pro-coagulant compounds and methods of use thereof
US8900822B2 (en)	2011-11-21	2014-12-02	Ethicon, Inc.	Fibrinogen assay
US20130309753A1 (en) *	2012-05-16	2013-11-21	Saint Louis University	Recombinant auto-activating protease precursors
CA2875247A1 (en)	2012-06-08	2013-12-12	Biogen Idec Ma Inc.	Chimeric clotting factors
WO2013185113A1 (en) *	2012-06-08	2013-12-12	Biogen Idec Ma Inc.	Procoagulant compounds
WO2014018120A1 (en)	2012-07-25	2014-01-30	Catalyst Biosciences, Inc.	Modified factor x polypeptides and uses thereof
ES2761730T3 (es)	2013-01-31	2020-05-20	Pfizer	Composiciones y procedimientos para contrarrestar la inhibición del factor Xa
FR3001729B1 (fr) *	2013-02-04	2015-03-06	Lab Francais Du Fractionnement	Mutants du facteur x
US9789209B2 (en)	2013-03-14	2017-10-17	The Regents Of The University Of California, Berke	Activatable membrane-interacting peptides and methods of use
WO2014144549A1 (en)	2013-03-15	2014-09-18	Biogen Idec Ma Inc.	Factor ix polypeptide formulations
EP2796145B1 (de)	2013-04-22	2017-11-01	CSL Ltd.	Ein kovalenter komplex bestehend aus von willebrand und faktor viii verbunden mit einer disulfidbrücke
EP3049434A1 (de)	2013-09-24	2016-08-03	Pfizer Inc.	Zusammensetzungen mit heterogenen populationen aus rekombinanten menschlichen proteinen mit dem gerinnungsfaktor xa
EP3065769A4 (de)	2013-11-08	2017-05-31	Biogen MA Inc.	Prokoagulatorische fusionsverbindung

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4992373A (en) *	1987-12-04	1991-02-12	Eli Lilly And Company	Vectors and compounds for direct expression of activated human protein C
US5851983A (en) *	1987-12-28	1998-12-22	Teijin Limited	Elastase inhibitory polypeptide and process for production thereof by recombinant gene technology
US5196404B1 (en) *	1989-08-18	1996-09-10	Biogen Inc	Inhibitors of thrombin
GB8927722D0 (en) *	1989-12-07	1990-02-07	British Bio Technology	Proteins and nucleic acids
US5589571A (en) *	1994-10-28	1996-12-31	Cor Therapeutics, Inc.	Process for production of inhibited forms of activated blood factors
AT405516B (de)	1997-02-27	1999-09-27	Immuno Ag	Faktor x-analoge mit modifizierter proteasespaltstelle
US6232456B1 (en) *	1997-10-06	2001-05-15	Abbott Laboratories	Serine protease reagents and methods useful for detecting and treating diseases of the prostate
FR2841904B1 (fr)	2002-07-03	2004-08-20	Inst Nat Sante Rech Med	Analogues de facteurs x clivables par la thrombine

2001
- 2001-10-19 FR FR0113492A patent/FR2831170B1/fr not_active Expired - Fee Related
2002
- 2002-10-18 WO PCT/EP2002/012191 patent/WO2003035861A2/en not_active Ceased
- 2002-10-18 AU AU2002357479A patent/AU2002357479B2/en not_active Ceased
- 2002-10-18 EP EP02801919A patent/EP1436389B1/de not_active Expired - Lifetime
- 2002-10-18 ES ES02801919T patent/ES2279010T3/es not_active Expired - Lifetime
- 2002-10-18 DE DE60217377T patent/DE60217377T2/de not_active Expired - Lifetime
- 2002-10-18 AT AT02801919T patent/ATE350470T1/de not_active IP Right Cessation
- 2002-10-18 JP JP2003538362A patent/JP4355924B2/ja not_active Expired - Fee Related
- 2002-10-18 US US10/492,191 patent/US7589178B2/en not_active Expired - Fee Related
- 2002-10-18 CA CA2463772A patent/CA2463772C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US7589178B2 (en)	2009-09-15
EP1436389B1 (de)	2007-01-03
AU2002357479B2 (en)	2008-03-06
US20050202527A1 (en)	2005-09-15
WO2003035861A3 (en)	2003-09-18
WO2003035861A2 (en)	2003-05-01
EP1436389A2 (de)	2004-07-14
DE60217377D1 (en)	2007-02-15
JP4355924B2 (ja)	2009-11-04
CA2463772C (en)	2014-07-29
DE60217377T2 (de)	2007-10-18
ES2279010T3 (es)	2007-08-16
FR2831170B1 (fr)	2004-03-19
CA2463772A1 (en)	2003-05-01
JP2005506086A (ja)	2005-03-03
FR2831170A1 (fr)	2003-04-25

Legal Events

Date	Code	Title	Description
2007-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE350470T1 (de)	2007-01-15	Durch thrombin spaltbare chimäre proteine
Gomis-Rüth et al.	2012	Functional and structural insights into astacin metallopeptidases
ATE496123T1 (de)	2011-02-15	Nukleinsäuren, welche für tramsmembran serin proteasen kodieren, die kodierten proteine und darauf basierende methoden
WO2007031559A3 (en)	2007-11-08	Human coagulation factor vii polypeptides
UA95438C2 (ru)	2011-08-10	Биспецифические антитела, которые замещают функциональные белки
IL217488A (en)	2014-02-27	Mt – sp1 polypeptides with specific or variable activity to the substrate with preparations and uses based on these polypeptides
DE69637307D1 (de)	2007-12-13	Aus d-aminosäuren abgeleitete cystein- und serinproteasehemmer
ATE317005T1 (de)	2006-02-15	Alkaline-phosphatase-defiziente, filamentöse pilze
DE60134230D1 (de)	2008-07-10	Substraten und nachweise zur wirksamkeit von beta-secretase
WO2001004146A3 (en)	2001-08-02	Ecarin polypeptides, polynucleotides encoding ecarin, and methods for use thereof
WO2005124341A3 (en)	2007-03-01	Stable isotope labeled polypeptide standards for protein quantitation
ATE457352T1 (de)	2010-02-15	Subtilisin-carlsberg-proteine mit verminderter immunogenität
Plaimauer et al.	2001	‘Shed’furin: mapping of the cleavage determinants and identification of its C-terminus
DE50204952D1 (de)	2005-12-22	Verfahren zur herstellung von rekombinantem trypsin
MY148447A (en)	2013-04-30	Method for amidating polypeptides with basic aminoacid d-terminals by means of specific endoproteases
MX2018009216A (es)	2018-11-09	Metodo para producir un hidrolizado de proteina empleando una tripeptidil peptidasa de aspergillus fumigatus.
Friedrich et al.	2005	Digestive versus regulatory proteases: on calpain action in vivo.
ATE493497T1 (de)	2011-01-15	Verfahren zur herstellung von oligopeptiden
EA200701778A1 (ru)	2008-02-28	Понижающие кровяное давление пептиды из гликомакропептида
EP2014676A4 (de)	2009-06-03	Mutante des hgf-precursor-proteins und aktivierte form davon
ATE394411T1 (de)	2008-05-15	Verfahren zur synthese und selektiven biokatalytischen modifizierung von peptiden, peptidmimetika und proteinen
WO2002093177A3 (en)	2003-02-06	Assays for identifying modulators of rhomboid polypeptides
Nicolaisen et al.	1992	Generation of Gla‐domainless FVIIa by cathepsin G‐mediated cleavage
BRPI0513267A (pt)	2008-05-06	variantes melhoradas de aprotinina
Vatandoost et al.	2016	The effects of influencing factors on γ-carboxylation and expression of recombinant vitamin K dependent coagulation factors