ATE353955T1 - Durch zelloberflächenmoleküle induzierte makrophagenaktivierung - Google Patents

Durch zelloberflächenmoleküle induzierte makrophagenaktivierung

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Publication number
ATE353955T1
ATE353955T1 AT99971035T AT99971035T ATE353955T1 AT E353955 T1 ATE353955 T1 AT E353955T1 AT 99971035 T AT99971035 T AT 99971035T AT 99971035 T AT99971035 T AT 99971035T AT E353955 T1 ATE353955 T1 AT E353955T1
Authority
AT
Austria
Prior art keywords
cell surface
macropage
surface molecules
activation induced
cell
Prior art date
Application number
AT99971035T
Other languages
English (en)
Inventor
Weng Tao
Shou Wong
William F Hickey
Joseph P Hammang
E Edward Baetge
Original Assignee
Neurotech Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurotech Sa filed Critical Neurotech Sa
Application granted granted Critical
Publication of ATE353955T1 publication Critical patent/ATE353955T1/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/06—Antipsoriatics
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    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
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    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/505—Cells of the immune system involving T-cells
    • G—PHYSICS
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
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    • A—HUMAN NECESSITIES
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    • A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

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  • General Physics & Mathematics (AREA)
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  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
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AT99971035T 1998-10-26 1999-10-21 Durch zelloberflächenmoleküle induzierte makrophagenaktivierung ATE353955T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/178,869 US6197294B1 (en) 1998-10-26 1998-10-26 Cell surface molecule-induced macrophage activation

Publications (1)

Publication Number Publication Date
ATE353955T1 true ATE353955T1 (de) 2007-03-15

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Application Number Title Priority Date Filing Date
AT99971035T ATE353955T1 (de) 1998-10-26 1999-10-21 Durch zelloberflächenmoleküle induzierte makrophagenaktivierung

Country Status (8)

Country Link
US (4) US6197294B1 (de)
EP (1) EP1124959B1 (de)
JP (1) JP4456275B2 (de)
AT (1) ATE353955T1 (de)
AU (1) AU775417B2 (de)
CA (1) CA2347928C (de)
DE (1) DE69935152T2 (de)
WO (1) WO2000024897A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197294B1 (en) * 1998-10-26 2001-03-06 Neurotech S.A. Cell surface molecule-induced macrophage activation
US6878543B1 (en) 1999-10-25 2005-04-12 Nsgene Sa Cultures of GFAP+ nestin+ cells that differentiate to neurons
EP1311549A2 (de) * 2000-08-22 2003-05-21 Micromet AG Zusammensetzung zur eliminierung autoreaktiver b-zellen
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US7829084B2 (en) * 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
KR100453877B1 (ko) * 2001-07-26 2004-10-20 메덱스젠 주식회사 연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 ＴＮＦＲ/Ｆｃ 융합 단백질, 상기 단백질을 코딩하는 ＤＮＡ, 상기 ＤＮＡ를 포함하는벡터, 및 상기 벡터에 의한 형질전환체
NZ537220A (en) 2002-05-16 2008-06-30 Absorber Ab Method of isolating an endothelial cell and method of donor specific crossmatching
US20040009528A1 (en) * 2002-07-11 2004-01-15 Shyh-Yu Shaw Protein chips
EP1447079A1 (de) * 2003-02-15 2004-08-18 Fraunhofer-Gesellschaft für angewandte Forschung e.V. Vesikel mit chimären Rezeptoren zur Induktion einer gerichteten T-Zellantwort in vivo
EP1407765A1 (de) * 2002-10-10 2004-04-14 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vesikel mit chimären Rezeptoren zur Induktion einer gerichteten T-Zellantwort in vivo
EP1620564A4 (de) * 2003-04-18 2008-03-12 Cytovia Inc Verfahren zur behandlung von auf apoptoseinduktion reagierenden krankheiten und screening-tests
EP1649000A4 (de) * 2003-06-30 2008-04-30 Lifescan Inc Aussetzen von pankreaszellen auf porösen matrizes
EP1660094A4 (de) 2003-08-26 2009-09-16 Univ Colorado Hemmer der serinprotease-aktivität und ihre verwendung bei verfahren und zusammensetzungen zur behandlung von bakterieninfektionen
ES2315842T3 (es) * 2004-01-19 2009-04-01 Nsgene A/S Celulas terapeuticas humanas que secretan factor de crecimiento nervioso.
KR100545720B1 (ko) * 2004-05-31 2006-01-24 메덱스젠 주식회사 당화된 면역글로불린 및 이를 포함하는 면역접합체
AU2005271452B2 (en) * 2004-08-03 2011-11-03 Vtv Therapeutics Llc RAGE fusion proteins and methods of use
ES2460517T3 (es) * 2005-07-25 2014-05-13 Emergent Product Development Seattle, Llc Reducción de células b mediante el uso de moléculas de unión específica a cd37 y de unión específica a cd20
AU2006308312A1 (en) * 2005-10-28 2007-05-03 Nsgene A/S Implantable Biocompatible Immunoisolatory Vehicle for Delivery of GDNF
EP1963786B1 (de) * 2005-12-23 2013-07-24 GCoder Systems AB Positionierungsmuster
AU2007215503A1 (en) * 2006-02-09 2007-08-23 Transtech Pharma, Inc. Rage fusion proteins and methods of use
WO2007130302A2 (en) 2006-05-05 2007-11-15 Transtech Pharma, Inc. Rage fusion proteins, formulations, and methods of use thereof
EP2418223A3 (de) * 2006-06-12 2013-01-16 Emergent Product Development Seattle, LLC Einkettige, multivalente Bindungsproteine mit Effektorfunktion
US8816106B2 (en) 2006-08-29 2014-08-26 Commonwealth Scientific And Industrial Research Organisation Synthesis of fatty acids
WO2008100470A2 (en) * 2007-02-15 2008-08-21 Transtech Pharma, Inc. Rage - immunoglobulin fusion proteins
CA2691819A1 (en) * 2007-07-06 2009-02-19 Trubion Pharmaceuticals, Inc. Binding peptides having a c-terminally disposed specific binding domain
PT2132228E (pt) * 2008-04-11 2011-10-11 Emergent Product Dev Seattle Imunoterapia de cd37 e sua combinação com um quimioterápico bifuncional
EP2389435B1 (de) 2009-01-23 2015-11-04 NsGene A/S Verbesserte zelllinien und ihre verwendung für verkapselte zell-bio-abgabe
EP2389191A2 (de) 2009-01-23 2011-11-30 NsGene A/S Expression von neuropeptiden in säugetierzellen
AU2010240569A1 (en) 2009-04-20 2011-10-20 Pfizer Inc. Control of protein glycosylation and compositions and methods relating thereto
NZ601743A (en) * 2010-02-12 2014-11-28 Oncomed Pharm Inc Methods for identifying and isolating cells expressing a polypeptide
CA2839917A1 (en) 2011-06-24 2012-12-27 The Regents Of The University Of Colorado, A Body Corporate Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
AU2013202648B2 (en) 2012-01-10 2016-05-19 Konkuk University Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
ES2713988T3 (es) 2012-08-01 2019-05-24 United Therapeutics Corp Tratamiento de hipertensión arterial pulmonar con células progenitoras endoteliales tratadas con prostaciclina
EP2879682B1 (de) 2012-08-01 2018-03-21 United Therapeutics Corporation Behandlung von pulmonal-arteriellem hochdruck mit mesenchymalen stammzellen
ES2963968T3 (es) 2013-01-09 2024-04-03 United Therapeutics Corp Tratamiento de la vasculopatía con prostaciclina y células madre mesenquimatosas
US20170007685A1 (en) * 2013-11-05 2017-01-12 The Board Of Regents Of The University Of Texas System TUMORS EXPRESSING IgG1 Fc INDUCE ROBUST CD8 T CELL RESPONSES
MX2018003292A (es) 2015-09-21 2018-08-01 Aptevo Res & Development Llc Polipéptidos de unión a cd3.
EP3534917B1 (de) 2016-10-24 2022-08-24 United Therapeutics Corporation Verbesserung der msc-immunmodulatorischen eigenschaften durch treprostinil

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2792610B2 (ja) 1989-04-03 1998-09-03 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ シクロデキストリンの区域選択的置換
AU2236395A (en) 1994-03-31 1995-10-23 Diacrin, Inc. Genetically modified cells for use in transplantation
CA2191891A1 (en) 1994-06-03 1995-12-14 Albert Edge Modified cells and methods for inhibiting hyperacute rejection of xenogeneic transplants
AU2828795A (en) 1994-06-17 1996-01-15 Alexion Pharmaceuticals, Inc. Monoclonal antibodies for the reduction of anti-xenogeneic immune responses
US5853717A (en) 1994-07-20 1998-12-29 Cytotherapeutics, Inc. Methods and compositions of growth control for cells encapsulated within bioartificial organs
CA2196311A1 (en) 1994-08-19 1996-02-29 David H. Sachs Genetically engineered swine cells
AU3409495A (en) 1994-08-26 1996-03-22 General Hospital Corporation, The Allogeneic and xenogeneic transplantation
US6204053B1 (en) 1994-11-08 2001-03-20 Diacrin, Inc. Porcine cortical cells and their use in treatment of neurological deficits due to neurodegenerative diseases
ATE277636T1 (de) 1995-01-13 2004-10-15 Quadra Logic Tech Inc Verfahren zur verhinderung von transplantatabstossung
AU721737B2 (en) 1995-09-27 2000-07-13 Bristol-Myers Squibb Company Method of inhibiting immune system destruction of transplanted viable cells
US6166288A (en) 1995-09-27 2000-12-26 Nextran Inc. Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor
US6197294B1 (en) * 1998-10-26 2001-03-06 Neurotech S.A. Cell surface molecule-induced macrophage activation

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DE69935152D1 (de) 2007-03-29
US20010046490A1 (en) 2001-11-29
WO2000024897B1 (en) 2000-07-13
JP2002528078A (ja) 2002-09-03
EP1124959B1 (de) 2007-02-14
JP4456275B2 (ja) 2010-04-28
AU1216900A (en) 2000-05-15
CA2347928A1 (en) 2000-05-04
AU775417B2 (en) 2004-07-29
WO2000024897A1 (en) 2000-05-04
CA2347928C (en) 2012-04-17
US20030120059A1 (en) 2003-06-26
US7189837B2 (en) 2007-03-13
US6197294B1 (en) 2001-03-06
DE69935152T2 (de) 2007-11-22
EP1124959A1 (de) 2001-08-22
US6506891B2 (en) 2003-01-14

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