ATE353649T1 - Substituierte 4-phenyl-4-(1h-imidazol-2-yl)- piperidinderivate und deren verwendung als selektive nicht-peptidische delta-opioid- agonisten mit antidepressiver und angstlösender aktivität - Google Patents

Substituierte 4-phenyl-4-(1h-imidazol-2-yl)- piperidinderivate und deren verwendung als selektive nicht-peptidische delta-opioid- agonisten mit antidepressiver und angstlösender aktivität

Info

Publication number
ATE353649T1
ATE353649T1 AT04726520T AT04726520T ATE353649T1 AT E353649 T1 ATE353649 T1 AT E353649T1 AT 04726520 T AT04726520 T AT 04726520T AT 04726520 T AT04726520 T AT 04726520T AT E353649 T1 ATE353649 T1 AT E353649T1
Authority
AT
Austria
Prior art keywords
anxiology
antidepressant
imidazole
phenyl
substituted
Prior art date
Application number
AT04726520T
Other languages
English (en)
Inventor
Thomas Horst Wolfgang Steckler
Frans Eduard Janssen Janssens
Joseph Elisabeth Leenaerts
Francisco J Fernandez-Gadea
Antonio Gomez-Sanchez
Theo Frans Meert
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE353649T1 publication Critical patent/ATE353649T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT04726520T 2003-04-11 2004-04-08 Substituierte 4-phenyl-4-(1h-imidazol-2-yl)- piperidinderivate und deren verwendung als selektive nicht-peptidische delta-opioid- agonisten mit antidepressiver und angstlösender aktivität ATE353649T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP0303879 2003-04-11

Publications (1)

Publication Number Publication Date
ATE353649T1 true ATE353649T1 (de) 2007-03-15

Family

ID=33154992

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04726520T ATE353649T1 (de) 2003-04-11 2004-04-08 Substituierte 4-phenyl-4-(1h-imidazol-2-yl)- piperidinderivate und deren verwendung als selektive nicht-peptidische delta-opioid- agonisten mit antidepressiver und angstlösender aktivität

Country Status (12)

Country Link
US (1) US20060287345A1 (de)
EP (1) EP1615644B1 (de)
JP (1) JP2006522775A (de)
AR (1) AR044010A1 (de)
AT (1) ATE353649T1 (de)
AU (1) AU2004228960A1 (de)
CA (1) CA2521186A1 (de)
CL (1) CL2004000754A1 (de)
DE (1) DE602004004771T2 (de)
ES (1) ES2282858T3 (de)
TW (1) TW200509913A (de)
WO (1) WO2004089372A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1390848B1 (it) 2008-07-31 2011-10-19 Neuroscienze Pharmaness S C A R L Composti farmaceutici
EP2149370A1 (de) 2008-07-31 2010-02-03 Neuroscienze Pharmaness S.C. A R.L. Diazabizyclischen Verbindungen und Mikroemulsionen, dieselben enthaltend
JP2011030565A (ja) * 2009-07-06 2011-02-17 Yokohama City Univ 社会的隔離モデル動物
IT1396951B1 (it) 2009-12-18 2012-12-20 Neuroscienze Pharmaness S C A R L Composti farmaceutici
ES2770978T3 (es) * 2013-05-24 2020-07-06 Alkermes Pharma Ireland Ltd Análogos de morfanos y morfinanos y métodos de uso
RU2762567C2 (ru) 2015-03-17 2021-12-21 Ниппон Кемифар Ко., Лтд. Производное морфинана
JPWO2018030382A1 (ja) 2016-08-09 2019-06-13 日本ケミファ株式会社 モルヒナン誘導体
JP6840155B6 (ja) 2016-09-16 2025-06-17 日本ケミファ株式会社 モルヒナン誘導体のオピオイドδ受容体アゴニスト関連疾患の治療のための使用
JOP20200272A1 (ar) 2018-05-01 2020-11-01 Merck Sharp & Dohme مُعدّلات تفارغية سبيروبيريدين لمستقبلات أستيل كولين نيكوتينية
AU2020385852A1 (en) 2019-11-22 2022-06-02 Nippon Chemiphar Co., Ltd. Pyrazolomorphinan derivative
WO2022181763A1 (ja) 2021-02-26 2022-09-01 学校法人東京理科大学 ストレス関連障害の治療又は予防用医薬組成物
JP2024511169A (ja) * 2021-03-26 2024-03-12 ピーエックス・アイエヌジー，エルエルシー 運動誘発性精神疲労を低減するためのパラキサンチンの使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5354863A (en) * 1992-01-21 1994-10-11 G. D. Searle & Co. Opioid agonist compounds
DE19805370A1 (de) * 1997-03-14 1998-09-17 Gruenenthal Gmbh Substituierte Aminoverbindungen und ihre Verwendung als analgetisch wirksame Substanzen
HN1999000149A (es) * 1998-09-09 2000-01-12 Pfizer Prod Inc Derivados de 4,4-biarilpiperidina
EP1038872A1 (de) * 1999-02-22 2000-09-27 Pfizer Products Inc. 4-Phenyl-4-heteroarylpiperdine Derivate als Opioid-Rezeptorligande
DE19939044A1 (de) * 1999-08-18 2001-03-15 Gruenenthal Gmbh Verwendung von Morphinanderivaten als Arzneimittel
SE0101767D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
CA2462374C (en) * 2001-10-15 2011-01-18 Janssen Pharmaceutica N.V. Substituted 4-phenyl-4-(1h-imidazol-2-yl)-piperidine derivatives for reducing ischaemic damage
JP4417108B2 (ja) * 2001-10-15 2010-02-17 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 新規な置換された４−フェニル−４−［１ｈ−イミダゾール−２−イル］−ピペリジン誘導体および選択的非ペプチドデルタオピオイドアゴニストとしてのそれらの使用

Also Published As

Publication number Publication date
DE602004004771D1 (de) 2007-03-29
EP1615644B1 (de) 2007-02-14
CL2004000754A1 (es) 2005-02-25
AR044010A1 (es) 2005-08-24
WO2004089372A1 (en) 2004-10-21
US20060287345A1 (en) 2006-12-21
EP1615644A1 (de) 2006-01-18
JP2006522775A (ja) 2006-10-05
ES2282858T3 (es) 2007-10-16
CA2521186A1 (en) 2004-10-21
DE602004004771T2 (de) 2007-12-06
TW200509913A (en) 2005-03-16
AU2004228960A1 (en) 2004-10-21

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