ATE353915T1 - Methoden für die konstruktion und screening von chemokine varianten - Google Patents

Methoden für die konstruktion und screening von chemokine varianten

Info

Publication number
ATE353915T1
ATE353915T1 AT02777276T AT02777276T ATE353915T1 AT E353915 T1 ATE353915 T1 AT E353915T1 AT 02777276 T AT02777276 T AT 02777276T AT 02777276 T AT02777276 T AT 02777276T AT E353915 T1 ATE353915 T1 AT E353915T1
Authority
AT
Austria
Prior art keywords
screening
methods
chemokine
variants
construction
Prior art date
Application number
AT02777276T
Other languages
English (en)
Inventor
Guy Gorochov
Oliver Hartley
Karim Dorgham
Patrice Debre
Robin Offord
Original Assignee
Univ Paris Curie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Paris Curie filed Critical Univ Paris Curie
Application granted granted Critical
Publication of ATE353915T1 publication Critical patent/ATE353915T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • AIDS & HIV (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
AT02777276T 2001-09-05 2002-09-05 Methoden für die konstruktion und screening von chemokine varianten ATE353915T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/945,665 US20030049603A1 (en) 2001-09-05 2001-09-05 Methods for construction and screening of libraries of chemokine variants

Publications (1)

Publication Number Publication Date
ATE353915T1 true ATE353915T1 (de) 2007-03-15

Family

ID=25483398

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02777276T ATE353915T1 (de) 2001-09-05 2002-09-05 Methoden für die konstruktion und screening von chemokine varianten

Country Status (7)

Country Link
US (3) US20030049603A1 (de)
EP (1) EP1423423B1 (de)
AT (1) ATE353915T1 (de)
AU (1) AU2002338854A1 (de)
CA (1) CA2459367C (de)
DE (1) DE60218183T2 (de)
WO (1) WO2003022884A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030022159A1 (en) * 2001-02-06 2003-01-30 James A. Thomson Method for identifying intercellular protein factors
WO2005056581A2 (en) * 2003-12-10 2005-06-23 Universite De Lausanne Peptide able to specifically bind a chemokine receptor and use thereof
GB0614755D0 (en) * 2006-07-25 2006-09-06 Univ Geneve Cytokine derivatives
DE602008003757D1 (de) * 2007-02-23 2011-01-13 New England Biolabs Inc Auswahl und anreicherung von proteinen durch in-vitro-untergliederung
WO2019229615A1 (en) 2018-05-28 2019-12-05 Université De Genève Methods of inhibiting cerebral inflammation

Also Published As

Publication number Publication date
DE60218183D1 (de) 2007-03-29
US20040258659A1 (en) 2004-12-23
WO2003022884A3 (en) 2003-07-24
US20090075874A1 (en) 2009-03-19
WO2003022884A2 (en) 2003-03-20
US7915221B2 (en) 2011-03-29
CA2459367A1 (en) 2003-03-20
AU2002338854A1 (en) 2003-03-24
US7211564B2 (en) 2007-05-01
DE60218183T2 (de) 2007-10-31
EP1423423B1 (de) 2007-02-14
EP1423423A2 (de) 2004-06-02
CA2459367C (en) 2013-05-28
US20030049603A1 (en) 2003-03-13

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Legal Events

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