ATE353955T1 - Durch zelloberflächenmoleküle induzierte makrophagenaktivierung - Google Patents
Durch zelloberflächenmoleküle induzierte makrophagenaktivierungInfo
- Publication number
- ATE353955T1 ATE353955T1 AT99971035T AT99971035T ATE353955T1 AT E353955 T1 ATE353955 T1 AT E353955T1 AT 99971035 T AT99971035 T AT 99971035T AT 99971035 T AT99971035 T AT 99971035T AT E353955 T1 ATE353955 T1 AT E353955T1
- Authority
- AT
- Austria
- Prior art keywords
- cell surface
- macropage
- surface molecules
- activation induced
- cell
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 title abstract 5
- 230000004913 activation Effects 0.000 title 1
- 239000002775 capsule Substances 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000003308 immunostimulating effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70582—CD71
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- C—CHEMISTRY; METALLURGY
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0006—Modification of the membrane of cells, e.g. cell decoration
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/5055—Cells of the immune system involving macrophages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0092—Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Wood Science & Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/178,869 US6197294B1 (en) | 1998-10-26 | 1998-10-26 | Cell surface molecule-induced macrophage activation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE353955T1 true ATE353955T1 (de) | 2007-03-15 |
Family
ID=22654240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99971035T ATE353955T1 (de) | 1998-10-26 | 1999-10-21 | Durch zelloberflächenmoleküle induzierte makrophagenaktivierung |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US6197294B1 (de) |
| EP (1) | EP1124959B1 (de) |
| JP (1) | JP4456275B2 (de) |
| AT (1) | ATE353955T1 (de) |
| AU (1) | AU775417B2 (de) |
| CA (1) | CA2347928C (de) |
| DE (1) | DE69935152T2 (de) |
| WO (1) | WO2000024897A1 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6197294B1 (en) * | 1998-10-26 | 2001-03-06 | Neurotech S.A. | Cell surface molecule-induced macrophage activation |
| US6878543B1 (en) | 1999-10-25 | 2005-04-12 | Nsgene Sa | Cultures of GFAP+ nestin+ cells that differentiate to neurons |
| WO2002016414A2 (en) * | 2000-08-22 | 2002-02-28 | Micromet Ag | Composition for the elimination of autoreactive b-cells |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US7829084B2 (en) * | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| KR100453877B1 (ko) | 2001-07-26 | 2004-10-20 | 메덱스젠 주식회사 | 연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 TNFR/Fc 융합 단백질, 상기 단백질을 코딩하는 DNA, 상기 DNA를 포함하는벡터, 및 상기 벡터에 의한 형질전환체 |
| US8173372B2 (en) | 2002-05-16 | 2012-05-08 | Absorber Ab | Methods of donor specific crossmatching |
| US20040009528A1 (en) * | 2002-07-11 | 2004-01-15 | Shyh-Yu Shaw | Protein chips |
| EP1407765A1 (de) * | 2002-10-10 | 2004-04-14 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Vesikel mit chimären Rezeptoren zur Induktion einer gerichteten T-Zellantwort in vivo |
| EP1447079A1 (de) * | 2003-02-15 | 2004-08-18 | Fraunhofer-Gesellschaft für angewandte Forschung e.V. | Vesikel mit chimären Rezeptoren zur Induktion einer gerichteten T-Zellantwort in vivo |
| WO2004094647A2 (en) * | 2003-04-18 | 2004-11-04 | Cytovia, Inc. | Methods of treating diseases responsive to induction of apoptosis and screening assays |
| EP1649000A4 (de) * | 2003-06-30 | 2008-04-30 | Lifescan Inc | Aussetzen von pankreaszellen auf porösen matrizes |
| PL2520654T3 (pl) | 2003-08-26 | 2017-08-31 | The Regents Of The University Of Colorado, A Body Corporate | Inhibitory aktywności proteazy serynowej i ich zastosowanie w sposobach i kompozycjach do leczenia zakażeń bakteryjnych |
| EP1709161B1 (de) * | 2004-01-19 | 2008-10-01 | Nsgene A/S | Nervenwachstumsfaktor sezernierende menschliche therapeutische zellen |
| KR100545720B1 (ko) * | 2004-05-31 | 2006-01-24 | 메덱스젠 주식회사 | 당화된 면역글로불린 및 이를 포함하는 면역접합체 |
| CN1993378A (zh) * | 2004-08-03 | 2007-07-04 | 转化技术制药公司 | Rage融合蛋白及使用方法 |
| EP2295080A3 (de) | 2005-07-25 | 2011-06-22 | Emergent Product Development Seattle, LLC | B-Zell-Verringerung mit CD37-spezifischen und CD20-spezifischen Bindungsmolekülen |
| EP1940471A1 (de) * | 2005-10-28 | 2008-07-09 | NsGene A/S | Implantierbares biokompatibles immunisolatorisches vehikel zur abgabe von gdnf |
| WO2007073272A1 (en) * | 2005-12-23 | 2007-06-28 | Gcoder Systems Ab | Positioning pattern |
| CN101410411A (zh) * | 2006-02-09 | 2009-04-15 | 转化技术制药公司 | Rage融合蛋白及使用方法 |
| BRPI0711193A2 (pt) | 2006-05-05 | 2013-06-18 | Transtech Pharma Inc | proteÍnas de fusço rage, formulaÇÕes e mÉtodos de uso dos mesmos |
| CN105837690A (zh) * | 2006-06-12 | 2016-08-10 | 新兴产品开发西雅图有限公司 | 具有效应功能的单链多价结合蛋白 |
| EP2059588A4 (de) | 2006-08-29 | 2010-07-28 | Commw Scient Ind Res Org | Fettsäuresynthese |
| US20080199467A1 (en) * | 2007-02-15 | 2008-08-21 | Mjalli Adnan M M | Immunoglobulin fusion proteins and methods of making |
| CN101990439A (zh) * | 2007-07-06 | 2011-03-23 | 特鲁比昂药品公司 | 具有置于c末端的特异性结合结构域的结合肽 |
| PT2132228E (pt) * | 2008-04-11 | 2011-10-11 | Emergent Product Dev Seattle | Imunoterapia de cd37 e sua combinação com um quimioterápico bifuncional |
| EP2389191A2 (de) | 2009-01-23 | 2011-11-30 | NsGene A/S | Expression von neuropeptiden in säugetierzellen |
| EP2389435B1 (de) | 2009-01-23 | 2015-11-04 | NsGene A/S | Verbesserte zelllinien und ihre verwendung für verkapselte zell-bio-abgabe |
| CN102803292A (zh) | 2009-04-20 | 2012-11-28 | 辉瑞公司 | 蛋白质糖基化的控制及其相关组合物和方法 |
| CA2789446A1 (en) | 2010-02-12 | 2011-08-18 | Oncomed Pharmaceuticals, Inc. | Methods for identifying and isolating cells expressing a polypeptide |
| KR20200044138A (ko) | 2011-06-24 | 2020-04-28 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 알파-1 안티트립신 융합 분자용 조성물, 방법 및 용도 |
| JP2015504675A (ja) | 2012-01-10 | 2015-02-16 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド,ア ボディー コーポレイトTHE REGENTS OF THE UNIVERSITY OF COLORADO,a body corporate | アルファ−1アンチトリプシン融合分子の組成物、方法、及び使用 |
| IN2015DN00934A (de) | 2012-08-01 | 2015-06-12 | United Therapeutics Corp | |
| ES2869701T3 (es) | 2012-08-01 | 2021-10-25 | United Therapeutics Corp | Tratamiento de hipertensión arterial pulmonar con células progenitoras endoteliales tratadas con prostaciclina |
| AU2014205557B2 (en) | 2013-01-09 | 2017-08-10 | United Therapeutics Corporation | Treatment of vasculopathy with prostacyclin and mesenchymal stem cells |
| WO2015069745A2 (en) * | 2013-11-05 | 2015-05-14 | The Board Of Regents Of The University Of Texas System | Tumors expressing igg1 fc induce robust cd8 cell responses |
| KR102784293B1 (ko) | 2015-09-21 | 2025-03-20 | 압테보 리서치 앤드 디벨롭먼트 엘엘씨 | Cd3 결합 폴리펩타이드 |
| US11571444B2 (en) | 2016-10-24 | 2023-02-07 | United Therapeutics Corporation | Enhancement of MSC immunomodulatory properties by treprostinil |
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| AU631628B2 (en) | 1989-04-03 | 1992-12-03 | Janssen Pharmaceutica N.V. | Regioselectively hydroxyalkylated cyclodextrins and process therefor |
| AU2236395A (en) | 1994-03-31 | 1995-10-23 | Diacrin, Inc. | Genetically modified cells for use in transplantation |
| WO1995033828A1 (en) | 1994-06-03 | 1995-12-14 | Diacrin, Inc. | Modified cells and methods for inhibiting hyperacute rejection of xenogeneic transplants |
| AU2828795A (en) | 1994-06-17 | 1996-01-15 | Alexion Pharmaceuticals, Inc. | Monoclonal antibodies for the reduction of anti-xenogeneic immune responses |
| US5853717A (en) | 1994-07-20 | 1998-12-29 | Cytotherapeutics, Inc. | Methods and compositions of growth control for cells encapsulated within bioartificial organs |
| WO1996006165A1 (en) | 1994-08-19 | 1996-02-29 | The General Hospital Corporation | Genetically engineered swine cells |
| AU3409495A (en) | 1994-08-26 | 1996-03-22 | General Hospital Corporation, The | Allogeneic and xenogeneic transplantation |
| US6204053B1 (en) | 1994-11-08 | 2001-03-20 | Diacrin, Inc. | Porcine cortical cells and their use in treatment of neurological deficits due to neurodegenerative diseases |
| EP0804238B1 (de) | 1995-01-13 | 2004-09-29 | QLT Inc. | Verfahren zur verhinderung von transplantatabstossung |
| WO1997011607A1 (en) | 1995-09-27 | 1997-04-03 | Emory University | Method of inhibiting immune system destruction of transplanted viable cells |
| US6166288A (en) | 1995-09-27 | 2000-12-26 | Nextran Inc. | Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor |
| US6197294B1 (en) * | 1998-10-26 | 2001-03-06 | Neurotech S.A. | Cell surface molecule-induced macrophage activation |
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- 1999-10-21 EP EP99971035A patent/EP1124959B1/de not_active Expired - Lifetime
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- 1999-10-21 JP JP2000578449A patent/JP4456275B2/ja not_active Expired - Fee Related
- 1999-10-21 CA CA2347928A patent/CA2347928C/en not_active Expired - Fee Related
- 1999-10-21 AT AT99971035T patent/ATE353955T1/de active
- 1999-10-21 AU AU12169/00A patent/AU775417B2/en not_active Ceased
- 1999-10-21 DE DE69935152T patent/DE69935152T2/de not_active Expired - Lifetime
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| US7189837B2 (en) | 2007-03-13 |
| US20030120059A1 (en) | 2003-06-26 |
| AU1216900A (en) | 2000-05-15 |
| US6197294B1 (en) | 2001-03-06 |
| WO2000024897B1 (en) | 2000-07-13 |
| EP1124959A1 (de) | 2001-08-22 |
| WO2000024897A1 (en) | 2000-05-04 |
| EP1124959B1 (de) | 2007-02-14 |
| DE69935152T2 (de) | 2007-11-22 |
| CA2347928A1 (en) | 2000-05-04 |
| US20010046490A1 (en) | 2001-11-29 |
| AU775417B2 (en) | 2004-07-29 |
| US6225448B1 (en) | 2001-05-01 |
| CA2347928C (en) | 2012-04-17 |
| JP2002528078A (ja) | 2002-09-03 |
| DE69935152D1 (de) | 2007-03-29 |
| US6506891B2 (en) | 2003-01-14 |
| JP4456275B2 (ja) | 2010-04-28 |
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